Doctor insights on:
Colon Cancer Chemo Necessary
Depends on stage: Chemotherapy is never used for stage 1 cancers (early). It is sometimes used in stage 2 cancers (early but more advanced than stage 1). Chemotherapy is definitely beneficial in stage 3 cancers (locally advanced) and in stage 4 cancers (distant spread). ...Read moreSee 2 more doctor answers
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
It depends ... : Dysphagia is a common side effect with many chemo therapeutic regimens. Some treatments can decrease a patient's ability to fight off fungal and bacterial overgrowth in the mouth and digestive systems. The diagnosis of this isn't usually difficult and can in many cases be treated with medications. ...Read moreSee 1 more doctor answer
So many variables: Too many variables to give you a pertinent answer. Consult your oncologist to help you with clinical decisions ...Read more
Depends: Believe it or not, it can sometimes still be cured. It depends on the disease burden in the liver. After resection, they can do adjuvant therapy and follow up with hepatic resections if it is limited. Also for palliative reasons - if it is causing an obstruction, then the obstruction needs to be relieved to allow for simple gut function. ...Read moreSee 1 more doctor answer
Pancreatic cancer, ampullary tumor. Whipple procedure. Spread to liver, not respectable. Chemo for 6 months and continuing. Prognosis?
Poor: While Whipple is the best approach for a primary pancreatic or ampullary lesion, the recurrence rate at 1-2 yrs is 90%. Chemo either of the FOLFIERI or Genciabine /Abraxane combo have limited effects on liver mets which in pancreas are not considered amenable to resection. There is an FDA protocol using specific monoclonals targeting pancreas that might be available but only after chemo failure ...Read more
Colon mets: Not having your chart and you in front of me makes it very hard to give you an accurate idea on prognosis. When chemo is started, that means your CA cells have gone beyond the boundaries which would have made txing it simple. The simpler the tx, the better the prgns. The harder the tx, the worse the prgns. On a positive note, f/u with your docs, stay faithful, and you might get a pleasant surprise ...Read more
Chemotherpay failed , irinotecan and oxyplatin in metastic colon cancer . Liver and peritoneal mets . Is there anything else ?
Sorry to: hear that. Discuss with your Oncologist what is the next step. Get family and spiritual support as well. Good luck ...Read more
Yes: Yes. Many people are cured with colon cancer. If found early surgery alone may be curable. If more advanced (eg, lymph node involvement or metastatic = spread to areas outside of colon), then chemotherapy may be needed. While less likely, even a few % of people with metastatic colon ca may be cured. ...Read moreSee 2 more doctor answers
Hepatocellular carcinoma.All spleen and partial liver resection.Later,secondary systemic cancer metastasis.any targeted therapy or immunotherapy?
Yes, for both: Hepatocellular Carcinoma is commonly treated with Sorafenib which is a type of targeted therapy. This is a good choice of treatment in case you have not yet received this drug. Immunotherapy using PD-1 inhibitors has also shown some modest evidence of benefit although it is not yet FDA approved for this indication. Ask your oncologist to guide your treatment further. ...Read more
Stage iii-b colon cancer removed surgically. Suspected liver lesion resected and analyzed with not malignancy. Is kras analysis needed for recurrence?
Possibly: For initial treatment after surgery, you shouldn't need to get kras testing. However, if this is metastatic or recurrent colon cancer, then it may help to determine if egfr based therapies like Cetuximab can help (they only work for kras "wild type"). Remember that if you do recur (god forbid), management may be different at that future time! not something to worry about with your current story. ...Read moreSee 1 more doctor answer
What kind of mets: it depends what kind of metastases we are talking about. if the spread to the lymph nodes, surgery and chemotherapy, and possible radiation therapy could be very helpful. if the spread to the liver the prognosis is less optimistic, unless the metastases are able to be resected. other metastases are less promising in spite of chemotherapy and radiation therapy .like bone and brain. ...Read moreSee 1 more doctor answer
Same drugs as other: Same chemotherapy drugs are used for treating both types of colon cancer. The only difference is lack of benefit from EGFR inhibitors(Cetuximab and Panitumumab). Avastin (bevacizumab) also works in both types. I trust that you know there are 3 chemo drugs that are widely used(5FU or Capecitabine, Irinotecan and Oxaliplatin) ...Read more
10 liver mets and a node in metastic colon cancer. Xeloda (capecitabine) irinitecan failed . Can anything be done ?
Yes: When colon Ca metastasizes to the liver it remains and progresses there with occasional node to porta. The first approach is to try chemoembolization after having an angiogram of the hepatic artery. This route can also be used for intrahepatic isotope administration. Systemically chemo plus avastin (bevacizumab) or Erbitux can be tried. New studies with Neo 102 are being offered in FDA trials . ...Read more
Some response: meds like Xeloda have some tempoary benefit suppressing DNA function as an oral 5FU (fluorouracil). Long term responses are not seen requiring combination therapy to give an optimjum response. Eventually if cancer does show a good response, malignant stem cells will repopulate the site of the original metastasis. ...Read more
Not often: Radiotherapy can be useful in certain select cases where the Cancer is localized to one or two spots only. This means 1 patient in 5 may be suitable candidate. But you need to seek consultation with a radiation oncologist before you can get a clear cut answer for your circumstances. ...Read moreSee 1 more doctor answer
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