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Doctor insights on: Clozaril

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Dr. Austina Cho
51 Doctors shared insights

Clozaril (Overview)

Clozaril is a serotonin-dopamine receptor blocker which is a kind of atypical anti-psychotic drug (drug for psychosis, psychiatric drug).


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Anyone out there taking clozapine (or clozaril)? What is it?

Anyone out there taking clozapine (or clozaril)? What is it?

Strong antipsychotic: Clozaril/clozapine is an effective antipsychotic medication with many cautions and potential side effects requiring regular blood tests. It can be effective for severe or difficult to treat schizophrenia. Given the potential side effects and requirement of blood tests, many doctors try other, safer medications or combinations first. ...Read more

Dr. Austina Cho
51 Doctors shared insights

Clozaril (Overview)

Clozaril is a serotonin-dopamine receptor blocker which is a kind of atypical anti-psychotic drug (drug for psychosis, psychiatric drug).


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Am under clozapine 100mg 3 times aday and verapamil once. Can you prescribe me something to lose wait need to lose at least 15 pds no hard exercise pls?

Am under clozapine 100mg 3 times aday and verapamil once. Can you prescribe me something to lose wait need to lose at least 15 pds no hard exercise pls?

No medications: Weight loss is a mathematical issue of portion sizes and caloric intake. An individual requires around 2000 calories a day to maintain his or her weight. If cut down caloric intake (less than 1600) and portion sizes (provided you do not have any other metabolic or hormonal disorder) you will loose weight. ...Read more

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Can clozaril (clozapine) be used to treat severe insmnia?

Overdo: In theory; but it s not indicated (off label) and hard to justify the risks involved (agranulocytosis, seizures, death) not to mention the monitoring required. It should not be an alternative. ...Read more

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Which anti psychotic drug is most effective for schizophrenia: clozapine or aripiprazole?

Which anti psychotic drug is most effective for schizophrenia: clozapine or aripiprazole?

Antipsychotics: Both are effective. The difference is the tolerability & side-effect profiles. ...Read more

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Clozaril (clozapine) long term side effect?

Clozaril (clozapine) long term side effect?

Has many.: There appear to be many side effects with this antipsychotic medication. Common ones are extreme constipation, bed-wetting, night-time drooling, muscle stiffness, sedation, tremors, orthostasis, hyperglycemia, and weight gain. Others are agranulocytosis, CNS depression, leukopenia, neutropenia, seizure disorder, bone marrow suppression, dementia, hypotension, and myocarditis. ...Read more

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I'm getting off clozapine cold turkey as I can't stand the side effects anymore. Drooling, nocturnal enuresis, delirium. What can I expect re w/d?

Back to prescriber.: Clozapine is a powerful antipsychotic medication which is often given as a 3rd resort because of the side-effects and the weekly blood tests that are required. The symptoms for which this drug was prescribed would come back such as auditory hallucinations, delusions and psychotic symptoms. You must go back to the doctor who prescribed the medicine so he/she can choose another medication ...Read more

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How can I get off clozaril (clozapine)?

Carefully: Clozaril (clozapine) is a very potent medication. If you are taking this be careful about discontinuing it. I would suggest you talk to your doctor about the advisability of stopping this medication. You may need to switch to a different medication. ...Read more

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Can clozaril (clozapine) be used to treat severe insmnia?

Overdo: In theory; but it s not indicated (off label) and hard to justify the risks involved (agranulocytosis, seizures, death) not to mention the monitoring required. It should not be an alternative. ...Read more

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Anyone out there taking clozapine (or clozaril)? What is it?

Strong antipsychotic: Clozaril/clozapine is an effective antipsychotic medication with many cautions and potential side effects requiring regular blood tests. It can be effective for severe or difficult to treat schizophrenia. Given the potential side effects and requirement of blood tests, many doctors try other, safer medications or combinations first. ...Read more

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Clozaril (clozapine) long term side effect?

Has many.: There appear to be many side effects with this antipsychotic medication. Common ones are extreme constipation, bed-wetting, night-time drooling, muscle stiffness, sedation, tremors, orthostasis, hyperglycemia, and weight gain. Others are agranulocytosis, CNS depression, leukopenia, neutropenia, seizure disorder, bone marrow suppression, dementia, hypotension, and myocarditis. ...Read more

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Clozapine (clozaril) 125mg and withdrawal, can you tell me more?

Rebound: Clozapine is a medication with outstanding features that help control symptoms other medications otherwise failed to control. It is very serious to stop the medication without careful planning & supervision by your treating physician. The most serious withdrawal consequence is a rebound of the symptoms being treated which may take a while to re control even with clozapine restarted. See ur Dr. ...Read more

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Is clozapine (clozaril) benzodiazepine?

Is clozapine (clozaril) benzodiazepine?

Dibenzodiazepine: Clozaril/clozapine is not a benzodiazepine like lorazepam/ativan or alprazolam/xanax. Its chemical structure is a dibenzodiazepine and it is a 2nd generation antipsychotic. ...Read more

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Haldol (haloperidol) and clozaril are examples of what?

Haldol (haloperidol) and clozaril are examples of what?

Antipsychotics: A group of medications called Neuroleptics / Antipsychotics ...Read more

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Can clozaril (clozapine) cause akathisia, restlessness?

Can clozaril (clozapine) cause akathisia, restlessness?

Can occur: These side effects would occur while taking Clozaril, but if you have stopped and instead suffer restless leg syndrome, would suggest checking iron metabolism, with ferritin level, and considering use of a dopamine agonist around the clock (suggest Neupro (rotigotine) patch). Talk to your doctor about these thoughts. ...Read more

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What is the definition or description of: Clozaril (clozapine) allergy?

What is the definition or description of: Clozaril (clozapine) allergy?

Clozaril allergy: Clozaril (clozapine) is an antipsychotic medication used for the treatment of schizophrenia. Allergic reactions could include swelling of tongue, throat, lips, mouth, face, hives or difficulty breathing. ...Read more

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Is clozapine (clozaril) good for bipolar?

Is clozapine (clozaril) good for bipolar?

Clozaril (clozapine): Is an atypical antipsychotic approved for use in treatment-resistant schizophrenia & is also used off-label to treat bipolar disorders. It is very effective as long as close monitoring of white blood cell count is done routinely. Some reported side-effects are seizures, myocarditis, agranulocytosis, diabetes, weight gain. It is not indicated if seizures, liver disease or low blood count. ...Read more

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Clozapine (clozaril) for good for bipolar?

Yes, however: Clozaril/clozapine is an effective antipsychotic medication with many cautions requiring regular blood tests. It can be effective for severe or difficult to treat bipolar disorder. Given the potential side effects and requirement of blood tests, many doctors try other, safer medications or combinations first. ...Read more

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What are the symptoms of a high white blood cell count resulting from clozaril (clozapine)?

What are the symptoms of a high white blood cell count resulting from clozaril (clozapine)?

Leukocytosis: Fever, bleeding or bruising, trouble breathing, pain or tingling, dizziness, trouble thinking, poor appetite, all depending on the cause. Also, can be asymptomatic. ...Read more

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Would clozaril be a good antipsychotic for paranoid schizophrenia I had in the past? Schiz in remission because of zyprexa (olanzapine) but don't like side effects

Would clozaril be a good antipsychotic for paranoid schizophrenia I had in the past? Schiz in remission because of zyprexa (olanzapine) but don't like side effects

Clozaril (clozapine): Is an atypical antipsychotic approved for use in treatment-resistant schizophrenia & is also used off-label to treat bipolar disorders. It is very effective as long as close monitoring of white blood cell count is done routinely. Some reported side-effects are seizures, myocarditis, agranulocytosis, diabetes, weight gain. It is not indicated if seizures, liver disease or low blood count. ...Read more

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I take 500mg of clozapine and haven't taken it for 5 days. How will this affect me?

Don't withdraw: You usually don't have withdrawl symptoms from these atypica antipsychotics. You will be fine, unless you have a relapse of the symptoms you were taking it for. ...Read more

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This is very embarrassing. But I seem to have been wetting my bed since I started clozapine. Is there a connection? Maybe a smaller dose?

This is very embarrassing. But I seem to have been wetting my bed since I started clozapine. Is there a connection? Maybe a smaller dose?

Yes, there could be: Clozapine is a helpful medication in certain cases of psychosis. Among its possible side effects, though, is urinary incontinence (1%-2% of patients). Other possibilities include seizures (3% of patients) which can also have urinary incontinence. Please tell your doctor about this -- it's important. Be well. ...Read more

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Should I go cold turkey off clozapine?

No: Coming off Clozapine should be done under medical supervision. ...Read more

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I am going cold turkey off clozapine, suggestions?

Yes: Don't do it. Please work with your prescribing provider to safely come off this medication. ...Read more

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Can you advise me on going cold turkey off clozapine?

Can you advise me on going cold turkey off clozapine?

Stopping Clonazepam: Depends upon the dose used. However, it is recommended that the medicine be weaned off as abrupt stoppage can lead to a seizure
spell. Check with your physician. ...Read more

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What could happen if I went cold turkey off clozapine?

Serious rebound: You can have a serious rebound of symptoms which may take long time to get under control again, Clozapine is the gold standard for addressing symptoms that didn't respond to other meds, so NEVER attempt to do that, ask your treating physician and work with him/her.
good luck and feel better ...Read more

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I was wondering what would happen if I went cold turkey off clozapine?

Shouldn't: You shouldn't, if you do, you end up with a rebound of symptoms that can sometimes be harder to treat. Consult with your prescriber ...Read more

Dr. Heidi Fowler
223 Doctors shared insights

Clozapine (Definition)

Clozapine is a serotonin-dopamine receptor blocker which is a kind of atypical anti-psychotic drug (drug ...Read more


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