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Doctor insights on: Clozaril

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Dr. Andrew Berry
50 Doctors shared insights

Clozaril (Overview)

Clozaril is a serotonin-dopamine receptor blocker which is a kind of atypical anti-psychotic drug (drug for psychosis, psychiatric drug).


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Anyone out there taking clozapine (or clozaril)? What is it?

Anyone out there taking clozapine (or clozaril)? What is it?

Strong antipsychotic: Clozaril/clozapine is an effective antipsychotic medication with many cautions and potential side effects requiring regular blood tests. It can be effective for severe or difficult to treat schizophrenia. Given the potential side effects and requirement of blood tests, many doctors try other, safer medications or combinations first.

Dr. Andrew Berry
50 Doctors shared insights

Clozaril (Overview)

Clozaril is a serotonin-dopamine receptor blocker which is a kind of atypical anti-psychotic drug (drug for psychosis, psychiatric drug).


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Am under clozapine 100mg 3 times aday and verapamil once. Can you prescribe me something to lose wait need to lose at least 15 pds no hard exercise pls?

Am under clozapine 100mg 3 times aday and verapamil once. Can you prescribe me something to lose wait need to lose at least 15 pds no hard exercise pls?

No medications: Weight loss is a mathematical issue of portion sizes and caloric intake. An individual requires around 2000 calories a day to maintain his or her weight. If cut down caloric intake (less than 1600) and portion sizes (provided you do not have any other metabolic or hormonal disorder) you will loose weight.

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Can clozaril (clozapine) be used to treat severe insmnia?

Overdo: In theory; but it s not indicated (off label) and hard to justify the risks involved (agranulocytosis, seizures, death) not to mention the monitoring required. It should not be an alternative.

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Which anti psychotic drug is most effective for schizophrenia: clozapine or aripiprazole?

Which anti psychotic drug is most effective for schizophrenia: clozapine or aripiprazole?

Antipsychotics: Both are effective. The difference is the tolerability & side-effect profiles.

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Clozaril (clozapine) long term side effect?

Clozaril (clozapine) long term side effect?

Has many.: There appear to be many side effects with this antipsychotic medication. Common ones are extreme constipation, bed-wetting, night-time drooling, muscle stiffness, sedation, tremors, orthostasis, hyperglycemia, and weight gain. Others are agranulocytosis, CNS depression, leukopenia, neutropenia, seizure disorder, bone marrow suppression, dementia, hypotension, and myocarditis.

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I'm getting off clozapine cold turkey as I can't stand the side effects anymore. Drooling, nocturnal enuresis, delirium. What can I expect re w/d?

Back to prescriber.: Clozapine is a powerful antipsychotic medication which is often given as a 3rd resort because of the side-effects and the weekly blood tests that are required. The symptoms for which this drug was prescribed would come back such as auditory hallucinations, delusions and psychotic symptoms. You must go back to the doctor who prescribed the medicine so he/she can choose another medication

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How can I get off clozaril (clozapine)?

Carefully: Clozaril (clozapine) is a very potent medication. If you are taking this be careful about discontinuing it. I would suggest you talk to your doctor about the advisability of stopping this medication. You may need to switch to a different medication.

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Can clozaril (clozapine) be used to treat severe insmnia?

Overdo: In theory; but it s not indicated (off label) and hard to justify the risks involved (agranulocytosis, seizures, death) not to mention the monitoring required. It should not be an alternative.

See 1 more doctor answer
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Anyone out there taking clozapine (or clozaril)? What is it?

Strong antipsychotic: Clozaril/clozapine is an effective antipsychotic medication with many cautions and potential side effects requiring regular blood tests. It can be effective for severe or difficult to treat schizophrenia. Given the potential side effects and requirement of blood tests, many doctors try other, safer medications or combinations first.

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Clozaril (clozapine) long term side effect?

Has many.: There appear to be many side effects with this antipsychotic medication. Common ones are extreme constipation, bed-wetting, night-time drooling, muscle stiffness, sedation, tremors, orthostasis, hyperglycemia, and weight gain. Others are agranulocytosis, CNS depression, leukopenia, neutropenia, seizure disorder, bone marrow suppression, dementia, hypotension, and myocarditis.

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Clozapine (clozaril) 125mg and withdrawal, can you tell me more?

Rebound: Clozapine is a medication with outstanding features that help control symptoms other medications otherwise failed to control. It is very serious to stop the medication without careful planning & supervision by your treating physician. The most serious withdrawal consequence is a rebound of the symptoms being treated which may take a while to re control even with clozapine restarted. See ur Dr.

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Is clozapine (clozaril) benzodiazepine?

Is clozapine (clozaril) benzodiazepine?

Dibenzodiazepine: Clozaril/clozapine is not a benzodiazepine like lorazepam/ativan or alprazolam/xanax. Its chemical structure is a dibenzodiazepine and it is a 2nd generation antipsychotic.

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Can clozaril (clozapine) cause akathisia, restlessness?

Can clozaril (clozapine) cause akathisia, restlessness?

Can occur: These side effects would occur while taking Clozaril, but if you have stopped and instead suffer restless leg syndrome, would suggest checking iron metabolism, with ferritin level, and considering use of a dopamine agonist around the clock (suggest Neupro (rotigotine) patch). Talk to your doctor about these thoughts.

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What is the definition or description of: Clozaril (clozapine) allergy?

What is the definition or description of: Clozaril (clozapine) allergy?

Clozaril allergy: Clozaril (clozapine) is an antipsychotic medication used for the treatment of schizophrenia. Allergic reactions could include swelling of tongue, throat, lips, mouth, face, hives or difficulty breathing.

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Is clozapine (clozaril) good for bipolar?

Is clozapine (clozaril) good for bipolar?

Clozaril (clozapine): Is an atypical antipsychotic approved for use in treatment-resistant schizophrenia & is also used off-label to treat bipolar disorders. It is very effective as long as close monitoring of white blood cell count is done routinely. Some reported side-effects are seizures, myocarditis, agranulocytosis, diabetes, weight gain. It is not indicated if seizures, liver disease or low blood count.

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Clozapine (clozaril) for good for bipolar?

Yes, however: Clozaril/clozapine is an effective antipsychotic medication with many cautions requiring regular blood tests. It can be effective for severe or difficult to treat bipolar disorder. Given the potential side effects and requirement of blood tests, many doctors try other, safer medications or combinations first.

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What are the symptoms of a high white blood cell count resulting from clozaril (clozapine)?

What are the symptoms of a high white blood cell count resulting from clozaril (clozapine)?

Leukocytosis: Fever, bleeding or bruising, trouble breathing, pain or tingling, dizziness, trouble thinking, poor appetite, all depending on the cause. Also, can be asymptomatic.

Dr. Heidi Fowler
222 Doctors shared insights

Clozapine (Definition)

Clozapine is a serotonin-dopamine receptor blocker which is a kind of atypical anti-psychotic drug (drug ...Read more