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Doctor insights on: Clozapine Side Effects

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How long does it take to get used to the sedating side effects of clozapine?

How long does it take to get used to the sedating side effects of clozapine?

Klonopin (clonazepam): Sedating effects can last up to one week, depending on dose and severity of underlying anxiety. ...Read more

Dr. Philip Greilich
220 doctors shared insights

Clozapine (Definition)

Clozapine is a serotonin-dopamine receptor blocker which is a kind of atypical anti-psychotic drug (drug ...Read more


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I want o quit colzapine due to its side effects. i am currently on aripiprazole and clozapine. how should safely stop taking clozapine?

Taper: One should taper off of clozapine. However, you may need to add another similar medication to help with the symptoms clozapine is controlling. Discuss this with your doctor. ...Read more

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Do you have to taper off one psychotic to begin the other one? From risperidone to clozapine. Tell me more about side effects too, e.G. Drooling.

Do you have to taper off one psychotic to begin the other one? From risperidone to clozapine. Tell me more about side effects too, e.G. Drooling.

No: While it depends to some degree upon the condition that the antipsychotic is treating, you do not generally have to taper one before beginning another. In the case of going from Risperidone to clozaril, (clozapine) as Clozaril (clozapine) has to be titrated, usually you would remain on Risperdal until on enough Clozaril (clozapine) to likely control symptoms. Then you would begin lowering the Risperidone gradually. ...Read more

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I'm getting off clozapine cold turkey as i can't stand the side effects anymore. Drooling, nocturnal enuresis, delirium. What can I expect re w/d?

I'm getting off clozapine cold turkey as i can't stand the side effects anymore. Drooling, nocturnal enuresis, delirium. What can I expect re w/d?

Back to prescriber.: Clozapine is a powerful antipsychotic medication which is often given as a 3rd resort because of the side-effects and the weekly blood tests that are required. The symptoms for which this drug was prescribed would come back such as auditory hallucinations, delusions and psychotic symptoms. You must go back to the doctor who prescribed the medicine so he/she can choose another medication ...Read more

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Would clozaril be a good antipsychotic for paranoid schizophrenia I had in the past? schiz in remission because of zyprexa (olanzapine) but don't like side effects

Would clozaril be a good antipsychotic for paranoid schizophrenia I had in the past? schiz in remission because of zyprexa (olanzapine) but don't like side effects

Clozaril (clozapine): Is an atypical antipsychotic approved for use in treatment-resistant schizophrenia & is also used off-label to treat bipolar disorders. It is very effective as long as close monitoring of white blood cell count is done routinely. Some reported side-effects are seizures, myocarditis, agranulocytosis, diabetes, weight gain. It is not indicated if seizures, liver disease or low blood count. ...Read more

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Clozaril (clozapine) long term side effect?

Clozaril (clozapine) long term side effect?

Has many.: There appear to be many side effects with this antipsychotic medication. Common ones are extreme constipation, bed-wetting, night-time drooling, muscle stiffness, sedation, tremors, orthostasis, hyperglycemia, and weight gain. Others are agranulocytosis, CNS depression, leukopenia, neutropenia, seizure disorder, bone marrow suppression, dementia, hypotension, and myocarditis. ...Read more

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Clozapine is making friend act weird, is that a normal side effect?

Clozapine is making friend act weird, is that a normal side effect?

No: Speak to your friend and feel free to call his/her physician. A true friend is ready to speak up when something like this happens. ...Read more

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Please, i need to know, will the drooling side effect of clozapine go away? It's driving me crazy.

Please, i need to know, will the drooling side effect of clozapine go away? It's driving me crazy.

Drooling & Clozapine: Drooling is a known side effect of Clozapine and it may be dose-related -- meaning that you & your doctor can discuss whether a lower dose of Clozapine will still protect you from psychotic symptoms. If so, this may help the drooling go away. If this isn't feasible, your doctor can also consider medicines to combat this: clonidine, benztropine, amitriptylene, & terazosin are a few options. ...Read more

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Could alcohol and cigarettes increase the drowsiness side effect of clozapine?

Could alcohol and cigarettes increase the drowsiness side effect of clozapine?

Alcohol and clonazep: Both alcohol and Clonazepam get metabolized in the liver using same pathway. Not only it will add to the sedation, the practice is very risky. I have not heard that tobacco could increase the sedative effect of the drug. ...Read more

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How long after being on clozapine does its sedating effects go away? I'm supposed to take it in the morning too but it's way too sedating so i don't.

How long after being on clozapine does its sedating effects go away? I'm supposed to take it in the morning too but it's way too sedating so i don't.

For many it does not: Many patients preferred to take their total dose at bedtime because of the fact that the sedation does not go away for many people. Years ago a study was done at harvard involving approximately 750 people with panic disorder and although the majority preferred to take their total daily dose of clonopin at bedtime, there were some who preferred to take about 25% of their dose in the morning. Please discuss this with your prescribing physician. I generally prescribed the total daily dose at bedtime unless the patient prefers to take a small dose in the morning as well. ...Read more

Dr. Neigatha Graney
48 doctors shared insights

Clozaril (Definition)

Clozaril is a serotonin-dopamine receptor blocker which is a kind of atypical anti-psychotic drug (drug ...Read more