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Doctor insights on: Clozapine Interactions

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Before starting Duloxetine 60mg I was 242.5 lbs and have remained similar weight since, however, my waist has gone 107cmto124cm. Could Duloxetine cause something eg swelling to explain this? or perhaps an interaction between clozapine and Duloxetine?

Before starting Duloxetine 60mg I was 242.5 lbs and have remained similar weight since, however, my waist has gone 107cmto124cm. Could Duloxetine cause something eg swelling to explain this? or perhaps an interaction between clozapine and Duloxetine?

Probable Interaction: There is a well established interaction between duloxetine & clozapine leading to various abnormalities including elevated clozapine blood levels and blood chemistry abnormalities. Anyone on this combination should be monitored closely by their prescriber(s) including lab studies on blood chemistries & clozapine serum levels along with the routine blood counts required on clozapine. ...Read more

Dr. Philip Greilich
220 doctors shared insights

Clozapine (Definition)

Clozapine is a serotonin-dopamine receptor blocker which is a kind of atypical anti-psychotic drug (drug ...Read more


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How can I get off clozaril (clozapine)?

Carefully: Clozaril (clozapine) is a very potent medication. If you are taking this be careful about discontinuing it. I would suggest you talk to your doctor about the advisability of stopping this medication. You may need to switch to a different medication. ...Read more

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Can clozaril (clozapine) be used to treat severe insmnia?

Overdo: In theory; but it s not indicated (off label) and hard to justify the risks involved (agranulocytosis, seizures, death) not to mention the monitoring required. It should not be an alternative. ...Read more

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Anyone out there taking clozapine (or clozaril)? What is it?

Strong antipsychotic: Clozaril/clozapine is an effective antipsychotic medication with many cautions and potential side effects requiring regular blood tests. It can be effective for severe or difficult to treat schizophrenia. Given the potential side effects and requirement of blood tests, many doctors try other, safer medications or combinations first. ...Read more

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I take 500mg of clozapine and haven't taken it for 5 days. How will this affect me?

Don't withdraw: you usually don't have withdrawl symptoms from these atypica antipsychotics. You will be fine, unless you have a relapse of the symptoms you were taking it for. ...Read more

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This is very embarrassing. But i seem to have been wetting my bed since i started clozapine. Is there a connection? Maybe a smaller dose?

This is very embarrassing. But i seem to have been wetting my bed since i started clozapine. Is there a connection? Maybe a smaller dose?

Yes, there could be: Clozapine is a helpful medication in certain cases of psychosis. Among its possible side effects, though, is urinary incontinence (1%-2% of patients). Other possibilities include seizures (3% of patients) which can also have urinary incontinence. Please tell your doctor about this -- it's important. Be well. ...Read more

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Is clozapine a benzodiazepine?

Is clozapine  a benzodiazepine?

No: Clozapine is considered a 2nd generation antipsychotic medication, typically used in schizophrenia, that antagonizes quite a few neurotransmitter receptors, eg Dopamine d1 & d4 plus serotonin 5ht2 & cholinergic muscarinic ones, too. It's a very effective drug when used under close observation but can only be prescribed under restricted distribution due high risk for agranulocytosis, etc. ...Read more

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Should i go cold turkey off clozapine?

No: Coming off Clozapine should be done under medical supervision. ...Read more

Dr. Linda Callaghan
48 doctors shared insights

Clozaril (Definition)

Clozaril is a serotonin-dopamine receptor blocker which is a kind of atypical anti-psychotic drug (drug ...Read more