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Doctor insights on: Clozapine Interactions

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How can I get off clozaril (clozapine)?

Carefully: Clozaril (clozapine) is a very potent medication. If you are taking this be careful about discontinuing it. I would suggest you talk to your doctor about the advisability of stopping this medication. You may need to switch to a different medication. ...Read more

Dr. Philip Greilich
219 doctors shared insights

Clozapine (Definition)

Clozapine is a serotonin-dopamine receptor blocker which is a kind of atypical anti-psychotic drug (drug ...Read more


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Can clozaril (clozapine) be used to treat severe insmnia?

Overdo: In theory; but it s not indicated (off label) and hard to justify the risks involved (agranulocytosis, seizures, death) not to mention the monitoring required. It should not be an alternative. ...Read more

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Anyone out there taking clozapine (or clozaril)? What is it?

Strong antipsychotic: Clozaril/clozapine is an effective antipsychotic medication with many cautions and potential side effects requiring regular blood tests. It can be effective for severe or difficult to treat schizophrenia. Given the potential side effects and requirement of blood tests, many doctors try other, safer medications or combinations first. ...Read more

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I take 500mg of clozapine and haven't taken it for 5 days. How will this affect me?

Don't withdraw: you usually don't have withdrawl symptoms from these atypica antipsychotics. You will be fine, unless you have a relapse of the symptoms you were taking it for. ...Read more

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This is very embarrassing. But i seem to have been wetting my bed since i started clozapine. Is there a connection? Maybe a smaller dose?

This is very embarrassing. But i seem to have been wetting my bed since i started clozapine. Is there a connection? Maybe a smaller dose?

Yes, there could be: Clozapine is a helpful medication in certain cases of psychosis. Among its possible side effects, though, is urinary incontinence (1%-2% of patients). Other possibilities include seizures (3% of patients) which can also have urinary incontinence. Please tell your doctor about this -- it's important. Be well. ...Read more

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Is clozapine a benzodiazepine?

Is clozapine  a benzodiazepine?

No: Clozapine is considered a 2nd generation antipsychotic medication, typically used in schizophrenia, that antagonizes quite a few neurotransmitter receptors, eg Dopamine d1 & d4 plus serotonin 5ht2 & cholinergic muscarinic ones, too. It's a very effective drug when used under close observation but can only be prescribed under restricted distribution due high risk for agranulocytosis, etc. ...Read more

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Should i go cold turkey off clozapine?

No: Coming off Clozapine should be done under medical supervision. ...Read more

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Clozaril (clozapine) long term side effect?

Clozaril (clozapine) long term side effect?

Has many.: There appear to be many side effects with this antipsychotic medication. Common ones are extreme constipation, bed-wetting, night-time drooling, muscle stiffness, sedation, tremors, orthostasis, hyperglycemia, and weight gain. Others are agranulocytosis, CNS depression, leukopenia, neutropenia, seizure disorder, bone marrow suppression, dementia, hypotension, and myocarditis. ...Read more

Dr. Ralph Wharton
47 doctors shared insights

Clozaril (Definition)

Clozaril is a serotonin-dopamine receptor blocker which is a kind of atypical anti-psychotic drug (drug ...Read more