Doctor insights on:
Clozapine Cause Hemolytic Anemia
Autoimmune reaction: Cephalosporins interact with red blood cell membranes. The body can sometimes produce antibodies against cephalosporins that also interact with the surface of red blood cells. These antibodies thus activate the body's immune system to attack its own red blood cells, causing hemolytic anemia. This is a rare but severe side effect of cephalosporins. ...Read more
Yes: Malaria symptoms show up a week to a few months after being infected by a mosquito bite. With treatment, the symptoms should go away in a couple of weeks. However, without treatment, and depending on the strain of malaria parasite, an infected person can have symptoms for a few years, up to a few decades. The person develops immunity over time, and his symptoms may decrease as the years go by. ...Read more
Ferritin=364.7ng/ml, Transferrin Saturation=57% (caused by chronic mild Hemolytic Anemia of unknown cause), should I be worried about the high iron?
Ferritin: Ferritin is the storage form of iron, rather than free serum iron in the blood. That value of 364 ng/ml falls within the normal range of most lab assays. The transferrin sat is a little high but likely that is due to the hemolysis. Basically it just says that 57% of the iron binding sites on the transferring molecules are being used. Abnormal but an expected finding in your case. ...Read more
Feels dizzy back of head. Example; sharp turn as passenger in car can cause feeling and can last hours. Worse lying down. Has minor Hemolytic anemia?
BPPV?: S/He might have benign paroxysmal postural vertigo. BPPV is very common, occuring in up to 5% of the population. Mostly in older persons but can occur at any age. Just like certain positions or movements can trigger it, positional procedures usually can reverse it quickly. Unrelated to anemia, hemolytic or other. Google BPPV for lots of websites; the Wikipedia article is pretty good. ...Read more
Can hemolytic anemia cause low blood vol. Thereby causing autonomic dysfunction? Does body see hemolysis as trauma thereby triggering stress hormones?
Whoa: Hemolytic anemia won't affect blood volume but will affect oxygen carrying capacity. Further, if the cause is microangiopathy, lupus, malaria, or any of a variety of others, there may be a huge number of different problems. I'm glad you have an inquiring mind, but there's no need to invoke "stress hormones"; you'd do well to stop reading "pop" explanations if someone's actually seriously sick. ...Read more
Mother had lupus and died suddenly of autoimmune hemolytic anemia that caused cardiogenic shock. Is that a lupus thing or do I need 2 worry. I have ra?
RBC breakdown: Hemolytic anemia is where red blood cells are destroyed too quickly. There are many possibilities that would cause this rbc breakdown. Antibodies, abnormal rbc membranes (spherocytosis), abnormal hemoglobins (sickle cell, thalassemia), abnormal rbc enzymes. If hemolytic anemia is suspected, many tests may be ordered to determine the cause. ...Read more
Cause of hemolysis: Once hemolysis is thought to be occurring, the cause is saught. The causes are many. Some are inherent to the red blood cell (sickle cell, spherocytosis, thalassemia, g6pd deficiency). Some are from antibodies. Some are from other causes of destruction within the blood vessels (mechanical heart valves, hemolytic uremic syndrome). This work up is quite involved. ...Read more
Possibly: Hemolytic anemia may have numerous causes including toxins, infections, genetic diseases, autoimmune diseases, drugs, certain types of food, etc. So theoretically if you know what the cause is then it can be avoided. Therefore, an adequate diagnostic workup by your doctor is necessary. ...Read more
No: It can be due to an underlying autoimmune disorder, such as lupus or rheumatoid arthritis. In this case, the underlying autoimmune disorder may be hereditary; but the autoimmune hemolytic anemia is not hereditary. It is simply the manifestation of the underlying disorder. There are also several causes of autoimmune hemolytic anemia that are not inherited. ...Read more
Stopping dapsone: The best way to treat Dapsone related anemia is by discontinuing dapsone. Dapsone causes hemolytic anemia which is dose-dependent and can be stopped only with discontinuing the drug. Usual practice is to use the lowest possible doses of Dapsone and support with vitamin E and folic acid. ...Read more
Find the cause: You have to find the cause of why the red blood cells are being destroyed (hemolysed) then target it; certains cause of hemolysis are medication, heredity, malignancy, infection, enlarged slpeen etc... ...Read more
Yes: You have to figure out why you are bleeding into your stomach and if there are any other places where you are bleeding and why and if you are making sufficient replacement blood and if not why not. This can be orchestrated, at least at first by your doc, and if things get really messy by a hematologist. Good luck! ...Read more
Uncommon. : This would be very uncommon. But it can happen. Definitely take the prescribed medicine and follow up with your doctor regularly. ...Read more
Cell membrane damage: Pyruvate a kinase deficiency results in reduced ability of red cells to make ATP -the "energy source" of cells. Atp is also necessary to protect cells from damaging compounds such as free radicals. With decreased energy supply the cell is not able to maintain appropriate concentrations of electrolytes and fluids, becomes distorted or stiff, and then is destroyed in the spleen or liver. ...Read more
Multifactoral: Coombs (-) hemolytic anemia means that you have evidence of hemolysis (RBC fragmentation) that is not immune mediated. Potential causes include medications, artificial valves, microangiopathic causes, and disorders involving the RBC membrane, etc. Large granular lymphocytosis may be reactive or represent a leukemia if absolute levels are 2-20,000 and sustained for >6 mo in your peripheral blood. ...Read more
Yes: Hemolytic anemia can be due to multiple causes such as medications, infections, cancers, autoimmune disorders, etc. Depending on the cause treatments can be done such as stopping causative drugs, treating infections or cancers, starting folic acid, sometimes transfusing blood, etc. ...Read more
Varies: Some people may be asymptomatic, others may have weakness, fatigue, fast heart rate, tire easily with exercise, shortness of breath with exercise, etc. Any form of anemia has to be diagnosed by a physician who will take a blood sample and run lab work. Once the cause of the anemia is properly diagnosed, it can be treated and the symptoms alleviated. ...Read more
Varies: Inherited hemolytic anemias such as sickle cell, thalassemias can run in families and are more common in african americans, hispanics, Asian indians for example. Acquired hemolytic anemias can be associated with blood cancer patients, patients with autoimmune disorders, infections (hiv, hepatitis), etc. ...Read more
Depends: There are basically two type of hemolytic anemia — congenital (your born with it) or acquired (you get it all of a sudden). Many acquired hemolytic anemias will run there course. The congenital hemolytic anemias will likely require some treatment and may never go away completely. ...Read more