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Doctor insights on: Clozapine Cause Hemolytic Anemia

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Dr. Philip Greilich
222 Doctors shared insights

Clozapine (Definition)

Clozapine is a serotonin-dopamine receptor blocker which is a kind of atypical anti-psychotic drug (drug ...Read more


Emily Lu Dr. Lu
3 doctors agreed:
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Why it is said that cephalosporins can cause hemolytic anemia?

Emily Lu Dr. Lu
3 doctors agreed:
Why it is said that cephalosporins can cause hemolytic anemia?

Autoimmune reaction: Cephalosporins interact with red blood cell membranes. The body can sometimes produce antibodies against cephalosporins that also interact with the surface of red blood cells. These antibodies thus activate the body's immune system to attack its own red blood cells, causing hemolytic anemia. This is a rare but severe side effect of cephalosporins.

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Can hemolytic anemia cause albumin in the urine?

Can hemolytic anemia cause albumin in the urine?

Indirectly: Yes, if it damages your kidneys, which may then "leak" Albumin in the urine.

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I was diagnosed with hemolytic anemia caused by malaria. Can it be cured?

I was diagnosed with hemolytic anemia caused by malaria. Can it be cured?

Yes: Malaria symptoms show up a week to a few months after being infected by a mosquito bite. With treatment, the symptoms should go away in a couple of weeks. However, without treatment, and depending on the strain of malaria parasite, an infected person can have symptoms for a few years, up to a few decades. The person develops immunity over time, and his symptoms may decrease as the years go by.

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Feels dizzy back of head. Example; sharp turn as passenger in car can cause feeling and can last hours. Worse lying down. Has minor Hemolytic anemia?

Feels dizzy back of head. Example; sharp turn as passenger in car can cause feeling and can last hours. Worse lying down. Has minor Hemolytic anemia?

BPPV?: Maybe benign paroxysmal postural vertigo. BPPV is very common, occuring sometimes in up to 5% of the population. It's most frequent in older persons but can occur at any age. Just as certain positions or movements can trigger it, positional procedures usually can reverse it quickly. Unrelated to anemia, hemolytic or other. Google BPPV for lots of websites; the Wikipedia article is pretty good.

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Can hemolytic anemia cause low blood vol. Thereby causing autonomic dysfunction? Does body see hemolysis as trauma thereby triggering stress hormones?

Can hemolytic anemia cause low blood vol. Thereby causing autonomic dysfunction? Does body see hemolysis as trauma thereby triggering stress hormones?

Whoa: Hemolytic anemia won't affect blood volume but will affect oxygen carrying capacity. Further, if the cause is microangiopathy, lupus, malaria, or any of a variety of others, there may be a huge number of different problems. I'm glad you have an inquiring mind, but there's no need to invoke "stress hormones"; you'd do well to stop reading "pop" explanations if someone's actually seriously sick.

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What is the definition or description of: hemolytic anemia?

What is the definition or description of: hemolytic anemia?

RBC breakdown: Hemolytic anemia is where red blood cells are destroyed too quickly. There are many possibilities that would cause this rbc breakdown. Antibodies, abnormal rbc membranes (spherocytosis), abnormal hemoglobins (sickle cell, thalassemia), abnormal rbc enzymes. If hemolytic anemia is is suspected, many tests may be ordered to determine the cause.

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What happens during a hemolytic anemia investigation?

What happens during a hemolytic anemia investigation?

Cause of hemolysis: Once hemolysis is thought to be occurring, the cause is saught. The causes are many. Some are inherent to the red blood cell (sickle cell, spherocytosis, thalassemia, g6pd deficiency). Some are from antibodies. Some are from other causes of destruction within the blood vessels (mechanical heart valves, hemolytic uremic syndrome). This work up is quite involved.

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Can hemolytic anemia be prevented?

Possibly: Hemolytic anemia may have numerous causes including toxins, infections, genetic diseases, autoimmune diseases, drugs, certain types of food, etc. So theoretically if you know what the cause is then it can be avoided. Therefore an adequate diagnostic workup by your doctor is necessary.

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Is autoimmune hemolytic anemia hereditary?

Is autoimmune hemolytic anemia hereditary?

No: It can be due to an underlying autoimmune disorder, such as lupus or rheumatoid arthritis. In this case, the underlying autoimmune disorder may be hereditary; but the autoimmune hemolytic anemia is not hereditary. It is simply the manifestation of the underlying disorder. There are also several causes of autoimmune hemolytic anemia that are not inherited.

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How is autoimmune hemolytic anemia diagnosed?

How is autoimmune hemolytic anemia diagnosed?

Bloodwork: An examination may reveal an enlarged spleen. Tests include: direct coombs' test hemoglobin in the urine indirect coombs' test red blood cell count and serum hemoglobin reticulocyte count serum bilirubin levels serum haptoglobin.

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How is dapsone induced hemolytic anemia treated?

How is dapsone induced hemolytic anemia treated?

Stopping dapsone: The best way to treat Dapsone related anemia is by discontinuing dapsone. Dapsone causes hemolytic anemia which is dose-dependent and can be stopped only with discontinuing the drug. Usual practice is to use the lowest possible doses of Dapsone and support with vitamin E and folic acid.

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Can a person with hemolytic anemia donate blood?

Can a person with hemolytic anemia donate blood?

Unwise.: If you have hemolytic anemia, you probably need to keep all the blood cells you've got! There are many different causes for hemolytic anemia. Check with your local red cross to find out if you qualify.

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What are effective treatments for hemolytic anemia?

What are effective treatments for hemolytic anemia?

Find the cause: You have to find the cause of why the red blood cells are being destroyed (hemolysed) then target it; certains cause of hemolysis are medication, heredity, malignancy, infection, enlarged slpeen etc...

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How are aplastic and hemolytic anemia differentiated?

How are aplastic and hemolytic anemia differentiated?

See below: Aplastic anemia is when the bone marrow stops producing blood cells. Hemolytic anemia is when red blood cells are being destroyed outside of the bone marrow.

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Hemolytic anemia diagnosed in laboratory, what to do?

See below: There are a number of conditions in the category of hemolytic anemia, trivial to serious in nature. Your primary care doctor may refer you to a hematologist (blood disease specialist).

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Can Hemorrhagic gastritis precipitate hemolytic anemia.

Yes: You have to figure out why you are bleeding into your stomach and if there are any other places where you are bleeding and why and if you are making sufficient replacement blood and if not why not. This can be orchestrated, at least at first by your doc, and if things get really messy by a hematologist. Good luck!

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Autoimmune hemolytic anemia is what sort of symptoms or problems?

Autoimmune hemolytic anemia is what sort of symptoms or problems?

Tiredness: In autoimmune hemolytic anemia (aiha) red cells get broken open due to destruction by antibodies which attach to the red cell. This leads to anemia and fatigue, tiredness, and sometimes yellow eyes (scleral icterus) and yellow skin (jaundice).

Dr. Eric Weisman
50 Doctors shared insights

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Dr. Steven Ginsberg
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