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Doctor insights on: Clostridium Difficile

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Dr. Stephen Scholand
447 doctors shared insights

Clostridium Difficile (Overview)

C. Diff, it is a spore forming bacillus that when the micro environment of the colon is modified by antimicrobials, it can germinate and elaborate a toxin causing pseudo membranous colitis, a potentially lethal disease.


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What is clostridium difficile and why is it so dangerous? 

What is clostridium difficile and why is it so dangerous? 

Infectious Colitis: C.Diff is a bacteria may result is a severe infectious colitis (inflammation of the colon). Because of which patients may have terrible diarrhea but most worrisome is toxic colitis requiring a colectomy (removal of your colon). Antibiotic use puts people at risk for c.Diff. ...Read more

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Dr. Stephen Scholand
447 doctors shared insights

Clostridium Difficile (Overview)

C. Diff, it is a spore forming bacillus that when the micro environment of the colon is modified by antimicrobials, it can germinate and elaborate a toxin causing pseudo membranous colitis, a potentially lethal disease.


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What are the symptoms of clostridium difficile?

What are the symptoms of clostridium difficile?

Diarrhea: Most often following antimicrobial therapy (or sometimes cancer chemotherapy), the patient develops watery diarrhea which often has a mousy, horse barn like odor. There can be fever and sometimes a quite elevated white blood cell count. Some strains, in the last few years, seem to be hyper producers of toxin with more severe symptoms likely. ...Read more

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Treating Clostridium Difficile Infection (Checklist)

Know it's a common complication of taking antibiotics
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Minimize use of broad spectrum antibiotics & stay out of hospitals
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Use probiotics to outcompete the clostridium difficile bacteria
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What are the tests for clostridium difficile infection?

What are the tests for clostridium difficile infection?

C. diff: Both the bacterial toxin and the gene coding for the toxin can be found in the diarrheal stool. Additionally, the diarrhea has a peculiar mousy/musty aroma. ...Read more

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Chances of someone getting clostridium difficile colitis from cefprozole ? And how would they know?

Chances of someone getting clostridium difficile colitis from cefprozole ? And how would they know?

Pretty Low: I think u r referring to cefprozil, a 2nd generation cephalosporin antibiotic. In theory any antibiotic can place you at risk for a clostridium difficile infection, but is much more likely in an elderly, hospitalized patient who might have a weakened immune system. Although Cefprozil is not particularly associated with c diff, using a probiotic or eating yogurt will help.If c diff, severe diarrhea. ...Read more

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Are there any antibiotics that can be used to treat clostridium difficile infection?

Are there any antibiotics that can be used to treat clostridium difficile infection?

Flagyl or Vancomycin: C. Difficile colitis almost always occurs when another oral antibiotic, used to treat a different infection, wipes out normal gut bacteria. Patients who develop c.Diff colitis should stop taking that initial oral antibiotic. Treatment is usually with Metronidazole (flagyl) or vancomycin (vancocin). For severe cases, doctors may prefer vanco. Newer drugs are available if this treatment fails. ...Read more

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Why are clostridium difficile infections hard to treat?

It produces spores: Partly it is the persons immune system and general health that makes it recur more often. The main problem is it comes back after treatment. Clostridium produces endospores. Endospore is is a tough structure in which the bacteria is dormant and not reproducing. Antibiotics don't affect the spores so after the symptoms are gone, the spores activate and then cause reinfection. ...Read more

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Can a relapsed infection of clostridium difficile be treated effectively?

Clostridium Difficil: Depended on the number relapses. If a patient has relapsed more than 3 times, the chance of treatment the bacteria is less effective and will require a longer time. However, there are effective treatments. ...Read more

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After a root canal treatment, I am worried about using clindamycin. There are warnings about intestinal problems and clostridium difficile. Symptoms may occur weeks after use.Should I use it?

After a root canal treatment, I am worried about using clindamycin. There are warnings about intestinal problems and clostridium difficile. Symptoms may occur weeks after use.Should I use it?

See below: What you state in your question is correct. You should still take the Clindamycin prescribed for you. You should also take a high dose probiotic like vsl#3 plus florastor to prevent antibiotic associated and c. Difficile diarrhea. If you develop diarrhea during or after treatment have your stool checked for c. Difficile toxin. Do not take Imodium (loperamide) or lomotil. ...Read more

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10 weeks pregnant tested positive for Clostridium Difficile. Needing second opinion on treatments recommended please.

10 weeks pregnant tested positive for Clostridium Difficile. Needing second opinion on treatments recommended please.

Second opinions: The HealthTap forum that you are currently using is for informational purposes only, and it is not appropriate for us to diagnose or suggest treatments here (this is for your safety!). If you request a personal consult with one of our HealthTap Prime physicians, a second opinion with advice can be offered. ...Read more

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Is there a medical cure for clostridium difficile?

Is there a medical cure for clostridium difficile?

Yes..a few options..: Most cases of c. Dif colitis can be treated by oral/iv metronidazole, oral vanocomycin, and maybe add of Cholestyramine resins. Newer agent Dificid (fidaxomicin) is effective, but $$$. Bacitracin has some use, but not standard of care. For persistent/recurrent cases after treatments with above, a stool-transplant (yes, stool transplant--u read it right) can be done. Consult your doc..Good luck. ...Read more

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How can you get rid of c.Diff. (clostridium difficile)?

Agree with above: The infection has a propensity to relapse hence, fecal matter transplantation should be considered in some cases to restore gut microbiome. Would try not taking antibiotics if can be avoided. ...Read more

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How to donate my feces to a clostridium difficile pill?

C.diff treatment: Interesting you know about how effective stool donations can be for helping C. diff patients. It works very well. C. diff is a horrible and devastating disease, killing up to 15% of victims according to the CDC. You may want to freeze your own stool if you're worried about it or concerned for a relative. Obviously keeping that separate from food is a must. There are no labs doing this yet. ...Read more