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Doctor insights on: Cll Lymphoma Diagnostic Panel

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Define differential diagnosis of prolymphocytic leukemia or mantle cell leukemia.

Define differential diagnosis of prolymphocytic leukemia or mantle cell leukemia.

They are too differe: There should be no confusion between these two entities. One is a lymphoma(nodal disease) the other one is a blood cancer that should not affect the lymph nodes. Rather easy diagnosis if you are seeing the right type of specialist! ...Read more

Dr. Michael Thompson
1,760 doctors shared insights

Lymphoma (Definition)

A malignancy that develops in the lymph glands that causes nodes ...Read more


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Are lymphocyte rich hodgkin's lymphoma and nodular lymphocyte predominant hodgkin's lymphoma the same?

Are lymphocyte rich hodgkin's lymphoma and nodular lymphocyte predominant hodgkin's lymphoma the same?

Sometimes: Both ate classified as hodgkin but they can behave differetlny. Both are treated te same with chemo abvd regimen. Some new data suggest adding Rituxan (rituximab) if cd 20 positive in lymphocyte predominantly disease. ...Read more

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Have low platelet, splenomegaly,high LDH, B2M and C-reactive protein, normal marrow, cytometry and pet scan,normal WBC, possible CML? fish ?PCR need?

Have low platelet, splenomegaly,high LDH, B2M and C-reactive protein, normal marrow, cytometry and pet scan,normal WBC, possible CML?  fish ?PCR need?

Autoimmune: Sounds like the good news is cancer had been ruled out. The tests and physical problems you listed can have many causes. Infections especially viral, are a cause. Medications or environmental exposures are possible. Autoimmune diseases are also a big possibility. Your next step should be a rheumatologist. ...Read more

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Multiple enlarged axilla lymph nodes (largest is 2cm) normal chest xray.High Wbc. High absolute neutropolis.High lymphocytes. Lymphoma Cancer?

Multiple enlarged axilla lymph nodes (largest is 2cm) normal chest xray.High Wbc. High absolute neutropolis.High lymphocytes. Lymphoma Cancer?

Dont assume cancer: never make assumptions regarding cancer...you are right to be concerned and you should pursue further work-up...this will include a history and complete exam with possible further x-rays....the enlarged nodes could represent infection and not cancer...be prepared for biopsy to make final diagnosis ...Read more

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Differentiate between hodgkin's lymphoma and non-hodgkin's lymphoma ?

Reed-Sternberg: Cell, usual logical predictable spread. Nhl may be cd-20+ & b-cell, less predictable, wide ranging prognosis, from chronic & long to quite aggressive. Both treate with multi-aget chemo + rituxin in nhl. ...Read more

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Docs overlooking lymphoma? Months w/ab pain, rectal blood (cscope ok), lymph pain, non-healing acne, episodic fuo. Neg mono test. Latest labs = high ldh, high lipase, low globulin, pos for atyp wbcs

Docs overlooking lymphoma? Months w/ab pain, rectal blood (cscope ok), lymph pain, non-healing acne, episodic fuo. Neg mono test. Latest labs = high ldh, high lipase, low globulin, pos for atyp wbcs

.: I'm not exactly sure what you mean by lymph pain. But if you are having episodes of fevers and chills, unexplained abdominal pain for months, high ldh, this could warrant a ct scan with contrast (if kidneys okay) to look for a cause. Could be lymphoma but most probably not as lymphoma is not that common. Talk to your doctor. ...Read more

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Would a CBC show lymphoma or leukemia?

Would a CBC show lymphoma or leukemia?

Likely for leukemia: Oftentimes leukemias can be picked up on routine CBC since it is a cancer of the blood and causes abnormal values of your red and white blood cells to appear. Lymphomas do not always affect the blood in a way that would be picked up on cbc. All leukemias however will not be picked up on routine CBC and CBC alone will not tell you what kind of leukemia specifically one might have. ...Read more

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Adult male,bone marrow biopsy show Erythroid hyperplasia RBC borderline on high side,thrombocytopenia fluctuate, Splenomegaly,negative for infections.

Adult male,bone marrow biopsy show Erythroid hyperplasia
RBC borderline on high side,thrombocytopenia fluctuate,
Splenomegaly,negative for infections.

CBC Results: If you can send us the complete blood count (CBC) report which includes Hb, WBC, Platelet counts done from 2 different dates, we can tell you if there is anything serious or how to manage your concerns. WE need to know the number of platelets(Count). RBC numbers are not useful...instead we use hemoglobin as a better test to reflect any problems with RBCs. ...Read more

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Does a CBC blood test detect cancer? Specifically lymphoma?

CBC & Lymphoma: There are a few lymphomas which can be detected on a CBC but most will not show up that way. In other words, if your CBC is normal doesn't mean you don't have lymphoma. A biopsy of any enlarged lymph node is suggested. ...Read more

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Is afirma thyroid fna analysis-molecular marker test by veracyte any good for diagnosing papillary thyroid cancer? Http://carolinaendocrine.Com

Is afirma thyroid fna analysis-molecular marker test  by veracyte  any good for diagnosing papillary thyroid cancer?
Http://carolinaendocrine.Com

Pathologist: Already answered(and saw some other answers) to this post earlier today; there is no better way to diagnose this than with a tissue biopsy and an experienced pathologist. ...Read more

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Pathologic diagnosis....Resected thymus shows reactive b cell hyperplasia vs low grade b cell lympho proliferative disorder. Is this lymphoma?

Pathologic diagnosis....Resected thymus shows reactive b cell hyperplasia vs low grade b cell lympho proliferative disorder.  Is this lymphoma?

Could be...: Certain lymphomas grow so slow that sometimes it is difficult for the pathologist to make the call between malignant or not. I suspect they may do additional work on the specimen and that your doctor will evaluate you further with labs, additional scans or another biopsy. If you have not seen a hematologist, maybe this is the time. Don't panic, just follow up his/her lead. Best to you. ...Read more

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What tests show leukemia?

What tests show leukemia?

CBCj, flow cytometry: Leukemia is suspected when abnormal cells our found in the blood, or when blood counts are very low. The first test is the CBC (complete blood count). If abnormal cells are in the blood, they can be identified by flow cytometry, which analyzes compounds on the surface of blood cells. The definitive test otherwise is a bone marrow aspirate and biopsy, usually taken from the pelvic bone. ...Read more

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Diagnosis. B.Cell non hodgkin, s lymphoma favor burkitt, s lymphoma. This us the result of biopsy taken during appendicectomy. D20 positive and tdt neg?

Diagnosis. B.Cell non hodgkin, s lymphoma favor burkitt, s lymphoma. This us the result of biopsy taken during appendicectomy. D20 positive and tdt neg?

CD20 is a B-Cell: Marker hence the assignment of a b-cell nhl. Tdt is an immunohistochemical stain used to classify blood cells. Burkitt's is a very aggressive process -- get started on a plan with a hematologist straight away. ...Read more

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CBP, ESR, Serum Iron, TIBC and identified RBC Morphology : Microcytic- Hypochromic smear seen, Anisocytosis-Poikilocytosis. what test covers etiology?

CBP, ESR, Serum Iron, TIBC and identified
RBC Morphology : Microcytic- Hypochromic smear seen, Anisocytosis-Poikilocytosis. what test covers etiology?

See your doctor: Hypochromic microcitic anemia is most likely due to iron deficiency, but if there is significant poikilocytosis other causes are possible. Your doc may want to send you to a hematologist if the etiology is unclear. Good luck. ...Read more

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What are the diagnostic tests for acute lymphoblastic leukemia?

Bone marrow biopsy : The diagnosis is typically with a bone marrow biopsy, cytogenetics (dna of leukemia cells), and flow cytometry (cell surface markers of leukemia cells). ...Read more

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Is there a reliable molecular test for assessing remission status of Mantle Cell Lymphoma?

Is there a reliable molecular test for assessing remission status of Mantle Cell Lymphoma?

Mantle Cell Lymphoma: ...is a type of non Hodgkin's lymphoma characterized by the genetic rearrangement of two chromosomes. This causes an abnormal fusion of two genes: Immunoglobulin (IgH) and Cyclin D1. Molecular studies that can detect this abnormality includes either FISH or RT-PCR. Flow cytometry is also good at identifying abnormal cells based on cell surface antigen expression. ...Read more

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Will cancer always cause an elevated CRP & ESR? Throat cancer, lymphoma?

Will cancer always cause an elevated CRP & ESR? Throat cancer, lymphoma?

No: Elevated ESR and CRP are markers of inflammation, not cancer. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, low fat milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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Is ldh always high with lymphoma patients? Any other tests (blood tests)

Is ldh always high with lymphoma patients?  Any other tests (blood tests)

No: Ldh may be high in lymphoma, but may not be. There are many laboratory and other tests used in the initial staging and prognostic testing for lymphoma. Also some tests are used before initial treatment because of concern of viral reactivation -- eg hiv, hepatitis studies. ...Read more

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Fnac report negative, but biopsy shows burkins lymphoma.Is it possible?Why?

Fnac report negative, but biopsy shows burkins lymphoma.Is it possible?Why?

Sampling error: Fine needle aspirate of lymph nodes are not ideal for ruling out abnormal findings. Especially, with lymphomas there may be areas within the ln that are not involved and sampling of these areas may be misleading. Excisional biopsy is the gold standard, as it allows for assessment of individual cells and architecture of lymph node and adequate tissue for specialty workup. ...Read more

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Wbc platelets absolute lymphs all came back high for 3rd time. Dr.says she is gonna continue to do test 1 a month. Why? Whats wrong? CLL or lymphoma?

Wbc platelets absolute lymphs all came back high for 3rd time. Dr.says she is gonna continue to do test 1 a month. Why? Whats wrong? CLL or lymphoma?

More info needed: There is not enough info to determine the problem. Why were the blood tests done. Any symptoms or physical examination findings? We're the possinpble causes of the problems discussed with the health care provider? ...Read more

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I have chronic lymphoproliferative disorder w/cll vs follicular lymphoma. Is it safe to get a shingles vaccination?

I have chronic lymphoproliferative disorder w/cll  vs follicular lymphoma.   Is it safe to get a shingles vaccination?

Probably: The degree of immunosuppression the average patient with cll has isn't bad enough to worry about getting disseminated zoster infections from the vaccine, but your physicians know your particular condition and how healthy or sick your immune system is. Ask them, especially your oncologist. ...Read more

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Can cll affect the time you have to live?

Depends: Cll usually occurs in older individuals and generally has an indolent course. It may shorten the life span of the person or the person may die with cll rather than of cll. ...Read more

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What would the recommended diet for a person with cll contain in terms of do's and dont's?

Enjoy life: Do the things you enjoy as long as they're good for you. Just like anyone else. Most cll isn't very aggressive. Don't give it more attention than it deserves. ...Read more

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Is cll leukemia curable?

Is cll leukemia curable?

Only sometimes...: I agree cll is not curable for most patients. For some patients who are robust, a consultation at a marrow /stem cell transplant center is warranted as there are investigational approaches that have helped some patients, some who appear cured. A note of caution- bone marrow transplant is the riskiest thing one can do to try to treat this disease and may lead to earlier death though. ...Read more

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What is the treatment for cll?

Depends on stage: For the patient with early stge cll the treatment is only observatio, meaning no therapy. When the disease stage advances or complications such as infections or low blood counts develop, at that point chemotherapy is started. Type of chemo depends on patient age, activity and can range from oral pills to combination regimens. ...Read more

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What is involved in cll treatment?

What is involved in cll treatment?

DEPENDS: Not all cll patients require treatment up front. Its a chronic disease and it is not curable. Treatment is offered if symptomatic or changes in blood counts. There are many options, mostly chemotherapy. The oncologist will help decide which is more appropriate. ...Read more

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Can a person with cll use sugar and/or honey?

Sure: Ignore all "pop" advice about diet for this illness, which is usually mild. Try to find out the results of flow cytometry on your case and read up. ...Read more

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What is the life expectancy of someone with cll leukemia?

Usually many yrs: Many pts survive many years with this diagnosis./ your doctor likely discussed the genetic tests and blood work that can help define the rate of progression expected with current therapy. A small percentage have a rapid course of disease. ...Read more

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High monocytes: does this mean it's more likely cml or cll?

Need to see all the : Results. How high is the count? What does the blood smear look like? A mild elevation of monocytes probably is not indication of any disease. Please note that all lab results need to be interpreted in the clinical context and your doctor is in the best position to do that. ...Read more

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What to do if I have high monocytes is it more likely cml or cll?

Depends : It would depend on the other lab values in your complete blood count (CBC), the full differential count, your history, physical exam, other labs. Also your doctor will have to look at your blood under the microscope (either your venous blood or bone marrow---if that is done). ...Read more

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is it possible to have sll or cll as well as relative polycythemia?

is it possible to have sll or cll as well as relative polycythemia?

Send us details: It is not a good idea to use abbreviations(?CLL? SLL? I have no idea what you mean from these terms! Send us the results of your blood counts(CBC). Then we can guide you further. ...Read more

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Diagnosed with cll. Told stage 0 but feeling bloated and on and off pains in shoulder blades.

Possible!: I think you are referring to rai stage 0. This means you have elevated lymphocytes but with no enlarged lymph nodes or spleen. If not done, you would need ct scan to check for enlarged spleen which can cause bloating and feeling full quickly. However, these symptoms are atypical and less likely to be directly related to cll. Check with your oncologist! ...Read more

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Have cll stage 0 recently diagnosed . Just lately have pain and abdomen is sensitive, left and middle of abdomen. Is ths related ?

Have cll stage 0 recently diagnosed . Just lately have pain and abdomen is sensitive, left and middle of abdomen. Is ths related ?

Unlikely: If it is truly stage-0 cll, then it should not cause any problems. But if the pain persists you should have ct scan scan done. That is the only way to find out if the lymph nodes in the abdomen may be getting bigger and your clllmay be of a higher stage. ...Read more

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What is the treatment for leukemia (cll) at stage zero?

Nothing: The indication for cll therapy are the following: stage 3 (hemoglobin <10), stage 4 (platelets<100, 000). A rapid lymphocyte doubling time is also a reason. It should not be treated at rai stage 0 or 1. It is not curable, so treatment is given only when needed. If the leukemia starts bothering the patient, then time to treat the leukemia. Hope this helps. ...Read more

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Are there causes for smudge cells and high WBC other than cll?

Are there causes for smudge cells and high WBC other than cll?

Yes.: Smudge cells are cells that are extremely fragile and easy to disrupt the cell membrane when making a blood smear. Therefore, if the cell is disrupted it can be very hard to identify what kind of cell it is. The most common and well known disease with smudge cells is cll. However, many other hematologic diseases also have smudge cells. Further testing is needed to be sure what cells are there. ...Read more

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With cll am i better to ask an oncologist my questions than you?

With  cll am i better to ask an oncologist my questions than you?

Additional : It will be up to you ultimately to decide. However, it is not our intention to replace your primary oncologist- in any case. As written on the disclaimer - answers on healthtap are not intended for individual treatment, prescription or diagnosis. Yes, in my opinion, it is always the best to ask and drect all your questions to your primary oncologist. ...Read more

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Chronic lymphoblastic leukemia (cll) is cll terminal? Is there a cure?

Chronic lymphoblastic leukemia (cll) is cll terminal? Is there a cure?

See below...: Chronic lymphoblastic leukemia does not exist. Cll stands for chronic lymphocytic leukemia. Lymphoblastic leukemias are acute.The only known complete cure for cll is stem cell transplantation; however, many patients do not need any form of therapy unless there are symptoms or adverse prognostic factors. Cll is usually not an aggressive form of leukemia and has a relatively good prognosis overall. ...Read more

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