Doctor insights on:
Clinical Significance Of Crp
Excellent question.: Monoclonal lymphocytes mean that a single lymphocyte has been stimulated to divide and create an expanded number of identical daughter cells. There are enough of them to be identified by a test (flow cytometry) but not enough to meet criteria for a leukemia. There may be a genetic predisposition. This is a benign condition, but there is uncertainty as to whether it might progress to malignancy. ...Read moreSee 1 more doctor answer
MGUS: Is a common precancerous condition affecting people 50 years of age and older. It was first described by mayo clinic researchers in 1978 and is characterized by the presence of an abnormal protein in the blood called a (monoclonal) protein or m protein.Mgus has a small risk (1 percent each year) of progressing to a blood cancer called multiple myeloma or a related condition. ...Read more
The best indicator: CRP is called an acute phase reactant because it can increase in response to acute conditions. The common belief is that CRP is the best objective indicator of inflammation. Some rheumatologists believe that it’s the only dependable inflammatory indicator for RA and other. ...Read moreSee 1 more doctor answer
Blood & urine tests: Mgus is the presence of an abnormal protrein in the blood made by a type of white blood cell called a plasmacyte. In most cases, it is at a low level and is something that just has to be followed. However, it can be the precursor of the disease called multiple myeloma and as such a hematologist or medical oncologist will order tests to rule this out which may include blood, urine and simple x-rays. ...Read moreSee 1 more doctor answer
Lab results WBC 15.6 mchc29.6, 649platlets 4.3lymthocytes 1.6 monocytes 9.7anc what does this mean. history of undiff mixed connective disease. ?
Not much-: An important thing to remember is that lab results are not useful unless there is a clinical context. Advice is based on focusing on the patient, not the numbers. Though you mention a history of undiff mixed connective tissue disease, where there symptoms when labs were drawn? Why were they drawn in the first place? Otherwise , it is best to ask your doctor what the results mean. ...Read moreSee 1 more doctor answer
Hx of seronegative RA yet recent labs show high crp/esr, absolute neutrophils and ANA by IFA but w/ no titer. What could that mean without a titer?
See below: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your lab results suggest active on-going inflammation. The titer of ANA is not particularly relevant. Wish you good health. ...Read more
What do these biopsy results of thyroid nodule mean ATYPIA OF UNDETERMINED SIGNIFICANCE OR FOLLICULAR LESION OF UNDETERMINED SIGNIFICANCE?
Re-FNA in 3-6 Months: Hi Jami, AUS/FLUS is a term that cytopathologists use for thyroid nodules that they basically are "unsure" about. Classic management for this diagnosis is to have a second repeat FNA in 3-6months. Nowadays though high tech molecular pathology tests can sometimes divide AUS/FLUS definitively into benign and malignant categories. Please setup a virtual consult with me for more information. ...Read more
Depends: If you have M protein from another class of immunoglobulin, then the cells producing this M protein would crowd out the other immunoglobulin producing cells in the bone marrow leading to a lower level of what that cell would ordinarily produce. Some Multiple myeloma cases are of no medical significance but needs to be followed. Many myeloma patients are prone to bacterial infections. ...Read more
I know ARD diagnosis depends on the whole clinical picture. Probability-wise, which ARDs are associated with a nuclear coarse speckled ANA pattern?
Depends on other lab: There are a number of rheumatologic diseases that could have that ANA pattern, and it's also possible to have a positive ANA without having a disease. Diagnosis depends on more than just the ANA -- your doctor will probably do other tests, and with all the lab results plus your physical exam, be able to give you a diagnosis. ...Read more
Predicts events.: Lipid profile tells you about risk for future heart / blood vessel disease. Smoking, hypertension, diabetes and lipids are modifiable risk factors. Non modifiable risk factors are male sex, getting older and having family history of early heart disease. At your age there is virtually no contribution of lipids to mortality within the next 20 years unless numbers very high or many risk factors. ...Read moreSee 2 more doctor answers
Recent blood work shows IgA of 4.16 and urine states "monoclonal IgA lambda detected." what does this indicate?
Mgt: FeNO reflects activation of a type of cell associated with allergic lung disease. It can be falsely elevated in some situations. If you have no symptoms, discussing why you had this test with your PCP is advised. If your doctor suspects that you have asthma, I would suggest having a lung function test performed. ...Read more