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Doctor insights on: Clinical Eds Test Vascular

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Why do some with clinical eds diagnoses test negative for veds, but have vascular events?

Why do some with clinical eds diagnoses test negative for veds, but have vascular events?

Older testing: If a comprehensive evaluation is done the people with vascular risk can be determined. The incidence of vascular complications reflects available testing about 15 years ago. With improved testing techniques unanticipated vascular complications are rare without additional risk factors to include smoking. ...Read more

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Dr. Scott Keith
5 doctors shared insights

Vascular (Definition)

"vasculum" ...Read more


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Do 10-25% of those with classical eds who tested negative for vascular eds have vascular issues?

Do 10-25% of those with classical eds who tested negative for vascular eds have vascular issues?

Depends: Would not focus so much on percentages, but instead would present your symptoms to your rheumatologist. Would try to seek out eds centers who understand the condition more than most and have seen a larger volume of eds patients (usually at university hospitals). ...Read more

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How come many patients with clinical eds diagnoses do not test positive yet have vascular issues?

How come many patients with clinical eds diagnoses do not test positive yet have vascular issues?

No simple test: Eds in one form (vascular eds) can cause weakness of the blood vessels. If the vessel ruptures seriousl consequences can occur. Eds causes a weakness or loss of elasticity which can lead to stretching, ballooning out and eventual rupture. Probably easiest way to diagnose is with ultrasound or ct with contrast. ...Read more

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Positive diagnosis (scleroderma, polymyositis) with negative blood tests? Is that common?

Positive diagnosis (scleroderma, polymyositis) with negative blood tests?  Is that common?

PM/Scl: The paradox of rheumatologic diseases is that there are more lab tests in this area than any other, and they of relatively less value compared to the history and physical findings than in other fields. If your rheumatologist is comfortable with the diagnosis of "scleromyositis", which usually features anti-pm/scl, i'd accept it even with a single negative result, and proceed. ...Read more

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What tests confirm peripheral arterial disease?

What tests  confirm peripheral arterial disease?

ABI/PRESSURES: Ankle brachial index(abi) measures the difference in blood pressures between the arms and legs and arterial ultrasound which is a type of imaging test can be used in conjunction with this to establish this diagnosis along with an appropriate history. ...Read more

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Which skeletal diagnostic tests are performed to diagnose Marfan syndrome?

Which skeletal diagnostic tests are performed to diagnose Marfan syndrome?

Several features: Features suggestive of marfan syndrome include: above-average height, long arms, long fingers, flat feet, high-arched palate, narrow face, crowded teeth, small lower jaw, pectus carinatum (pigeon chest), pectus excavatum (sunken chest), hunchback (hunchback), scoliosis (crooked back), hypermobile/hyperflexible joints, etc... ...Read more

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P-Anca positive, negative MPO??? Wegener's vasculitis suspected due to clinical symptoms. 6 yr old with juvenile arthritis.

P-Anca positive, negative MPO??? Wegener's vasculitis suspected due to clinical symptoms. 6 yr old with juvenile arthritis.

Autoimmune: The positive ANCA test supports the diagnosis of an autoimmune disorder but with a negative MPO test (of one the proteins in the neurophils targeted by the disease) the possible diagnoses are many including Wegener's, RA, and others. Further testing including a biopsy may be required. ...Read more

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Is a blood test to diagnose paraneoplastic syndrome experimental?

Is a blood test to diagnose paraneoplastic syndrome experimental?

Maybe: Some defined antibodies are associated with paraneoplastic syndromes (note: plural). In those cases the testing may be positive. However, a person could have a paraneoplastic syndrome with negative testing for the known paraneoplastic antibodies. It is possible that studies are being done to characterize tests for paraneoplastic syndromes. That might be experimental. ...Read more

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Given a positive RNP antibody test, what are the clinical diagnostic criteria for MCTD?

Given a positive RNP antibody test, what are the clinical diagnostic criteria for MCTD?

MCTD: Usually considered diagnostic if high RNP titer, and two or more of the following: Raynauds, myositis, synovitis and swollen fingers/hands. ...Read more

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Transthoracic echocardiogram, chest x ray, renal sonogram, lots of blood work by hematologist, lupus test found nothing after splenic infarct. Am i ok?

Splenic infarct: You have a lot of normal tests. This is a good thing. You should discuss with your doctor(s) who know you best what their impression is. ...Read more

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Where do collagen vascular diseases show up?

Where do collagen vascular diseases show up?

Different areas: Collagen vascular diseases or multi-system diseases are just that. They are a group of diseases characterized by autoimmune aberrations. Varied organ systems can be involved - skin, joints or any internal organs - heart, kidneys, blood or nervous system. The way a disease presents itself depends on which areas are involved. See you doctor or rheumatologist. ...Read more