Doctor insights on:
New antihistamine: Clarinex is the brand name for desloratadine, the major metabolite of Loratadine (claritin). This makes it a new generation antihistamine. Desloratadine is approved for treatment of seasonal and perennial allergic rhinitis as well as chronic hives. Clarinex is available as a tablet, reditab, oral solution and as a combination product with a decongestant. ...Read more
Is there a prescription medication that is stronger than clarinex (desloratadine) d? I've been taking it for over a week. Allergies hit today like I've taken no meds.
Can my girlfriend take medications such as clarinex (desloratadine) and nyquil while on birth control?
Should be ok: Assuming that you're talking about birth control pills, there should be no problem with taking birth control pills with these medications. ...Read more
Can a pregnant woman take desloratidine tablets as antihistamine medication during the first month of pregnancy or is it a contraindication?
Probably not: This drug is classified as category c in pregnancy and thus you should consider taking those with category b classification with pregnancy. In fairness, I have not seen much data linking fetal anomalies to any of the approved antihistamines. However it is better to be safe than sorry. ...Read more
A purified form: Loratidine is a mixture of equal parts desloratidine & its inactive mirror image compound. In biochemistry there are many such molecules with identical chemical formula that act differently because of "handedness". The inactive part of loratidine is safely removed by your body. Effects & side-effects are the same. Major difference: loratidine is over-the-counter; desloratidine is prescription. ...Read more
Desloratadine: Or clarinex, requires prescription, the brand costs 3 times as much as the generic, which costs around 80$ for one month supply, (30 tablets) ...Read more
Des/loratadine: Desloratadine is the primary metabolite is loratadine. The advantage is thought to be quicker onset of action and longer action of anti-histamine effect. There is a small percentage of patients in which neither drug is able to be metabolized adequately. At usual doses, both are considered non-sedating specific h1 antagonists. Clinically speaking both are useful drugs for typical allergies. ...Read more
Seasonal allergies: Clarinex is another form of the antihistamine medicine-claritin. The generic name is loratidine. It helps with allergies, like hay fever. There are many current examples of medications which have become generic, so drug companies try and make an alternative form that they can market with a brand name. If you take claritin-your body converts it into clarinex. Another example is Nexium (esomeprazole) and prilosec. ...Read more
Follow manufacturer: We all know that medications last beyond their expiration dates. But who would pay for studies to check this? Not the manufacturer who has an interest in you buying more drugs. A recent review in JAMA in 2012 reviewed this subject. But no, if you need to use a drug, I would follow the expiration date on the package. ...Read more
Almost identical: Despite claims, in practice Not much. Just a minor modification of the molecule as one is a metabolic derivative of the other. The efficacy is about the same. ...Read more
Metabolite: Clarinex (desloratadine) is des-loratadine and Claritin is loratadine. Clarinex (desloratadine) is the active metabolite of claritn. So (according to the manufacturer) you have the benefits of loratidine with minimal side effects. It is common in the pharmaceutical industry to use active metabolites or isomers of drugs. This potentially gives you a more active compound while minimizing the potential side effect. ...Read more
15-30min: Antihistamines in general can take up to 30min or so to work. It should not take you more than a couple of days to know if that medicine will work for you or not. ...Read more
Expiration date: Check the expiration date on the medication label. The potency of the medication cannot be guaranteed beyond the expiration date. A medication without potency very likely has less effectiveness. ...Read more
Yes: Simplified: Claritin (loratadine) is made up of 2 parts of the molecule- the active part and an inactive part. Clarinex is made up of just the active component. Some people find using Clarinex better relief than claritin (loratadine). However to others the effectiveness is the same. ...Read more
3 days: For the typical patient clarinex (desloratadine) will be out of the system and not interfere with allergy testing in 3 days however some people can clear this medication slower or faster than others. ...Read more
The first time: Time from ingestion to full activity is about 1 to2 hours. The same dose will act in the same way each time you take it, but may not seem as effective if your exposure to allergen is greater. ...Read more
What are the differences between loratadine and desloratidine in how well it works or how long it lasts?
Take one, get both: When you take loratidine, your liver breaks it down to desloratine which is actually responsible for the anti-histamine effects you need. Desloratidine has a much longer effect (28 hours) than loratidine (8 hours) which is why loratidine lasts such a long time. ...Read more
Avoid Clarinex (desloratadine): Allergy to Clarinex (desloratadine) is unusual. However, you should avoid Clarinex (desloratadine) in the future if you have had an adverse reaction. ...Read more
Clarinex (desloratadine) has only slight differences in chemical structure from the original product of Claritin and in my clinical experience you will not notice any difference in relieving your allergy symptoms.
The generic of claritin, loratadine, is also much less expensive and is available at most drug stores. ...Read more