Doctor insights on:
Chronic Pancytopenia Anemia
Depends on cause: Chronic pancytopenia means low white & red cells and low platelets. Reversible causes such as nutritional deficinecies, immune disorders, drug-related can be treated effectively. However, patientsw with inherited conditions or bone marrow disorders need a detailed work-up and treatments may not be effective. ...Read moreSee 1 more doctor answer
Early IDA possible: Hypochromic suggests low iron (which can be measured by ferritin, transferrin, etc). Usually this would be from blood loss. Usually iron deficiency anemia (ida) is also assoc w/ microcytic (low mcv) red blood cells (rbcs). It depends on the numbers, other tests & history, but could be early iron deficiency/blood loss &/or more than one process -- eg b12/folate deficiency & ida. See md. ...Read more
Not clear: No clear evidence for the causal-effect relationship between the two. PA is an autoimmue-mediated destruction of parietal cells in stomach, resuling in impairmnent of B12 absorption. Certainly it is possible that pernicious anemia may co-exist or exacerbate duodenitis via immune process or loss of balance in duodenal fluid, or anemia. But the causal-effect relationship is not well established. ...Read moreSee 2 more doctor answers
Complex problem: It appears that your bone marrow is not making new blood, so you have anemia due to the failure of production. If you have pancytopenia then the problem is much more than anemia alone. Such situation are either due to leukemia or preleukemic conditions like Myelodysplastic syndrome(MDS). You need a blood specialist to help you sort it out and guide you further. ...Read more
DDx: There are many potential causes of low platelet count (thrombocytopenia). In general platelet production can be low from various bone marrow disorders including cancer and other problems. If the bone marrow is producing platelets they can be destroyed in the body such as immune thrombocytopenic purpura (itp) or sequestered in the spleen if the spleen is enlarged (eg alcohol related splenomegaly). ...Read more
Decreased Hemoglobin: Red blood cells (rbcs) are essentially little bags carrying lots of hemoglobin (hb). Iron is an important constituent of the hb molecule. Low iron = low hemoglobin = less packing into rbc. Since the RBC is now filled less, a microcytic anemia results. ...Read moreSee 1 more doctor answer
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