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Doctor insights on: Chronic Myeloid Leukamia

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What is chronic myeloid leukemia?

What is chronic myeloid leukemia?

Marrow cancer: CML is a marrow malignancy characterized by excessive number of white blood cells with various degrees of maturation. Most CML patients have deficient number of red cells and platelets. CML responds dramatically to oral agents called tyrosine kinase inhibitors. Examples are Gleevec and Sprycel (dasatinib). ...Read more

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What are some treatments for chronic myeloid lukemia?

What are some treatments for chronic myeloid lukemia?

See below...: First of all, the treatment for any type of leukemia should be coordinated by a hematologist/oncologist. To answer your question, chemotherapy is usually necessary like for any other type of leukemia; however, there is also a special drug that is central in the chronic treatment of cml, namely Gleevec (imatinib), with a specific benefit in this type of leukemia. ...Read more

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Which systems are affected by chronic myeloid leukemia?

Which systems are affected by chronic myeloid leukemia?

Primarily the blood: While it is a cancer of the white blood cells, if it is not well controlled, then CML can affect the whole body by affecting your immune system and blood supply. ...Read more

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Can you die from chronic myeloid leukemia if it is only in it's first stages?

Can you die from chronic myeloid leukemia if it is only in it's first stages?

Possible but unlikel: There have been excellent therapies for this disease with Gleevec (imatinib) and newer drugs. The data is suggesting that for many patients their survival can be close to the normal population. The drugs make the disease behave. There are a small percentage who do not respond well. Your doctor can give you precise info on your situation and how you will know that you are responding well to treatment. ...Read more

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What is there to expect in the last stage of leukemia, chronic myeloid leukemia?

What is there to expect in the last stage of leukemia, chronic myeloid leukemia?

The last: Stage of CML is known as "blast crisis." it behaves like a treatment refractory acute myeloid leukemia. The typical survival is weeks to a few months. ...Read more

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Why there is increase in transcobalamin ||| in chronic myeloid leukemia?

Nobody knows: This will be abundantly clear to you after you read the last major review from Oxford, 2013. They simply gloss over the "why". http://qjmed. Oxfordjournals. Org/content/early/2013/02/27/qjmed. Hct051 ...Read more

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What is the life expectancy for a 20 year old with chronic myeloid leukaemia?

Maybe normal.: If the CML is diagnosed in early chronic phase, if it responds to treatment with a complete molecular response, long term survival is excellent. We only have 10 year or so information for the new drugs used in cml, but for those patients who are out 10 years, we think their survival may be unaffected by the leukemia. That is why bone marrow transplant is no longer the initial treatment for cml. ...Read more

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I need to know if there is a cure for chronic myeloid leukemia (cml)?

I need to know if there is a cure for chronic myeloid leukemia (cml)?

Yes: CML used to be bad, 50% dead in 5 years. Today treatment with tyrosine kinase inhibitors results in 95% of patients being alive 5 years after diagnosis. So far, treatment with tkis does not seem to permanently eliminate the leukemia, requiring continued rx. A smaller proportion of patients who fail tki rx can get transplants and be truly cured, but at the risk of complications. See a good hem/onc! ...Read more

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How is acute myeloid leukemia different from chronic lymphoma leukemia?

Different cell type: Leukemias typically originate when one of the white blood cell types starts multiplying out of control and preventing the normal cells from doing their job. There are many types of white blood cells and the subtype of leukemia or lymphoma or myeloma depends on which subtype is out of control. ...Read more

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My mother is diagnosed with chronic myeloid leukemia (cml).\nplease advice?

CML: We have several medications now to treat this and there is typically a high response rate. The most common drug used is called imatinib but there are 2 others that are approved for first line treatment, Dasatinib and nilotinib. It also depends on the stage, chronic or blast phase. Hope this helps. ...Read more

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I'm having symptoms of blood cancer - how to tell if it could be chronic myeloid leukemia (cml)?

I'm having symptoms of blood cancer - how to tell if it could be chronic myeloid leukemia (cml)?

CBC: Get a blood count. Can be reviewed under the microscope. Then if felt to be abnormal, then the hematologist will obtain what is called BCR-ABL by FISH to confirm. Hope this helps. ...Read more

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What occurs after a bone marrow transplant is needed for chronic myeloid leukemia?

What occurs after a bone marrow transplant is needed for chronic myeloid leukemia?

Hopefully cure: CML is a major success story. About 30 years ago up until about 2000, the standard for cure was allogeneic bone marrow transplantation. Now, new drugs can achieve long term remissions of a decade or more. This is the new standard of care but despite this, when these drugs fail, bone marrow transplant is still the gold standard and still the only curative therapy. There are many complications. ...Read more

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Could you tell me what happens when a bone marrow transplant is needed for chronic myeloid leukemia?

Could you tell me what happens when a bone marrow transplant is needed for chronic myeloid leukemia?

This is: By definition a failure of the tyrosine kinase inhibitors. If the patient is chronic phase the curability with transplant should still be about 60%. ...Read more

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Is bone marrow transplantation is curative for chronic myeloid leukemia caused by (Philadelphia chromosome)?

Is bone marrow transplantation is curative for chronic myeloid leukemia caused by (Philadelphia chromosome)?

Yes: In 70 to 80 percent of cases. The availability of tyrosine kinase inhibitors such as gleevec (imatinib) has moved transplant to 3rd line treatment ...Read more

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What does mild myeloid hypoplasia mean?

What does mild myeloid hypoplasia mean?

Not much: Hypoplasia means less than normal number of cells. It appears, it is from a sample of bone marrow where the myeloid cells (premature white cells) reside but their existence is patchy. So it is not a very exact science when you assess the numbers from a bone marrow. When the word 'mild' is used in medical reports, it usually means, the reporting person is not so sure, so they use terms like this ...Read more

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About acute myeloid luekemia, can you survive if elderly?

About acute myeloid luekemia, can you survive if elderly?

Difficult: It really depends on age and type of aml. Some have better prognosis than others. It also depends on co-morbid status. Patients who evolve from mds also do very poorly. The issue is does that patient have a good prognosis or bad prognosis aml. If they are a condidate for treament can they tolerate agressive treatment or not. Most will do poorly unfortunately, especially above 80. ...Read more

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Any information on myeloid sarcoma?

Any information on myeloid sarcoma?

Leukemia Tumor: To understand this, you need to understand acute leukemia, which is the abnormal proliferation of white blood cells. This usually happens in the bone marrow. These millions of leukemia cells usually spill into the blood. Rarely, however, they can clump together to form a solid mass somewhere else in the body, like in a muscle or skin. This is called a myeloid sarcoma. ...Read more

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What's acute myeloid leukemia?

What's acute myeloid leukemia?

Blood cancer: AML is a blood cancer affecting a type of white blood cells called myeloid cells. It often occurs in late adult/elderly patients and has a short development phase usually (hence acute). Intensive chemotherapy and often bone marrow transplant can be effective with long term survival in 40-50% cases. AML in the elderly is more difficult to treat and results are worse. ...Read more

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