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Doctor insights on: Chronic Myelocytic Leukemia In Blast Crisis

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How should I treat chronic myelogenous leukemia?

How should I treat chronic myelogenous leukemia?

By oncologist: This is a somewhat indolent form of leukemia which responds to treatment and can be carried for many years without major illenss. You could only have known about this if you had a bone marrow and blood test from your oncologist whose recommendations i would continue to follow. ...Read more

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Dr. Liawaty Ho
1,144 doctors shared insights

Leukemia (Definition)

A malignant hematologic neoplasm that originates in the bone marrow and represents a clonal proliferation of hematopoietic elements belonging to any of the myeloid, lymphoid, erythroid, and megakaryocytic lineages. Of note, other hematologic neoplasms like lymphoma or myeloma may demonstrate a leukemic phase without actually originating in the bone marrow ...Read more


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What are the tests for chronic myelogenous leukemia?

What are the tests for chronic myelogenous leukemia?

Blood, bone marrow: Common tests include blood review, floww cytometry, and a bone marrowe and biopsy. ...Read more

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What are the symptoms of chronic myelogenous leukemia?

What are the symptoms of chronic myelogenous leukemia?

Fatigue: Fatigue is the most common symptom. Examination may show an enlarged spleen. The diagnosis is suspected by blood testing and confirmed by bone marrow biopsy. ...Read more

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What kind of disorder is chronic myelogenous leukemia?

Myeloproliferative: It is in a group of disorders referred to as myeloproliferative neoplasms. There are essentially four: chronic myelogenous leukemia, essential thrombocytosis, polycythemia rubra vera and myelofibrosis. Hope this helps. ...Read more

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What sort of disease is chronic myelogenous leukemia (c.M.L.)?

Bcr-abl: CML is a clonal disorder (cancer) of the white blood cells in the blood (= -emia part). Other leukemias include cll, aml, all, etc. CML is often diagnosed by testing on peripheral blood or bone marrow. The bcr-abl translocation (philadelphia chromosome) is found in cml. Treatment may be a variety of pills. The most common initial treatment has been gleevec (imatinib). Other drugs are available. ...Read more

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What are the tip-offs that you might have chronic myelogenous leukemia?

What are the tip-offs that you might have chronic myelogenous leukemia?

Symptoms: Many people with CML are found incidentally on blood tests done for an unrelated problem. Symptoms can be bleeding, easy bruising, fatigue, frequent infections, shortness of breath, abdominal fullness, or weight loss. ...Read more

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What's the genotype of chronic myelogenous leukemia?

9-22 translocation: A portion of chromosome 9 is tranferred to chromosome 22...When a cytogeneticist looks at this...They see the characteristic "philodephia chromosome" named after the city where the research was conducted. ...Read more

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What happens genetically that causes chronic myelogenous leukemia?

What happens genetically that causes chronic myelogenous leukemia?

Translocation: A big word but dna is always recombining when cells divide. In this case, a piece of dna from chromosome 9 moves over to chromosome 22 which essentially turns on a switch that produces an enzyme that promotes uncontrolled cell division and leukemia. Modern drugs are targeted to prevent the action of this enzyme. ...Read more

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What are the treatments for chronic myelogenous leukemia?

Multiple: There are medications called tyrosine kinase inhibitors. They block this enzyme and treat the leukemia. There are currently three on the market, imatinib, nilotinib and dasatinib. Other treatments include bone marrow transplant but rarely done now because these medications are available. Hope this helps. ...Read more

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What is chronic myelogenous leukemia?

A blood cancer: CML is a blood cancer that develops slowly (hence chronic). If untreated it will eventually be life threatening. It is associated a unique chromosomal injury, the philadelphia chromosome. New drugs (tkis) target this damage and reliably produce remissions in early stage patients that often are long lasting. ...Read more

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Dangers of chronic myelogenous leukemia?

Can be fatal: This is a disease that was associated with a shortened life span. The discovery of a specific cancer cell mutation and medications that attack that mutation have dramatically affected the outcome. This is now a disease that people can live for many years and be functional and productive. ...Read more

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What is chronic myelogenous leukemia (cml)?

What is chronic myelogenous leukemia (cml)?

White cell cancer: The bone marrow cells that produce granulocytes (needed to fight infections) grow out of control and are present in large numbers in the blood and other organs. The disease is quite treatable these days because of targeted therapy and long lasting remissions are possible in most people. ...Read more

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What are different ways to treat chronic myelogenous leukemia?

What are different ways to treat chronic myelogenous leukemia?

CML: CML is associated with philadelphia chromosome that result in the abnormal bcr-abl fusion gene. This becomes the target of treatment in cml. Oral tyrosine kinase inhibitor (tki) is the treatment of cml. The 1st generation is gleevec. Other tki that is more specific to block the bcr/abl fusion gene also available- sprycel and tasigna (nilotinib). Bone marrow transplant is available only for specific case. ...Read more

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What's the type of inheritance of chronic myelogenous leukemia (cml)?

Not inherited: CML is associated with chromosome damage (the philadelphia chromosome). This is not inherited. The damage is to bone morrow stem cells and occurs long after birth. So the disease is not passed on to children. ...Read more

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What is the definition or description of: Chronic myelogenous leukemia?

What is the definition or description of: Chronic myelogenous leukemia?

CML: there are two types of CML ,juvenile and adult . each manifests marked clinical , hematological,and cytogenetic differences. ...Read more

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If you have chronic myelogenous leukemia does that also affect your body externally?

Pallor: Most patient don't show obvious signs. If anemic one might be pale. Enlarged lymph nodes in the neck might be noticeable. If the spleen is big, the abdomen might protrude a bit. Otherwise visible signs usually are lacking. ...Read more

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Sure, i've heard of chronic myelogenous leukemia. But now that I have it, I want to know what is really happening in my body.?

Sure, i've heard of chronic myelogenous leukemia. But now that I have it, I want to know what is really happening in my body.?

Cancer of WBC: CML is a chronic leukemia- cancer of the white blood cells. The bad news is that you have cancer. The good news is that you can control-perhaps to "cure" this leukemia with pill that you take at daily basis. The prognosis majority is very good. Only for a few cases-that people need bone marrow transplantation for cml- nowadays. For further detail info- read at www.Nccn.Com for patient resource. ...Read more

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How can chronic myelogenous leukemia cause hepatomegaly?

Infiltration: The speen does enlarge in this disease. The causes include direct inflitration. Another is production of other blood elements (extramedullary hematopoesis) in the speen in response to either replacement of the marrow with CML or scar. The scarring is called myelofibrosis. ...Read more

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Can chronic myelogenous leukemia affect cellular metabolism?

It is Complex!: Why is it so important to know the answer to this question for your practical purpose and guidance, it does not. But if you want to conduct research on this matter be my guest! ...Read more

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What complications arise when a person with chronic myelogenous leukemia (cml) becomes pregnant?

Difficult situation: This has happened to many women taking Imatinib (Gleevec) for CML. Most women have had a normal baby, others aborted the baby with help from a Gynecologist. I believe it is safe to carry the baby to term but there is some risk the drugs can harm the bay but it is not proven. So if you want to keep the baby then you should take this risk, but be closely monitored by a CML expert. First 3 months are ...Read more