Doctor insights on:
Chronic Myelocytic Leukemia In Blast Crisis
Can Philadelphia chromosome positive Chronic Myeloid Leukemia turn into Pre-B-Acute Lymphoblastic Leukemia?
A malignant hematologic neoplasm that originates in the bone marrow and represents a clonal proliferation of hematopoietic elements belonging to any of the myeloid, lymphoid, erythroid, and megakaryocytic lineages. Of note, other hematologic neoplasms like lymphoma or myeloma may demonstrate a leukemic phase without actually originating in the bone marrow ...Read more
Different cell type: Leukemias typically originate when one of the white blood cell types starts multiplying out of control and preventing the normal cells from doing their job. There are many types of white blood cells and the subtype of leukemia or lymphoma or myeloma depends on which subtype is out of control. ...Read moreSee 1 more doctor answer
If a person has AML - acut emyeloid leukemia, what percent of blast would suggest acute myeloblastic leukemia?
Blasts in blood/marr: Blasts are made in the bone marrow. Normally they are under 5% of all the white cells. So a Blast count in the bone marrow over 6% raises the question of Acute leukemia. Anything >30% blast count confirms a diagnosis of acute leukemia. As the blast cell numbers increase in the marrow, Blasts start to appear in the peripheral blood. That is how Leukemia is first diagnosed. ...Read more
AML: AML is the most common acute leukemia in adults and accounts for approximately 80 % of cases in this group. In us and europe, the incidence has been stable at 3 to 5 cases per 100, 000 population. In contrast, AML accounts for less than 10 % of acute leukemias in children less than 10 years of age. ...Read more
I believe you have: These diagnoses confused. Chronic leukemias display an elevated # of wbcs with morphologic and functional features similar to the mature cells of that lineage (lymphoid-cll vs myeloid-cml). Think of it as not turning off the spigot when the bucket is full. Acute leukemias have features of immature cells for a lineage (aml vs all). Acute leukemias can arise from chronic ones. This is blast crisis. ...Read moreSee 2 more doctor answers
AML is a cancer.....: Of the bone marrow (actually a group of cancers) whose precise causes are unknown, but about which we know considerable molecular detail and are learning more each day. The disease arises from the hematopoietic stem/progenitor cells in the bone marrow when these cells acquire mutations that allow them to escape controls on growth and apoptosis. Subtype info is found on the nci website. ...Read moreSee 2 more doctor answers
Rephrase question?: Can you rephrase your question? Are you asking about treatment for aml? Treatment would depend on the type and biology/cytogenetic profiles of the aml. Generally speaking- in majority cases would need to get a combination of chemo as an induction then plus minus stem cell transplantation. A derivative of vitamin a- sometimes is given to certain case of aml. Discuss in detail with your oncologist. ...Read more
Can be fatal: This is a disease that was associated with a shortened life span. The discovery of a specific cancer cell mutation and medications that attack that mutation have dramatically affected the outcome. This is now a disease that people can live for many years and be functional and productive. ...Read more
20-30: It depend to the type of ALL ,B cell ,T cell ,age of diagnosis ,bellow 2 years or above 9 years ,CNS involvement at diagnosis,but about 20-25% ...Read more
See below: About 80-90% of patients will achieve remission, but some of these patients will relapse and not be cured. Overall cure is achieved in about 40%. Those numbers come from this link: http://www.Cancer.Org/cancer/leukemia-acutelymphocyticallinadults/overviewguide/leukemia-all-overview-survival-rates. ...Read more
Most less severe: Most are less severe in sickle cell thalassemia, but depends. HbS/B(0)thal: similar to HbSS in severity maybe slightly less severe. HbS/B(+)thal: has 60% HbSS and 30% HbA, thus less severe than HbSS (sickle cell alone). HbS/A-thal: less severe than HbSS due to decreased HbSS amount. ...Read more
Is bone marrow transplantation is curative for chronic myeloid leukemia caused by (Philadelphia chromosome) ?
Bone marrow cancer: White blood cells live and grow in the bone marrow and enter the blood stream where they travel throughout the body to fight infection. If these cells become cancerous, they grow out of control choking out the normal blood cells in the bone marrow and leaving the person vulnerable to infection, bleeding and anemia because there are not enough normal cells. All ages get AML but usually younger. ...Read moreSee 1 more doctor answer
Yes! AML can kill.: Acute myeloid leukemia can be very aggressive. Generally it is treated at major clinical centers with a lot of expertise in leukemia especially at first. AML is seen in both children and adults. I would recommend that if either you or a family member is diagnosed with this to seek out a center of excellence. ...Read moreSee 1 more doctor answer
Symptomatology level of what would be the difference between acute myeloid leukemia and acute lymphoid leukemia?
AML vs. ALL: The symptoms of AML and all can be quite similar since both cause anemia (low red cells) and low platelets (which causes bruising and bleeding). In addition, they both cause an increased risk of various infections. AML is more likely to cause swollen gums and lumps on the skin. All is more likely to cause neurological symptoms since it can sometimes get into the brain or spinal fluid. ...Read moreSee 1 more doctor answer
Can chronic low & giant platelets (80-125) w/o a cause be ITP in adult w. Henoch Schonlein? In/out of HSP remission, Plts same, WBC/RBC vary low-norml
Hsp: hsp doesn't cause any changes in platelet count. I am not sure what do you mean been in and out of remission. The chronic issues with hsp is the blood in the urine, butost of the time it is microscopic. Blood pressure need to be monitored. If you have other issues with platelet count, you probably need to see hematologist to help you sort it out ...Read more