Doctor insights on:
Chronic Lymphocytic Leukemia And Knee Pain
37female.tiredness,back ache,knee pain.palpitation,weakness.wbc3.7.hb.11.9(hbE)neutrophils low.all other cell counts normal.m Asian.leukemia?what?
A malignant hematologic neoplasm that originates in the bone marrow and represents a clonal proliferation of hematopoietic elements belonging to any of the myeloid, lymphoid, erythroid, and megakaryocytic lineages. Of note, other hematologic neoplasms like lymphoma or myeloma may demonstrate a leukemic phase without actually originating in the bone marrow ...Read more
18 son complains w knee pain, hasn't injured it been sick last while stomach issues can this be lukemia ?
Not necessarily at -:
All. There isn't much to go on to make a diagnosis like that.
Get him see his pcp to be evaluated with an examination and some labs. While any disease is a possibility, its not very probable, as there are more common causes of painful knee in a 18 year old.
Do yourself a favor and stop worrying, by getting him into seeing his pcp soon.
Good luck. ...Read more
My 3 yr old has a sed rate of 32, very high neutrophils, very low lymphocyte counts. Has feet, hand, knee pain, fever. Other than jra, what can it be?
Need more info: You are obviously seeing a pediatrician for this. Without a full history and the ability to examine your baby and review its medical records it would be incredibly inappropriate to attempt a diagnosis over the internet. Discuss with you pediatrician, and if not fully satisfied ask for a referral to pediatric rheumatologist for second opinion. Good luck and hope your child feels better soon. ...Read more
Your oncologist can: Ask your treating doctor. The stages of cll are based on the extent of disease which requires both blood tests as well as physical exam and ct scans of the chest and abdomen to look for lymph node enlargement and or splenomegaly. ...Read more
Cll affects older white men more that other parts of the population and the cause is unknown in most cases. Exposure to certain herbicides and insecticides, including agent orange used during the vietnam war, have been linked to an increased risk. For more information
http://www.Mayoclinic.Com/health/chronic-lymphocytic-leukemia/ds00565/dsection=risk. ...Read more
CLL: Simplisticly it is an overgrowth of lymphocytes. Since these cells are usually slow growing the disease tends to progress at a relatively slow rate compared to other types of leukemias and in general may take years to begin to harm a patient. Treatment is usually withheld until the patient becomes symptomatic. ...Read more
A test 2 assess risk: The correct name is igvh mutational status assay. This is a gene test performed only on leukemic cells of patients with cll to assess risk of progression, and death from cll. The readout is either mutated (which is favorable) or unmutated (unfavorable). Igvh mutations happen during the normal generation of antibodies in white cells. ...Read more
Cure?: There are many treatnents used to treat cll. However the only therapy that may be curative is a stem cell or bone marrow transplant from a donor. ...Read more
Please explain the difference between chronic lymphocytic leukemia and non-hodgkin's lymphoma. Is hashi's a risk factor?
Depends on the stage: In early case, patient will be asymptomatic and the only thing abnormal is the blood test. In later stage- one can have low blood counts (anemia, low platelet), fatigue , tired, lack of energy, bruising easily/bleeding also, you could feel lymph nodes enlargement on the neck, arm pits, groin etc as cll involves more to the lymph nodes. Increase abdominal girth, fever, chils, weight loss can happen. ...Read more
See below...: Cll stands for chronic lymphocytic leukemia, a form of blood cancer. Cll is usually not an aggressive form of leukemia and has a relatively good prognosis overall. Many patients are asymptomatic for a long period of time (years) and do not need any form of therapy unless there are symptoms or adverse prognostic factors. ...Read more
CLL: Cll is a clonal disorder (cancer) of the white blood cells (specifically lymphocytes) in the blood (= -emia part). Other leukemias include cml, aml, all, etc. Cll is often diagnosed by flow cytometry on peripheral blood. Additional studies may include ct scans and bone marrow biopsy. One staging system is rai 0 to iv. Treatment ranges from observation (rai 0-1) to various tx individualized to pt. ...Read more
Yes: But it is quite rare before age 40. ...Read more
About 10-20%: Fatigue is nonspecific. Here we talked about extreme fatigue not very common. Most people with cll, especially at early stage, are asymptomatic. About 10-20% people will experience so-called b symptoms (fatigue, fever, night sweat, or weight loss). This number could go higher as disease progresses, but no linear relationship. ...Read more
A friend had chronic demyelinating polyneuropathy (cidp), then got chronic lymphocytic leukemia 2 years later. Is cidp paraneoplastic syndrome sometimes?
Not likely: Chronic inflammatory demyelinating polyradiculopathy (cidp) is almost always an autoimmune condition incited by some antecedent infection--c. Jejuni, ebv, cmv, or another infection. Antibodies produced against the virus/ bacteria/ pathogen cross-react with the myelin sheath on the nerve roots, first causing guillain-barre (aidp), then later cidp. It's exceedingly rare that cancer could cause this. ...Read more
Rare: There have been familial cases reported and my partner and i had a brother and a sister. The brother has never required therapy yet but the sister did. Mayo clinic is doing a study on familial cases. Mainly taking blood and studying it. It is an ongoing study so the results are not available yet. Hope this helps. ...Read more
See below...: The only known complete cure for cll is stem cell transplantation; however, many patients do not need any form of therapy in the beginning and treatment is only started if the patient develops symptoms or adverse prognostic factors are present. Cll is usually not an aggressive form of leukemia and has a relatively good prognosis overall. ...Read more
Rai stage 0 cll infrequently progresses to higher-stage disease. The median survival is at least 130 months as reported in 2009:
the disease is "heterogeneous, " which means that different patients have different experiences, making progression hard to predict in any one individual. ...Read more
How many years do you have to have it before you are called "chronic" in chronic lymphocytic leukemia?
Even at the time of diagnosis, a patient with this cancer is said to have "chronic lymphocytic leukemia, " so the amount of time is not the determining factor.
Chronic lymphocytic leukemia (cll) refers to an often slow-growing leukemia that likely develops over time, in contrast to acute leukemia (which develops rapidly and must be treated rapidly). ...Read more
I was diagnosed with chronic lymphocytic leukemia and would like to know if there anything known to slow the progression when one is asymptomatic.?
If you have a severely weakened immune system due to chronic lymphocytic leukemia, do vaccines even work?...And...Are they safe?
Yes, and most are: Unless you have been treated (chemo, radiation, etc.), your immune system should still produce some normal-functioning cells in addition to leukemic ones. So, you can get some benefit from vaccines. Most vaccines are safe, as they are made from killed viruses and bacteria. But ones made from live viruses (varicella and oral polio, e.g.) may cause problems. See your hematologist for info. ...Read more
Are there any new findings on chronic lymphocytic leukemia regarding preventive treatment /protocol to slow progression of disorder while asymptomtic?
Yes (but...): Yes, but minimal and does not change the standard of care. Dr. Shanafelt and colleagues at mayo clinic have looked at green tea extract in rai 0-ii cll showing a 67% response rate. http://www.asco.org/ascov2/meetings/abstracts?&vmview=abst_detail_view&confid=74&abstractid=47574 -- conclusion: egcg containing green tea extracts may have potential as disease stabilizing agents... ...Read more
Options available: There are a lot of treatment options available. However not everybody with cll need to get treated right away at the first initial diagnosis. There are some indications to start one on therapy. Nowadays, treatment is personalized and tailored to the biology of the cancer. There are some prognostic/predictive markers that can be tested to guide treatment selection, discuss with your oncologist. ...Read more