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Doctor insights on: Chronic Lymphocytic Leukemia And Knee Pain

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Dr. Liawaty Ho
1,151 doctors shared insights

Leukemia (Definition)

A malignant hematologic neoplasm that originates in the bone marrow and represents a clonal proliferation of hematopoietic elements belonging to any of the myeloid, lymphoid, erythroid, and megakaryocytic lineages. Of note, other hematologic neoplasms like lymphoma or myeloma may demonstrate a leukemic phase without actually originating in the bone marrow ...Read more


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18 son complains w knee pain, hasn't injured it been sick last while stomach issues can this be lukemia ?

18 son complains w knee pain, hasn't injured it been sick last while stomach issues can this be lukemia ?

Not necessarily at -: All. There isn't much to go on to make a diagnosis like that.
Get him see his pcp to be evaluated with an examination and some labs. While any disease is a possibility, its not very probable, as there are more common causes of painful knee in a 18 year old.
Do yourself a favor and stop worrying, by getting him into seeing his pcp soon.
Good luck. ...Read more

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My 3 yr old has a sed rate of 32, very high neutrophils, very low lymphocyte counts. Has feet, hand, knee pain, fever. Other than jra, what can it be?

My 3 yr old has a sed rate of 32,  very high neutrophils, very low lymphocyte counts. Has feet, hand, knee pain, fever. Other than jra, what can it be?

Need more info: You are obviously seeing a pediatrician for this. Without a full history and the ability to examine your baby and review its medical records it would be incredibly inappropriate to attempt a diagnosis over the internet. Discuss with you pediatrician, and if not fully satisfied ask for a referral to pediatric rheumatologist for second opinion. Good luck and hope your child feels better soon. ...Read more

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4 weeks into chemotherapy for all leukemia, have insane knee pains in bed. any advise please?

See details: Speak with your oncologist. Without knowing the specific chemotherapeutic agents used, it is difficult to know whether the knee pain is related to the drugs or the disease. ...Read more

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How to determine chronic lymphocytic leukemia stages?

How to determine chronic lymphocytic leukemia stages?

Your oncologist can: Ask your treating doctor. The stages of cll are based on the extent of disease which requires both blood tests as well as physical exam and ct scans of the chest and abdomen to look for lymph node enlargement and or splenomegaly. ...Read more

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What causes people to get chronic lymphocytic leukemia?

What causes people to get chronic lymphocytic leukemia?

Mostly unknown: Cll affects older white men more that other parts of the population and the cause is unknown in most cases. Exposure to certain herbicides and insecticides, including agent orange used during the vietnam war, have been linked to an increased risk. For more information
consult:
http://www.Mayoclinic.Com/health/chronic-lymphocytic-leukemia/ds00565/dsection=risk. ...Read more

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What is the definition or description of: chronic lymphocytic leukemia?

CLL: Simplisticly it is an overgrowth of lymphocytes. Since these cells are usually slow growing the disease tends to progress at a relatively slow rate compared to other types of leukemias and in general may take years to begin to harm a patient. Treatment is usually withheld until the patient becomes symptomatic. ...Read more

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What is the definition or description of: chronic lymphocytic leukemia ivgh?

What is the definition or description of: chronic lymphocytic leukemia ivgh?

A test 2 assess risk: The correct name is igvh mutational status assay. This is a gene test performed only on leukemic cells of patients with cll to assess risk of progression, and death from cll. The readout is either mutated (which is favorable) or unmutated (unfavorable). Igvh mutations happen during the normal generation of antibodies in white cells. ...Read more

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Is hydroxyurea a cure for chronic lymphocytic leukemia?

Is hydroxyurea a cure for chronic lymphocytic leukemia?

Cure?: There are many treatnents used to treat cll. However the only therapy that may be curative is a stem cell or bone marrow transplant from a donor. ...Read more

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Please explain the difference between chronic lymphocytic leukemia and non-hodgkin's lymphoma. Is hashi's a risk factor?

CLL is : Diagnosed when the main presentation is elevated lymphatic in the blood. The indolent nhl small lymphocytic lymphoma is the same process with a nodal presentation. There are many other forms of nhl. ...Read more

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What does chronic lymphocytic leukemia do to your body?

What does chronic lymphocytic leukemia do to your body?

Depends on the stage: In early case, patient will be asymptomatic and the only thing abnormal is the blood test. In later stage- one can have low blood counts (anemia, low platelet), fatigue , tired, lack of energy, bruising easily/bleeding also, you could feel lymph nodes enlargement on the neck, arm pits, groin etc as cll involves more to the lymph nodes. Increase abdominal girth, fever, chils, weight loss can happen. ...Read more

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Is likely that chronic lymphocytic leukemia (cll) live?

Is likely that chronic lymphocytic leukemia (cll) live?

Yes: Many CLL patient's live a long and productive life. Having said that it is a leukemia , it will eventually need therapy. ...Read more

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Can you tell me what chronic lymphocytic leukemia (cll) is?

Can you tell me what chronic lymphocytic leukemia (cll) is?

See below...: Cll stands for chronic lymphocytic leukemia, a form of blood cancer. Cll is usually not an aggressive form of leukemia and has a relatively good prognosis overall. Many patients are asymptomatic for a long period of time (years) and do not need any form of therapy unless there are symptoms or adverse prognostic factors. ...Read more

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What sort of disease is chronic lymphocytic leukemia (c.L.L.)?

What sort of disease is chronic lymphocytic leukemia (c.L.L.)?

CLL: Cll is a clonal disorder (cancer) of the white blood cells (specifically lymphocytes) in the blood (= -emia part). Other leukemias include cml, aml, all, etc. Cll is often diagnosed by flow cytometry on peripheral blood. Additional studies may include ct scans and bone marrow biopsy. One staging system is rai 0 to iv. Treatment ranges from observation (rai 0-1) to various tx individualized to pt. ...Read more

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How common is fatigue with stage i chronic lymphocytic leukemia?

About 10-20%: Fatigue is nonspecific. Here we talked about extreme fatigue not very common. Most people with cll, especially at early stage, are asymptomatic. About 10-20% people will experience so-called b symptoms (fatigue, fever, night sweat, or weight loss). This number could go higher as disease progresses, but no linear relationship. ...Read more

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Can chronic lymphocytic leukemia cause lumps around the nipple in males?

No: It should not be related to cll. Ask your doctor to examine you and to find the cause of these lumps. I do not think they are related to your(?) leukemia. ...Read more

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A friend had chronic demyelinating polyneuropathy (cidp), then got chronic lymphocytic leukemia 2 years later. Is cidp paraneoplastic syndrome sometimes?

A friend had chronic demyelinating polyneuropathy (cidp), then got chronic lymphocytic leukemia 2 years later. Is cidp paraneoplastic syndrome sometimes?

Not likely: Chronic inflammatory demyelinating polyradiculopathy (cidp) is almost always an autoimmune condition incited by some antecedent infection--c. Jejuni, ebv, cmv, or another infection. Antibodies produced against the virus/ bacteria/ pathogen cross-react with the myelin sheath on the nerve roots, first causing guillain-barre (aidp), then later cidp. It's exceedingly rare that cancer could cause this. ...Read more

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What're the effects of chronic lymphocytic leukemia?

See below: Cll is form of blood cancer, usually a slowly progressing one. It may cause fever, enlarged lymph nodes, weight loss, anemia etc. See this site for more info.
http://www.ncbi.nlm.nih.gov/pubmedhealth/pmh0001559/. ...Read more

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What're the chances of someone inheriting chronic lymphocytic leukemia?

What're the chances of someone inheriting chronic lymphocytic leukemia?

Rare: There have been familial cases reported and my partner and i had a brother and a sister. The brother has never required therapy yet but the sister did. Mayo clinic is doing a study on familial cases. Mainly taking blood and studying it. It is an ongoing study so the results are not available yet. Hope this helps. ...Read more

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How typical is it for a 24 years old male to have chronic lymphocytic leukemia?

Yes, very rare: Chronic lymphocytic leukemia(cll) is a cancer of the elderly folks but it can occur in middle aged folks too. It is very rare before the age of 30. ...Read more

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Can someone in there early 40s with early chronic lymphocytic leukemia get cured?

See below...: The only known complete cure for cll is stem cell transplantation; however, many patients do not need any form of therapy in the beginning and treatment is only started if the patient develops symptoms or adverse prognostic factors are present. Cll is usually not an aggressive form of leukemia and has a relatively good prognosis overall. ...Read more

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Will chronic lymphocytic leukemia (cll) at stage 0 progress to stage 1, 2, 3 or 4?

Sometimes: Rai stage 0 cll infrequently progresses to higher-stage disease. The median survival is at least 130 months as reported in 2009:
http://asheducationbook.Hematologylibrary.Org/content/2009/1/421/t2.Expansion.Html

the disease is "heterogeneous, " which means that different patients have different experiences, making progression hard to predict in any one individual. ...Read more

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How many years do you have to have it before you are called "chronic" in chronic lymphocytic leukemia?

How many years do you have to have it before you are called "chronic" in chronic lymphocytic leukemia?

Good question: Even at the time of diagnosis, a patient with this cancer is said to have "chronic lymphocytic leukemia, " so the amount of time is not the determining factor.

Chronic lymphocytic leukemia (cll) refers to an often slow-growing leukemia that likely develops over time, in contrast to acute leukemia (which develops rapidly and must be treated rapidly). ...Read more

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Chronic sinusitis and chronic lymphocytic leukemia--not good together?

Low IgG?: agreed. Frequent bacterial infection associated with CLL may be due to hypogammaglobulinemia (Low amount of antibodies, also called low IgG). That's treatable with monthly infusion of IVIG (intravenous immune globulin). Discuss with hematologist/oncologist. ...Read more

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I was diagnosed with chronic lymphocytic leukemia and would like to know if there anything known to slow the progression when one is asymptomatic.?

I was diagnosed with chronic lymphocytic leukemia and would like to know if there anything known to slow the progression when one is asymptomatic.?

Clinical Trials: There are ongoing clinical trials to determine if there is any benefit to treating patients with asymptomatic chronic lymphocytic leukemia. The current approach is to observe is the patient with cll is asymptomatic. ...Read more

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If you have a severely weakened immune system due to chronic lymphocytic leukemia, do vaccines even work?...And...Are they safe?

Yes, and most are: Unless you have been treated (chemo, radiation, etc.), your immune system should still produce some normal-functioning cells in addition to leukemic ones. So, you can get some benefit from vaccines. Most vaccines are safe, as they are made from killed viruses and bacteria. But ones made from live viruses (varicella and oral polio, e.g.) may cause problems. See your hematologist for info. ...Read more

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Are there any new findings on chronic lymphocytic leukemia regarding preventive treatment /protocol to slow progression of disorder while asymptomtic?

Yes (but...): Yes, but minimal and does not change the standard of care. Dr. Shanafelt and colleagues at mayo clinic have looked at green tea extract in rai 0-ii cll showing a 67% response rate. http://www.asco.org/ascov2/meetings/abstracts?&vmview=abst_detail_view&confid=74&abstractid=47574 -- conclusion: egcg containing green tea extracts may have potential as disease stabilizing agents... ...Read more

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Chronic lymphocytic leukemia is a very slow disease?

Chronic lymphocytic leukemia is a very slow disease?

Can be: Based on the genetic factors of the leukemia (cll) it can be a slow-growing disease that may not require therapy for a long time, if ever. ...Read more

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I have chronic lymphocytic leukemia. What can I do to fight against this disease?

Options available: There are a lot of treatment options available. However not everybody with cll need to get treated right away at the first initial diagnosis. There are some indications to start one on therapy. Nowadays, treatment is personalized and tailored to the biology of the cancer. There are some prognostic/predictive markers that can be tested to guide treatment selection, discuss with your oncologist. ...Read more

Dr. Frederick Buechel, jr. md
1,163 doctors shared insights

Knee Pain (Definition)

The knee joint is the joint between three bone of the lower leg: the proximal tibia, the distal femur, and the patella. There are multiple causes of knee pain including degenerative, ...Read more