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Doctor insights on: Chronic Lyme And Negative Western Blot

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what is difference between IgM and IgG for western blot for lyme. positive for IgM but not IgG, what does that mean? tks

what is difference between IgM and IgG for western blot for lyme. positive for IgM but not IgG, what does that mean? tks

Recent infection: Hi. IgM is present only with recent infection. After IgM levels fall away, IgG takes over for ongoing and recurrent exposure to antigen. (The antibodies in this picture are IgG's). I'm glad your doc was on the ball. She/he may have saved you a world of hurt by making the diagnosis promptly. Good luck! ...Read more

Dr. Randy Baker
642 doctors shared insights

Lyme Disease (Definition)

A condition caused by borrelia burgdorferi. Acute symptoms can include bullseye rash, headaches, joint pain, fever, and flu-like sx. Chronic symptoms can include fibromyalgia symptoms, nerve pain in extremities, mood swings, brain fog, heart problems. Lab diagnoses are not very reliable, and sometimes clinical ...Read more


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What would cause a positive Lyme titer but negative western blot?

What would cause a positive Lyme titer but negative western blot?

see details: The lyme titer is nonspecific and can be positive by itself if the presence of other autoimmune diseases, viral infections or a history of lyme in the distant past. I negative western blot rules out active lyme disease. ...Read more

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Can you have Lyme disease and still have a negative test result on the western blot test?

Can you have Lyme disease and still have a negative test result on the western blot test?

Possible: Lab tests have false negatives and false positives. Each lab test result needs to be interpreted in the clinical context. A person may have infection with lyme disease and may not make appropriate antibody and have a negative test while the test is working properly. ...Read more

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With lyme disease you have ELISA and western blot but what if you tested ELISA negative is Lyme disease impossible? Or wise to do western blot?

With lyme disease you have ELISA and western blot but what if you tested ELISA negative is Lyme disease impossible? Or wise to do western blot?

Lyme blood test: In early Lyme Disease Elisa can be negative. No use testing Western Blot if Elisa is negative. Follow patient clinically and if symptoms of Lyme disease occur re-test Elisa. ...Read more

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Lyme antibody positive and western blot negative. Where can I find a complete list of other id's associated with a positive igm/igm antibody screen?!

Lyme antibody positive and western blot negative. Where can I find a complete list of other id's associated with a positive igm/igm antibody screen?!

Probably have Lyme!: I don't know where to find such a list as I am not sure the causes of a false positive are known, but, esp. If the western blot did not include the 34 ; 39 bands i would not rely upon it; please do the igenex western blot, which is much more sensitive ; specific for lyme. Even if that is negative 20-30% with lyme can have a negative WB test. Other tests may be indicated. See http://bit.Ly/1aaqjgc. ...Read more

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how accurate is Lyme disease western blot?

how accurate is Lyme disease western blot?

High disease area?: The Western Blot is the 2nd (after the ELISA) in a 2-step process. An individual in an area where Lyme disease is common & with high exposure to Lyme-disease carrying tick bite who has been bitten by an engorged tick is highly likely to have Lyme disease if these tests are positive. Without these risk factors, a positive test could be falsely positive. ...Read more

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Please tell me, is western blot good in diagnosing Lyme disease?

Please tell me, is western blot good in diagnosing Lyme disease?

Not great: But it is used to diagnoses lyme disease as it is one of the better tests we have. The cdc recently stated it believes lyme infections are about ten times higher than predicted due to false negatives related to current testing. Hope that helps! ...Read more

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Please tell me, is western blot test effective in diagnosing lyme?

Please tell me, is western blot test effective in diagnosing lyme?

Not great: But it is used to diagnoses lyme disease as it is one of the better tests we have. The cdc recently stated it believes lyme infections are about ten times higher than predicted due to false negatives related to current testing. Hope that helps! ...Read more

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Can a positive Lyme disease western blot strip test be mistaken for another disease?

Yes!: No lab test is perfect, including the westen blot for lyme. There is an approximately 4% chance of a positive being a "false positive" test. There is also an approximately 20% chance of false negatives, someone with lyme not having a positive western blot. This is why lyme is ultimately a clinical diagnosis, with labs used to support a diagnosis. Other tests may also be useful. Please see comment:. ...Read more

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How can someone test positive for two Lyme-specific bands on western blot and NOT have been exposed to Lyme disease? What is magic about 5 bands?

Immune complexities: Lyme disease is caused by a certain type of bacteria called a 'spirochete'- they are a whole class actually of bacteria and believe it or not can be found commonly in the mouth or elsewhere in the environment. You have to reach a certain 'threshold' with Lyme testing because there could be some cross-reactivity coming from these other types of bacteria. The immune system is extraordinarily complex ...Read more

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Tested positive for Lyme disease IgM but my western blot test came back negtive?

Then it's not Lyme: Lyme disease can be tricky -and you want to make sure you see someone like an Infectious Diseases doctor who knows how to treat it. The diagnosis is actually based on clinical findings, and the lab testing is generally 'supportive'. Since you're Western blot is negative, then it's very unlikely you have Lyme. There are other diseases that could cause 'Lyme-like' symptoms -and good to get evaluated ...Read more

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From Minnesota but live in Madrid and got a western blot for Lyme back for: sensu strictu, afzelii, garinii, spielmanii. Is MN tick covered here?

Tick: most common ticks in minnesota are the black legged tick, american dog tick, brown dog tick and the bat tick. Not sure if those are covered in Madrid. Better check with the Health Department there to determine for sure. ...Read more

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My doctor is checking me for lyme..Is the western blot a reliable test to check for it?

My doctor is checking me for lyme..Is the western blot a reliable test to check for it?

Not great: But it is used to diagnoses lyme disease as it is one of the better tests we have. The cdc recently stated it believes lyme infections are about ten times higher than predicted due to false negatives related to current testing. Hope that helps! ...Read more

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what is difference between IgM and IgG for western blot for lyme. positive for IgM but not IgG, what does that mean? tks

Recent infection: Hi. IgM is present only with recent infection. After IgM levels fall away, IgG takes over for ongoing and recurrent exposure to antigen. (The antibodies in this picture are IgG's). I'm glad your doc was on the ball. She/he may have saved you a world of hurt by making the diagnosis promptly. Good luck! ...Read more

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When are lyme igg antibodies most present in the body.if I was exposed around 7 months ago would the igg western blot be positive?

When are lyme igg antibodies most present in the body.if I was exposed around 7 months ago would the igg western blot be positive?

IgG: Upon appropriate stimulation, body begins to produce new specific IgG within about 2 weeks. A maximal response can be expected within 4 weeks. Can occur more quickly depending on dose of challenge/infection. ...Read more

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Why would my lyme disease western blot test show 4 igg bands as reactive? Could this mean I have the disease? None of the igm bands were reactive.

Not necessarily: IgM antibody means recent infection. IgG antibody usually means remote infection. You may not have the disease, just that you may have been infected at one time. ...Read more

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2 years ago i had lyme ab screen mildly elevevated but western blot all non reactive. Now im testing pos for igm 23 and igm 41. What does this mean?

Interpret clinically: Lyme is known to be 'tricky'. The first set of tests I would ignore, since the Western blot was totally negative. In the second case, this could indicate an acute exposure since you've got 2 out of 3 IgM bands. You definitely need to talk to the doctor about these- since the lab work needs to be interpreted in the right clinical context. Sometimes lab tests come up as 'false positive'. See ID doc. ...Read more