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Doctor insights on: Chronic Ischemic White Matter Disease

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White Matter (Definition)

White matter is one of the two components of the central nervous system and consists of glial cells and myelinated axons that transmit signals from one region of the cerebrum to another and between the cerebrum and lower brain centers. White matter tissue of the freshly cut brain appears pinkish white to the naked eye because myelin is composed largely of lipid ...Read more


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What is chronic white matter ischemic disease?

What is chronic white matter ischemic disease?

Lack of blood deep : In the brain. This condition is most commonly seen in individuals with one or all of the following: 1. Hypertension 2. Diabetes 3. Hyperlipidemia (high cholesterol) 4. Cigarette smoking 5. Family history of stroke of course there are others but these are most important. Please meet with your neurologist to discuss why and what you can do to help your situation. Good luck and well wishes. ...Read more

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What is chronic periventricular white matter microvascular ischemic disease?

What is chronic periventricular white matter microvascular ischemic disease?

Patchy insulation: Chronic means this process has been going on for years in the brain. White matter is the part of the brain where the "communication cables" are, and they are "white" because of myelin insulation. The ventricles are fluid-filled "shock absorber" spaces inside the brain. Ischemic means they have been deprived oxygen, microvascular means in tiny blood vessels. Mini-stroke strips off some insulation. ...Read more

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Can ischemic small vessel disease cause gliosis? How would ischemic small vessel disease be treated in a minimal area of white matter in the brain?

Can ischemic small vessel disease cause gliosis?  How would ischemic small vessel disease be treated in a minimal area of white matter in the brain?

Yes.: White matter changes frequently seen on brain MRI are the result of chronic small vessel ischemic disaease and it is the resulting small focus of gliosis that shows on the MRI imaging. Treating your underlying cardiovascular heath is key, not the MRI finding. ...Read more

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I recently had an MRI of the brain. The results where as follows mild atrophy and mild periventricular white matter ischemic small vessel disease. Wh?

I recently had an MRI of the brain. The results where as follows mild atrophy and mild periventricular white matter ischemic small vessel disease.  Wh?

Arteriosclerosis : You are taking hydrocodone, tramadol & Lyrica (pregabalin) for nagging pain plus Ambien for sleep and Buspirone for anxiety. Combination is heavy stuff. Had migraine but not any more? Microvascular disease is the blockage of tiny vessels-arteriosclerosis. These can happen in heart & kidney as well. Check your lipid profile and possible use of statin. For headache & reevaluation of all your meds see neurologist. ...Read more

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What is the meaning of chronic ischemic changes in bilateral frontparietal sub cortical white matter.what is the medicne for this?

What  is the meaning of  chronic ischemic changes in bilateral frontparietal sub cortical white matter.what is the medicne for this?

Aspirin...: Blood supply to the mentioned areas are compromised. HTN, DM, Vasculitis, Atherosclerosis, Embolism,can be responsible. Starting with aspirin and doing WU is better. ...Read more

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What is mild chronic ischemic changes in bilateral periventricular white matter?

What is mild chronic ischemic changes in bilateral periventricular white matter?

Described often: Presume on mri, white matter lesions as noted, which are usually nonspecific, but can be associated with hypertension, diabetes, or high blood fats causing "hardening of the arteries" (aka, microvascular angiopathy). This pattern might be consistent with ms in some cases, so needs correlation for relevance. Not a description of stroke, but an indication for prevention of future stroke. ...Read more

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Dad, 66, is affected with "chronic ischemic changes in periventri white matter" and "disprop prominence of ventri system c/p to cortical sulci" cure?

Dad, 66, is affected with "chronic ischemic changes in periventri white matter" and "disprop prominence of ventri system c/p to cortical sulci" cure?

Chronic ischemia: What you are seeing on the mr are common aging changes seen on mr. As for a "cure" being available, not at the moment and likely years before any solution. ...Read more

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What is mild chronic ischemic changes in bilateral frontal periventricular white matter?

What is mild chronic ischemic changes in bilateral frontal periventricular white matter?

Nonspecific WM: Nonspecific periventricular white matter changes- These are normally small spots without clinical relevance. They are more common for people with high blood pressure, diabetes, head injuries or in people who smoke. They do not have a defined clinical meaning. ...Read more

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Mild genaralized atrophy and chronic white matter ischemic changes in my mom report is it serious matter please tell me?

Mild genaralized atrophy and chronic white matter ischemic changes in my mom report is it serious matter please tell me?

Maybe: Mild general atrophy can be seen on ct scans of people with or without symptoms. Chronic white matter ischemic changes can also be seen in symptomatic or asymptomatic people. Be sure your mom gets checked for obstructive sleep apnea, diabetes, hypertension and high cholesterol. These can cause ischemic changes. ...Read more

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MRI result: "Mild presumed chronic small vessel ischemic changes in the supratentorial white matter." Should I be concerned?

MRI result: "Mild presumed chronic small vessel ischemic changes in the supratentorial white matter."  Should I be concerned?

Atherosclerosis : No. This is normal aging of the brain. However going forward, make sure that there is good blood pressure control, maintain normal cholesterol and blood sugar levels, and avoid smoking. These steps will slow the progression of atherosclerosis in the brain. ...Read more

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Age 66; right hearing loss; MRI; dx: mild chronic deep white matter ischemic changes in the periventricular and subcortical white matter. Please expla?

Age 66; right hearing loss; MRI; dx: mild chronic deep white matter ischemic changes in the periventricular and subcortical white matter. Please expla?

Becoming a senior: These changes in signal in the white matter are believed to be due to small vessels losing their flow. This is a finding in older or senior citizens. It remains to be seen if they amount to anything as we age ...Read more

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38y f. Brain MRI shows left maxillary polyp, partial empty sella, small chronic ischaemic lesions in subcorticle frontoparietal white matter. Cure?

38y f. Brain MRI shows left maxillary polyp, partial empty sella, small chronic ischaemic lesions in subcorticle frontoparietal white matter. Cure?

Nothing to cure: But try to prevent further damage. Maxillary sinus polyp is nothing to worry about unless sinus symptoms, then ENT consult. Partial empty sella cannot be fixed, and nothing to worry about unless abnormal pituitary function - may need to see an endocrinologist. Ischemic lesions may be within normal limits (allowed 1 per decade of life), but need to understand cause(s) and try to prevent more. ...Read more

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Mri report says morphology says in favour of smallt2 and flair hyperintensefoci in bilateral frontal white matter-? Ischemic/? Significant

Mri report says morphology says in favour of smallt2 and flair hyperintensefoci in bilateral frontal white matter-? Ischemic/? Significant

Usually not: This is a very common finding on mris of the brain. Typically it is not significant. However, if you are experiencing neurological symptoms these foci may represent something more sinister and you should see your doctor. ...Read more

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My MRI shows "MILD WHITE MATTER MICROVASCULAR ISCHEMIC CHANGES". Could this be a reason for my memory issues and word-finding issues?

My MRI shows "MILD WHITE MATTER MICROVASCULAR ISCHEMIC CHANGES". Could this be a reason for my memory issues and word-finding issues?

Vascular dementia.: The second most common form of dementia (after Alzheimer's) is vascular dementia, also known as multi-infarct dementia. An accumulation of tiny infarcts, much like those imaged on your MRI, leads to symptoms of dementia. We tend to see this form of dementia in people with hypertension, diabetes, high cholesterol. So this could be related to your symptoms. Ask your doctor if u can take aspirin. ...Read more

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MRA revealed mild ischemic white matter changes. I'm 28. What does that mean??

MRA revealed mild ischemic white matter changes. I'm 28. What does that mean??

Why did you get it?: If the radiologist knew your age and still read the report in that way I think that is a little bit unusual. But, it kind of depends on the reason you had the MRI done in the first place. Typically, that type of a read would be more common for someone who had long-standing hypertension, diabetes, high cholesterol, smoker for many years and so forth. Do you have a copy of the report or the films ...Read more

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I have tremors on right side for 9 years; left side is normal; I have white matter ischemic changes+ lacune infarcts; no significant plaque; Dx?

I have tremors on right side for 9 years; left side is normal; I have white matter ischemic changes+ lacune infarcts;  no significant plaque; Dx?

See a neurologist: Focal tremors could be a sign of Parkinson's disease. You do describe prior strokes, and many lacunar infarcts can also cause tremors. The focality does concern me as I would want to rule out obstruction of carotid or vertebral artery in neck. An experienced neurologist should be able to pin down the causation ...Read more