Top
30
Doctor insights on: Chronic Ischemic Demyelination

Share
1

1
What is ischemic demyelination?

What is ischemic demyelination?

Lack of blood flow: Causing a loss of myelin in the central nervous system. This condition is most commonly seen in the periventricular white matter in both hemispheres. There appears to be 5 major risk factors for these lesions:
1. Hypertension
2. Hyperlipidemia
3. Diabetes
4. Smoking
5. Family history of stroke

please be evaluated to minimize the risk for stroke and consider antiplatelet therapy if appropriate. ...Read more

Demyelination (Definition)

Nerve fibers have a central axon insulated by myelin covering. Demyelination is damage to the myelin, and typically experienced in multiple sclerosis due to an autoimmune attack by lymphocytes, but may be seen also in hereditary leukodystrophies, acute encephalomyelitis, ...Read more


2

2
The MRI show ischemic demyelination secondary to small vessel disease. What cause this and what type or treatment are?

The MRI show ischemic demyelination secondary to small vessel disease. What cause this and what type or treatment are?

My interpretation: Will answer generically, and state that you could have a disorder termed Binswanger's disease, which is most often associated with hypertension. Such MRI changes may be seen with head trauma, cigarette smoking, aging, etc. ...Read more

3

3
What is chronic microvascular ischemic disease?

What is chronic microvascular ischemic disease?

Parse the words: Chronic = long-standing. Microvascular = small blood vessel. Ischemic = insufficient blood flow. Technically such a condition can affect any organ in the body but this condition gets most attention due to neurologic involvement. Certain genetic & environmental factors contribute to this condition--that is, there is more than one cause. ...Read more

4

4
What are the symptoms of chronic small vessl ischemic disease?

What are the symptoms of chronic small vessl ischemic disease?

It depends: There may be no symptoms. Otherwise the symptoms depend on the area of the brain involved with the ischemia. ...Read more

5

5
What is chronic white matter ischemic disease?

What is chronic white matter ischemic disease?

Lack of blood deep: In the brain. This condition is most commonly seen in individuals with one or all of the following:
1. Hypertension
2. Diabetes
3. Hyperlipidemia (high cholesterol)
4. Cigarette smoking
5. Family history of stroke

of course there are others but these are most important. Please meet with your neurologist to discuss why and what you can do to help your situation. Good luck and well wishes. ...Read more

7

7
What does chronic age related ischaemic changes to the cerebrum mean?

What does chronic age related ischaemic changes to the cerebrum mean?

Ischemica cerebrum: You have had damage to your brain blood vessels most likely caused by high blood pressure. But many other causes. ...Read more

8

8
What is meant by diffuse chronic ischaemic changes to the brain?

What is meant by diffuse chronic ischaemic changes to the brain?

Small artery Disease: Diffuse chronic ischemic changes in the brain are often reported on MRI scans of those over 50. Diffuse: scattered through the brain. Chronic: it's been there awhile. Ischemic: not enough blood. Neuroscientists believe this is small arteries not supplying enough blood in tiny areas of brain. Some tiny brain areas stop working w/o adequate blood supply; this is seen as white dots/spots on MRI ...Read more

9

9
What is chronic small vessel ischemic disease and can it be treated?

What is chronic small vessel ischemic disease and can it be treated?

Misnomer: Great question. Ther is no chronic sm vessel ishchemic disease. It is invented by radiologists. It does not have treatment. ...Read more

10

10
What is the meaning of chronic ischemic changes in bilateral frontparietal sub cortical white matter. What is the medicne for this?

What is the meaning of chronic ischemic changes in bilateral frontparietal sub cortical white matter. What is the medicne for this?

Aspirin...: Blood supply to the mentioned areas are compromised. HTN, DM, Vasculitis, Atherosclerosis, Embolism, can be responsible. Starting with aspirin and doing WU is better. ...Read more

11

11
What is mild chronic ischemic changes in bilateral periventricular white matter?

What is mild chronic ischemic changes in bilateral periventricular white matter?

Described often: Presume on mri, white matter lesions as noted, which are usually nonspecific, but can be associated with hypertension, diabetes, or high blood fats causing "hardening of the arteries" (aka, microvascular angiopathy). This pattern might be consistent with ms in some cases, so needs correlation for relevance. Not a description of stroke, but an indication for prevention of future stroke. ...Read more

12

12
Is there a correlation between chronic microvascular ischemic disease and anemia?

Is there a correlation between chronic microvascular ischemic disease and anemia?

Only in the sense: That a patient with severe small vessel disease may be chronically ill. I would not directly relate the anemia without sorting out potentially reversible causes. ...Read more

13

13
Dad, 66, is affected with "chronic ischemic changes in periventri white matter" and "disprop prominence of ventri system c/p to cortical sulci" cure?

Dad, 66, is affected with "chronic ischemic changes in periventri white matter" and "disprop prominence of ventri system c/p to cortical sulci" cure?

Chronic ischemia: What you are seeing on the mr are common aging changes seen on mr. As for a "cure" being available, not at the moment and likely years before any solution. ...Read more

14

14
Microvascular chronic ischemic in brain can affect memory?

Microvascular chronic ischemic in brain can affect memory?

Sure can: We term multiple small strokes, lacunar infarcts, and these can mount up and produce "etat lacunaire", or full blown vascular dementia. Here, the job involves prevention with an appropriate stroke anti platelet, or anti-coagulant approach. ...Read more

16

16
What is chronic periventricular white matter microvascular ischemic disease?

What is chronic periventricular white matter microvascular ischemic disease?

Patchy insulation: Chronic means this process has been going on for years in the brain. White matter is the part of the brain where the "communication cables" are, and they are "white" because of myelin insulation. The ventricles are fluid-filled "shock absorber" spaces inside the brain. Ischemic means they have been deprived oxygen, microvascular means in tiny blood vessels. Mini-stroke strips off some insulation. ...Read more

17

17
What is mild chronic ischemic changes in bilateral frontal periventricular white matter?

What is mild chronic ischemic changes in bilateral frontal periventricular white matter?

Nonspecific WM: Nonspecific periventricular white matter changes- These are normally small spots without clinical relevance. They are more common for people with high blood pressure, diabetes, head injuries or in people who smoke. They do not have a defined clinical meaning. ...Read more

18

18
My MRI report says I have chronic microvascular ischemic disease with scattered lacunar infarcts. Could you explain what this means, please?

My MRI report says I have chronic microvascular ischemic disease with scattered lacunar infarcts. Could you explain what this means, please?

WMC: White matter changes in MRI is non-specific, but mostly is due to insufficiency of very small vessels in brain of people with high blood pressure or diabetes.
Small strokes causes lacunar infarcts.
Please discuss it with pcp. ...Read more

19

19
Mild genaralized atrophy and chronic white matter ischemic changes in my mom report is it serious matter please tell me?

Mild genaralized atrophy and chronic white matter ischemic changes in my mom report is it serious matter please tell me?

Maybe: Mild general atrophy can be seen on ct scans of people with or without symptoms. Chronic white matter ischemic changes can also be seen in symptomatic or asymptomatic people. Be sure your mom gets checked for obstructive sleep apnea, diabetes, hypertension and high cholesterol. These can cause ischemic changes. ...Read more

21

21
Is it normal for a 42 yr old female to have chronic microvascular ischemic changes of the brain & what could be the cause? History chronic muscle pn

Is it normal for a 42 yr old female to have chronic microvascular ischemic changes of the brain & what could be the cause? History chronic muscle pn

Brain: My opinion on chronic microvascular changes...Most important is how bad. Sometimes there are a few small speckles seen in people with migraines that are definitely not worrisome. Otherwise risk factors for this are: smoking, high bp/cholesterol, diabetes, drug use, and genetics...Among other rare causes. My biggest recs would be to work on any changeable things like some of these. ...Read more

22

22
I'm a diabetic and my MRI shows chronic microvascular ischaemic changes. What is this and what are the symptoms. I have recently have memory problems

I'm a diabetic and my MRI shows chronic microvascular ischaemic changes. What is this and what are the symptoms. I have recently have memory problems

Brain MRI right?: On brain MRI your radiology physician saw small signal abnormalities that he or she thought were related to ischemia. These are not uncommon in older patients. What would be good to know is your age and the quantity of the disease that was seen on mr.

Your ordering physician will want to put these 2 pieces of information together and talk to you about controlling risk factors to minimize brain dz. ...Read more

23

23
Hello dr, I had a MRI of my brain. It came back as slight chronic microvascular ischemic changes. What does that mean? Also what does a air cell mean?

Hello dr, I had a MRI of my brain. It came back as slight chronic microvascular ischemic changes. What does that mean? Also what does a air cell mean?

Aging changes: As we get older, arteries harden and we see small vessel changes in the brain due to aging. They simply mean the brain doesn't work as well as it did when we are young and mostly attest to our slowly diminishing function. These are microvascular ischemic changes. You probably don't notice these changes.
Air cells are bony areas of the skull with air spaces in them- normal. ...Read more

24

24
Had an MRI that showed chronic small vessel ischemic disease -- is this a precursor to dementia?

Had an MRI that showed chronic small vessel ischemic disease -- is this a precursor to dementia?

Precursor for nothin: That's a phrase used by radiologists reading MRI's & doesn't specify any particular process. Is seen as part of the normal aging process as well as part of expected findings in people who have been diagnosed and are being treated for diabetes, high cholesterol, smokers, and those with high blood pressure. Cannot predict dementia by any means. ...Read more

25

25
MRI result: "Mild presumed chronic small vessel ischemic changes in the supratentorial white matter." Should I be concerned?

MRI result: "Mild presumed chronic small vessel ischemic changes in the supratentorial white matter." Should I be concerned?

Atherosclerosis: No. This is normal aging of the brain. However going forward, make sure that there is good blood pressure control, maintain normal cholesterol and blood sugar levels, and avoid smoking. These steps will slow the progression of atherosclerosis in the brain. ...Read more

26

26
What is chronic microvascular ischemic disease, chronic migraine, and a disseminating process such as multiple sclerosis mean on MRI? Do I have MS?

What is chronic microvascular ischemic disease, chronic migraine, and a disseminating process such as multiple sclerosis mean on MRI? Do I have MS?

You're the patient..: ...not the MRI. Presumably you didn't just wander into an MRI facility & make an impulse purchase. The MRI was ordered by your doctor & for a reason. The radiologist isn't paid to diagnose YOU; (s)he just looks at studies & reports what (s)he sees. Go back to the ordering MD; diagnosing YOU is his/her job. Ask to see the MRI: in radiology, 1 picture is worth 1000 words. ...Read more

27

27
77 year old's MRI - chronic microvascular ischemic disease & shrinking of brain. No diabetes or high BP. Hasn't smoked for 30 yrs. What's the cause?

77 year old's MRI - chronic microvascular ischemic disease & shrinking of brain. No diabetes or high BP. Hasn't smoked for 30 yrs. What's the cause?

Well that's the question: As we age the brain tends to lose fluid content. There are many seniors who do not have this issue while others do. The micro vascular ischemia is not dependent upon diabetes but small vessels that become blocked by many things including blood clots and cholesterol. Often times it doesn't affect the function of the individual. Occasionally it will. ...Read more

29

29
Age 66; right hearing loss; MRI; dx: mild chronic deep white matter ischemic changes in the periventricular and subcortical white matter. Please expla?

Age 66; right hearing loss; MRI; dx: mild chronic deep white matter ischemic changes in the periventricular and subcortical white matter. Please expla?

Becoming a senior: These changes in signal in the white matter are believed to be due to small vessels losing their flow. This is a finding in older or senior citizens. It remains to be seen if they amount to anything as we age ...Read more

30

30
What do my mri results mean; chronic microvas ischemic changes noted, frontal bone lesion & slightly abnormally shaped & low lying cerebellar tonsil.

What do my mri results mean; chronic microvas ischemic changes noted, frontal bone lesion & slightly abnormally shaped & low lying cerebellar tonsil.

Hard to say: Urs best to discuss this with a neurology doctor, who can get full history. Picture by itself is just a picture-need medical hx and exam. So far it may look that there are changes- probably due to long history of smoking or other vascular disease. ... As far as the shape of the brain parts and frontal lesion- it's impossible to tell without more info ...Read more