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Doctor insights on: Chromosomal Incompatibility In Pregnancy

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Rh incompatibility in second pregnancy; how does it happen?

Rh incompatibility in second pregnancy; how does it happen?

Sensitization: Mom is rh negative. Dad is rh positive. The baby, possibly both, are also rh positive. The first pregnancy will sensitize mom causing her to produce an rh antibody. This antibody will decrease over time. But with a second pregnancy, the memory cells cause tremendous antibody production. This antibody crosses through placenta and breakdown the red blood cells of the infant. ...Read more

Dr. Sewa Legha
4 doctors shared insights

Pregnancy (Definition)

When your due date arrives, you will be more than ready to have your baby! Most women deliver the baby somewhere between 37 and 42 weeks. According to the American College of Obstetricians and Gynecologists, only 5% of babies arrive on the exact due date. Approximately 7% of babies are not delivered by 42 weeks, and when that happens, it is referred to ...Read more


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Why rhd incompatibility of the mother and fetus doesn't affect the present fetus but subsequent pregnancies?

Why rhd incompatibility of the mother and fetus doesn't affect the present fetus but subsequent pregnancies?

See below: The incompatibility occurs when the mother is exposed to the blood of the new baby. This usually occurs at delivery. The mother then makes antibodies to that "foreign substance" and this can adversely affect the next pregnancy as the mother's immune system will see it as a "foreign" body and want to get rid of it. This problem is usually treatable with an injection at the birth of the first child. ...Read more

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Im 42. Im miscarrying for the 3rd time. 1st were due to chromosome defects. What are my chances of having a successful pregnancy next time.

Im 42. Im miscarrying for the 3rd time. 1st were due to chromosome defects.  What are my chances of having a successful pregnancy next time.

It depends.: You would only really be able to tell if you and your husband had genetic studies to see if you are carrying an abnormality. Even if both of you are normal, your risk is higher than average at age 42. For a more detailed response www.Askyourgynecologist.Org. ...Read more

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is it possible to have normal quad test in the pregnancy if i have same chromosome translocation for chromosome 21 ?

is it possible to have normal quad test  in the pregnancy if i have same chromosome translocation for chromosome 21 ?

Yes but unlikely: There are such things as false negative tests. However, the quad test has a pretty good predictive value for negative results. ...Read more

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I had a previous down syn pregnancy,translocation type,im afraid all my babies will have DS?is it possible that i have same chromosome translocation?

I had a previous down syn pregnancy,translocation type,im afraid all my babies will have DS?is it possible that i have same chromosome translocation?

Possible: Yes it is possible you have a chromosomal abnormality. It's also possible that this was an isolated new event in that pregnancy. It would be an excellent idea to consult with a geneticist and/or a maternal-fetal medicine specialist prior to another conception to decide if you want or need to be tested and what all of your options are with another pregnancy. SO much info is available to you! ...Read more

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My pregnancy was terminated in 2nd month and karyotyping of foetus shows monosomy of chromosome 20.What are the chances of its recurrence.

My pregnancy was terminated in 2nd month and karyotyping of foetus shows monosomy of chromosome 20.What are the chances of its recurrence.

Unlikely : Based on your age it is unlikely. You are at higher risk than other women your age but yet it is still unlikely you would have another baby with the same genetic issue. ...Read more

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Is there any chromosome test that can be taken to find the cause of molar pregnancy? to prevent another molar?

Is there any chromosome test that can be taken to find the cause of molar pregnancy? to prevent another molar?

No cause: Apart from a few rare genetic syndromes, molar pregnancies "just happen." The two major types have two different chromosome types. Nothing you did and almost certainly nothing you inherited caused this disappointing outcome. Recurrences are rare. You can almost certainly have a healthy baby. ...Read more

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Can MRI effect the development of sperm cells or impact sperm in anyway, pre-pregnancy that could contribute to chromosomal translocation?

Can MRI effect the development of sperm cells or impact sperm in anyway, pre-pregnancy that could contribute to chromosomal translocation?

No: I am unaware of any evidence in the scientific literature that a standard diagnostic MRI has any adverse effect on sperm, developing sperm, or on a person who is pregnant or the fetus. The literature suggests that the strength of the mr field at diagnostic levels does not affect dna synthesis, cell cycle, or proliferation kinetics in a fetus. ...Read more