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Doctor insights on: Chromophobe Renal Cell Carcinoma Eosinophilic Variant Grade 2

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Is there a difference in the prognosis for typical and eosinophilic variant of chromophobe renal cancer?

Is there a difference in the prognosis for typical and eosinophilic variant of chromophobe renal cancer?

Yes: Chromophobe renal cell carcinomas are classified into typical and eosinophilic variants depending on the predominant cell type. The evcrcc is not as common as the typical variant and is likely to be mistaken for oncocytoma because of the predominance of type i cells and hence the significance. The eosinophilic variant has been reported to have a better prognosis than typical variant. ...Read more

Dr. Barry Rosen
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Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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So far I've survived two surgeries having recurrent renal cell carcinoma. I've developed numerous lumps which I assumed were incisional hernias now th?

So far I've survived two surgeries having recurrent renal cell carcinoma. I've developed numerous lumps which I assumed were incisional hernias now th?

Full description? Q?: You already shared a complex past history. I'm glad you survived 2 surgeries for RCC. I'm not certain of what you are describing now - lumps in the location of the incision for the surgeries? - but if you have concerns about your recovery, you should either (1) talk to the surgeon who performed your (most recent) operation or (2) use HealthTap Prime to share pictures & go over a plan. Good Luck! ...Read more

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The size of my renal cell carcinoma is 7.2 x 7.2 x 8 cm what should I do?

The size of my renal cell carcinoma is 7.2 x 7.2 x 8 cm what should I do?

See a Urologist: You should see a Urologist and a Medical Oncologist. Much information is needed on imaging and rate of growth and other factors. This won't resolve using the internet. ...Read more

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What exactly does grade 1, 2, 3, 4 of the tumor mean in clear cell renal cell carcinoma?

What exactly does grade 1, 2, 3, 4 of the tumor mean in clear cell renal cell carcinoma?

How cells look: Grading refers to how closely the cancer cells resemble normal kidney cells. Cells that are more abnormal (ie higher grade) are associated with a worse prognosis. ...Read more

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Is renal cell carcinoma stage 4 an aggressive cancer?

Is renal cell carcinoma stage 4 an aggressive cancer?

Stage 4 : Stage 4 renal cell carcinoma usually means that the cancer has spread to other parts of the body. At this stage, the cancer is consider very aggressive. www.peedoc.com @drhtay. ...Read more

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Does renal cell carcinoma lead to chronic renal failure?

Does renal cell carcinoma lead to chronic renal failure?

Not necessarily: Only if both the kidneys have to be removed if cancer on both sides. If only one kidney or a part of kidney only is removed and the remaining kidney is healthy dialysis is not required. ...Read more

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How is tobacco smoking a risk factor for developing renal cell carcinoma?

How is tobacco smoking a risk factor for developing renal cell carcinoma?

Increased risk.: Smoking introduces many very carcinogenic compounds into the bloodstream, which is filtered by the kidney. These carcinogens, along with the decreased tissue oxygenation caused by smoking, is theorized to increase the risk of renal cell carcinoma. A meta-analysis of 24 studies (hunt, int j cancer 114:101-108, 2005) showed this significantly increased risk, & it is considered causal by the ussg. ...Read more

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What's life expectancy having renal cell carcinoma stage 3 a year after having kidney removed?

What's life expectancy having renal cell carcinoma stage 3 a year after having kidney removed?

About 5 years: The 5 year survival for stage 3 renal cell cancer is about 50%. This number may shift up or down a little because there are subcategoroes of stage 3 tumors whci will affect the prognosis. ...Read more

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What r the chances of getting back renal cell carcinoma for an old male (63 yrs) after being cured by nephrectomy & taking nexavar (sorafenib) ?

What r the chances of getting back renal cell carcinoma for an old male (63 yrs) after  being cured by nephrectomy & taking nexavar (sorafenib) ?

It depends: This is not an easy answer, because it depends upon the stage of your original tumor and your surgical pathology. I would ask this question of your urologist or oncologist, who know the specifics of your case. ...Read more

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Will renal cell carcinoma spread to the hip bone?

Will renal cell carcinoma spread to the hip bone?

Its possible. : When renal cell carcinoma metastasizes, it is most likely to spread to neighboring lymph nodes, the lungs, the liver, the bones, the adrenal glands, or the brain. Spread to the bone is often to the spine, but may be anywhere. Radiotherapy is often used in in cases of bone metastases, to reduce pain and lower the risk of pathologic fracture. ...Read more

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For what length of time can a person live with renal cell carcinoma (matastatic)?

Possibly curable: Sunitinib, a new multitargeted tyrosine-kinase inhibitor (TKI), has shown high activity in patients with metastatic renal cell carcinoma (mRCC) and has demonstrated improvement in survival of those patients with metastatic disease. Sunitinib inhibits the vascular endothelial growth factor (VEGF) receptor and other tyrosine kinases, including the platelet-derived growth factor (PDGF) and c-kit receptor at nanomolar concentrations. ...Read more

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What all can renal cell carcinoma spread to? And where would it most likely spread to first?

What all can renal cell carcinoma spread to? And  where would it most likely spread to first?

Lymph nodes first: Most of the time renal cell cancer is not detected in early stages, 25%- 30% cases already has metastasis at the time of diagnosis. As tumor grows invades capsule and spread to lymph nodes, then spread to liver, bone , lungs and brain. ...Read more

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Can renal cell carcinoma spread to somebody's skin?

Can renal cell carcinoma spread to somebody's skin?

Unusual but possible: Metastasis (spread) to the skin is uncommon for renal cell carcinoma. Lung is a much moe common site of spread. However, skin metastasis has been described. In fact, there are patients who were originally diagnosed solely through the biopsy of a suspicious skin lesion. Fortunately, unusual skin lesions are often accessible for biopsy which should decrease the uncertainty of diagnosis. ...Read more

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Can renal cell carcinoma eventually spread to the skin?

Can renal cell carcinoma eventually spread to the skin?

Yes: Usually expands locally, then in veins, then lung is common.But when metastasis occurs it can end up secondarily anywhere. ...Read more

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What is the prognosis for stage 4 renal cell carcinoma?

What is the prognosis for stage 4 renal cell carcinoma?

Poor: Unfortunately even with chemo, stage IV renal cell has a short survival time. Some reasonably good chemo agents are coming available but present therapies may work for a while, then quit working. ...Read more

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How long would someone with stage 4 renal cell carcinoma have?

How long would someone with stage 4 renal cell carcinoma have?

Varies: Even within stage 4, there are varying severities of disease. Survival can occasionally go beyond five years though most people will succumb in two or less years. ...Read more

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Is there a cure for stage 4 renal cell carcinoma?

Is there a cure for stage 4 renal cell carcinoma?

Stage 4 renal CA: Not likely but depends on what type of renal cell CA it is. Stage 4 means it is outside of kidney which is bad. Discuss with your team. ...Read more

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Where is the best medical center for treating renal cell carcinoma in california?

Many facilities: There are many academic facilities that treat renal cell carcinoma. These include, ucsf, usc, city of hope, and ucla. ...Read more

Dr. Terence Chapman
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