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Doctor insights on: Cholinesterase W Dibucaine Inhib

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Azd 6244- mek inhibitor- a selective mitogen-activated protein kinase (mek) inhibitor. Mk 2206- akt inhibitor. Why prescription for me? It ? Nsclc/mets

Azd 6244- mek inhibitor- a selective mitogen-activated protein kinase (mek) inhibitor.    Mk 2206-  akt inhibitor.  Why  prescription for me? It ? Nsclc/mets

Molecular targeting: These agents are designed to selectively knock out key pathways your tumor may use to grow. Presumably you already had your tumor tested for these different mutations. Ask the doctor offering these options to explain their rationale. These are investigational studies and many of the treatment costs may be covered-ask. ...Read more

Dr. Sheila Smith
13 doctors shared insights

Nupercainal (Definition)

Nupercainal ...Read more


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Dear doc, is cod liver oil safe to take with: 1. bp meds (beta blockers, calcium channel blockers) 2. proton pump inhibitors & 3. VitD3 supplements?

Dear doc, is cod liver oil safe to take with: 
1. bp meds (beta blockers, calcium channel blockers)
2. proton pump inhibitors & 
3. VitD3 supplements?

Yes: It's fine to take with the blood pressure medications and the proton pump inhibitor. I would probably stop the vitamin D supplement as cod liver oil has vitamin A and D as the main vitamin sources. Vitamin D is one you can get in trouble with because it is fat soluble and can accumulate in your organs if you take too much. ...Read more

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Do dipeptidyl peptidase-4 inhibitors cause cancer, if used in type 2 dm?

Do dipeptidyl peptidase-4 inhibitors cause cancer, if used in type 2 dm?

Not known now. : These drugs were aqpproved for use recently (sitagliptin 2006), and although they have been observed to have side effects in clinical studies, long term effects, including cancer are inconclusive. One "in vitro" study found them to encourage cancer cell metastasis, but long term preclinical studies have not confirmed cancer causing effect. ...Read more

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Femara (letrozole) is metabolized in liver by cytochrome p450 system. Astaxanthin says "use cautiously w drugs metabolized by liver's cytochrome p450 enzyme system; does this mean don't use astaxanthin w femara (letrozole)?

Femara (letrozole) is metabolized in liver by cytochrome p450 system. Astaxanthin says "use cautiously w drugs metabolized by liver's cytochrome p450 enzyme system; does this mean don't use astaxanthin w femara (letrozole)?

Not necesarilly but: Virtually all drugs are metabolized by cytochrome p450 enzymes.Astaxanthin can stimulate these, so it could lead to lower blood levels of "certain drugs" according to http://www.Naturalmedicinejournal.Com/article_content.Asp?Article=293. I no of no evidence that Femara (letrozole) is one of the drugs it interacts with. Small amounts of astaxanthin are unlikely to have much effect.Ask the doc who prescribed it. ...Read more

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9wk preg. No m.S can I take drug w/ cyproheptadine hydrochloride 4mg, thiamine hydrochloride 1.5mg, riboflvn 1.5mg, pyridoxine hydrochloride 1mg, calcium pantothenate? Is it safe? Helps me eat.

9wk preg. No m.S can I take drug w/ cyproheptadine hydrochloride 4mg, thiamine hydrochloride 1.5mg, riboflvn 1.5mg, pyridoxine hydrochloride 1mg, calcium pantothenate? Is it safe? Helps me eat.

Consult wpharmacist : If you're in your first trimester pregnancy, you need to discuss this with your ob/gyn doctor. Also the clinical pharmacist can help you in terms of looking up certain supplements, and their safety profile during pregnancy. It's always good to be informed about the safety of anything that you're taking right now. So glad you asked. It's important that your nutrition is optimal during this period for both you and your baby. ...Read more

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If avodart & flomax are cy3a4 substrates & sprycel (dasatinib) is an inhibitor, why do interaction checkers show a prob. With sprycel (dasatinib) & avodart but not w/flomax?

If avodart & flomax are cy3a4 substrates & sprycel (dasatinib) is an inhibitor, why do interaction checkers show a prob. With sprycel (dasatinib) & avodart but not w/flomax?

Good Question: Avodart (dutasteride) is extensively metabolized in humans by the cyp3a4 and cyp3a5 isoenzymes. Flomax (tamsulosin) is extensively metabolized, mainly by cyp3a4 and cyp2d6 isoenzymes. Sprycel (dasatinib) is also extensively metabolized by the cyp3a4 isoenzyme but is also a weak time-dependent inhibitor of cyp3a4 and may therefore potentially increase the concentrations of Avodart and flomax. ...Read more

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What are the benefits of azd 6244 mek inhibitor & mk 2206 akt inhib. For adenocarcinoma. 70yrs..115lbs (lost 40)..8mth chemo..Radio..Gamma-11mth diag?

What are the benefits of azd 6244 mek inhibitor & mk 2206 akt inhib. For adenocarcinoma. 70yrs..115lbs (lost 40)..8mth chemo..Radio..Gamma-11mth
diag?

These are brand new: The drugs that you have mentioned are new anticancer drugs which are still experimental, not fda approved for general use. Your doctor(oncologist) has to answer all your questions that you ask before signing up for receiving these drugs. There is not a lot known about them yet. But azd6244 has been tested and found to have some anticancer activity. But more can be found out from your oncologist. ...Read more

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Which is lidocaine hydrochloride oral topical solution udp 2% ?

Which is lidocaine hydrochloride oral topical solution udp 2% ?

Anesthetic Solution: It is a solution of anesthetic that is used to reduce pain in your mouth due to an ulcer, painful tooth or even recent surgery. ...Read more

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Quick help pls. Need to use (ccb based)diltiazem ointment 2% for 2 weeks. Will it interact/have contradiction with bb (bystolic) or CCB amlodpine.

Quick help pls. Need to use (ccb based)diltiazem ointment 2% for 2 weeks. Will it interact/have contradiction with bb (bystolic) or CCB amlodpine.

Topical diltiazem: The data suggest a low incidence of side effects with this agent and minimal systemic effects so it should be ok with other antihypertensives. There is always someone however who deviates from the usual. Discuss with your prescribing dr. Who knows you. ...Read more

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Are these meds more for dad whose bp is 130/80 .Trentol400 2 times,dilizem once, amtas m50 ,tazloc trio80 once & ecosirin & sexaglptin & blisto once!!

Are these meds more for dad whose bp is 130/80 .Trentol400 2 times,dilizem once, amtas m50 ,tazloc trio80 once & ecosirin & sexaglptin & blisto once!!

Blood pressure meds: his BP you have stated is not abnormal- in terms these number meds best to ask the doc who prescribed them and knows your dad's problems ...Read more

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Can using 0.3ml lidocaine with 1:100, 000 epinephrine during dental work interacts with bystolic, (nebivolol) benicar/hct or isosorbide mononitrate medicine.?

Can  using 0.3ml lidocaine with 1:100, 000 epinephrine during dental work interacts with bystolic, (nebivolol) benicar/hct or isosorbide mononitrate medicine.?

Probably not: Although Lidocaine is a vasodilator, there is no clinical evidence of any drug interactions or special precautions needed. However, if during the injection, some of the anesthetic were to be introduced directly into a blood vessel, the Epinephrine could cause a minor and short acting increase in heart rate. ...Read more

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S it fine to take glutathione 500mg,milk thistle extract 100mg, alpha lipoic acid 50mg, combined with d alpha tocopheryl acetate 400 iu?

S it fine to take glutathione 500mg,milk thistle extract 100mg, alpha lipoic acid 50mg, combined with d alpha tocopheryl acetate 400 iu?

Analysis: Why do you take all these items?. Where did you find such advice? Glutathione is a wonderful anti-oxidant, but does NOT cross into the brain, so of questionable value in bloodstream. Milk thistle extract has questionable benefit in most cases. Alpha lipoic useful in peripheral and central nerve disorders. You are far better off using mixed tocopherols, especially with gamma. See holistic doc ...Read more

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What are the below drugs used for? 1) famotab 20 tab; 2) voltaren (diclofenac) 50mg & 3) vit b1612? Thanks!

What are the below drugs used for? 1) famotab 20 tab; 2) voltaren (diclofenac) 50mg & 3) vit b1612? Thanks!

INTERESTING MIX: Famtab is Famotidine for ulcers or to reduce stomach acid. Voltaren is an non-steroidal antiinflammatory agent and B12 helps with a lot of things like anemia and nervous system. Vitamin b6 (pyridoxine) is required for the synthesis of the neurotransmitters serotonin and norepinephrine. And for myelin formation. ...Read more

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Why tyramine is contraindicated with mao inhibitor?

Why tyramine is contraindicated with mao inhibitor?

Increase BP: Tyramine in large doses can raise your blood pressure, that can cause a stroke and death. Small doses don't do that because there is enough MAO in your intestinal tract to metabolize the tyramine. When you take a MAO inhibitor, tyramine is no longer metabolized in the gut, so it is free to raise your blood pressure to a very high level. This is less likely to happen with topical MAO called emsam. ...Read more

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DoesPrazosin/other alpha blocks act on non-vascular smooth muscle e.g. the throat?If sudafed is alpha stim and contricts nasal,wouldnt it make sense?

DoesPrazosin/other alpha blocks act on non-vascular smooth muscle e.g. the throat?If sudafed is alpha stim and contricts nasal,wouldnt it make sense?

Good question: Alphablockers used to treat hypertension seem to be specific for their action on arteriolar musculature as far as I can tell clinically. Sudafed constricts smooth muscle in vessel walls, but can stimulate smooth muscle in the lower urinary tract and cause urinary retention at times. A pharmacologist would be best qualified to answer your question however. ...Read more