Top
30
Doctor insights on: Cholestasis Of Pregnancy

Share
Dr. Katherine Kohari
38 Doctors shared insights

Cholestasis Of Pregnancy (Overview)

A condition where the flow of bile, a digestive fluid produced by the liver, slows or stops. As a result, the bile enters the bloodstream and causes "intense itching" in the mother on the palms and soles of the feet.


1

1
What meds are good for cholestasis of pregnancy? I had it once and don't want to experience it again.

What meds are good for cholestasis of pregnancy? I had it once and don't want to experience it again.

UCDA: Ursodeoxycholic acid (udca) is used in the treatment of intrahepatic cholestasis of pregnancy (icp). We don't know exactly how udca works, but we think it improves bile salt loss from the liver into the bile, which reduces serum bile acid, liver enzyme, and bilirubin levels. This reduces itching, and the risk to the fetus/mother, allowing deliver closer to term. Udca is safe to use in pregnancy. ...Read more

Dr. Katherine Kohari
38 Doctors shared insights

Cholestasis Of Pregnancy (Overview)

A condition where the flow of bile, a digestive fluid produced by the liver, slows or stops. As a result, the bile enters the bloodstream and causes "intense itching" in the mother on the palms and soles of the feet.


2

2
My wife has been diagnosed with cholestasis. How does this affect pregnancy?

My wife has been diagnosed with cholestasis. How does this affect pregnancy?

In bad way: Upon diagnosis, most providers will prescribe ursodeoxycholic acid. While there is no cure for for it, and no way to guarantee a successful outcome, studies have shown a slightly better fetal and maternal outcome from administration of ursodeoxycholic acid, whereas Cholestyramine appears to only relieve itching. Giving vit k during delivary.

Delivery by 37 completed weeks is considered crucial ...Read more

3

3
What causes cholestasis of pregnancy and what are the symptoms?

Itching & Jaundice: As well as elevated blood levels of bile acids. More common in scandinavia, south america, and multiple gestation pregnancy. An increased sensitivity of some women to the estrogen hormones of pregnancy lead to a reduced ability of their bodies to eliminate bile acids, causing them to accumulate. The condition usually resolves within 2-3 weeks of delivery. ...Read more

4

4
How is cholestasis of pregnancy diagnosed?

History/Physical/Lab: Cholestasis is diagnosed by doing a complete medical history, physical examination, and blood tests that evaluate liver function, bile acids, and bilirubin. Additionally, an ultrasound can de done to rule out gall bladder stones causing blockage. 1-2 preg/1000 is affected by cholestasis of pregnancy. It may be related to adverse pregnancy events like preterm labor, or at worse, stillbirth. ...Read more

5

5
What are the tests for intrahepatic cholestasis of pregnancy?

What are the tests for intrahepatic cholestasis of pregnancy?

LFTs, bile acids.: Liver function tests (alt/ast/alkaline phosphatase) and bile acids can clinch the clinical diagnosis of intrahepatic cholestasis of pregnancy - in the absence of cholelithiasis. ...Read more

7

7
What are tests, treatment for cholestasis of pregnancy?

What are tests, treatment for cholestasis of pregnancy?

Med, early delivery: Intrahepatic cholestasis is usually first noticed when a pregnant woman complains of itching all over the body but no rash. Testing will show abnormal bile salt levels and liver function tests. There is a medication that relieves the itching and lowers bile salt, but there is increased risk for stillbirth, so close monitoring of the pregnancy and delivery as soon as feasible is usual management. ...Read more

8

8
Could I have icp (intrahepatic cholestasis of pregnancy)? What are the risks?

Icp causes itching: I have only had one patient with icp in 27 years of practicing obstetrics. Diagnosis is made by elevated bile salts (detectable by lab test) and the treatment is cholestyramine. Pregnancy outcome should be unaffected by the condition. So icp is rare and makes you miserable, but should not affect your baby. One case however hardly makes me an expert so second opinions welcome. ...Read more

9

9
What are the chances of having cholestasis of pregnancy in consecutive pregnancies?

70% recurrance risk: Recurrance risk for cholestasis of pregnancy can be as high as 70% in subsequent pregnancies. There is no current therapy to lessen the risk or prevent those recurrances. ...Read more

10

10
Can cholestasis reoccur outside once you have had Cholestasis in Pregnancy?

Can cholestasis reoccur outside once you have had Cholestasis in Pregnancy?

Cholestasis: If someone developed cholestasis in pregnancy then they are at risk to get it again in future pregnancies. If they are having issues while not pregnant then a complete liver and and gallbladder evaluation should be done to look for underlying hepatic and biliary disease ...Read more

11

11
What is cholestasis of pregnancy?

What is cholestasis of pregnancy?

See below please: Cholestasis of pregnancy is a condition in which the normal flow of bile in the gallbladder is affected by the high amounts of pregnancy hormones. Cholestasis is more common in the last trimester of pregnancy. 1-2 pregnancies/1000 are affected by cholestasis. In severe cases, but not all, cholestasis may increase the risks for fetal distress, preterm birth, or stillbirth. Blood tests are key. ...Read more

12

12
How is cholestasis of pregnancy diagnosed?

History/Physical/Lab: Cholestasis is diagnosed by doing a complete medical history, physical examination, and blood tests that evaluate liver function, bile acids, and bilirubin. Additionally, an ultrasound can de done to rule out gall bladder stones causing blockage. 1-2 preg/1000 is affected by cholestasis of pregnancy. It may be related to adverse pregnancy events like preterm labor, or at worse, stillbirth. ...Read more

14

14
What causes cholestasis of pregnancy and what are the symptoms?

Itching & Jaundice: As well as elevated blood levels of bile acids. More common in scandinavia, south america, and multiple gestation pregnancy. An increased sensitivity of some women to the estrogen hormones of pregnancy lead to a reduced ability of their bodies to eliminate bile acids, causing them to accumulate. The condition usually resolves within 2-3 weeks of delivery. ...Read more

15

15
What meds are good for cholestasis of pregnancy? I had it once and don't want to experience it again.

UCDA: Ursodeoxycholic acid (udca) is used in the treatment of intrahepatic cholestasis of pregnancy (icp). We don't know exactly how udca works, but we think it improves bile salt loss from the liver into the bile, which reduces serum bile acid, liver enzyme, and bilirubin levels. This reduces itching, and the risk to the fetus/mother, allowing deliver closer to term. Udca is safe to use in pregnancy. ...Read more

16

16
How far along in pregnancy does cholestasis or pregnancy start? And what is cholestasis of pregnancy?

Cholestasis: Cholestasis of pregnancy is a condition in which the normal flow of bile in the gallbladder is affected by the high amounts of pregnancy hormones. Cholestasis is more common in the last trimester of pregnancy when hormones are at their peak, but it usually goes away within a few days after delivery. ...Read more

17

17
IS it uncommon for someone to develop cholestasis of pregnancy during a third pregnancy (never had it). Feeling sporadic itchines all overand 28 week?

Cholestasis: Cholestasis of pregnancy is not particularly common to begin with, however, any woman can get it during any pregnancy. This is serious business, so if you are having symptoms, alert your OB pronto! Good luck. ...Read more

18

18
What can be done for intraheptic cholestasis of pregnancy?

What can be done for intraheptic cholestasis of pregnancy?

Ursodiol/hydroxyzine: Delivery is the ultimate therapy for cholestasis gravidarum, by 36-38 weeks with 1-2/week fetal surveillance to avoid fetal demise. Oral ursodiol and Hydroxyzine cab help control the bile acid level in the mother's blood stream and decrease her pruritus. ...Read more

19

19
What are the chances of having cholestasis of pregnancy in consecutive pregnancies?

70% recurrance risk: Recurrance risk for cholestasis of pregnancy can be as high as 70% in subsequent pregnancies. There is no current therapy to lessen the risk or prevent those recurrances. ...Read more

20

20
Is intrahepatic cholestasis of pregnancy painful?

Is intrahepatic cholestasis of pregnancy painful?

NO: Cholestasis of pregnancy does not generally cause pain. The most common symptoms is pruritis (itching). It almost always starts with itching on the palms of the hands and soles of the feet, and it is first noticed at night. The itching spreads to other parts of the body over time. Treatment with ursodiol (bile salts) can improve symptoms. Consultation with a high risk OB is recommended. ...Read more

21

21
What are tests, treatment for cholestasis of pregnancy?

Med, early delivery: Intrahepatic cholestasis is usually first noticed when a pregnant woman complains of itching all over the body but no rash. Testing will show abnormal bile salt levels and liver function tests. There is a medication that relieves the itching and lowers bile salt, but there is increased risk for stillbirth, so close monitoring of the pregnancy and delivery as soon as feasible is usual management. ...Read more

22

22
What are the tests for intrahepatic cholestasis of pregnancy?

LFTs, bile acids.: Liver function tests (alt/ast/alkaline phosphatase) and bile acids can clinch the clinical diagnosis of intrahepatic cholestasis of pregnancy - in the absence of cholelithiasis. ...Read more

23

23
What about Intrahepatic cholestasis of pregnancy? What are the symptoms?

Itching: And possibly jaundice and can be associated problems with baby ...Read more

24

24
Are some people more prone to getting intrahepatic cholestasis of pregnancy?

Yes: There may be some familial predisposition to this disorder as it seems to apear in clusters of related women. It is also more common with multiple pregnancies (twins/triplets) and recurrence risk is as high as 50% or more in subsequent pregnancies. Resolution of symptoms is usually very prompt after delivery. ...Read more

25

25
Are there things I can do for intrahepatic cholestasis of pregnancy at home?

Uncertain: Cause and treatment of intra-hepatic cholestasis are uncertain. Since it is often associated with itching, you need to protect your skin with emollients and refrain from scratching your skin. ...Read more

26

26
How long does it take ursodeoxycholic acid to work when you have cholestasis of pregnancy?

How long does it take ursodeoxycholic acid to work when you have cholestasis of pregnancy?

Not long.: Ursodiol can pretty quickly decrease the bile acid levels in cases of intrahepatic cholestasis of pregnancy, however the pruritius may continue until Hydroxyzine is taken. ...Read more

29

29
Could I have icp (intrahepatic cholestasis of pregnancy)? What are the risks?

Icp causes itching: I have only had one patient with icp in 27 years of practicing obstetrics. Diagnosis is made by elevated bile salts (detectable by lab test) and the treatment is cholestyramine. Pregnancy outcome should be unaffected by the condition. So icp is rare and makes you miserable, but should not affect your baby. One case however hardly makes me an expert so second opinions welcome. ...Read more

30

30
How long does pruritus associated with intrahepatic cholestasis of pregnancy last?

Until pregnancy ends: Cholestasis of pregnancy is a considition which generally occurs in the 3rd trimester and is characterized by intense pruritis without rash and increase serum levels of free bile acids. The condition lasts until the pregnancy ends. The pruritis sometimes can be controlled with medications, such as ursodiol. ...Read more

Dr. James Dukelow
4 Doctors shared insights

Pregnancy (Definition)

When your due date arrives, you will be more than ready to have your baby! Most women deliver the baby somewhere between 37 and 42 weeks. According to the American College of Obstetricians and Gynecologists, only 5% of babies arrive on the exact due date. Approximately 7% of babies are not delivered by 42 weeks, and when that happens, it is referred to ...Read more


Dr. Adam Lewis
79 Doctors shared insights

Cholestasis (Definition)

When the flow of bile (chole) is held back (stasis). It can be from the liver cells not moving it (often from medications), or from the biliary tree being plugged by ...Read more


Find us on Facebook