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Doctor insights on: Cholestasis Of Pregnancy

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Dr. Katherine Kohari
33 doctors shared insights

Cholestasis Of Pregnancy (Overview)

Cholestasis of pregnancy is a condition where the flow of bile, a digestive fluid produced by the liver, slows or stops. As a result, the bile enters the bloodstream and causes "intense itching" in the mother on the palms and soles of the feet. There is little threat to the mother, but this condition has been linked to premature delivery and stillbirth, therefore early delivery is often induced. Following delivery, the condition usually gets better on its own without any long term effects.


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What meds are good for cholestasis of pregnancy?I had it once and don't want to experience it again.

What meds are good for cholestasis of pregnancy?I had it once and don't want to experience it again.

UCDA: Ursodeoxycholic acid (udca) is used in the treatment of intrahepatic cholestasis of pregnancy (icp). We don't know exactly how udca works, but we think it improves bile salt loss from the liver into the bile, which reduces serum bile acid, liver enzyme, and bilirubin levels. This reduces itching, and the risk to the fetus/mother, allowing deliver closer to term. Udca is safe to use in pregnancy. ...Read more

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Dr. Katherine Kohari
33 doctors shared insights

Cholestasis Of Pregnancy (Overview)

Cholestasis of pregnancy is a condition where the flow of bile, a digestive fluid produced by the liver, slows or stops. As a result, the bile enters the bloodstream and causes "intense itching" in the mother on the palms and soles of the feet. There is little threat to the mother, but this condition has been linked to premature delivery and stillbirth, therefore early delivery is often induced. Following delivery, the condition usually gets better on its own without any long term effects.


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My wife has been diagnosed with cholestasis. How does this affect pregnancy?

My wife has been diagnosed with cholestasis. How does this affect pregnancy?

In bad way: Upon diagnosis, most providers will prescribe ursodeoxycholic acid. While there is no cure for for it, and no way to guarantee a successful outcome, studies have shown a slightly better fetal and maternal outcome from administration of ursodeoxycholic acid, whereas Cholestyramine appears to only relieve itching. Giving vit k during delivary. Delivery by 37 completed weeks is considered crucial ...Read more

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What causes cholestasis of pregnancy and what are the symptoms?

Itching & Jaundice: As well as elevated blood levels of bile acids. More common in scandinavia, south america, and multiple gestation pregnancy. An increased sensitivity of some women to the estrogen hormones of pregnancy lead to a reduced ability of their bodies to eliminate bile acids, causing them to accumulate. The condition usually resolves within 2-3 weeks of delivery. ...Read more

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How is cholestasis of pregnancy diagnosed?

History/Physical/Lab: Cholestasis is diagnosed by doing a complete medical history, physical examination, and blood tests that evaluate liver function, bile acids, and bilirubin. Additionally, an ultrasound can de done to rule out gall bladder stones causing blockage. 1-2 preg/1000 is affected by cholestasis of pregnancy. It may be related to adverse pregnancy events like preterm labor, or at worse, stillbirth. ...Read more

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What are the tests for intrahepatic cholestasis of pregnancy?

What are the tests for intrahepatic cholestasis of pregnancy?

LFTs, bile acids.: Liver function tests (alt/ast/alkaline phosphatase) and bile acids can clinch the clinical diagnosis of intrahepatic cholestasis of pregnancy - in the absence of cholelithiasis. ...Read more

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What are tests, treatment for cholestasis of pregnancy?

What are tests, treatment for cholestasis of pregnancy?

Med, early delivery: Intrahepatic cholestasis is usually first noticed when a pregnant woman complains of itching all over the body but no rash. Testing will show abnormal bile salt levels and liver function tests. There is a medication that relieves the itching and lowers bile salt, but there is increased risk for stillbirth, so close monitoring of the pregnancy and delivery as soon as feasible is usual management. ...Read more

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Could I have icp (intrahepatic cholestasis of pregnancy)? What are the risks?

Icp causes itching: I have only had one patient with icp in 27 years of practicing obstetrics. Diagnosis is made by elevated bile salts (detectable by lab test) and the treatment is cholestyramine. Pregnancy outcome should be unaffected by the condition. So icp is rare and makes you miserable, but should not affect your baby. One case however hardly makes me an expert so second opinions welcome. ...Read more

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What are the chances of having cholestasis of pregnancy in consecutive pregnancies?

70% recurrance risk: Recurrance risk for cholestasis of pregnancy can be as high as 70% in subsequent pregnancies. There is no current therapy to lessen the risk or prevent those recurrances. ...Read more

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What is cholestasis of pregnancy?

What is cholestasis of pregnancy?

See below please: Cholestasis of pregnancy is a condition in which the normal flow of bile in the gallbladder is affected by the high amounts of pregnancy hormones. Cholestasis is more common in the last trimester of pregnancy. 1-2 pregnancies/1000 are affected by cholestasis. In severe cases, but not all, cholestasis may increase the risks for fetal distress, preterm birth, or stillbirth. Blood tests are key. ...Read more

Dr. Lonnie Smith
4 doctors shared insights

Pregnancy (Definition)

When your due date arrives, you will be more than ready to have your baby! Most women deliver the baby somewhere between 37 and 42 weeks. According to the American College of Obstetricians and Gynecologists, only 5% of babies arrive on the exact due date. Approximately 7% of babies are not delivered by 42 weeks, and when that happens, it is referred to ...Read more


Dr. Debra Rosenblatt
69 doctors shared insights

Cholestasis (Definition)

This means the flow of bile (chole) is held back (stasis). It can be from the liver cells not moving it (often from medications), or from the biliary tree being plugged by stone, tumor, scar, ...Read more