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Doctor insights on: Cholestasis Emedicine

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What causes elevated bilirubin after gallbladder surgery?

What causes elevated bilirubin after gallbladder surgery?

Depends on how: Much of elevation and how soon after surgery. If it is sudden elevation shortly after surgery, it could mean something bad, like retained stone, obstruction of common duct, liver damage, etc. Conversely, if is is a slight elevation years after surgery, then it is probably not even related. ...Read more

Dr. Daniel Saurborn
79 doctors shared insights

Cholestasis (Definition)

When the flow of bile (chole) is held back (stasis). It can be from the liver cells not moving it (often from medications), or from the biliary tree being plugged by ...Read more


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Is primary sclerosing cholangitis rare?

Is primary sclerosing cholangitis rare?

Yes: The goal of managing acute attacks is antibiotics and IV fluids. In about 15%, emergency decompression or surgery is needed. Prevention of future attacks of cholangitis is based on removing biliary stones and debris, dilation or resection of strictures, and establishing optimal biliary drainage. Also important to rule out the clonorchis parasite. Your GI doctor can discuss newest treatments. ...Read more

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I have elevated liver enzyme ast(sgot)412 ALT (sgpt) 317 GGT 186 dilation of the common bile duct 1 CM no gallbladder?

I have elevated liver enzyme ast(sgot)412 ALT (sgpt) 317  GGT 186 dilation of the common bile duct 1 CM no gallbladder?

Liver issue: Enzymes ast and alt are inside liver cells. When liver is injured by disease or medication, enzymes leak out, resulting in elevation. Can be due to many reasons, including medications like statins. An elevated GGT suggest biliary problems, but is not that specific. The normal common bile duct measures less than 0.8 cm, but after the gb is removed, can be 1cm. Complete history needed for this. ...Read more

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Why is igm elevated in primary biliary cirrhosis (cholangitis)?

Why is igm elevated in primary biliary cirrhosis (cholangitis)?

Immune dysregulation: The immune system is not functioning normally in primary biliary cirrhosis. That and the chronic inflammation contrive to raise IgM. ...Read more

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Is primary biliary cirrhosis hereditary?

Is primary biliary cirrhosis hereditary?

Basically no: There's a pair of genes that carry the ability to develop the disease and these run in families, but it's not inherited like sickle cell, huntington's or some of the other familiar entities. http://www.medicalnewstoday.com/releases/151640.php. ...Read more

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My test result: Bilirubin total: 3.2 Mg/dl Bilirubin direct:0.5Mg/dl SGOT: 18 IU/L SGPT: 18 IU/L ALK PHP: 168 IU/L any need to visit a doctor?

My test result: Bilirubin total: 3.2 Mg/dl  Bilirubin direct:0.5Mg/dl  SGOT: 18 IU/L SGPT: 18 IU/L ALK PHP: 168 IU/L  any need to visit a doctor?

You might want to,,,: Your bilirubin is high, especially the indirect fraction. The alkaline phosphatase is also high but not very. You might need more tests to find out the cause but it appears you've got some process increasing the liver activity and possibly hemolysing (breaking up) your red cells. It'd be best to see your doctor for more tests on your liver and blood cells and an exam to find the cause. ...Read more

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What causes intrahepatic ductal dilation w/ focal narrowing @ rt. Hepatic duct? Lft's: ast:853, alt:710, alp:173 fatigue, vomiting, fever, itching. Gb removed 2010, NASH st. 2, gr.2, gastric byp. 2011

Hard to say,,: It looks like, from your history, that you've had a great deal of issues. Your gallbladder being removed may have, at least in part, been due to gallstones which would explain a lot of the bile duct situation. Gastric bypass also has complications. But your liver also has something going on now that you need to see your doctor soon to find the cause and treat before it gets worse. Good luck. ...Read more

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What is primary biliary cirrhosis (liver) like?

What is primary biliary cirrhosis (liver) like?

It's variable.: Depends on how long you have had it. Usually without symptoms early in the disesae. May be associated with itching, hypythyroidism, fatigue, osteoporosis and dry eyes. Can progress to cirrhosis over time. If you have pbc, you should talk with your doctor about what stage your disease is. ...Read more

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What causes biliary dyskinesia ?

Biliary dyskinesia: Sphincter of oddi dysfunction, or biliary dyskinesia, is defined by bile duct manometry showing sphincter spasm, increased phasic contraction frequency (tachyoddia), paradoxical contraction response to cck, & abnormal propagation of phasic waves. Response to sphincterotomy is predicted by associated abnornalities in serum liver functions as well as manometry findings.Pain alone may not so respond. ...Read more

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What is the definition or description of: primary biliary cirrhosis diagnostic panel, comprehensive?

PBC: Primary biliary cirrhosis is an autoimmune disease of the liver marked by the slow progressive destruction of the small bile ducts within the liver. When these ducts are damaged, bile builds up in the liver and over time damages the tissue. This can lead to scarring, fibrosis and cirrhosis. ...Read more

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Is a hida scan (cholescintigraphy) dangerous for people w/ lupus or autoimmune diseases?

Is a  hida scan (cholescintigraphy) dangerous for people w/ lupus or autoimmune diseases?

No.: No higher incidence of problems with autoimmune disease, ie .Lupus. One of the best tests for determiing gall bldder function. Wouldn't worry! ...Read more

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Elevated liver enzyme , mrcp indicated mild intrahepatic ductal dilatation, mild splenomegaly, normal ercp, what causes that, how it treated?

Elevated liver enzyme , mrcp indicated mild intrahepatic ductal dilatation, mild splenomegaly, normal ercp, what causes that, how it treated?

Inflammation: Ductal dilation can be obstructive or non obstructive. Causes of obstruction such as stones, stricture, tumor etc to be ruled out. Usually when not obstructed mild dilation can be related to inflammation or cholangitis. These inflammatory processes usually treated medically. ...Read more

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My liver function tests results bilirubin total-4.35 sgot- 468 sgpt- 908 ggt- 132 alkaline phosphatase-175.8 anything serious, could this be jaundice?

My liver function tests results
bilirubin total-4.35
sgot- 468
sgpt- 908
ggt- 132
alkaline phosphatase-175.8
anything serious, could this be jaundice?

See details: These results suggest significant liver disease and this must be evaluated immediately. Speak with the doctor who ordered the tests. Get screened for hepatitis and consider a referral to a GI specialist. ...Read more

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Liver Cancer patient SGPT(ALT)=84 U/L, SGOT(AST)=121 U/L, BILIRUBIN=10.91 with no bile duct obstrcton in Ultra Sound. Does this mean liver is failing?

Liver Cancer patient SGPT(ALT)=84 U/L, SGOT(AST)=121 U/L, BILIRUBIN=10.91 with no bile duct obstrcton in Ultra Sound. Does this mean liver is failing?

Can't tell w/ these.: The bilirubin level is high (whether direct or indirect bilirubin) & this can lead to jaundice. However, the TREND is more important than 1 lab value - without knowing your history & past lab results better, it is hard to determine. Also, liver "function" is also measured by cholesterol, complement, & coagulation tests (INR, PTT). Even with these blood tests, sometimes a biopsy is needed. TTYD. GL ...Read more

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Tot Bilirubin 1.9, Direct 0.4; ALBUMIN 5.6, ALK.PHOSPHATASE 66, AST (SGOT) 17, ALT(SGPT) 21, GGT 20 Possible cause for elevation?

Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, If you have had a persistently elevated bilirubin without any symptoms, the likely explanation is Gilbert's disease, which is essentially harmless. Beyond that you require additional history, physical examination and may be additional tests. ...Read more

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Usg wa shows liver parenchymal disease..how to cure?

Usg wa shows liver parenchymal disease..how to cure?

Liver Ultrasound: Hi, if I want to have a wild guess with this little info has been provided I would say you possibly have Fatty Liver, lose weight, eat right, exercise more, take fish oil and that should help the liver. For further information regarding that Parenchymal dx you better talk to the ordering physician as there are lots of various diseases that could involve the liver. ...Read more

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Hepatology: 24y.O healthy non alcoholic, no meds, fully negative workup including rare causes except biopsy for elevated ALT 171 and AST 60 incidental?

Hepatology: 24y.O healthy non alcoholic, no meds, fully negative workup including rare causes except biopsy for elevated ALT 171 and AST 60 incidental?

Fatty liver disease: Fatty liver disease is the most common cause of abnormal lfts and is caused by excessive fat accumulation in the the liver. Fatty liver can lead to complications including hardening of the liver called cirrhosis. If your bmi is too high, then losing weight will help mitigate your long term associated health risks. Sometimes a blood test called fibrosure helps clarify the diagnosis. Good luck! ...Read more