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Doctor insights on: Chlorpheniramine Hydrochloride Sedating Antihistamine

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Can taking the OTC chlorpheniramine maleate (antihistamine) make you sweaty?

Can taking the OTC chlorpheniramine maleate (antihistamine) make you sweaty?

Possible, unlikely: It can cause you to be sweaty, but this would be unlikely. ...Read more

Dr. Abraham Jaskiel
9 doctors shared insights

Chlorpheniramine Hydrochloride (Definition)

Chlorpheniramine hydrochloride is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more


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Itchy scalp&skin from hair dye.No visible reaction.can it get worse/serious?Chlorpheniramine (antihistamine) tablets available here.Safe to use?

Itchy scalp&skin from hair dye.No visible reaction.can it get worse/serious?Chlorpheniramine (antihistamine) tablets available here.Safe to use?

Yes: As I mentioned earlier, as long as you will not be driving or engaging in other complex or dangerous activity, it is okay to take antihistamine medication. ...Read more

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Whats the difference between a first generation antihistamine like chlorpheniramine and second generation antihistamines like allegra (fexofenadine)?

Whats the difference between a first generation antihistamine like chlorpheniramine and second generation antihistamines like allegra (fexofenadine)?

1st and second: First generation antihistamines are sedating and short acting and have usually other properties such as anticholinergic or drying properties. Second generation antihistamines are long aciting, usually dosed once a day, and are less or non sedating and selective antihistamines with less active properties on other receptors. ...Read more

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I regularly take a four-hour antihistamine, chlorpheniramine maleate, because it seems to help with digestion. Are there any issues with extended use?

I regularly take a four-hour antihistamine, chlorpheniramine maleate, because it seems to help with digestion. Are there any issues with extended use?

Yes: First is tolerance, meaning that you would have to increase the dose to get the same effect. Second, side effects are more prone to appear with extended use, and some are serious, hence the need of medical supervision. Third, it isn't meant to help digestion, if you have a problem with digestion / indigestion and not resolved , you need to see your doctor. Good luck ...Read more

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For educational purposes, i look up any meds i take. Which cytochrome p450 enzymes metabolize the first-gen antihistamine periactin (cyproheptadine hydrochloride)? Or are effected?

Cyproheptadine: Aromatic ring hydroxylation ( followed by glucuronide conjugation), and n-demethylation, end heterocyclic ring oxidation were shown to occur in man. The principal metabolite, however, was identified tentatively as a quaternary ammonium. Glucuronide-like conjugate of cyproheptadine. The exact mechanisms for the glucuronidation are not entirely clear. ...Read more

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Is it ok to take percocet with cetirizine hydrochloride 10 mg antihistamine ?

Yes: The antihistamine Cetirizine is a very safe medication and can be used with most other medications. A very small percentage of people will have drowsiness. This potentially could be worsened by combining with percocet, but not nearly as significant as using benadryl (diphenhydramine). ...Read more

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Currently taking Claritin and Benadryl (diphenhydramine) for allergies. Would it be safe to instead take clairtin and chlorpheniramine? Should be temporary.

Currently taking Claritin and Benadryl (diphenhydramine) for allergies. Would it be safe to instead take clairtin and chlorpheniramine? Should be temporary.

If necessary: All the medications mentioned are antihistamines. Claritin (loratadine) is a new generation one and Benadryl (diphenhydramine) and chlorpheniramine are first generation ones. While short term use likely has no serious side effects, there should be a treatment that doesn't require both. Also, the reason for the symptoms should be addressed in an effort to prevent symptoms. ...Read more

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Is naphazoline hydrochloride an antihistamine?

Is naphazoline hydrochloride an antihistamine?

Not an antihistamine: Naphazoline is a vasoconstrictor and an Alpha agonist. It is not an antihistamine, although it can be combined with one. ...Read more

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Dr. Paul Carter
601 doctors shared insights

Antihistamine (Definition)

Sedating and non-sedating antihistamines prevent and treat allergic reactions, and are ...Read more


Aller0chlor (Definition)

Aller-Chlor is a sedating antihistamine which is a kind of antihistamine type drug (common ...Read more