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Doctor insights on: Chlor Trimeton Sedating Antihistamine

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I regularly take a four-hour antihistamine, chlorpheniramine maleate, because it seems to help with digestion. Are there any issues with extended use?

I regularly take a four-hour antihistamine, chlorpheniramine maleate, because it seems to help with digestion. Are there any issues with extended use?

Yes: First is tolerance, meaning that you would have to increase the dose to get the same effect. Second, side effects are more prone to appear with extended use, and some are serious, hence the need of medical supervision. Third, it isn't meant to help digestion, if you have a problem with digestion / indigestion and not resolved , you need to see your doctor. Good luck

Dr. Paul Carter
630 doctors shared insights

Antihistamine (Definition)

Sedating and non-sedating antihistamines prevent and treat allergic reactions, and are ...Read more


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Can taking the OTC chlorpheniramine maleate (antihistamine) make you sweaty?

Can taking the OTC chlorpheniramine maleate (antihistamine) make you sweaty?

Possible, unlikely: It can cause you to be sweaty, but this would be unlikely.

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What are sedating antihistamines for insomnia?

What are sedating antihistamines for insomnia?

Benadryl (diphenhydramine).....: is probably the most readily available sedating antihistamine. It is a common ingredient in over-the-counter (OTC) preparations for sleep, such as Tylenol (acetaminophen) PM -- the PM part is diphenhydramine, the generic name for Benadryl. Another one I like to use is hydroxyzine (also known as Vistaril or Atarax) but that is only available as a prescription, however its metabolite is Zyrtec, which is OTC.

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I understand that one cannot become addicted to antihistamines, however, can't people become addicted to the sedating effects of drugs?

Tolerance: You become tolerant to the sedative effect of first generation antihistamines and with time you will no longer feel sedated from them. If you are using then as a sleep aid, will you need more with time to achieve the same level of sedation. It is not an addiction, it is tolerance to the medication.

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I have anaphylaxis from Benadryl (diphenhydramine) (documented by ED mds), is chlor trimeton ok to take instead?

I have anaphylaxis from Benadryl (diphenhydramine) (documented by ED mds), is chlor trimeton ok to take instead?

No guarantee: Chlortimeton is a different chemical compared to benadryl (diphenhydramine) (Alkylamine vs Ethanolamine derivatives) so in theory it should be ok.Actual anaphylaxis reaction to antihistamines is not only rare, but every case report, there have been other drugs involved (co-ingested). Consider specific allergy testing because anaphylaxis is life-threatening and if it wasn't the benadryl (diphenhydramine) you need to know absolutely.

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Do chlortrimeton's effects last as long as benadryl's?

Do chlortrimeton's effects last as long as benadryl's?

Much longer: Benadryl (diphenhydramine) leaves the system about twice as fast. It's half-life (time for 1/2 of it to leave the body) is 3.4 to 9.2 hours. Chlor-trimeton (chlorpheniramine)'s half-life is 20-24 hrs for adults and 10-13 hrs in children. That means Benadryl is 75% gone in 7-18h rs and chlor-trimeton's still going strong after 40-48 hrs (in adults).

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If I have developed resistance to benadryl's sedating effects( +/-150mg), will it still work4allergy?

If I have developed resistance to benadryl's sedating effects( +/-150mg), will it still work4allergy?

Give it a try: Diphenhydramine (benedryl) is a very effective antihistamine, holding on to histamine binding sites better than some products. Its drawback other than sedation has been its limited duration of effect, eclipsed by products like zyrtec (cetirizine) that can last all day. Sedation is not a measure of its worth, only its ability to get into your brain and mess with neurotransmitters.

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If i take Benadryl (diphenhydramine) before getting on a plane, will the sedation from it help with my plane anxiety?

If i take Benadryl (diphenhydramine) before getting on a plane, will the sedation from it help with my plane anxiety?

Causes drowsiness: Might suggest this be dealt with like one handles stage fright. Try a beta-blocker like propanalol or timolol. Another choice, alprazolam, which could keep you more awake. Talk to your doc, as these approaches are all generic and relatively cheap.

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I am taking Benadryl (diphenhydramine) with minimal side effects only light sedation. Going to try hydroxyzine. Will I get more side effects than Benadryl (diphenhydramine)?

I am taking Benadryl (diphenhydramine) with minimal side effects only light sedation. Going to try hydroxyzine. Will I get more side effects than Benadryl (diphenhydramine)?

Hydroxzine: It depends upon the dose you were taking. Benedryl is a antihistamine that is usually very sedating. If you were on a small dose of benedryl and now u You are going on a large dose of Hydroxzine you may have more sedation.

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My son is scheduled for dental work with sedation tomorrow & has to fast from tonight. Is it safe to give Benadryl (diphenhydramine) in the morning for motion sickness?

My son is scheduled for dental work with sedation tomorrow & has to fast from tonight. Is it safe to give Benadryl (diphenhydramine) in the morning for motion sickness?

Not our decision: If your son is being put to sleep for his treatment, the medication may interact with the general anesthetic. The doctor rendering the treatment must make this decision. Call them.

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Can you take aspirin with the anti-histamine chlorpheniramine maleate?

Yes: These two drugs have no cross over and will neither enhance or interfere with each others activity. They are both over the counter, inexpensive and surprisingly effective.

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What is the best time to take an antihistamine?

What is the best time to take an antihistamine?

Any time: You can take antihistamines any time of the day.Take them same time of day everyday.

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Can i die by taking too many antihistamine tablets?

Can i die by taking too many antihistamine tablets?

Taking lethal over: Dose would do that. Lethal overdoses of antihistamines are rare. Are you considering taking an overdose of antihistamines? If so, please get help right away. You can use national suicide hotlines 24/7 at 1-800-suicide (1-800-784-2433) or 1-800-273 – talk (1-800-273-8255). If you have accidentally taken too many antihistamines please contact 1-800-222-1222 (poison control hotline). Take care.

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Is it possible to die from an overdose of antihistamine pills?

Is it possible to die from an overdose of antihistamine pills?

Which one: First generation antihistamines are sedating, second generation ones are not, overdosing on the latter hardly kills, but may cause sedation. Overdosing on first generation antihistamines may be more of a problem, but again they are safe in high doses.

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Can you use antihistamine and wine?

Can you use antihistamine and wine?

Not a good idea: Antihistamines (especially the older ones such as benadryl) can cause drowsiness and impairment and this can be worsened by the effect of alcohol even at regular doses. There are other allergy medications available that can be taken if a glass of wine is desired.

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Which antihistamine dries up drainage best?

Which antihistamine dries up drainage best?

1st generation: as diphenhydramine, because of more anticholinergic effects, but would cause more sedation, read the labels well, don't drive or operate machinery while using them, if they still don't work, see your doctor for better diagnosis and management

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Which is the best antihistamine for children?

Which is the best antihistamine for children?

Several are good: Loratedine (Alavert,Claritin), Cetirizine( Zyrtec)and Fexofenadine (Allegra)are all effective. Dyphenhydramine (Benadryl) is short acting so if you want the reaction not to come back in the middle of the night then one of the above would be better. Remember that you should not give children under 2 antihistamines without checking with your doctor. Between 2-4 y/o you should also ask. Not for colds

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Is loratadine the best antihistamine out there?

Which one works: the best for you is the best one for you.

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Dr. Debra Rosenblatt
46 doctors shared insights

Sedating Antihistamine (Definition)

Sedating antihistamines are a kind of antihistamine type drug (common ...Read more