Doctor insights on:
Childhood Leukemia And Fertility
Please clarify: I am unclear as to what your question is. Please clarify. ...Read more
A malignant hematologic neoplasm that originates in the bone marrow and represents a clonal proliferation of hematopoietic elements belonging to any of the myeloid, lymphoid, erythroid, and megakaryocytic lineages. Of note, other hematologic neoplasms like lymphoma or myeloma may demonstrate a leukemic phase without actually originating in the bone marrow ...Read more
Usually they thrive: The cure rate for all childhood leukemias has improved tremendously over the past few decades, and much effort now is directed toward minimizing long term side effects, such as numbness, secondary cancers, or slowed mentation. A very reasonable goal today is for the child to be cured and lead a perfectly normal life. ...Read moreSee 1 more doctor answer
Please list childhooddiseases that cause low white red and platelets and slow activity in bone marrow, no previous illnesses and luekemia isnt present?
Viral illness: A viral illness can affect those cells your are describing. Children can have a viral illness and not show many signs or symptoms. If a blood work, called Complete Blood Cell Count, is done during the illness it can be a surprise when it shows a possible viral illness in an otherwise healthy child. ...Read more
What are the chances of my child getting a secondary cancer after her leukemia treatment is completed? Daughter, age 9, treated for acute lymphoblastic leukemia, no radiation, 2.5 years of intrathecal and oral chemo meds.
Diagnosed with Acute Myeloid Leukemia (AML). 95% blast cells in BM test. Doc starting 7+3 chemo course. What are the chances? Any other treatment?
AML: If you have been accurately diagnosed with AML, further subtyping of your diagnosis must take place before treatment is started or prognosis is estimated. This is based on examination of cell morphology, immunophenotype, genetics (karyotype), and clinical features (age at diagnosis; functional status and comorbidities). Age >55 at time of diagnosis is a negative prognosticator. ...Read more
Several!: Currently over 80% of children diagnosed with cancer will be cured of their disease, due to advances in the treatment of common childhood cancers such as acute lymphoblastic leukemia; over 90% of children with that diagnosis are now cured. Many types of brain tumors, wilm's tumor, and lymphomas are also very curable. Metastatic bone and soft tissue tumors and neuroblastoma are still challenging. ...Read moreSee 1 more doctor answer
CML cyclic thrombocytopenia: Yes, multiple variations exists on this topic. Recently, a number of patients has been reported who presented de novo with the acute blastic crisis of CML.4.9 This type of leukemia was confirmed by the presence of a Ph1 chromosome in bone marrow metaphases. These patients apparently never had the 3- to 4-year phase of overproduction of marrow myeloid elements which typifies the usual case of CML. These observations suggest that CML can manifest itself as a highly variable clinical picture. One extreme is represented by the patient who presents de novo with the blastic cell crisis, the other by the patient who shows a prolonged phase of leukocytosis periodically interrupted by a spontaneous or chemotherapeutic induced remission. The current patient, although presenting with an infrequently recognized stage of this disease, would suggest that the evolution of CML may be characterized by a chronic relapsing and spontaneously remitting course ...Read more
Not much: Sickle cell disease is seldom subtle. Patients have intermittent periods of intense pain, often in bone, they have all manifestations of profound anemia, including diminished exercise tolerance, shortness of air, generalized fatigue, etc. This is a very bad disease with few subtle manifestations. ...Read more
I've high monocyte counts, sporadic high general wbc counts and ALL other physical symptoms listed online. im 23. could i have acute myeloid leukemia?
This isn't leukemia: Acute myeloid leukemia is not subtle in its presentation. And the cells are distinctively abnormal, not healthy-looking monocytes. Reference ranges are set by labs so that a few percent of healthies fall outside on either end. I wasn't able to see your symptom list -- it's your physician's task to make the call. TB's a concern with high monocytes and ill-defined symptoms, but leukemia isn't. ...Read more
Sure: Some things would have to be established first, however. Are there any other pituitary hormone deficiencies, persistent gh deficiency, or abnormalities around the brain and pituitary gland from childhood mri? Any other medical condition? Many kids grow up to be adults who no longer have gh deficiency, but an endocrinologist or reproductive endocrinologist should be consulted prior to pregnancy. ...Read more
What are some good concrete metrics in defining remission for waldenstrom's macroglobulinemia - in terms of bone marrow analysis and IgM level?
50%, 90%, 100%: Con?rmation of response in wm has been adopted from response criteria for multiple myeloma. See http://www.Iwmf.Com/docs/ghobrial_clincial_trials.Pdf especially see tables xi, xii. The treatment of wm is aimed at control of symptomatic disease. Risk/benefits of various therapies are highly individualized based on patient and disease characteristics. ...Read moreSee 2 more doctor answers
Latest findings on when brain development--especially executive skills--is thought to be complete in most young adults?
see below: Most studies indicate by age 25 or 26, in males, the final frontal lobe development is in place, especially orbital frontal areas. Does occur a few years earlier in females. ...Read more
Viral infection: There are dozens of different viruses, and yes, some are capable of inhibiting bone marrow cell synthesis with subsequent low cell counts. This does not mean, however, that your results are necessarily related to a viral illness and you deserve to have further investigation. ...Read moreSee 1 more doctor answer
Chronic high white blood cell count for 2 years, from 11k to 32k, have had many blood test, IV pic, bone marrow test, spinal tap, all negative?
Test: Iif there is other symptom related ( unintentional weight loss, bleeding, abdominal pain etc). - consider to get imaging- ct scans. Also cancer screening- colonoscopy, papsmear, mammogram etc if you smoke- please quit smoking. Also sometimes medication can increase WBC - although usually not more than 15k. What is the WBC differential? ...Read moreSee 2 more doctor answers
Recent research on bisphenol-a and development of prolactinoma in young men? Are more young men showing up with prolactinomas these days?
Not in my practice.: Bpa acts as a weak estrogen and it is known that estrogen increases prolactinomas. Prolactinomas are a fairly common endocrine disease, but there is currently no real evidence that there is an increased incidence of the disease. It is also difficult to determine because of better lab tests and imaging studies which means we might just be able to find them better. ...Read more
For what length of time can someone in there early 40s with early chronic lymphocytic leukemia live?
A long time: The old but tried an true prognostic test is the lymphocyte doubling time. That i, the length if time it takes for the count to go up times two. There are other lab markers that reflect higher risk disease. Discuss with your doc as more aggressive options when needed in a younger patient. ...Read more