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Doctor insights on: Chemotherapy Liver Damage

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After 4 cycles of chemotherapy should a liver met start reducing in size ? Is 16 mm classed large ?

After 4 cycles of chemotherapy should a liver met start reducing in size ? Is 16 mm classed large ?

Kinetics of response: Faster growing tumors tend to respond quicker, but tumors can be resistant. Typically 4 cycles of chemotherapy is enough time to know whether the disease is responding. Whether to continue treatment depends on the goals of care. Stable disease is better than progression, so more treatment may be fine if side effects are manageable. 16 mm is not large yet still represents millions of tumor cells. ...Read more

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Dr. Eric Weisman
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Liver (Definition)

This organ plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. It lies below the diaphragm in the abdominal-pelvic region of the abdomen. It produces bile, an alkaline compound which aids in digestion via the emulsification of ...Read more


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How effective is chemotherapy irinotecan for a liver met and node.? Does it only work in some patients ?

How effective is chemotherapy irinotecan for a liver met and node.? Does it only work in some patients ?

Good drug: Irinotecan hydrochloride or Camptosar, (irinotecan) CPT-11 is a chemotherapy drug made from a plant alkaloid known as a topoisomerase I inhibitor. It works by blocking an enzyme in cells called topoisomerase I. needed to keep DNA in shape when dividing. The drug useful in metastatic colon cancer to liver where it can convert the mets to resectable. ...Read more

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If I have colon or rectal cancer that has spread to the liver, should I have chemotherapy first?

If I have colon or rectal cancer that has spread to the liver, should I have chemotherapy first?

Find a good team: Colorectal cancer with spread to the liver is a hotly debated and controversial topic. Multiple variables include - the location of the tumor, the symptoms it is producing, the location of the liver mets and their potentail for surgical removal. You need an experienced team that deals with this commonly (surgical and medical oncologists, maybe rad onc, as well). Good ct/pet is vital. ...Read more

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My father operated for ca rectum now he had multiple mets in liver what's is prognosis of chemotherapy in this case and what is life expectancy???

Hard to say: I am sorry for your father's illness. We can not say how long anyone might live, and response to chemotherapy can vary among different people. Your father's oncologist can best explain the expected response to treatment. Spending time with your father will help both of you through this time. ...Read more

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What If no forms of chemotherapy work on a colon cancer pt who has a liver met ? Are there other options ?

What If no forms of chemotherapy work on a colon cancer pt who has a liver met ? Are there other options ?

Radiation and surgery: Aside from chemotherapy, the 2 types of treatment for cancer are radiotherapy & surgery. Liver mets, if they block a duct or cause a "local" problem can be treated with radiation beam to alleviate suffering. If the patient is strong enough to withstand it, surgery and/or brachytherapy (radiation implants) can be tried; however, colon cancer is a systemic problem and chemo is the main modality. GL. ...Read more

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Do these CEA readings mean chemotherapy not working in a colon cancer pt August 9.8, October 8, dec 9, jan 10. Met to the liver ?

Do these CEA readings mean chemotherapy not working in a colon cancer pt
August 9.8, October 8, dec 9, jan 10. Met to the liver ?

Stable: Ams an oncologist I would say those levels are stable. Follow your oncologist advice and do not stop chemo based on your CEA levels, they look good. ...Read more

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Life expectancy terminal lung cancer with liver mestasis with chemotherapy stopped?

Life expectancy terminal lung cancer with liver mestasis with chemotherapy stopped?

Bad news: Prognosis is grim, but I would suggest in the interim good symptom control through a palliative care line or hospice care. A variety of factors play in determining life expectancy, that is usually in such cases less than 6 months. ...Read more

Dr. Devon Webster
945 doctors shared insights

Chemotherapy (Definition)

The term chemotherapy typically is used to describe using chemicals to treat ...Read more