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Doctor insights on: Chemotherapy Hormone Receptor Positive Node Breast Cancer

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Chemotherapy hormone receptor positive node breast cancer?

Chemotherapy hormone receptor positive node breast cancer?

D/W oncologist: Treatment will depend not only the stage but also the biology of the cancer- whether it is estrogen positive, her2neu positive, whether it is lymph node positive or not. Also depends on your preference and overall health condition. Different test like oncotype dx, mammaprint can give you more info-re- recurrence risk of cancer and will be helpful in choosing the right therapy for you.D/w your md. ...Read more

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Dr. Barry Rosen
1,337 doctors shared insights

Breast Cancer (Definition)

Breast cancer results when glandular cells lining the milk ducts and lobules of the human breast begin to grow in an unregulated manner. The growth occurs initially inside the ducts but eventually breaks outside into the breast tissue and ultimately spreads both to the lymph nodes in the armpit and via the bloodstream to other parts of the body. Because of the promoting affect of estrogen almost all breast cancer occurs in women and is a rarity in men. The unregulated growth is due to both inherited and acquired genetic defects. It is the most common malignancy in women but it often curable if found early and treated effectively with surgery, hormonal therapy, chemotherapy and targeted therapy, or a combination thereof. Early detection before the malignancy becomes large enough to be felt depends on mammography/sonography and MRI imaging of the breast ...Read more


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Is there a benefit to chemotherapy in hormone receptor positive, node positive postmenopausal breast cancer?

Is there a benefit to chemotherapy in hormone receptor positive, node positive postmenopausal breast cancer?

Often: There is increasing data based on the oncotype DX test in women with 1-3 positive notes that shows that some women will not get much benefit from chemo and some will get a great deal. It can be useful in cases where a woman is reluctant to take chemo. This is done on tissue that has been already removed. Most oncologists believe that women who have multiple positive nodes should get chemotherapy. ...Read more

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Hormonal effects of chemotherapy for breast cancer?

Hormonal effects of chemotherapy for breast cancer?

Please clarify.: It is unclear from your question what you are asking. Most breast cancers are estrogen-sensitive and can be treated with anti-estrogen medication (tamoxifen, aromatase inhibitors). Many women who are peri menopausal when receiving traditional chemotherapy develop ovarian suppression from the chemo and effectively "go into" menopause. I hope this helps. ...Read more

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What is the relationship of her2 and p53 with hormone receptors in breast cancer?

What is the relationship of her2 and p53 with hormone receptors in breast cancer?

Complicated: Her-2 is an oncogene usually (not always) associated with er- tumors. We know that it is in general associated with a worse prognosis, but women with her 2+ tumors may respond dramatically to Herceptin (trastuzumab) - a monoclonal antibody. P53 is a tumor suppressor gene. The relationship between p53 and er is currently under study - it may be that p53 mutations may play a role in tamoxifen responsiveness. ...Read more

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Im a breast cancer positive, stage 1 with her2 positive, is completly necesary the chemotherapy in my case?

Im a breast cancer positive, stage 1 with her2 positive, is completly necesary the chemotherapy in my case?

Breast CA: It really depends on your risk factors and tumor characteristics. You should have a through consultation with a medical oncologist to determine the best course. ...Read more

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How long is the chemotherapy for a stage 2a node negative breast cancer?

How long is  the chemotherapy for a stage 2a node negative breast cancer?

It depends: There are several chemotherapy options for stage 2a breast cancer. Characteristics of the patient and the cancer are required to make a decision on the type of chemotherapy (and whether chemotherapy is even necessary). Chemotherapy would be anywhere from about 8 weeks to a year (herceptin-or trastuzumab treatment, if recommended, requires a year of treatment). ...Read more

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Are all stage 1 breast cancer patients with no lymph node involvement recommended to take chemotherapy?

No: Most important factors are tumor size, age and overall health, estrogen receptor status and her-2-neu status. In general, most young healthy people with a tumor greater than 1 cm will receive chemo and/or hormonal therapy. Smaller tumors are treated if er negative or her-2 positive. Some small er+ tumors are treated with chemo, but the relative benefits are smaller - an oncotype DX is helpful. ...Read more

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I have breast cancer spread only to lymph nodes after surgery chemotherapy and radiation ,can came back and spread to bone or other organs?

I have breast cancer spread only to lymph nodes after surgery chemotherapy and radiation ,can came back and spread to bone or other organs?

Hopefully not: It depends on the stage and type of Breast Cancer. What kind of surgery- Mastectomy or Lumpectomy?Are post menopausal? Was it ER/PR positive? HER 2 positive? This is the best case scenerio. Your Oncologist will be able to give you the proper information. Keep Positive attitude, Love your life, Exercise regularly when you can, Eat more greens- Lots of Vegetables which has Antioxidents. ...Read more

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What are common proven alternatives to chemotherapy for breast cancer treatment?

What are common proven alternatives to chemotherapy for breast cancer treatment?

Alternative to what?: Chemotherapy is the administration of a drug that circulates throughout the body and kills cancer cells. Our goal is to choose the most effective drug tailored to one's specific cancer subtype. If by "alternative" you mean alternative to proven, standard therapy...No. However, many of our "standard" drugs are well-tolerated w/o traditional side-effects like hair loss, nausea, etc. ...Read more

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Dr. Barry Rosen
4,223 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


Receptor (Definition)

An organ, cell or molecule that accepts an outside signal and causes an internal change. Eyes receive light, touch receptors send messages to the brain when stimulated by pressure and estrogen receptors bind Estradiol causing responses of normal breast, ovary and uterus cells to rising and falling levels of the female steroid hormones. Most of the time "receptor" refers to one ...Read more