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Doctor insights on: Chemotherapy For Bile Duct Cancer

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Is radiation therapy possible for bile duct cancer?

Is radiation therapy possible for bile duct cancer?

Yes: Surgery is the first and most important treatment. Often radiation and chemo will be needed because these cancer can recur easily. ...Read more

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Dr. Barry Rosen
4,459 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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Is biliary duct cancer a form of primary liver cancer?

Is biliary duct cancer a form of primary liver cancer?

No: Primary liver cancer is when the liver cells themselves, the hepatocytes, transform into cancer cells. Bile duct cancer is when the cells lining the bile duct transform into cancer. Primary liver cancer tends to grow large nodules in one place, and doesn't give a lot of symptoms until the tumors are large. Bile duct cancer tends to obstruct the bile ducts and create symptoms, such as jaundice. ...Read more

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Pancreatic cancer, ampullary tumor. Whipple procedure. Spread to liver, not respectable. Chemo for 6 months and continuing. Prognosis?

Pancreatic cancer, ampullary tumor. Whipple procedure.  Spread to liver, not respectable. Chemo for 6 months and continuing. Prognosis?

Poor: While Whipple is the best approach for a primary pancreatic or ampullary lesion, the recurrence rate at 1-2 yrs is 90%. Chemo either of the FOLFIERI or Genciabine /Abraxane combo have limited effects on liver mets which in pancreas are not considered amenable to resection. There is an FDA protocol using specific monoclonals targeting pancreas that might be available but only after chemo failure ...Read more

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What are the survival rates for bile duct cancer?

What are the survival rates for bile duct cancer?

Not very good: Bile duct cancers are difficult cancers to control unless caught early when they are still localized to one area. Often they are advanced and metastatic at the time of diagnosis, then they are difficult to get rid of. Yet it all depends on the location and the stage of cancer. ...Read more

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Which chemo therapy is most effective for KRAS mutant metastic colon cancer ?

Which chemo therapy is most effective for KRAS mutant metastic colon cancer ?

Same drugs as other: Same chemotherapy drugs are used for treating both types of colon cancer. The only difference is lack of benefit from EGFR inhibitors(Cetuximab and Panitumumab). Avastin (bevacizumab) also works in both types. I trust that you know there are 3 chemo drugs that are widely used(5FU or Capecitabine, Irinotecan and Oxaliplatin) ...Read more

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Is liver resection possible for brother w/stage 4 colon cancer mest to liver w/lots of tumor.

Is liver resection possible for brother w/stage 4 colon cancer mest to liver w/lots of tumor.

Possibly: Removal of liver metastases can sometimes be helpful for patients with colon cancer. A remarkable amount of cancer can be removed usually after there has been some response to chemotherapy. If surgery is not recommended alternatives such as radioembolization, chemoembolization, radiosurgery, or rfa or cryoablation may be considered. Get with an experienced team to determine the best course! ...Read more

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Hepatocellular carcinoma.All spleen and partial liver resection.Later,secondary systemic cancer metastasis.any targeted therapy or immunotherapy?

Hepatocellular carcinoma.All spleen and partial liver resection.Later,secondary systemic cancer metastasis.any targeted therapy or immunotherapy?

Yes, for both: Hepatocellular Carcinoma is commonly treated with Sorafenib which is a type of targeted therapy. This is a good choice of treatment in case you have not yet received this drug. Immunotherapy using PD-1 inhibitors has also shown some modest evidence of benefit although it is not yet FDA approved for this indication. Ask your oncologist to guide your treatment further. ...Read more

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What is prognosis With chemotherapy for metastic colon Cancer ?

What is prognosis With chemotherapy for metastic colon
Cancer ?

So many variables: Too many variables to give you a pertinent answer. Consult your oncologist to help you with clinical decisions ...Read more

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Can pancreatic/biliary duct, stomach, colon cancer or leukemia skip a generation?

Can pancreatic/biliary duct, stomach, colon cancer or leukemia skip a generation?

Variable: Family incidence doesn't mean you will have the disease only that you MAY get it and should be more vigilant. For example colon cancer. Start colonoscopy at age 30 rather than 50, etc.. ...Read more

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If chemotherapy fails what options lfd metastic colon cancer? Mets to liver , peritoneal , lymph node ?

If chemotherapy fails what options lfd metastic colon cancer? Mets to liver , peritoneal , lymph node ?

Experimental therapy: Some cancer centers do research on patients with aggressive cancers or cancers who do not respond to usual treatment. Although after chemotherapy, there are not very many options and people would like to keep patients as comfortable as possible. Hope it is helpful. ...Read more

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Chemotherpay failed , irinotecan and oxyplatin in metastic colon cancer . Liver and peritoneal mets . Is there anything else ?

Sorry to: hear that. Discuss with your Oncologist what is the next step. Get family and spiritual support as well. Good luck ...Read more

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Can chemo for colon cancer damage the liver?

Can chemo for colon cancer damage the liver?

It may: Almost all chemotherapeutic drugs have unwanted effects on other organs, including the liver. ...Read more

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Why is colon resection still done for colon cancer in cases with liver metastasis?

Why is colon resection still done for colon cancer in cases with liver metastasis?

Depends: Believe it or not, it can sometimes still be cured. It depends on the disease burden in the liver. After resection, they can do adjuvant therapy and follow up with hepatic resections if it is limited. Also for palliative reasons - if it is causing an obstruction, then the obstruction needs to be relieved to allow for simple gut function. ...Read more

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Will avastin (bevacizumab) increase survival significantly for metastic colon cancer with liver mets ? Is it a risky drug

Will avastin (bevacizumab) increase survival significantly for metastic colon cancer with liver mets ?

Is it a risky drug

Slight benefit: Bevacizumab (Avastin (bevacizumab)) is one of those drugs that is extremely expensive and often has limited benefit. Patients with metastatic colon cancer who received Avastin (bevacizumab) plus chemotherapy lived 1-2 months longer on average than those receiving chemo only. Because it has marginal benefit but costs ~$30,000 the U.K. Health Service won't pay for it. It can cause skin rash, bleeding or wound healing problems. ...Read more

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Can Radiotherapy be used for metastic colon cancer if chemotherapy is resistant ?

Can
Radiotherapy be used for metastic colon cancer if chemotherapy is resistant ?

Not often: Radiotherapy can be useful in certain select cases where the Cancer is localized to one or two spots only. This means 1 patient in 5 may be suitable candidate. But you need to seek consultation with a radiation oncologist before you can get a clear cut answer for your circumstances. ...Read more

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Dysphagia and chemotherapy for colon cancer?

Dysphagia and chemotherapy for colon cancer?

It depends ... : Dysphagia is a common side effect with many chemo therapeutic regimens. Some treatments can decrease a patient's ability to fight off fungal and bacterial overgrowth in the mouth and digestive systems. The diagnosis of this isn't usually difficult and can in many cases be treated with medications. ...Read more

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Sent home to be with family with no more treatment options for pancreatic cancer. Tumors in liver blocking bile duct with drainage tube. Time left?

Sent home to be with family with no more treatment options for pancreatic cancer. Tumors in liver blocking bile duct with drainage tube. Time left?

I am sorry to : hear of this. But, it would be best to ask the oncologist/ treating physician who knows the full medical history. ...Read more

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What are the signs and symptoms of bile duct cancer?

Jaundice: Bile duct cancer is uncommon but carries a poor prognosis. It will typically impede the flow of bile from the liver to the small intestine thus causing obstructive jaundice (yellowish discoloration of eyes and skin). Pain in the upper abdomen, weight loss and nausea may be noted. ...Read more

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Does anybody know which chemo is more affective for bile duct cancer?

Does anybody know which chemo is more affective for bile duct cancer?

It will..: ...Depend on the circumstances and whether you are getting radiation as well but if i'm gonna give only chemo for biliary cancer, i usually go with Cisplatin and gemcitabine (gemzar). ...Read more

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Can you tell me about bile duct cancer?

Can you tell me about bile duct cancer?

Bile ducts: Are buried in the liver, and also are outside, picking up gall bladder secretions before joining the pancreatic ducts. Biliary cancers are divided by their location, and that indicates means of treatment. They are not common, called klatskin tumors, few are resectable; most are not. Ca-19-9 may be quite hi. ...Read more

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What can you tell me about bile duct cancer?

What can you tell me about bile duct cancer?

Aggressive tumor: Tumor can arise intrahepatically requiring partial hepatectomy id possible. It is also found in the common duct outside the liver. The jaundice present can be relieved by a stent from ERCP. Chemo and radiation frequently employed. Within the liver distant metastasis frequently develops. Pancreatic drugs like Gemcitabine may help. ...Read more

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What are the survival rates for bile duct cancer?

Not very good: Bile duct cancers are difficult cancers to control unless caught early when they are still localized to one area. Often they are advanced and metastatic at the time of diagnosis, then they are difficult to get rid of. Yet it all depends on the location and the stage of cancer. ...Read more

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If my sister had bile duct cancer, is it likely i'll also get it?

Not likely: This is a very uncommon cancer and is not known to be a familial type of cancer. ...Read more

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Please explain which food can my father have if he has bile duct cancer?

Please explain which food can my father have if he has bile duct cancer?

It's up to him: If he becomes very jaundiced, he may need to restrict fat. There is no magic food that will affect his cancer for better or worse. ...Read more

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What happens if recurrent bile duct cancer has spread to the bone it is difficult to treat?

What happens if recurrent bile duct cancer has spread to the bone it is difficult to treat?

Very difficult: Bile duct cancers behave in a similar fashion to pancreatic cancer. When localized to the common duct and resected, the patient has a chance, especially post RT with gemcitabine. When the tumor spreads to bone Im not sure that combo chemo with any of the available monoclonal can demonstrate any effect on survival. ...Read more

Dr. Liawaty Ho Dr. Ho
4 doctors agreed:
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Dad's dying from bile duct cancer&has reached stage where he's bed bound, not eating&has become confused.Worried he's suffering.How long can this last?

Dr. Liawaty Ho Dr. Ho
4 doctors agreed:

Palliative care: I would recommend you to talk to his oncologist and ask for palliative care team/hospice care- to help him. Unfortunately , from your limited information, I do not expect this will last long. To make sure that he is not suffering etc- strongly consider hospice care. ...Read more

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Help please! is colon cancer and bile duct cancer basically the same thing?

Help please! is colon cancer and bile duct cancer basically the same thing?

Completely different: Colon cancer originates in the colon. Bile duct cancer originates in the bile ducts either within the liver or in the parts of the bile duct system outside of the liver (common hepatic and common bile ducts). ...Read more

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Mother died from bile duct cancer. She was so healthy her whole life , never had any problems . This Cancer came out of nowhere . Causes?

Here's a link for U: To learn more about cholangiocarcinoma, consider this educational link from the American Cancer Society -- http://www.cancer.org/cancer/bileductcancer/detailedguide/ ...Read more

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Is bile duct cancer hereditary ? My mother died from it at age 65 in 2001.Do I need any special tests ? What is the cause ? Any new treatments ?

No screening: Bile duct cancer very rare. Appears with jaundice and with work up is either intrahepatic Klatskin tumor which can be resected or in Porta, a common duct lesion. Most cholangiolar Ca are virulent and metastasize to all sites in body. Chemo similar to that of pancreatic Ca but overall response poor. No preventative work up of value. ...Read more

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My dad has been diagnosed with bile duct cancer. He has severe swelling of legs. He has been put on diuretics. How long for this fluid to go?

My dad has been diagnosed with bile duct cancer.  He has severe swelling of legs. He has been put on diuretics.  How long for this fluid to go?

It depends: he will need to follow up with his doctor to decide whether he still needs to be on diuretics. You do not want to take too much diuretic as that may cause problem to his kidney . ...Read more

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I have urq pain, now bone pain on the right side and get night sweats. Can a CT scan always pick up pancreatic or bile duct cancer?

I have urq pain, now bone pain on the right side and get night sweats. Can a CT scan always pick up pancreatic or bile duct cancer?

No test is perfect!: No test is 100 percent accurate. Although a multiphase ct with contrast is a very good test for pancreatic or bile duct cancer, it is not a perfect test. Mri, mrcp and ERCP are all tests that may be useful. Generally, imaging for this problem begins with a ct, with the additional tests based on the ct results, as well as lab tests and other examinations. ...Read more

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Is radiation therapy possible for bile duct cancer?

Yes: Surgery is the first and most important treatment. Often radiation and chemo will be needed because these cancer can recur easily. ...Read more

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What kind of monoclonal antibody is used for treatment bile duct cancer?

What kind of monoclonal antibody is used for treatment bile duct cancer?

Nothing good yet: There is as of yet, no proven monoclonal antibody(moab) for this type of cancer. For some of the GI cancers, anti-egfr antibody like cetuximab(erbitux) has been modestly useful. You can ask your oncologist whether he/she will consider adding this moab to your chemotherapy regimen in case you are still on chemo or being offered chemotherapy with Cisplatin and gemcitabine. ...Read more

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Can there be a treatment for bile duct cancer if the doctor says they can't operate?

Can there be a treatment for bile duct cancer if the doctor says they can't operate?

Bile duct cancer: Yes; 1. You can play. 2. You can put a stent in to keep it open or 3. You can put a drain in so bile comes out in a bag. But discuss with your Dr who knows you best. Good luck. If it is you you are talking about i would take care of everything you need to take care of soon. But as Yogi said its hard to make predictions. Especially about the future. ...Read more

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My sister was told her extra hypetic biliary duct was enlarged is that bile duct cancer? She has lost about 30 lbs in less than 2 mo's, has really sharp stomach pains, diarriha, no appetite, & nausea. Was admitted to the hosp & was told what test revealed

My sister was told her extra hypetic biliary duct was enlarged is that bile duct cancer? She has lost about 30 lbs in less than 2 mo's, has really sharp stomach pains, diarriha, no appetite, & nausea. Was admitted to the hosp & was told what test revealed

The : The liver makes bile, the substance that makes the stool brown. The bile comes out from the liver through bile ducts. Normally the bile goes into the gallbladder, where the bile is concentrated and stored for excretion into the intestine after eating, to assist in digestion. The bile ducts are classified as: intrahepatic (within the liver) and extrahepatic (outside the liver, i.e. From the liver to the duodenum thru the common bile duct). The common bile duct tranverses the pancreas where the pancreatic duct joins and then exits through the ampulla of vater. Therefore blockage at the ampulla, in the pancreas and in the common bile duct itself can lead to extrahepatic dilitation. The most common reason for a slightly enlarged bile duct is after the gallbladder is removed and the bile duct enlarges to accommodate the increased flow of bile. This is usually not associated with any abnormalities in the liver function tests. If there is a blockage due to a stone in the bile duct, or from a mass, such as a cancer or from scarring such as from pancreatitis, the liver function tests will be abnormal and the patient may become jaundiced, or yellow. The second most common reason for bile duct dilation is a common bile duct stone, usually associated with gallstones. The weight loss, loss of appetite is concerning and she should have additional testing, including an ultrasound or ct scan as well as bloodwork. She should see a gastroenterologist or general surgeon. ...Read more

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My grandads cancer has come back and not grown much and has destroyed his bile duct apparently is it correct that doctors can't do anything about it?

My grandads cancer has come back and not grown much and has destroyed his bile duct apparently is it correct that doctors can't do anything about it?

I don't know the ful: I don't know the full details of your grandfather's diagnosis. Bile duct cancer is often unresponsive to therapy. This is a very difficult diagnosis to treat. ...Read more

Dr. Adam Levy
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Biliary (Definition)

Biliary means anything related to the production, storage, secretion, or flow of bile, whether in the liver, bile ducts, gallbladder, ...Read more


Upper Abdomen (Definition)

Draw a transverse line through the umbilicus and the upper abdomen includes every part of the belly above this line and below the ...Read more