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Doctor insights on: Chemotherapy Effects On Liver

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After 4 cycles of chemotherapy should a liver met start reducing in size? Is 16 mm classed large?

After 4 cycles of chemotherapy should a liver met start reducing in size? Is 16 mm classed large?

Kinetics of response: Faster growing tumors tend to respond quicker, but tumors can be resistant. Typically 4 cycles of chemotherapy is enough time to know whether the disease is responding. Whether to continue treatment depends on the goals of care. Stable disease is better than progression, so more treatment may be fine if side effects are manageable. 16 mm is not large yet still represents millions of tumor cells. ...Read more

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Dr. Daniel Saurborn
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Liver (Definition)

This organ plays a major role in metabolism and has a number of functions in the body, including glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. It lies below the diaphragm in the abdominal-pelvic region of the abdomen. It produces bile, an alkaline compound which aids in digestion via the emulsification of ...Read more


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How effective is chemotherapy irinotecan for a liver met and node.? Does it only work in some patients?

How effective is chemotherapy irinotecan for a liver met and node.? Does it only work in some patients?

Good drug: Irinotecan hydrochloride or Camptosar, (irinotecan) CPT-11 is a chemotherapy drug made from a plant alkaloid known as a topoisomerase I inhibitor. It works by blocking an enzyme in cells called topoisomerase I. needed to keep DNA in shape when dividing. The drug useful in metastatic colon cancer to liver where it can convert the mets to resectable. ...Read more

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If I have colon or rectal cancer that has spread to the liver, should I have chemotherapy first?

If I have colon or rectal cancer that has spread to the liver, should I have chemotherapy first?

Find a good team: Colorectal cancer with spread to the liver is a hotly debated and controversial topic. Multiple variables include - the location of the tumor, the symptoms it is producing, the location of the liver mets and their potentail for surgical removal. You need an experienced team that deals with this commonly (surgical and medical oncologists, maybe rad onc, as well). Good ct/pet is vital. ...Read more

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My father operated for ca rectum now he had multiple mets in liver what's is prognosis of chemotherapy in this case and what is life expectancy???

My father operated for ca rectum now he had multiple mets in liver what's is prognosis of chemotherapy in this case and what is life expectancy???

Hard to say: I am sorry for your father's illness. We can not say how long anyone might live, and response to chemotherapy can vary among different people. Your father's oncologist can best explain the expected response to treatment. Spending time with your father will help both of you through this time. ...Read more

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What If no forms of chemotherapy work on a colon cancer pt who has a liver met? Are there other options?

What If no forms of chemotherapy work on a colon cancer pt who has a liver met? Are there other options?

Radiation and surgery: Aside from chemotherapy, the 2 types of treatment for cancer are radiotherapy & surgery. Liver mets, if they block a duct or cause a "local" problem can be treated with radiation beam to alleviate suffering. If the patient is strong enough to withstand it, surgery and/or brachytherapy (radiation implants) can be tried; however, colon cancer is a systemic problem and chemo is the main modality. GL. ...Read more

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Do these CEA readings mean chemotherapy not working in a colon cancer pt August 9.8, October 8, dec 9, jan 10. Met to the liver?

Do these CEA readings mean chemotherapy not working in a colon cancer pt August 9.8, October 8, dec 9, jan 10. Met to the liver?

Stable: Ams an oncologist I would say those levels are stable. Follow your oncologist advice and do not stop chemo based on your CEA levels, they look good. ...Read more

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What is the treatment for class 4 colon cancer spread to liver? Is chemotherapy an only option?

What is the treatment for class 4 colon cancer spread to liver? Is chemotherapy an only option?

No: If there are only a few cancer areas (nodules) surgery may be an option. Depends on the number and location of the cancerous nodules, a surgeon should review a CAT scan of the liver. ...Read more

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Life expectancy terminal lung cancer with liver mestasis with chemotherapy stopped?

Life expectancy terminal lung cancer with liver mestasis with chemotherapy stopped?

Bad news: Prognosis is grim, but I would suggest in the interim good symptom control through a palliative care line or hospice care. A variety of factors play in determining life expectancy, that is usually in such cases less than 6 months. ...Read more

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Chemotherapy for ovarian cancer with a liver transplant patient?

Chemotherapy for ovarian cancer with a liver transplant patient?

If needed yes: Liver transplant patients need chemotherapy will be given with close monitoring, working as team. Interesting observation, in liver transplant patients the incidence of ovarian cancer is less than the normal population. ...Read more

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Is the chemotherapy protocol at a major medical university cancer center usually the same for liver cancer as it is for pancreatic (no mets) cancer?

Is the chemotherapy protocol at a major medical university cancer center usually the same for liver cancer as it is for pancreatic (no mets) cancer?

Yes and no: The choice of treatment for liver Cancer is Sorafenib which is not a chemotherapy but it is called a Targeted agent. Chemo is often used for Cholangiocarcinoma, a type of Cancer arising from bile ducts of the liver. This latter type of Cancer is treated with chemo drugs which are more or less similar but not exactly same as those used forpancreas cancer (Gemcitabine +Cisplatin or oxaliplatin) ...Read more

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How long can I survive with stage 4 breast cancer that has spread to my liver without chemotherapy?

How long can I survive with stage 4 breast cancer that has spread to my liver without chemotherapy?

Hard to say: Hello - there are many treatment options for stage 4 breast cancer. If your cancer is ER or PR positive, hormonal tx can be used. If it is Her2 positive, Herceptin (trastuzumab) and other targeted, non-chemos can be used. If the breast cancer is triple negative then chemo is your best option. There are "mild" chemos, some oral, that can be tried. Average lifespan is usually quite long with treatment. Best ...Read more

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If chemotherapy fails what options lfd metastic colon cancer? Mets to liver, peritoneal, lymph node?

If chemotherapy fails what options lfd metastic colon cancer? Mets to liver, peritoneal, lymph node?

Experimental therapy: Some cancer centers do research on patients with aggressive cancers or cancers who do not respond to usual treatment. Although after chemotherapy, there are not very many options and people would like to keep patients as comfortable as possible. Hope it is helpful. ...Read more

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What is the life expectancy of a 78 year old, Stage 4 colon cancer spread to liver and lungs? Having chemotherapy (tablets) but losing weight.

What is the life expectancy of a 78 year old, Stage 4 colon cancer spread to liver and lungs? Having chemotherapy (tablets) but losing weight.

Life expectancy: At 78, with stage IV colon cancer, the survival is about 4-6 months without treatment. With the new treatments combining chemo with biological drugs, survival times are in the range of 24-30 months. With a less aggressive treatment I estimate an AVERAGE survival of 9-12 months. Keep in mind these estimates are just a ball park figure, keep things one month at a time. ...Read more

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My father has been diagnosed with bowel cancer that has spread to the lungs and liver. Surgery is not being offered only chemotherapy. Prognosis pls?

Ask the oncologist: The oncologist treating your father is the best person to ask this question, and will have all of the necessary data to offer an estimated prognosis. In addition, the oncologist will be able to assess the response to chemotherapy. ...Read more

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Chemotherapy embolization helpful for advanced liver metastatic cancer after getting high enzymes and fatigue from normal chemo? Patient is 65 yrs old

Chemotherapy embolization helpful for advanced liver metastatic cancer after getting high enzymes and fatigue from normal chemo? Patient is 65 yrs old

Apparently, yes.: This procedre involves chemotherapy given through the main blood vessel of the tumor and then putting an embolizsation agent in the vessel to block it. This allows for the highest possible concentration to be in contact with the tumor for a longer time period. It can be painful, and you need to be immobile for up to 6 hours afterward. But it is used most often for liver cancer. Best of luck. ...Read more

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If chemotherapy fails, and there is a tiny new lung nodule, 1 liver met and 1 node can anything b done in colon cancer pt aged 65?

Sometimes: Depending on co-morbidities and surgical risk, some studies have shown survival benefit with surgical resection of metastatic lesions. Consult with cancer surgeon. ...Read more

Dr. Devon Webster
963 Doctors shared insights

Chemotherapy (Definition)

The term chemotherapy typically is used to describe using chemicals to treat ...Read more