Doctor insights on:
Chemotherapy Cause Colon Cancer
If colon cancer was there several can chemotherapy actually cause cancer to spread ? As all was fine before chemo ( no distant spread ) ?
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
Improves survival: Chemo may help improve survival but does not result in cure. It is used pre operatively as neo adjuivant chemo to help improve resection or as adjuvant after surgery to help prolong survival. It is best employed in combination chemo such as FOLFOX to optimize response. ...Read more
It is an old regimen: It is one of the effective treatment regimens for metastatic colon Cancer which first appeared on the scene more than 5 years back and became popular for a while to be soon upgraded with other more effective modern regimens which also include Avastin (bevacizumab) in combination with chemotherapy. ...Read more
Ask your oncologist: That's an interesting question. It would depend on the regimen you were on, so ask your oncologist at your next visit. He/she can describe dosage , complications, and general expectations. Good luck. ...Read more
It depends ... : Dysphagia is a common side effect with many chemo therapeutic regimens. Some treatments can decrease a patient's ability to fight off fungal and bacterial overgrowth in the mouth and digestive systems. The diagnosis of this isn't usually difficult and can in many cases be treated with medications. ...Read moreSee 1 more doctor answer
So many variables: Too many variables to give you a pertinent answer. Consult your oncologist to help you with clinical decisions ...Read more
See an oncologist : Colon chance chemotherapy has a lot options now, and a thoughtful short and potential long term plan is what i necessary. Some oncologist believe that one day soon metastatic colon cancer may even be able to be treated as a chronic disease. I have certainly seen patients live for a decade with stage 4 disease. I wish you all the best. ...Read moreSee 2 more doctor answers
What kind of mets: it depends what kind of metastases we are talking about. if the spread to the lymph nodes, surgery and chemotherapy, and possible radiation therapy could be very helpful. if the spread to the liver the prognosis is less optimistic, unless the metastases are able to be resected. other metastases are less promising in spite of chemotherapy and radiation therapy .like bone and brain. ...Read moreSee 1 more doctor answer
Relatively good: According to the Journal of Clinical Oncology XELOX is a highly effective first-line treatment for metastatic colon cancer. To be more accurate (55%) of patients achieve a response, and 30% experience disease stabilization for more than 3 months following treatment. Always consult with your oncologist. ...Read more
Some effect: Single drug chemotherapy has failed to produce significant improvement in colorectal Ca. Combination chemo as in FOLFIRI with irinotecan has added about 5 month prolongation in survival and with immunotherapy using Avastin (bevacizumab) or Erbitux an additional 2-3 months can be observed. Chemo-Immuno with a mAb targeting the immunogenic protein appears to be giving further enhancement. ...Read more
Better than chemo: Combining bevacizumab (BV)—a recombinant, humanized mAb targeting VEGF with irinotecan, fluorouracil (FU), and leucovorin (LV; IFL) has increased survival of patients with metastatic colorectal Ca compared with IFL It appears necessary to use combination therapy in treatment and has supported the concept that the use of immunochemotherapy improves results over chemo alone. ...Read more
What can prognosis b like for metastic colon cancer that chemotherapy oxyplatin and raltitrexed ?
Colon mets: Not having your chart and you in front of me makes it very hard to give you an accurate idea on prognosis. When chemo is started, that means your CA cells have gone beyond the boundaries which would have made txing it simple. The simpler the tx, the better the prgns. The harder the tx, the worse the prgns. On a positive note, f/u with your docs, stay faithful, and you might get a pleasant surprise ...Read more
With colon cancer with mets ,Why is it that chemotherapy has not been working since the start at all ?
Different mutation: Metastatic colon cancer not always sensitive to chemo. If bx raken and fresh specimen sent for chemosensitivity then at times various combination can be found to work but all are temporary. Immnunochemo may be more helpful using Ervitux, an epithelial growth factor inhibitor with chemo or Avastin (bevacizumab) with chemo. Newer mAbs including Neo 102- may be found to target the tumor more effectively. ...Read more
I mean if chemotherapy does not work fir metastic colon cancer , can anything be done , any new drugs ?
Yes: Depending where mets are, direct therapy can be offered resecting lung lesions locally, using chemoembolization for lesions in liver and hyperthermic perfusion for peritoneal seeding. Immunotherapy for VEGF and epidermal growth factors can also be employed as well as new drugs in Phase II-III such as mAbs targeting post translational modification of MUC5ac and CEAcam 5,6`oncofetal proteins/ ...Read moreSee 1 more doctor answer
How does chemotherapy target exactly your colon cancer? Does it kill off a lot of normal colon cells too?
It doesnt: Chemo works by inhibiting/killing cells which grow faster than normal cells. There are side effects because normal cells divide as a normal function, so yes, normal cells are affected too. The trick is to give enough to kill the bad cells, and not so much that the side effects are intolerable. ...Read more
Some response: meds like Xeloda have some tempoary benefit suppressing DNA function as an oral 5FU (fluorouracil). Long term responses are not seen requiring combination therapy to give an optimjum response. Eventually if cancer does show a good response, malignant stem cells will repopulate the site of the original metastasis. ...Read more
Not often: Radiotherapy can be useful in certain select cases where the Cancer is localized to one or two spots only. This means 1 patient in 5 may be suitable candidate. But you need to seek consultation with a radiation oncologist before you can get a clear cut answer for your circumstances. ...Read moreSee 1 more doctor answer
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