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Doctor insights on: Chemo Savvy

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Chemo for --- ibc marginally successful. Then mastectomy, 7 lymph nodes positive. Now the surgeon wants rad, onc wants different chemo. Help!

Chemo for ---  ibc marginally successful. Then mastectomy, 7 lymph nodes positive. Now the surgeon wants rad, onc wants different chemo. Help!

Yes for rad: Definitely you should get an adjuvant radiation therapy following mastectomy. As per- chemo- if you get chemo first before surgery and unfortunately the response is only marginal- that indicates that your cancer is likely is resistant to chemo.So, adding more chemo post mastetcomy doubtfully will give you any benefit. Is this er+ or er-? If this is er+- then you should get aromatase inhibitor. ...Read more

Dr. Devon Webster
973 doctors shared insights

Chemotherapy (Definition)

The term chemotherapy typically is used to describe using chemicals to treat ...Read more


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Stage 2B idc breast cancer-neoadjuvant ... Had taxol/herceptin (trastuzumab) for 16wks. Now a/c chemo.. Is it risky to be without herceptin (trastuzumab) until surgery in jan?

Stage 2B idc breast cancer-neoadjuvant ... Had taxol/herceptin (trastuzumab) for 16wks. Now a/c chemo.. Is it risky to be without herceptin (trastuzumab) until surgery in jan?

Should be okay: You are receiving ac now and i think (and i hope) it should take care you cancer well --to shrink it down further- so you can have surgery in january. It is not safe to combine adriamyicn and Herceptin (trastuzumab) as it could give you significant problem with your heart. Once you are done with surgery- you will need Herceptin (trastuzumab) to be continued for 1 year. ...Read more

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Ihow effective are uft chemotherapy pills for metastic colon cancer ?

Ihow effective are uft chemotherapy pills for metastic colon cancer ?

Modestly effective: Fluoropyrimidines (5-FU, Capecitabine and UFT) as a class have modest activity and one of these 3 needs to be combined with Oxaliplatin and or Irinotecan to achieve best results ,as combination chemo is far superior in efficacy than any single chemo drug ...Read more

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Side effects to chemo. He's being treated for colon cancer stage 4.?

Side effects to chemo. He's being treated for colon cancer stage 4.?

Depends on chemo: The side effects of chemotherapy depend on the chemos involved. In general bone marrow suppression (bms) causing lower red blood cells (rbcs) with anemia, lowered wbcs with increased risk of infection, and lowerd platelets with increased risk of bleeding. Oxalipaltin ("o" in folfox) can cause numbness or cold induced nerve pain. Irinotecan ("i" in folfiri) causes diarrhea. Etc... ...Read more

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Compare and contrast chemotherapy for aml with chemo for prostate cancer?

Compare and contrast chemotherapy for aml with chemo for prostate cancer?

Different drugs. : Chemotherapy for a hematologic cancer such as AML differs in the drugs & regimens from an epithelial cancer like prostatic carcinoma. AML typically uses Cytarabine and an anthracycline on a specific schedule. In prostate cancer, docetaxel and cabazitaxel are frequently used drugs. Of note, chemotherapy is not as common a treatment for prostate cancer, where hormonal therapy is often used. ...Read more

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Pancreatic cancer, ampullary tumor. Whipple procedure. Spread to liver, not respectable. Chemo for 6 months and continuing. Prognosis?

Pancreatic cancer, ampullary tumor. Whipple procedure.  Spread to liver, not respectable. Chemo for 6 months and continuing. Prognosis?

Poor: While Whipple is the best approach for a primary pancreatic or ampullary lesion, the recurrence rate at 1-2 yrs is 90%. Chemo either of the FOLFIERI or Genciabine /Abraxane combo have limited effects on liver mets which in pancreas are not considered amenable to resection. There is an FDA protocol using specific monoclonals targeting pancreas that might be available but only after chemo failure ...Read more

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Which chemo therapy is most effective for KRAS mutant metastic colon cancer ?

Which chemo therapy is most effective for KRAS mutant metastic colon cancer ?

Same drugs as other: Same chemotherapy drugs are used for treating both types of colon cancer. The only difference is lack of benefit from EGFR inhibitors(Cetuximab and Panitumumab). Avastin (bevacizumab) also works in both types. I trust that you know there are 3 chemo drugs that are widely used(5FU or Capecitabine, Irinotecan and Oxaliplatin) ...Read more

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Best institution for experimental protocol to add to nexavar (sorafenib) for metastatic HCC - 34 yo Asian male, s/p omental resection?

Best institution for experimental protocol to add to nexavar (sorafenib) for metastatic HCC - 34 yo Asian male, s/p omental resection?

Many: The top Cancer Centers are located in Houston(MD Anderson) and New York(Sloan Kettering Center. Tell us which state you live in, we might be able to help you find someone closer to your home ...Read more

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Chemo drugs for lung cancer ?

Chemo drugs for lung cancer
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Yes: Depending on the stage, how advanced the disease is and what type of lung cancer it is, chemotherapy can play a major role in treatment of lung cancer. ...Read more

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Stage 2B IDC breast cancer, her2+/ER/PR+Neoadjuvant taxol, (paclitaxel)A/C,lumpectomy,rads, lymphovascular invasion. What does this mean for prognosis & follow up?

Stage 2B IDC breast cancer, her2+/ER/PR+Neoadjuvant taxol, (paclitaxel)A/C,lumpectomy,rads, lymphovascular invasion. What does this mean for prognosis & follow up?

Prognosis fair: Stage IIb breast cancer is usually palpable at 2-5 cm. and at time of procedure to remove lesion, sentinel nodes are + suggesting axillary dissection and reason for neoadjuvant therapy. Lymphovascular invasion increases chance for recurrence. With Her2+ Herceptin (trastuzumab) with chemo should be used and PET/CAT needed to assure met foci not missed in distal organs. Carful follow up needed. ...Read more

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What can prognosis b like for metastic colon cancer that chemotherapy oxyplatin and raltitrexed ?

What can prognosis b like for metastic colon cancer that chemotherapy oxyplatin and raltitrexed ?

Colon mets: Not having your chart and you in front of me makes it very hard to give you an accurate idea on prognosis. When chemo is started, that means your CA cells have gone beyond the boundaries which would have made txing it simple. The simpler the tx, the better the prgns. The harder the tx, the worse the prgns. On a positive note, f/u with your docs, stay faithful, and you might get a pleasant surprise ...Read more

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How hopeful can a patient be with stage IV non hodgkin lymphoma on chemotherapy ?

How hopeful can a patient be with stage IV non hodgkin lymphoma on chemotherapy ?

It can be cured: And you are likely on retuximab too. Please ask your doctor why thaey have not made clear what your chances are, and why you should be optimistic. ...Read more

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Experts, might someone recommend nexavar (sorafenib) for a stage 4 inactive neuroendocrine pancreatic cancer patient?

Experts, might someone recommend nexavar (sorafenib) for a stage 4 inactive neuroendocrine pancreatic cancer patient?

Possibly: Stage 4 indicates that you have net at a site distant from the pancreas or regional lymph node, likely the liver. Not clear what you mean by"inactive", whether you mean it is stable or not secreting any substance. In any case, sorafenib (nexavar) is being tested in metastatic net in clinical trials (http://clinicaltrials.Gov/ct2/show/nct00131911) & (http://www.Ncbi.Nlm.Nih.Gov/pubmed/23475104). ...Read more

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Is folfiri alone effective for metastic colon cancer than irinotecan alone ?

Is folfiri alone effective for metastic colon cancer than irinotecan alone ?

Two drugs vs one dru: Folfiri contains two drugs in the combination: 5-FY(Folinic acid) and Irinotecan. This combination is more effective than using irinotecan alone. It is often combined with Avastin (bevacizumab) in case it is being used to treat colon cancer. ...Read more

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My dad has spine metastes frm primary prostate cancer, terminal, indefinate hormone therapy...Whats average prognosis please?

Depends how long: How long on hormones? If just started the cancer may respond for average of several years. If he was already on hormones for long time prognosis is worse months to a year or two using other option such as different drugs or chemotherapy. Not cureable at this point just delaying progression. Some are offering Provenge (sipuleucel-t) but it's new and not known how effective, this is a vaccine type of therapy. ...Read more

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Stage 3 breast cancer her2 positive how many herceptin (trastuzumab) cycle she must undergo?

Stage 3 breast cancer her2 positive how many herceptin (trastuzumab) cycle she must undergo?

Up to 1 year's worth: Herceptin (trastuzumab) can be given together with initial chemotherapy for the first 4-6 months then subsequently by itself for a total of 1 year. If chemotherapy was given first without Herceptin (trastuzumab) then Herceptin (trastuzumab) can be given for a full year by itself. The usual cycle runs every 3 weeks (17-18 cycles in one full year). ...Read more

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Do people with stage IV metastatic breast cancer often undergo chemo?

Yes.: Under certain circumstances hormone therapy might be the initial treatment, but most stage 4 patients eventually undergo chemotherapy treatment. This will depend on age, tolerence for treatment, hormone responsiveness and other tumor characteristics. ...Read more

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