Doctor insights on:
Some effect: Single drug chemotherapy has failed to produce significant improvement in colorectal Ca. Combination chemo as in FOLFIRI with irinotecan has added about 5 month prolongation in survival and with immunotherapy using Avastin (bevacizumab) or Erbitux an additional 2-3 months can be observed. Chemo-Immuno with a mAb targeting the immunogenic protein appears to be giving further enhancement. ...Read more
Moderately useful: FOLFIRI-Bev is the standard, commonly used first line chemotherapy for metastatic Colon cancer. It can add about 12 to 18 months extra to your life such that an average patient can live for 2 to 3 years(some live upto 5-6 years... depending on sites of metastases and their response to chemotherapy. You need tell us more about your history such as dates of diagnosis and treatments/results so far?? ...Read more
Better than chemo: Combining bevacizumab (BV)—a recombinant, humanized mAb targeting VEGF with irinotecan, fluorouracil (FU), and leucovorin (LV; IFL) has increased survival of patients with metastatic colorectal Ca compared with IFL It appears necessary to use combination therapy in treatment and has supported the concept that the use of immunochemotherapy improves results over chemo alone. ...Read more
Relatively good: According to the Journal of Clinical Oncology XELOX is a highly effective first-line treatment for metastatic colon cancer. To be more accurate (55%) of patients achieve a response, and 30% experience disease stabilization for more than 3 months following treatment. Always consult with your oncologist. ...Read more
It is an old regimen: It is one of the effective treatment regimens for metastatic colon Cancer which first appeared on the scene more than 5 years back and became popular for a while to be soon upgraded with other more effective modern regimens which also include Avastin (bevacizumab) in combination with chemotherapy. ...Read more
What would be best chemo / treatment after irinotecan n Xeloda (capecitabine) failed for colon cancer with mets?
Difficult to answer.: recommended chemotherapy regimens change regularly depending on the results of studies. Your oncologist should keep on top of those studies and will be able to recommend the next approved therapy or any experimental trials which may be available. I would talk further with your oncologist before making any plans. Good luck. ...Read more
Ciii ovarian cancer in 06, 1212, surgery and chemo paxitaxtel/carboplatin. In remission. Recurrence treated with tamoxifen, carboplatin alone, abraxan, then topotacan to no avail. Which chemo next?
Many options: Choosing chemo depends on many factors, so only your doctor can decide what might work for you. Drugs you haven't mentioned include altretamine, capecitabine, cytoxan, (cyclophosphamide) vinorelbine, ifosfamide, etoposide, and irinotecan. There are also several hormonal agents. And a clinical trial might be an option. Check out www.Cancer.Gov for more info. And good luck. ...Read moreSee 1 more doctor answer
Modestly well: Your doctor can address this question better as I do not have details of your tumor sites and bulk of metastases. In general, chemo for metastatic Colon cancer is palliative which means it can be treated and kept under check for months/years but often not curable unless the tumor is amenable to surgical excision following a partial tumor regression with chemotherapy. Good luck. ...Read more
Very!: TAC stands for Taxotere, Adriamycin, (doxorubicin) and Cyclophosphamide. It is one of the strongest regimens for treating breast cancer, and some would say too strong. Depending on the type of breast cancer you have, or the stage, you might be able to receive a gentler regimen. If you want to know more, get a second opinion. ...Read more
No, not all of them: Most chemotherapy programs are used for 4-6 cycles but in some cancers , continuing a milder form of chemotherapy in the form of maintenance has been shown to be useful and is a good option of treatment which your oncologist can explain to you, if necessary or indicated in your case.. ...Read moreSee 1 more doctor answer
Stage 2B IDC breast cancer, her2+/ER/PR+Neoadjuvant taxol, (paclitaxel)A/C,lumpectomy,rads, lymphovascular invasion. What does this mean for prognosis & follow up?
Prognosis fair: Stage IIb breast cancer is usually palpable at 2-5 cm. and at time of procedure to remove lesion, sentinel nodes are + suggesting axillary dissection and reason for neoadjuvant therapy. Lymphovascular invasion increases chance for recurrence. With Her2+ Herceptin (trastuzumab) with chemo should be used and PET/CAT needed to assure met foci not missed in distal organs. Carful follow up needed. ...Read more
Restate question: Hi jsalyers9. Can you restate your question with a little more information. What is being treated? What treatments have already occurred? Thanks. ...Read more
What option is there if chemo fails for met colon cancer ?xeloda (capecitabine) n irinotecan failed
Oxaliplatin is good: Another good chemo drug is Oxaliplatin. This is often used in combination with 5-FU and Avastin (bevacizumab). If your tumor is KRAS wild type, then EGFR inhibitors(like Cetuximab and Panitumumab) also become relevant choices to use alone or in combination with other drugs. ...Read more
Yes: If a 2b lesion has been completely resected with a lobectomy and there is no problem 6 months post surgery the best approach is for careful follow up. Adjuvant radiation for this stage of disease has shown no survival benefit and adjuvant chemo if initiated following surgery has only shown a 5% improvement in survival. ...Read more
Partially: Chemotherapy in all of its forms is only partially helpful in improving the survival of colon cancer. When there is an effective neoadjuvant response the remaining lesion can be successfully resected. complete surgical extirpation is the needed result. As immunochemo becomes more effective then the combination with surgery will even produce better results. ...Read more
Liver and peritoneal mets for mcrc patient . What is approx survival
With chemo , oxyplatin and raltitrexed ?
We can not guess: We can not tell you what the approx. survival as we do not have all the information to make a comment on the approx. survival You should discuss with your treating Oncologist There are second and third line treatments as well which may change the course ...Read more