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Doctor insights on: Ch50 Complement

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Complement (Definition)

The complement system is an important effector mechanism of both humoral and innate immunity. Its functions are to promote phagocytosis of microbes, to stimulate inflammation, and to induce lysis of these organisms. The system is highly complex and comprised of over 50 effector and regulatory molecules. It is activated via one of three pathways: antibody, lectin, or by ...Read more


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What to do if I have high levels of total complement (ch50) and c-reactive protein. What does that mean?

What to do if I have high levels of total complement (ch50) and c-reactive protein. What does that mean?

Need to determine: Cause of elevation. Both of these are markers of inflammation. You should see your doctor to determine what may be causing inflammation. It does not have to be an infection. It is not feasible to be more helpful in this forum. ...Read more

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Could rosacea and ocular rosacea cause an elevated Total Complement (CH50)? I am healthy, very active, feel great.

Could rosacea and ocular rosacea cause an elevated Total Complement (CH50)? I am healthy, very active, feel great.

Ocular rosea: Roscea can be an autoimmune disorder and as such can have elevated immune markers. Alternatively could be lupus. Did they check other markers like dsDNA Sm antibody? F/u /w dermatology


https://www. Ncbi. Nlm. Nih. Gov/pmc/articles/PMC3834698/ ...Read more

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What means very high CH50 complement? Mine is 277 CAE, C3 and C4 normal. Ref ranges for lab are only greater than 60, but I read high could be pathologis

What means very high CH50 complement? Mine is 277 CAE, C3 and C4 normal. Ref ranges for lab are only greater than 60, but I read high could be pathologis

How do you feel?: The complement system is a chaotic system -- like the butterfly effect. Most-impacted by this is CH40. The CH50 test is subject to so many variables and artifacts that as long as you feel reasonably well and don't have some bizarre, mysterious illness, I wouldn't give an elevated value a second thought. ...Read more

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Nucleolar pattern on ANA 1:160 (up until now it has always been a centromere pattern at 1:1280) ccp at 28, complement ch50 at 63 just stopped methotr?

Nucleolar pattern on ANA 1:160 (up until now it has always been a centromere pattern at 1:1280) ccp at 28, complement ch50 at 63 just stopped methotr?

Not enough info: Anas must always be evaluated in the context of the entire clinical picture. You have given no information about the clinical problem and why you are taking methotrexate. The ANA patterns can change from test to test. The patterns only mean something if they fit the clinical symptoms. ...Read more

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Haven't been feeling well had lyme test done only band 18, 23 + ana was also + Complement, CH50 high. Google now scared I have cancer or something bad?

Haven't been feeling well had lyme test done only band 18, 23 + ana was also + Complement, CH50 high. Google now scared I have cancer or something bad?

Abnormal labs: A positive ANA does not mean you have a specific disease. The high complement level is a good sign - low is not good. I recommend seeing a rheumatologist for further evaluation. ...Read more

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Crp 2.73, ESR 22, ANA + speckled 1:40, complement ch50 is >60. 15 years of fatigue/malaise, headaches, ibs, aches and pains. Any correlation?

Crp 2.73, ESR 22, ANA + speckled 1:40, complement ch50 is >60. 15 years of fatigue/malaise, headaches, ibs, aches and pains. Any correlation?

Chronic Lyme?: Have you been tested properly for chronic Lyme? Consider iSpot Lyme test, not conventional western blot. ...Read more

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Can you have a normal ch50 (total complement) blood test result, but still have low C3 and/or C4 levels? ...Or would low C3 or C4 show up on ch50 test?

Can you have a normal ch50 (total complement) blood test result, but still have low C3 and/or C4 levels? ...Or would low C3 or C4 show up on ch50 test?

CH50: Ch50 measures the terminal or classical pathway. Deficiency of this test requires further investigation. Low C3 and C4 levels suggest activation of the classical pathway.
Low C3 and normal C4 levels suggest activation of the alternate pathway.
C4 could be low with a normal ch50. ...Read more

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What is complement total (ch50) elevated over 60 mean? Any significance?

Basically no: It's more worrisome if it's low. Lab reference ranges are set so that maybe 5% of healthies fall outside on either end. Don't worry. ...Read more

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My complement Total (CH50) was elevated in July. Four months later, it was low (33). What can cause this?

It fluctuates: These levels vary tremendously with minor illness, even little viral stuff that you don't know you have. And reference ranges are set so that a few percent of healthies fall outside on either end. These labs are only small pieces in diagnostic puzzles. ...Read more

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If complement c3, ch50, serum protein electrophoresis, and immunofixation suggest severe infection, why is CBC normal? I've never had blood culture.

If complement c3, ch50, serum protein electrophoresis, and immunofixation suggest severe infection, why is CBC normal? I've never had blood culture.

Lab data: Without placing values in a clinical context with full history, exam and all data it is pointless to speculate. You need to be evaluated by a physician and if the one you are seeing cannot provide answers, get a second opinion. Try seeing an infectious diseases expert. ...Read more

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Crp of 8.4 and total complement of >63 are these elevated or just on the high end of normal?

Probably normal.: These numbers are non specific. Unless you have a specific syndrome or symptoms these numbers really mean nothing. ...Read more

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I have normal levels of complement C2 and c4. C3 level is low. Ch50 is high-normal (57 u/ml)- (all are serum tests)-what are the possible causes?

Labwork: Proper medicine would be not to treat lab values but the patient. Based on the lab values you provided it is impossible to suggest any kind of diagnosis. We would need to know your presentation and other labwork that was done in order to help you sort it out. ...Read more

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Ana titer 1:80 - positive vitamin d - 17 complement, total >60 ch50 any idea what I might have? I am scared that it is cancer.

Ana titer 1:80 - positive vitamin d - 17 complement, total >60 ch50 any idea what I might have? I am scared that it is cancer.

Nothing to suggest..: Cancer. You are vitamin d deficient! As are 1/2 of my patients. Your ANA titerbis insignificant. Please, nothing would suggest cancer by these tests! ...Read more

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What does high hemolytic complement mean?

Likely response to: Inflammation. Complement is one of the acute phase reactants that increase in response to inflammation in the body. All lab results need to be interpreted in the clinical context and the doctor who ordered the test is usually in the best position to do that. ...Read more

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What would having low complement levels indicate?

What would having low complement levels indicate?

Low complement: Low levels of complement are seen in persons with complement deficiency who are prone to recurrent infections as well as in certain autoimmune conditions, inherited angioedema conditions, and hives associated with vasculitis (inflammed blood vessels). These can all be serious. Collection of blood to measure complement is tricky and needs to be done right or low level could occur. ...Read more

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What do low complement levels indicate is going on?

What do low complement levels indicate is going on?

Some things: To consider:
1) autoimmunity (particularly sle)
2) immunodeficiency
3) blood dyscrasia or cancer. ...Read more

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What does complement alternative pathway test show?

Mechanism for diseas: If you have a disease compatible with a complemented activated disorder, this test may be performed. It is an attempt to detect a mechanism for your disease condition. ...Read more

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What does high immunoglobulin IG m and complement mean?

What does high immunoglobulin IG m and complement mean?

Depends: The "normal ranges" for all lab tests include 95% of the "normal" population; thus, 2.5% of people are above the upper limit, and 2.5% are below the lower limit. There's nothing to worry about if your values are a little bit above the normal range, but a very elevated IgM could be a sign of a problem. You need to check with the physician who ordered the tests to interpret your results. ...Read more

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I have type 1 obesity. What is the best pill to complement my diet?

I have type 1 obesity. What is the best pill to complement my diet?

Weight loss diet: If you are on a weight loss diet, you may be at risk for vitamin deficiencies, especially if you are avoiding fruits, which you should, if you want to lose efficiently. A good multivitamin may be your best friend in this situation. I have my weight loss patients take multivitamins, calcium, potassium, and fish oil. They are on a very low carb, medically supervised diet and they lose quickly. ...Read more

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Can someone please explain what "complement" is in your immune system?

Can someone please explain what "complement" is in your immune system?

Immune swat team: Antibodies are like folks in line at the post office studying the wanted posters. Later they spot a felon (bacteria), grab 'em by the arm & summon the complement swat team. Complement is a group of proteins circulating in extracellular fluid. The team arrives on the scene, assembles in a specific sequence & then punches holes in the bacteria killing it. Antibodies identify; complement rubs 'em out. ...Read more

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Does the human body even use the complement system at all to fight-off viruses?

Does the human body even use the complement system at all to fight-off viruses?

Yes: If viral antigens or epitopes are expressed on the surface of the infected cell, then yes. They may "fix complement" leading to lysis. ...Read more

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I am complement deficient without an autoimmune disorder. What is making me sick?

I am complement deficient without an autoimmune disorder. What is making me sick?

See rheumatologist: Something is eating up your complement and you may need a very good rheumatologist to find why whether there is an autoimmune process going on since negative ANA and RF do not rule out all autoimmune processes. If no cause can be found by your local MD, consider going to an university center. ...Read more

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Why are some complement fragments called opsonins, anaphylatoxins or chemotactic factors?

Why are some complement fragments called opsonins, anaphylatoxins or chemotactic factors?

Related to function: Opsonins bind microbes, particles and cell fragments flagging them for uptake/engulfment by macrophages or neutrophils. Anaphylatoxins, when released, bind to their receptors on macrophages and mast cells to activate the cells. Subsequently, the activated cells release mediators (eg histamine) involved in anaphylaxis and/or inflammation. Chemotactic factors guide WBCs to site of inflammation ...Read more

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What might a slightly elevated total hemolytic complement mean? (ref. Range 52-128, mine-131). Any need for concern?

No: Reference ranges are established so that 95% of healthy couch potatoes fall into them. If your physician is not concerned, I would not be either. ...Read more

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What is complement c3?

What is complement c3?

Complement C3: Complement C3 is a blood test that measures the activity of a certain protein that is part of the complement system. The complement system is a group of proteins that move freely through your bloodstream. The proteins work with your immune system and play a role in the development of inflammation. This test is usually elevated in immune diseases or infections. ...Read more