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Doctor insights on: Ch50 Complement

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Complement (Definition)

The complement system is an important effector mechanism of both humoral and innate immunity. Its functions are to promote phagocytosis of microbes, to stimulate inflammation, and to induce lysis of these organisms. The system is highly complex and comprised of over 50 effector and regulatory molecules. It is activated via one of three pathways: antibody, lectin, or by ...Read more


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What to do if I have high levels of total complement (ch50) and c-reactive protein. what does that mean?

What to do if I have high levels of total complement (ch50) and c-reactive protein. what does that mean?

Need to determine: cause of elevation. Both of these are markers of inflammation. You should see your doctor to determine what may be causing inflammation. It does not have to be an infection. It is not feasible to be more helpful in this forum. ...Read more

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What means very high CH50 complement? Mine is 277 CAE,C3 and C4 normal.Ref ranges for lab are only greater than 60,but I read high could be pathologis

What means very high CH50 complement? Mine is 277 CAE,C3 and C4 normal.Ref ranges for lab are only greater than 60,but I read high could be pathologis

How do you feel?: The complement system is a chaotic system -- like the butterfly effect. Most-impacted by this is CH40. The CH50 test is subject to so many variables and artifacts that as long as you feel reasonably well and don't have some bizarre, mysterious illness, I wouldn't give an elevated value a second thought. ...Read more

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Nucleolar pattern on ANA 1:160 (up until now it has always been a centromere pattern at 1:1280) ccp at 28, complement ch50 at 63 just stopped methotr?

Nucleolar pattern on ANA 1:160 (up until now it has always been a centromere pattern at 1:1280) ccp at 28, complement ch50 at 63  just stopped methotr?

Not enough info: Anas must always be evaluated in the context of the entire clinical picture. You have given no information about the clinical problem and why you are taking methotrexate. The ANA patterns can change from test to test. The patterns only mean something if they fit the clinical symptoms. ...Read more

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Haven't been feeling well had lyme test done only band 18, 23 + ana was also + Complement, CH50 high. Google now scared I have cancer or something bad?

Haven't been feeling well had lyme test done only band 18, 23 + ana was also + Complement, CH50 high. Google now scared I have cancer or something bad?

Abnormal labs: A positive ANA does not mean you have a specific disease. The high complement level is a good sign - low is not good. I recommend seeing a rheumatologist for further evaluation. ...Read more

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Can you have a normal ch50 (total complement) blood test result, but still have low C3 and/or C4 levels?...Or would low C3 or C4 show up on ch50 test?

Can you have a normal ch50 (total complement) blood test result, but still have low C3 and/or C4 levels?...Or would low C3 or C4 show up on ch50 test?

CH50: Ch50 measures the terminal or classical pathway. Deficiency of this test requires further investigation. Low c3 and c4 levels suggest activation of the classical pathway. Low c3 and normal c4 levels suggest activation of the alternate pathway. C4 could be low with a normal ch50. ...Read more

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What is complement total (ch50) elevated over 60 mean? Any significance?

Basically no: It's more worrisome if it's low. Lab reference ranges are set so that maybe 5% of healthies fall outside on either end. Don't worry. ...Read more