Doctor insights on:
Diagnosed with high levels of total complement (ch50) and c-reactive protein. What does that mean?
Inflammation: It means that you have some sort of inflammatory process going on inside of the body presently. ...Read more
The complement system is an important effector mechanism of both humoral and innate immunity. Its functions are to promote phagocytosis of microbes, to stimulate inflammation, and to induce lysis of these organisms. The system is highly complex and comprised of over 50 effector and regulatory molecules. It is activated via one of three pathways: antibody, lectin, or by ...Read more
What to do if I have high levels of total complement (ch50) and c-reactive protein. what does that mean?
What means very high CH50 complement? Mine is 277 CAE,C3 and C4 normal.Ref ranges for lab are only greater than 60,but I read high could be pathologis
How do you feel?: The complement system is a chaotic system -- like the butterfly effect. Most-impacted by this is CH40. The CH50 test is subject to so many variables and artifacts that as long as you feel reasonably well and don't have some bizarre, mysterious illness, I wouldn't give an elevated value a second thought. ...Read more
Nucleolar pattern on ANA 1:160 (up until now it has always been a centromere pattern at 1:1280) ccp at 28, complement ch50 at 63 just stopped methotr?
Not enough info: Anas must always be evaluated in the context of the entire clinical picture. You have given no information about the clinical problem and why you are taking methotrexate. The ANA patterns can change from test to test. The patterns only mean something if they fit the clinical symptoms. ...Read more
Haven't been feeling well had lyme test done only band 18, 23 + ana was also + Complement, CH50 high. Google now scared I have cancer or something bad?
Could my severe vitamin d deficiency be the cause of my extremely high complement ch50 level? C3 and C4 are normal.
No: I'd ignore the high ch50 levels. This is a lab test that's hard to do and even harder to interpret. ...Read more
Crp 2.73, ESR 22, ANA + speckled 1:40, complement ch50 is >60. 15 years of fatigue/malaise, headaches, ibs, aches and pains. Any correlation?
Can you have a normal ch50 (total complement) blood test result, but still have low C3 and/or C4 levels?...Or would low C3 or C4 show up on ch50 test?
CH50: Ch50 measures the terminal or classical pathway. Deficiency of this test requires further investigation. Low c3 and c4 levels suggest activation of the classical pathway. Low c3 and normal c4 levels suggest activation of the alternate pathway. C4 could be low with a normal ch50. ...Read moreSee 1 more doctor answer
Basically no: It's more worrisome if it's low. Lab reference ranges are set so that maybe 5% of healthies fall outside on either end. Don't worry. ...Read more