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Doctor insights on: Cell Metaplasia

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Gastric biopsy result: antral mucosa revealing mild to moderate chronic inflamation with associated extensive intestinal metaplesia. What that mean?

Gastric biopsy result: antral mucosa revealing mild to moderate chronic inflamation with associated extensive intestinal metaplesia. What that mean?

Precancer: The antrum is that portion of the lower stomach above the pylorus. Having chronic inflammation with extensive intestinal metaplasia is the precursor for developing gastric cancer. Left alone one would find an eventual gastric ulcer and invasive cancer. Partial gastrectomy would probably be indicated at this time. ...Read more

Metaplasia (Definition)

"metaplasia" refers to one tissue type undergoing a change to another, such as bronchial lining (which is usually a single layer of cells, "respiratory epithelium" becoming multi-layered and heavily keratinized, so-called squamous metaplasia. This is common in smokers. Other such changes can produce tissue such as ...Read more


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What does this mean?Endometrial biopsy:benign proliferative endometrium with ciliated cell metaplasia without hyperplasia or malignancy

What does this mean?Endometrial biopsy:benign proliferative endometrium with ciliated cell metaplasia without
hyperplasia or malignancy

Normal : It's benign tissue that shows estrogen effect (proliferative endometrium), cell changes that are benign (ciliated metaplasia) & no precancerous or cancerous cells. It's normal and usually means you can avoid major surgery if you have bleeding. Consider hormonal management or an ablation if you have bleeding problems. Take care. ...Read more

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What does increase cellularity of lamina propria w eosin, lymphoid nod, and paneth cell metaplasia mean in colonic biopsy of terminal ileum?

What does increase cellularity of lamina propria w eosin, lymphoid nod, and paneth cell metaplasia mean in colonic biopsy of terminal ileum?

Chronic inflammation: Paneth cell metaplasia occurs when the bowel mucosa undergoes chronic inflammatory damage and then regenerates. The findings are commonly seen in association with inflammatory bowel disease (ulcerative colitis or crohn's). ...Read more

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I recently had a FNA of my thyroid nodule. The results showed "benign, hyperplastic nodule with extensive Hurthle cell metaplasia". Should I worry?

I recently had a FNA of my thyroid nodule. The results showed "benign, hyperplastic nodule with extensive Hurthle cell metaplasia".  Should I worry?

Needs surgery: see your doctor. You need a referral to a surgeon. Hurtle cell can be benign or malignant. It is impossible to tell whether it is benign or cancerous on a fine needle aspiration. You need surgery to remove that side of your thyroid in order to know100% if it is one or the other. ...Read more

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Had a colonoscopy and the biopsies showed a change is the cell type, called interstinal metaplasia. What does that mean?

Had a colonoscopy and the biopsies showed a change is the cell type, called interstinal metaplasia. What does that mean?

Need follow up: Metaplasia means area of biopsy , did not have normal looking mucosa , cells are changing , it does not mean cancer , still cell are normal cells , if unchecked theses areas may transform to malignant cells , if cluster of cancer cells are formed , if they are not invading to adjacent membrane is called ' in situ cancer ' earliest possible stage .Do not worry just follow your doctors advise , . ...Read more

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Hyperplasia & metaplasia & chronic inflammatory cell infiltration into the stroma = carcinoma?

Hyperplasia & metaplasia & chronic inflammatory cell infiltration into the stroma = carcinoma?

Not yet: Hyperplasia is a lot of benign cells that are not yet malignant. Metaplasia is transformation of one benign cell type into another benign cell type. "dysplasia" or "atypical hyperplasia" would be a warning of premalignancy. The chronic inflammatory cells are not cancer. This is a benign biopsy -- either no cancer or it was not at the biopsy site. Please follow up as appropriate. ...Read more

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Hyperplasia & metaplasia & chronic inflammatory cell infiltration into the stroma = carcinoma?

Hyperplasia & metaplasia & chronic inflammatory cell infiltration into the stroma = carcinoma?

No: The description you provided is not consistent with a diagnosis of carcinoma. It is more consistent with changes due to chronic inflammation. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, low fat milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more

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What is the definition or description of: metaplasia?

What is the definition or description of: metaplasia?

Changed tissue: "metaplasia" refers to one tissue type undergoing a change to another, such as bronchial lining (which is usually a single layer of cells, "respiratory epithelium" becoming multi-layered and heavily keratinized, so-called squamous metaplasia. This is common in smokers. Other such changes can produce tissue such as bone in abnormal sites. ...Read more

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Help! I've been having chronic endocervisitis with squamaous metaplasia?

Help! I've been having chronic endocervisitis with squamaous metaplasia?

Need to see doctor: You apparently saw a doctor and may be had a PAP. Your doctor can determine if an intervention is needed. It is not feasible to provide a meaningful opinion without examining you. ...Read more

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Whats gastric metaplasia?

Whats gastric metaplasia?

Abnormal esophagus: "metaplasia" describes transformation of one tissue type to another. In the lower esophagus, which is lined by squamous epithelium, abnormal exposure to gastric acid juices from reflux can lead the epithelium to convert itself to the kind of glandular lining seen in the stomach. This can be a pre-cancerous change. ...Read more

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Whats squamous metaplasia?

Whats squamous metaplasia?

Benign / worrisome: Usually this is a pap smear finding. Metaplasia is replacement of a normal mature tissue type with another normal mature tissue type, in the cervix the columnar epithelium in the endocervix replaced by a squamous type. It is usually caused by the hpv virus and depending on the strain may present a slightly increased risk for progression toward something that is actually dangerous. ...Read more

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Is intestinal metaplasia bad?

Is intestinal metaplasia bad?

It can get better: "barrett's esophagus" is the most common "intestinal metaplasia.". Repeated irritation of the esophagus from stomach acid causing heartburn can make the lining of the esophagus change to look like the intestinal lining. This is a warning sign; if repeated injury continues a cancer could form. A GI doctor can help your body fix things by minimizing the reflux & checking the area with a scope. ...Read more

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What is focul intestinal metaplasia without displasia?

What is focul intestinal metaplasia without displasia?

A reactive change: "intestinal metaplasia" occurs when some other epithelial lining (like esophagus) is changed over time into intestinal epithelium- like found in the intestine. "focal" means this involves a limited area. "without dysplasia" means that although this intestinal epithelium is in the wrong place, it is healthy and not showing changes that are atypical or in danger of turning into a cancer. ...Read more

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What is "atypical squamous metaplasia" ?

What is "atypical squamous metaplasia" ?

Abnormal cells: These are abnormal cells but they are not cancerous at present. So you need it rechecked as instructed by your doctor as there may be increased risk of developing cancer in this location in the future. ...Read more

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What's the difference between metaplasia and dysplasia?

What's the difference between metaplasia and dysplasia?

Benign vs precancer: Metaplasia (on the cervix) is simply cell changes that are not typical for that area. It is not considered dangerous or pre-malignant so nothing is usually done. Dysplasia, on the other hand, is a pre-cancerous change. Dysplasia can be mild or severe and usually requires surveillance or treatment. I hope that helps. ...Read more

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What does "intestinal metaplasia" mean?

What does "intestinal metaplasia" mean?

Reversible: You probably mean intestinal metaplasia in the stomach. In any case, the term "metaplasia" means reversible change in one tissue type into an other. ...Read more

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Is intestinal metaplasia a reversible condition?

Is intestinal metaplasia a reversible condition?

Yes: Metaplasia is a reversible change in cell types. However, for the change to reverse, the insult, stimulus, factor causing the change has to be removed. ...Read more

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