Doctor insights on:
Cell Mechanism To Form Fat
What is the mechanism that the body uses to create fat cells in adults? And how does the body choose where to produce/store fat?
Physiology: You are asking us a question that would take a whole textbook to answer. This forum is not designed to teach you science or provide you with a whole textbook lesson on physiology. We are happy to answer specific question about specific symptoms or problems. But you are asking something that we cannot answer specifically in only 400 characters. ...Read more
Unregulated growth: The "cell clock" is often referred to as the cell cycle. Think of this as a series of stop and go lights during the lifetime of a cell. Mutations can change a "stop light" to a "green light" resulting in unregulated growth of cells. That unregulated growth can result in the cancer. ...Read more
Since isotretinoins mechanism of action causes DNA damage and cell death is it possible for it 2 damage healthy cells or impact DNA in a negative way?
Isotretinoin: Is an amazing drug. When used for the right reasons it is life changing. But like any drug it is not without its side effects. I think it's gotten a bad reputation with too many unsubstantiated lawsuits. If you truly have severe cystic acne or other unusual conditions that your derm feels it is appropriate for, I would take it! I have had many patients on it in my 18 years of practice without any ...Read more
Milan study says smokers who give up have higher risk of cancer due to cell repair mechanism leading to unrestrained cell growth. True?
Must be distorted: This is simply not true epidemiologically. As a pathologist, there's a lot more cell turnover in a current smoker's lung than there is after they stop. The molecular pathways of cancer are numerous and being clarified as we go, but this doesn't make sense. I've noticed over the years that medical research from italy in particular tends to get scrambled in the media even worse than other science. ...Read more
Graft vs leukemia: A stem cell transplant (SCT) is often given after high doses of chemotherapy, which by itself is very effective against leukemia. But that's not the whole story. Typically, SCT for leukemia are donated by another person (allogeneic). Minor antigenic differences between donor and patient will cause immune cells in the graft to react against against the tumor (graft vs tumor effect). ...Read more
Since reduced blood flow will cause spermatogonial cell dna repair mechanism & cell replication process to be affected, won’t it cause more mutation?
Some basic science: The fastest dividing cells in the human body are hair and skin, G.I. and sperm. If increasing cell replication caused increased mutations, it would be obvious and a scientific fact. Cell replication is very well protected. The few errors that occur, such as Down syndrome caused by an older father are due to problems and the mechanisms of replication, not mutation ...Read more
Please explain mechanism of reccurance in low grade acinic cell carcinoma? After tumor excision only and after total parotidectomy? Thank you
Hematogenic and lymp: Complicated different in a case by case basis ...Read more
What mechanism that high potassium causes cardiac arrest? I just know high k+ causes hyper excitability of cells?
Cell repolarization: When cardiac muscle cells fire, they use up part of the electrochemical gradient they maintain in life. They are repolarized by an outward potassium (K+) flux across the plasma membrane. This outward K+ current depends on the K+ electrochemical gradient. If the "outside" K+ (in blood & interstitial fluid) is very high, that destroys the K+ electrochemical gradient, the cells can't repol; they stop ...Read more
Poorly defined: It may not even be true. Over the past two decades, there's been much discussion about why the public / diet advisors believe this. There was talk of saturated fats reducing LDL-receptor mediated clearance of LDL's, or saturated fats making LDL receptors less abundant. I tried following this for a while and it never got settled. I remain skeptical. ...Read more
Is it true we have a fat-saving mechanism that doesn't get turned off for the night until we eat breakfast in the morning?
Sort of true...: During the night you don't need as much energy and your metabolism slows down. Once you wake up, your metabolism speeds up again, but without a healthy breakfast to provide the nutrients and energy your body needs, your metabolism can't sustain a higher level for long. You burn more calories during the day and are less likely to gain weight. ...Read more
They don't: In fact, they're loaded with calories. Don't use fish oils for weight loss. ...Read more
Coping methods: There are many - good self care that includes proper sleep, activity and hobbies, and overall healthy eating. With regard to work, achieving a good work-life balance as far as time. Other self care tips include, having good social support, continued personal development and learning (ie, taking a class in something fun interesting). Consider looking up models of holistic wellness for more ideas. ...Read more
Control mechanism: A regulatory mechanism for physiological functions in which there is responsive action to feedback. ...Read more
No: In fact, it is likely to have an anxiety provoking effect. If you feel the need to fake happiness, then you should see a psychologist and explore why happiness naturally eludes you. Happiness may be less important than meaning and purpose in life. Some say that happiness is getting and meaning and purpose is giving. Don't chase happiness but do look for satisfaction in life. ...Read more
See below: In freudian psychoanalytic theory, defence mechanisms (or defense mechanisms) are psychological strategies brought into play by the unconscious mind to manipulate, deny, or distort reality (through processes including, but not limited to, repression, identification, or rationalization), and to maintain a socially acceptable self-image or self-schema. ...Read more
Insect allergy: This just happens and there is no good predictor for it, it is more common in people who already have environmental allergies. ...Read more
Yes I can :): Fever results from a chemical cascade in response to a pyrogen. Infection causes the release of pyrogens which in turn cause the body to produce a chemical called prostaglandin e2 (pge2). Pge2 then stimulates a special part of our brain's hypothalamous called the pre-optic area (poa). The poa then integrates this information and sends a signal to our autonomic nervous system to create heat. ...Read more
Acetazolamide: This drug works in the kidneys by inhibiting an enzyme called carbonic anhydrase. Carbonic anhydrase is the enzyme responsible for moving bicarbonate (sodium bicarbonate) (a base) from the kidney back into the blood stream. Acetazolamide blocks this action, resulting in more acidic blood/more basic urine. This drug has a half-life of 15 hours, so depending on the dose may take a few days to clear. ...Read more
Acid feedback loop: Gastrin is a hormone that responds to the amount of stomach acid produced--not enough acid causes gastrin levels to rise to stimulate acid production. Gastrin is suppressed when acid levels are adequate in normal patients. However, in those with hypersecretory states like zollinger-ellison syndrome, gastrin is continually produced in high concentration resulting in excess acid, diarrhea, ulcers. ...Read more
Replace the damage: Organ transplants are performed to replace the lost function of the damaged or failing organs in patients. ...Read more
Hypothermia: Hypothermia is a condition in which the body's temperature drops below that required for normal metabolism and body functions. This is generally considered to be less than 35.0 °C (95.0 °F). Symptoms depend on the temperature. In mild hypothermia there is shivering and mental confusion. In severe hypothermia the heart rate slows and can stop. The internal mechanisms cannot replace lost heat. ...Read more
A Book Chapter: That's a huge question you just asked, and 400 characters isn't going to cut it. Short answer: irritability (triggered and automatic rhythms) and the heart's electricity getting caught in a loop (reentrant rhythms). If you want to drop a lot of cash, I can recommend some great books explaining the basis of these arrhythmias. ...Read more
Mass effect: Something is pushing the eye out of its socket. This is not normal. See an orbital disease specialist. ...Read more
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