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Doctor insights on: Cell Disorder

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How can you be checked for a mast cell disorder or disease. Like mastcytosis or mcad? Is there a certain test that can verify or rule it out?

How can you be checked for a mast cell disorder or disease.  Like mastcytosis or mcad?  Is there a certain test that can verify or rule it out?

Biopsy: Biopsy looking for increased mast cells is the best way . One will also measure tryptase levels and other mediators in the blood. The organ to be biopsied depends on the spectrum of disease. There are some physical signs as well. Would see an allergist or a gastroenterologist who has some knowledge of this disease process. If localized to the skin a dermatologist might be of help. Bone marrow ? ...Read more

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What is/are the best test(s) for detecting a monoclonal plasma cell disorder? How sensitive are these tests? Which types of mpcds can they detect?

What is/are the best test(s) for detecting a monoclonal plasma cell disorder? How sensitive are these tests? Which types of mpcds can they detect?

SPEP: The best test is a serum protein electrophoresis. It is very sensitive and specific. The disease is rare in anyone under the age of 40. For the vast majority of people the disease does not progress for many years 10-20+ so there is no role for screening. ...Read more

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What is red blood cell disorder; some examples?

What is red blood cell disorder; some examples?

Many: 1/3 the field of hematology is devoted to RBC disorders ( the other 2/3 is platelets and wbc's). The most common disorder is anemia which may be caused by a large variety of conditions. One could have the opposite disorder of too many red blood cells and this is known as erythrocytosis. One could have red cells that are filled with unusual hemoglobin such as the thalassemias. ...Read more

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Is there any permanent cure for sickle cell disorder in a child?

Is there any permanent cure for sickle cell disorder in a child?

Yes: A bone marrow transplant will cure sickle cell disease. However, bmt is a very complex and potentially dangerous medical treatment that should only be performed if the benefits outweigh the significant risks. For most children with sickle cell disease, temporary treatment is the only realistic therapy. ...Read more

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Pillcam = many small + large bowel AVMs. Yet 2 colonoscopies earlier that year showed none. Could sudden lesions b related to mast cell disorder?

Pillcam = many small + large bowel AVMs. Yet 2 colonoscopies earlier that year showed none. Could sudden lesions b related to mast cell disorder?

AVM's in colon: Intestinal arteriovenous malformations are possible to see with a camera, and may have been missed at colonoscopy, which looks mainly for masses not flat lesions such as AVM's. Such can appear quickly, but usually only secondary to bowel inflammatory episodes. It depends on whether you were symptomatic when you had either the camera or the colonoscopies ...Read more

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19 month old has 4 swelling lymph nodes in her neck red blood cells disorder neutrophil 18(24-62), lymphocytes 75(31-65)+ severe family history of cll?

19 month old has 4 swelling lymph nodes in her neck red blood cells disorder neutrophil 18(24-62), lymphocytes 75(31-65)+ severe family history of cll?

No need to worry: Most lymphadenopathy in infants are viral in origin. Only concern would be anemia. Without low hemoglobin or significant abnormalities in lymphs or neutros, ok to observe. If nodes get secondarily infected treat with appropriate antibiotics. Little cause to be concerned about cll in that age group. ...Read more

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What is nonclonal mast cell activation disorder?

Newly characterized: It's a mimic for disorders caused by a neoplastic clone of mast cells. This is hematology subspecialist stuff and i would much rather have this than one of the clonal forms. http://www.ncbi.nlm.nih.gov/pubmed/23212667. ...Read more

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What isms st cell activation disorder? How is it diagnosed? How is it treated ? What are the symptoms?

What isms st cell activation disorder?  How is it diagnosed?  How is it treated ?  What are the symptoms?

Caution!: If you casually read what's on the internet, you will be told that mast cell activation disorder is the cause of fibromyalgia, chronic fatigue syndrome, etc - disorders with no known cause. If you want the truth, read this: (from the national institute of health) http://www.Ncbi.Nlm.Nih.Gov/pmc/articles/pmc3069946/. ...Read more