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Doctor insights on: Celiac Ig A Deficiency

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What IgA levels indicate celiac's or gluten sensitivity?

What IgA levels indicate celiac's or gluten sensitivity?

TTg-IgA: The IgA antibody to Tissue Transglutaminase is currently the best blood test to screen for Celiac disease. If this level is elevated, further evaluation should be considered. ...Read more

Dr. Zamaneh Mikhak
70 doctors shared insights

Iga Deficiency (Definition)

Inability to make a class of antibody (IgA) that plays a major role in mucosal immunity (gut and respiratory tract predominantly). May result in recurrent infection, but is often discovered incidentally. May also forecast the development of a more severe immune problem called combined variable immune deficiency (CVID) or be a risk factor for an anaphylactic reaction to ...Read more


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Do elevated gliadin antibodies IgG and IgA mean gluten sensitivity?

Do elevated gliadin antibodies IgG and IgA mean gluten sensitivity?

TTG: I woul recommend having a ttg IgA antibody and possible duodenal bx , in doing so a diagnosis of celiac disease can be made. If if asymptomatic, there may be benefit from a gluten free diet especially if small bowel inflammation noted. ...Read more

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IgA TTG POSITIVE low level of ferritin?

IgA TTG POSITIVE low level of ferritin?

Gluten sensitivity: Typical findings for gluten intolerance with reduced iron absorption and thus the low ferritin. Need to avoid gluten and take some iron supplement (or even shots) ...Read more

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Is IGA Nephropathy genetic/hereditary?

Is IGA Nephropathy genetic/hereditary?

IgA neph: Data have shown a genetic clustering for IgA nephropathy - however its genetic nature is not certain - ...Read more

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Why is gluten intolerence called celiac disease?

Why is gluten intolerence called celiac disease?

Because it causes: Celiac disease is autoimmune disorder of small intestines that occurs in genetically predisposed individuals of all ages.It is caused by a reaction to gluten a protein found in wheat, barley and rye. That's why it is called gluten intolerance.Once the source of gluten, that is diet free from wheat, rye and barley is introduced the symptoms get better. ...Read more

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How is celiac disease gluten sensitivity inherited?

How is celiac disease gluten sensitivity inherited?

Genetics celiac: This is a complex answer best answered by an expert. Go to http://www.Celiac.Com/articles/1046/1/understanding-the-genetics-of-gluten-sensitivity-by-dr-scot-lewey/page1.Html. ...Read more

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Antitissuetransglutaminase iga 0.5 u/ml is this ok?

Antitissuetransglutaminase iga	0.5 u/ml is this ok?

Probably: If this is considered normal value by your lab then it is normal. However this test is only reliable when you are consuming gluten. If you have avoided gluten for some time, then you will need to get alternate tests. ...Read more

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My serum test is negative for endomysial antibody iga, ttg tissue transglutasminase iga, gliadin antibody igg. But positive for gliadin antibody iga?

My serum test is negative for endomysial antibody  iga, ttg tissue transglutasminase iga, gliadin antibody igg. But positive for gliadin  antibody iga?

Treat the person: Lab tests mean nothing in isolation, and have many false positives and false negatives. The decision to make a trial of a gluten-free diet will be between you and your gastroenterologist or dermatologist based on the big picture. ...Read more

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How common is celiac disease (gluten sensitivity)?

How common is celiac disease (gluten sensitivity)?

1 in 3,000: But still more people are allergic to wheat, which is a different problem with a similar treatment: avoid it! fyi the only other grains with they type of gluten to avoid in celiac sprue are rye and barley. ...Read more

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What autoimmune disorder has celiacs, gastroparesis, hypothyroidism?

What autoimmune disorder has celiacs, gastroparesis, hypothyroidism?

connective tissue : Connective tissue disease: test for sjogren's (blood & sialogram) autoimmune thyroid, explore with your doctor : omeoprazole & Erythromycin & domperidone. Botox injections into pylorus muscle for stomach pain and nausea. Avoid raw veggies, grind food up when things are very bad. There does not need to be one primary autoimmune disorder. ...Read more

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Can seborrheic dermatitis cause a positive tissue transglutaminase IgA antibody, low level?

Can seborrheic dermatitis cause a positive tissue transglutaminase IgA antibody, low level?

No: In and of itself , seborrheic dermatitis does not cause any significant immunologic disorders although certain diseases do have an association with seborrheic dermatitis-like rashes such as zinc deficiency syndromes and parkinsonism, for instance. ...Read more

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How are gluten intolerance and celiac disease diagnosed?

How are gluten intolerance and celiac disease diagnosed?

Celiac: Typically people get blood work for specific celiac antibodies but there is a lot of debate on how accurate a negative result is. Most accurate is an endoscopy with biopsy looking specifically for the celiac antibodies or pathology. ...Read more

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Iron deficiency anemia wid calcium deficiency?

Iron deficiency anemia wid calcium deficiency?

Fe -Ca: Ida is common in young menstruating females. Calcium deficiency? Quite odd at any age. Wonder if your Albumin is normal giving a falsely low calcium.... Why would anyone check a calcium in a healthy 18 yo? Maybe there is more to this story. Maybe you should talk to doc who drew your labs. ...Read more

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Can infants have celiac disease or gluten intolerance?

Yes: Yes, but may not show symptoms for years. While milk fed, will not seee any symptoms until those foods are introduced. ...Read more

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Constipation, celiac disease?

Constipation, celiac disease?

Constipation celiac: Celiac disease may have no GI symptoms, and may present with fatigue and anemia, bur classical symptoms are pale loose and greasy stools and weight loss, abdominal pain and cramps and distension, ulcers in the mouth.It can lead to lactose intolerance and may give symptoms of irritable bowel syndrome like constipation alternating with diarrhea, but it is not that common presentation. ...Read more

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Is autoimmune hemolytic anemia hereditary?

Is autoimmune hemolytic anemia hereditary?

No: It can be due to an underlying autoimmune disorder, such as lupus or rheumatoid arthritis. In this case, the underlying autoimmune disorder may be hereditary; but the autoimmune hemolytic anemia is not hereditary. It is simply the manifestation of the underlying disorder. There are also several causes of autoimmune hemolytic anemia that are not inherited. ...Read more

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Is it common to have celiac disease if you have SLE? I have selective IgA deficiency

Is it common to have celiac disease if you have SLE? I have selective IgA deficiency

Yes there is: celeac desease ,IGA deffifficiency are all immune mediated disorders it is advisable that you have an immunologist involved in your care stay well! ...Read more

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I have negative celiac blood test and no IgA deficiency but biopsy shows chronic non-specific duodenitis and celiac symptoms are present.Need help. ?

I have negative celiac blood test and no IgA deficiency but biopsy shows chronic non-specific duodenitis and celiac symptoms are present.Need  help.
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Be more specific: If IgA tTG was negative, there is a very little chance that you have celiac disease. However, other conditions may mimic gluten-sensitivity and some people may actually be allergic to wheat itself causing similar symptoms. The biopsy findings should be quite specific for gluten intolerance. What actually are your symptoms? ...Read more

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My daughter found out she has IgA deficiency/what is that?

My daughter found out she has IgA deficiency/what is that?

Immune problem: Iga is an antibody produced by our immune system. It can be found in the blood but is mainly secreted into mucous membranes -- sinuses for example. It is the most common immunodeficiency. Go to www.Primaryimmune.Org for some really good info on IgA deficiency. ...Read more

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Hi doctors, can you tell me what is IgA deficiency and how can it be helped?

IgA deficiency: or rather selective IgA deficiency, still a rare disease, but the most common type of immunodeficiency, at times associated with IgG subclass deficiency, usually asymptomatic, but can have upper respiratory problems, can be prone to auto-immune diseases, need to be cautious with blood or blood products infusion, if diagnosed or suspected please get evaluated by an allergist/immunologist, take care ...Read more

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How often does partial IgA deficiency turn into cvid? pigad diagnosed at 26.

Selective IgA defic.: Most persons with this remain without significant illness. It is not known exactly how many individuals with IgA deficiency will eventually develop complications; estimates range from 25% to 50%, but these people often have severe deficiencies, often accompanied by defects in other immunoglobulins or other elements of the immune system. ...Read more

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How often does IgA deficiency progress to cvid? I was tested at 26 and don't have cvid. Is it likely to turn into cvid?

Depends on level: If there is true deficiency, 20 % get symptoms before 16 years of age. Most people developed in their 3rd or 4th decade of life.Male and female equally. Recurrent infections of nose, ear, sinus, lung, abdomen, enlarged lymph nodes in neck and abdomen etc. But first of all one should determine if deficiency exit or not by using more sophisticated tests. ...Read more

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Is an IgA level of 38 mg/dl considered IgA deficiency? I keep reading it has to be under 5 mg/dl to be called an IgA deficiency.Why would mine be low?

Low, not low enough: When normal IgA levels are determined, they are usually based on the average values of the population tested and the age of the patient. There are usually 2-5 % of normals that are included in the low range. You can relax. Even though 38 may be low, it is high enough to protect you against infections. If you have levels less than 20 mg/dl then you would be at risk for recurrent infection. ...Read more

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What are the tests for IgA deficiency?

What are the tests for IgA deficiency?

Blood test: To determine if you have an IgA deficiency, a simple blood test can be done. ...Read more

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Anybody know much about this IgA deficiency?

Anybody know much about this IgA deficiency?

Maybe no issue: Ig a is one of the 5 known immunoglobulins in human. Isolated IgA deficiency occurs in 1/500 of the population and is not usually associated with susceptibility to infections unless there is an igg deficiency as well. If you are healthy otherwise, don't worry about it. On the other hand, was the blood test obtained because she gets frequent sinus or lung infections in the first place? ...Read more

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What is IgA deficiency and does it need to be treated?

What is IgA deficiency and does it need to be treated?

Maybe no issue: Ig a is one of the 5 known immunoglobulins in human. Isolated IgA deficiency occurs in 1/500 of the population and is not usually associated with susceptibility to infections unless there is an igg deficiency as well. If you are healthy otherwise, don't worry about it. On the other hand, was the blood test obtained because she gets frequent sinus or lung infections in the first place? ...Read more

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How common is a partial IgA deficiency? Mine is 37 mg/dl

Selective IgA defic.: Prevalence varies by population, but is on the order of up to 1 in 333 people making it relatively common for a genetic disease. It is more common in males than in females. IgA is primarily in secretions of the mucosal surfaces, including tears, saliva, colostrum, genital, respiratory and gastrointestinal secretions, and if symptoms develop they are usually related to infections in these areas. ...Read more

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What is the definition or description of: IgA deficiency?

IgA deficiency: Inability to make a class of antibody (IgA) that plays a major role in mucosal immunity (gut and respiratory tract predominantly). May result in recurrent infection, but is often discovered incidentally. May also forecast the development of a more severe immune problem called combined variable immune deficiency (CVID) or be a risk factor for an anaphylactic reaction to blood products with IgA. ...Read more

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Iga is 38mg/dl. My dr said it's not considered IgA deficiency and some people just fall below the average. True?

May be it is normal: Normal Values fall between 100 - 600 mg/dl.Many are below 100,but not considered deficiency in Iga, and are asymptomatic.But may need more screening like DOUBLE IMMUNODIFFUSION ASSAY TEST normal value is 2 - 4 mg/dl.If ...Read more

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Iga was measured to be low at 40 mg/dl. Range was above 68mg/dl. Dr said it isn't IgA deficiency because it's too high. What caused this then?

Iga was measured to be low at 40 mg/dl. Range was above 68mg/dl. Dr said it isn't IgA deficiency because it's too high. What caused this then?

No IgA deficiency: Your IgA is a little lower than the average. It is not low enough to be called deficiency. Iga deficiency used to be IgA of less than 30mg/dl, occurring in 1 in 500 people. A level of less than 1mg/dl occurs in 1 in 2000 people. The primary cause is unknown, but there is failure of certain b lymphocytes to mature into IgA producing plasma cells. If you have no symptoms - no treatment necessary. ...Read more

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Gf diagnosed with IgA deficiency, now diagnosed with scid. Related?

Gf diagnosed with IgA deficiency, now diagnosed with scid. Related?

SCID: Scid stands for severe combined immunodeficiency. By definition, people with this disorder have no t cells, so they cannot fight any diseases or produce any antibodies. Iga is one type of antibody, so a deficiency of it would be expected as part of the scid disorder. This disorder is fatal in infancy without aggressive management, so not likely to be diagnosed in an adult. Cvid more likely. ...Read more

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Could an IgA deficiency prevent my body from making antibodies?

Could an IgA deficiency prevent my body from making antibodies?

IgA deficiency: Iga is an antibody, so a deficiency of IgA means your body is having trouble making that type of antibody. Iga deficiency does not cause you to be unable to make other antibodies. It just means you aren't able to make the IgA class of antibodies, so antibodies of that type will probably not be detected if they are sought, for example, in a blood test for celiac or other diseases. ...Read more

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I have IGA deficiency and get sick a lot . When sound I get my kids tested for it and yes they all have HLA-B27. ?

I have IGA deficiency and get sick a lot . When sound I get my kids tested for it and yes they all have HLA-B27. ?

Hereditary: If there are symptoms or signs of an autoimmune disease, a positive HLA-B27 test may confirm the diagnosis. However, HLA-B27 is normally found in a small number of Caucasians and does not always mean you have a disease. Hope the kids stay free of illness. ...Read more

Dr. John Chiu
642 doctors shared insights

Celiac Disease (Definition)

A disease caused by an immune system reaction to eating gluten, a protein found in ...Read more