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Doctor insights on: Celiac Disease Panel Blood Test

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How accurate is the blood test for celiac disease?

How accurate is the blood test for celiac disease?

Not very: It is perhaps about 50% accurate. We believe it when positive but not when negative. Even biopsy can miss the diagnosis. Best to test celiac genetic panel. Mayo lab and enterolab can do this. Google enterolab and order the test yourself $150. ...Read more

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Dr. John Chiu
621 Doctors shared insights

Celiac Disease (Definition)

An immune reaction to eating gluten, a protein found in ...Read more


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Can celiac disease be 100% ruled out with the blood test?

Can celiac disease be 100% ruled out with the blood test?

Yes: If genetic markers (DQ 4, 8) are negative and there is not antibody to gliadin peptide, celiac disease can be ruled out. ...Read more

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My endoscopy biopsy looked exactly like something caused by Celiac disease but my blood test came back negative, what else could it be?

My endoscopy biopsy looked exactly like something caused by Celiac disease but my blood test came back negative, what else could it be?

Biopsy definitive.: In regards to celiac disease, the biopsy is more diagnostically reliable than the blood test, so if the blood test showed typical evidence of celiac disease, I'd believe it. ...Read more

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Is it possible for a toddlers blood test to be negative for celiac disease but upon endoscopy or colonoscopy be found to indeed have celiac disease?

Is it possible for a toddlers blood test to be negative for celiac disease but upon endoscopy or colonoscopy be found to indeed have celiac disease?

Possibly: If the correct test was done (measurement of IgA antibody to human recombinant TTG is recommended for initial testing for CD by NASPGHAN) and was negative, AND if a child has chronic diarrhea or failure to thrive OR if they have selective IgA deficiency or a + family hx of CD, a biopsy might be recommended. Consult with a pediatric GI physician if this is the case. Best of luck! ...Read more

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I have not checked for Celiac disease. Should I get a blood test? I have been under a lot of stress lately. I also drink a lot of caffeine.

I have not checked for Celiac disease. Should I get a blood test? I have been under a lot of stress lately. I also drink a lot of caffeine.

Maybe: Your question does not provide enough info to confirm or exclude need for a celiac screening. It is a real problem with some subtle symptoms and effects. Screening is simple but confirmation requires an intestinal biopsy.You should have it confirmed before trying a gluten free lifestyle, which has a cult like following. True celiacs have other associated risks that need to be explored. ...Read more

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What other methods is there of diagnosing celiac disease besides the blood test/gluten free diet/endoscopy? I can't afford endoscopy or the blood test

What other methods is there of diagnosing celiac disease besides the blood test/gluten free diet/endoscopy? I can't afford endoscopy or the blood test

Don't eat bread: If you think you have celiac disease and yet you don't want to have a diagnostic workup the answer is quite simple avoid all gluten containing products such as flour bread products there are many gluten-free alternatives in all the markets just do that and don't cheat on it. ...Read more

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Two negative blood test for celiac disease is it possible to still have it and it be the cause of bone loss? How do I test and make sure 100%

Two negative blood test for celiac disease is it possible to still have it and it be the cause of bone loss? How do I test and make sure 100%

There's no 100%: The labs are probably not totally sensitive / specific but they're pretty good. Have you had a biopsy? This is one to work out with your physician. Bone loss won't be the primary manifestation of celiac disease despite "pop" wisdom. "Low blood pressure" isn't an illness. A full workup, including some zebras like porphyria or other neuropathies, may be a consideration along with supportive Dr. ...Read more

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I tested positive for celiac disease through a blood test but waiting to get my biopsy done, but liver & spleen are enlarged can it be cancer?

I tested positive for celiac disease through a blood test but waiting to get my biopsy done, but liver & spleen are enlarged can it be cancer?

Organomegaly: Celiac disease is not usually associated with enlargement of liver and spleen. While some leukemias/lymphomas might cause this, they are not common in your age group, and might be associated with abnormalities of CBC or other tests. If you have solid anti-gliadin antibody test, then a small bowel biopsy is probably not essential. Fatty liver, cirrhosis, circulatory issues might be worth excluding. ...Read more

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I have symptoms of celiacs disease but don't have it due to just having a negative blood test, what could it be?

I have symptoms of celiacs disease but don't have it due to just having a negative blood test, what could it be?

Depends: It depends on your symptoms. Also, blood tests can be negative at some times and later can be positive. Depending on how severe your symptoms are, you can always see a gastroenterologist so they can get a full history, review your lab tests and see if they can help you with a diagnosis of celiac disease or something else that explains your symptoms. ...Read more

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Celiac disease blood testing involves what tests usually?

Celiac disease blood testing involves what tests usually?

TTG IgA, others: Arguably the most accurate is the ttg IgA level. In those who are IgA deficient, I believe a dpg igg is the best. Others include anti-endomysial antibodies. The gold standard is duodenal biopsies obtained during endoscopy. ...Read more

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Constipation and diarrhea for over 8 weeks now, I got a blood test for celiacs disease, but they said it was just fibre. What else could it be?

Constipation and diarrhea for over 8 weeks now, I got a blood test for celiacs disease, but they said it was just fibre. What else could it be?

Many causes: By far, celiac disease is the lowest in the list of possibility in a person with a 8-week history of constipation and diarrhea. Have your traveled to the developing world shortly before this happened? You need to consult a gastroenterologist if you family doctor cannot provide you with an answer. ...Read more

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Do you have to change your diet if doing a celiac sprue blood test, to get the correct results?

Do you have to change your diet if doing a celiac sprue blood test, to get the correct results?

Must eat gluten: The antibody tests for gluten enteropathy fall into the normal range if you stay away from gluten for a long enough time. To get a positive test if you have celiac disease you must be eating gluten for some time when the test is done. How long? At least several weeks. ...Read more

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Can blood tests check for celiac disease?

Yes: Blood tests can be done as well as if an egd is done, a biopsy can be done that is more specific to test for celiac. ...Read more

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