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Doctor insights on: Cd57 Cd3 Cd8 Flow Cytometry

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Is there any thing of concern in my flow cytometry when it states "degenerating T cells also noticed" 23% of the lymphoid population are large granular lymphocytes, an inverted cd4:cd8 ratio, and under the Blasts section it stayed that cd45 dim makes up 3

Is there any thing of concern in my flow cytometry when it states "degenerating T cells also noticed" 23% of the lymphoid population are large granular lymphocytes, an inverted cd4:cd8 ratio, and under the Blasts section it stayed that cd45 dim makes up 3

Please talk to your: Doctor, flowcytometry is a specialized complex blood test, your Doctor or the Doctor who ordered that test are the best to educate you on the results in the context of the whole clinical picture, goodluck ...Read more

Cd8 (Definition)

Cd8(cluster of differentiation8)is a transmembrane glycoprotein that serves as a co-receptor for the tcell receptor(tcr) like the tcr, cd8 binds to a major histocompalibility complex(mhc) molecule, but is specific for the class 1 mhc protein there are two isoforms of the protein, Alpha and beta, each encoded in a different gene in humans.Both genes are located on ...Read more


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What would cd8+/cd57+ large granular lymphocytes found in peripheral blood flow cytometry mean with loss of cd7 ?

What would cd8+/cd57+ large granular lymphocytes found in peripheral blood flow cytometry mean with loss of cd7 ?

Want to read report: Hi. Usually the purpose of flow cytometry is to determine whether an elevated white cell population (e.g., lymphocytes) is monoclonal and thus indicative of leukemia. Flow cytometry uses specific antibodies against specific cell surface white cell proteins (CD's, or Classification Determinants) to assess for monoclonalitiy of cell populations. What is report conclusion? Good luck! ...Read more

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What would tcells 83% cd4/cd8 ratio of 6.5, Nk 2%, polytypic bcells 15% mean? I've been having abnormal blood work so they completed a flow cytometry.

What would tcells 83% cd4/cd8 ratio of 6.5, Nk 2%, polytypic bcells 15% mean? I've been having abnormal blood work so they completed a flow cytometry.

Not that much: cannot say in your particular case, but generally, there's a lot of variability in these. BUT in HIV or other immunosuppression, the T cell count is low and the CD4 ratio is LOW.. below 2 not above 5. BUT the polytypia, the elevated counts all imply an ongoing chronic infection such as TB, chronic viral infection (non-HIV) syphillis, lyme, etc. ...Read more

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Is there any thing of concern in my flow cytometry when it states "degenerating T cells also noticed" 23% of the lymphoid population are large granular lymphocytes, an inverted cd4:cd8 ratio, and under the Blasts section it stayed that cd45 dim makes up 3

Please talk to your: Doctor, flowcytometry is a specialized complex blood test, your Doctor or the Doctor who ordered that test are the best to educate you on the results in the context of the whole clinical picture, goodluck ...Read more

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Does a low result for HNK1 CD8-CD57+ Lymphs (15/uL, ref 60-360) indicate that further investigation or treatment is required?

Does a low result for HNK1 CD8-CD57+ Lymphs (15/uL, ref 60-360) indicate that further investigation or treatment is required?

Yes: This is only a part of the picture, doesn't look normal, different causes lead to such, certain medicines can do, as immuosuppressants, please confer with your doctor ...Read more

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What is the difference between CD8+CD57+ and CD8-CD57+ ? I see studies on CD8+CD57+ but not CD8-CD57+, which I had a Labcorp test for.

CD markers: CD stands for cluster of differentiation and can help distinguish cell types. CD8+ usually identifies a cell as a killer T cell. CD8- identifies a cell as NOT a killer T cell. In immunology, CD57+ cells usually are NK or T cells. Hence, CD8+CD57+ would reflect a killer T cell with CD57 expression. CD8-CD57+ could be a NK cell with CD57 expression (note non-immune cells also express CD57). ...Read more

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Where can I find a doctor to help me figure out the cause of an abnormal HNK1 CD8-CD57+ Lymphs test? (I was 15/uL, ref 60-360) No obvious symptoms.

Where can I find a doctor to help me figure out the cause of an abnormal HNK1 CD8-CD57+ Lymphs test? (I was 15/uL, ref 60-360) No obvious symptoms.

The MD who ordered: the test is the one to explain the results in view of the clinical picture and reason the test was ordered, otherwise an Immunologist, an ID specilaist , or a hematologist can help you, but again a full history and physical exam are needed, not a snapshot lab result ...Read more

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Does a low result for HNK1 CD8-CD57+ Lymphs (15/uL, ref 60-360) indicate that further investigation or treatment is required, if I have Celiac disease?

Probably: One will need to evaluate a test based on the whole disease presentation. The question is why was the test obtained in th4e first place since this is not the usual test to monitor celiac disease. Another consideration is whether this was a lab error especially when the finding is not compatible with the disease suspected. ...Read more

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What are the possible causes for a below normal result on the Labcorp HNK1 CD8-CD57+ Lymphs test? (I was 15/uL, ref 60-360) No obvious symptoms.

Low CD57 lymphs : These are "natural killer" cells, parts of the body's adaptive immune system. Low counts often point to a chronic infection, like Lyme disease, if you are in a Lyme-disease prone area and may have been in the woods, etc., it is worth checking your Lyme titers. ...Read more

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Hematologist wants to repeat flow cytometry. Any risks?

No: It is a specialized blood test which does not have any harmful effects on the patient, other than a needle stick to draw a blood sample or a biopsy of the tissue to be tested. ...Read more