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Doctor insights on: Cd57 Cd3 Cd8 Flow Cytometry

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Is there any thing of concern in my flow cytometry when it states "degenerating T cells also noticed" 23% of the lymphoid population are large granular lymphocytes, an inverted cd4:cd8 ratio, and under the Blasts section it stayed that cd45 dim makes up 3

Is there any thing of concern in my flow cytometry when it states "degenerating T cells also noticed" 23% of the lymphoid population are large granular lymphocytes, an inverted cd4:cd8 ratio, and under the Blasts section it stayed that cd45 dim makes up 3

Please talk to your: Doctor, flowcytometry is a specialized complex blood test, your Doctor or the Doctor who ordered that test are the best to educate you on the results in the context of the whole clinical picture, goodluck ...Read more

Cd8 (Definition)

Cd8 (cluster of differentiation8)is a transmembrane glycoprotein that serves as a co-receptor for the tcell receptor (tcr) like the tcr, cd8 binds to a major histocompalibility complex (mhc) molecule, but is specific for the class 1 mhc protein there are two isoforms of the protein, Alpha and beta, each encoded in a different gene in humans. Both genes are located on ...Read more


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What would cd8+/cd57+ large granular lymphocytes found in peripheral blood flow cytometry mean with loss of cd7?

What would cd8+/cd57+ large granular lymphocytes found in peripheral blood flow cytometry mean with loss of cd7?

Want to read report: Hi. Usually the purpose of flow cytometry is to determine whether an elevated white cell population (e.g., lymphocytes) is monoclonal and thus indicative of leukemia. Flow cytometry uses specific antibodies against specific cell surface white cell proteins (CD's, or Classification Determinants) to assess for monoclonalitiy of cell populations. What is report conclusion? Good luck! ...Read more

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What would tcells 83% cd4/cd8 ratio of 6.5, Nk 2%, polytypic bcells 15% mean? I've been having abnormal blood work so they completed a flow cytometry.

What would tcells 83% cd4/cd8 ratio of 6.5, Nk 2%, polytypic bcells 15% mean? I've been having abnormal blood work so they completed a flow cytometry.

Not that much: Cannot say in your particular case, but generally, there's a lot of variability in these. BUT in HIV or other immunosuppression, the T cell count is low and the CD4 ratio is LOW. Below 2 not above 5. BUT the polytypia, the elevated counts all imply an ongoing chronic infection such as TB, chronic viral infection (non-HIV) syphillis, lyme, etc. ...Read more

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Is there any thing of concern in my flow cytometry when it states "degenerating T cells also noticed" 23% of the lymphoid population are large granular lymphocytes, an inverted cd4:cd8 ratio, and under the Blasts section it stayed that cd45 dim makes up 3

Please talk to your: Doctor, flowcytometry is a specialized complex blood test, your Doctor or the Doctor who ordered that test are the best to educate you on the results in the context of the whole clinical picture, goodluck ...Read more

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Does a low result for HNK1 CD8-CD57+ Lymphs (15/uL, ref 60-360) indicate that further investigation or treatment is required?

Does a low result for HNK1 CD8-CD57+ Lymphs (15/uL, ref 60-360) indicate that further investigation or treatment is required?

Yes: This is only a part of the picture, doesn't look normal, different causes lead to such, certain medicines can do, as immuosuppressants, please confer with your doctor ...Read more

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What is the difference between CD8+CD57+ and CD8-CD57+? I see studies on CD8+CD57+ but not CD8-CD57+, which I had a Labcorp test for.

CD markers: CD stands for cluster of differentiation and can help distinguish cell types. CD8+ usually identifies a cell as a killer T cell. CD8- identifies a cell as NOT a killer T cell. In immunology, CD57+ cells usually are NK or T cells. Hence, CD8+CD57+ would reflect a killer T cell with CD57 expression. CD8-CD57+ could be a NK cell with CD57 expression (note non-immune cells also express CD57). ...Read more

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Where can I find a doctor to help me figure out the cause of an abnormal HNK1 CD8-CD57+ Lymphs test? (I was 15/uL, ref 60-360) No obvious symptoms.

Where can I find a doctor to help me figure out the cause of an abnormal HNK1 CD8-CD57+ Lymphs test? (I was 15/uL, ref 60-360) No obvious symptoms.

The MD who ordered: The test is the one to explain the results in view of the clinical picture and reason the test was ordered, otherwise an Immunologist, an ID specilaist, or a hematologist can help you, but again a full history and physical exam are needed, not a snapshot lab result ...Read more

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Does a low result for HNK1 CD8-CD57+ Lymphs (15/uL, ref 60-360) indicate that further investigation or treatment is required, if I have Celiac disease?

Probably: One will need to evaluate a test based on the whole disease presentation. The question is why was the test obtained in th4e first place since this is not the usual test to monitor celiac disease. Another consideration is whether this was a lab error especially when the finding is not compatible with the disease suspected. ...Read more

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What are the possible causes for a below normal result on the Labcorp HNK1 CD8-CD57+ Lymphs test? (I was 15/uL, ref 60-360) No obvious symptoms.

Low CD57 lymphs: These are "natural killer" cells, parts of the body's adaptive immune system. Low counts often point to a chronic infection, like Lyme disease, if you are in a Lyme-disease prone area and may have been in the woods, etc., it is worth checking your Lyme titers. ...Read more

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Hematologist wants to repeat flow cytometry. Any risks?

No: It is a specialized blood test which does not have any harmful effects on the patient, other than a needle stick to draw a blood sample or a biopsy of the tissue to be tested. ...Read more

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How long does it take to receive results from a peripheral blood flow cytometry test?

How long does it take to receive results from a peripheral blood flow cytometry test?

Cytometry test: Hard to say as time various greatly with each doctor and lab. Best bet is to call the doctors office and ask. ...Read more

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The lymphoid population consists of polyclonal b cells cd19, cd20, cd45 pos, cd5, cd10 neg w/o light chain. What does this mean on flow cytometry?

This is normal: We would worry if you had Monoclonal Lymphocyte excess, a polyclonal pattern is normal.
But why did you have the Flow cytometry done in the first place? Give us more detailed history if you need our guidance. ...Read more

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Can an excisional lymph node biopsy of begnin be accurate when the node didn't have enough cells to do a flow cytometry?

Can an excisional lymph node biopsy of begnin be accurate when the node didn't have enough cells to do a flow cytometry?

Yes: If the the lymph node biopsy is adequate for evaluation in terms of sample size for the pathologist, then a benign lymph node diagnosis should be adequate even in the absence of flow cytometry data. Flow cytometry is helpful as ancillary data when working up a diagnosis of lymphoma or leukemia in conjunction with the biopsy. But if the biopsy is benign it doesn't add much. ...Read more

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Marrow aspirate flow cytometry. What's importance of the dominant markers in lymphocyte vs. Blast gates? Eg. Lymph CD2~5~7~38 Blast 22~34~45~117~hladr

Marrow aspirate flow cytometry. What's importance of the dominant markers in lymphocyte vs. Blast gates? Eg. Lymph CD2~5~7~38 Blast 22~34~45~117~hladr

Exactly400Characters: I'm not here to answer. This is beyond my expertise. But I would like to remind you, & others, that we are restricted to 400 characters (not words, but individual letters, etc).I would suspect that a question like this would require some more information before someone would want to commit to an answer and, anyways, the person who ordered and/or did the aspirate should be consulted for definitive answers. ...Read more

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Will a flow cytometry test exclude lymphomas such as hodgekins and non hodgekins, plus what other cancers will it exclude? Done at BAYLOR COLLEGE OF

Will a flow cytometry test exclude lymphomas such as hodgekins and non hodgekins, plus what other cancers will it exclude? Done at BAYLOR COLLEGE OF

Lymphomas: Flowcytometery test will exclude non-hodgkins lymphoma. However, it does not exclude hodgkins lymphoma.
Flowcytometery is done to diagnose and classify blood/bone marrow and lymph node cancers (leukemia and lymphomas). Leukemias are of many type; some of them can not be diagnosed with this test such as myeloproliferative diseases (CML, ET, polycythemia vera etc) and MDS (myelodysplastsic syndrome ...Read more

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Can a lymph node fna with flow cytometry rule out lymphoma?

Can a lymph node fna with flow cytometry rule out lymphoma?

Not 100%: Many enlarged lymph nodes are not cancerous are instead benign and a result of another disease process. An fna is a good starting test for evaluating lymph nodes that appear to not be associated with other things that go along with lymphoma, but if suspicion is high, a fine needle aspiration (fna) is not enough and an excisional biopsy is preferred. ...Read more

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Why would you do flow cytometry if EBV serology is positive and no blasts were seen in wbc?

Why would you do flow cytometry if EBV serology is positive and no blasts were seen in wbc?

Lymphoma?: Ebv has been associated with post-transplant lumphoprolifeative disorder and I believe this is your question. What the doctors are looking for is the clonality of the b lymphocytes and any rearrangements in the normal genes of your immunoglobulins or antibodies with some of the ebv genes. In many instances there will be no circulating blasts. ...Read more