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Doctor insights on: Cd31 Angiogenesis

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What is hemagglutinin (ha) gene and neuraminidase (na) gene?

What is hemagglutinin (ha) gene and neuraminidase (na) gene?

Flu virus genes: The hemaglutinin and neuraminidase genes are in influenza viruses. They code for proteins that are found on the surface of the flu virus. The viruses are named according to which type of hemaglutinin and neuraminidase proteins are on their surfaces (for example: h1n1 or h7n9). ...Read more

Angiogenesis (Definition)

Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels. This is distinct from vasculogenesis, which is the de novo formation of endothelial cells from mesoderm cell precursors. The first vessels in the embryo form through vasculogenesis, after which angiogenesis is responsible for most, if not all, blood ...Read more


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What's the normal range in percentage for cd3, cd4, cd8, cd5, cd19 and cd20 antigens in peripheral blood for female adults?

What's the normal range in percentage for cd3, cd4, cd8, cd5, cd19 and cd20 antigens in peripheral blood for female adults?

Why do you ask?: You are of course talking about percentages of either all white blood cells or of lymphocytes. This question does not arise in general clinical medicine, and if someone has offered this to you without a strong suspicion of immunodeficiency or leukemia, you need to insist on an explanation. And in such workups, the search is either for a mutant clone or a grave deficiency; percentages are moot. ...Read more

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Hello docs, is gene therapy suitable for pancreatic cancer patients?

Hello docs, is gene therapy suitable for pancreatic cancer patients?

Not available: Gene therapy for cancers, including pancreatic cancer is not in common use. See this site for more info. http://www.mayoclinic.com/health/gene-therapy/my00105. ...Read more

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Using avastin (bevacizumab) for macula degeneration treatment?

Using avastin (bevacizumab) for macula degeneration treatment?

Avastin (bevacizumab): Avastin (bevacizumab) is a drug that is commonly used in the treatment of wet macular degeneration and other eye conditions involving leakage of fluid from blood vessels in the retina. ...Read more

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Neovascularization and angiogenesis, any difference?

Neovascularization and angiogenesis, any difference?

About same: Both imply new blood vessel formation. Sometimes it is due to benign causes , then it is called neovascularization. When it is due to cancer, it is often called angiogenesis. ...Read more

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49 year old male has stage vi lung adenocarcinoma. No gene mutations receiving chemo and avastin (bevacizumab) received radiation on foot and brain. What prognosis?

49 year old male has stage vi lung adenocarcinoma. No gene mutations receiving chemo and avastin (bevacizumab) received radiation on foot and brain. What prognosis?

It varies according : Patients with stage 4 lung cancer have an average survival of 12 months but there is a wide range from 9 months to 18 months. Some patients can live for 2-5 years but that is rare and only happens if their tumor shows a great response to chemotherapy. ...Read more

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Stem cell therapy for scheuremann's disease?

Stem cell therapy for scheuremann's disease?

Consider: Stem Cell Therapy or Platelet procedures to help with healing and strengthen ligaments. While it will not cure Schuermann's Disease it can help decrease pain and strengthen ligaments in the surrounding muscles and facet joints. Check out Regenexx.Com for more info. ...Read more

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What are options following optimal debulking for gr. 1 stage 3c endometrioid ovarian ca? Carbo/taxol? Aromatase inhibitor? Other? Clinical trials?

What are options following optimal debulking for gr. 1 stage 3c endometrioid ovarian ca?  Carbo/taxol?  Aromatase inhibitor? Other? Clinical trials?

Treatment: We always encourage clinical trials as first line option. Standard therapy will include use of taxane and platinum compound like carboplatin/taxol combo. I would not use arimidex. 2nd line drugs include cisplatin, taxotere, doxil, gemzar, avastin, (bevacizumab) topotecan etc. ...Read more

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10% lymphocytes positive cd20, cd3 cd79a negative for cd10. Results indicate a mixed b and t cell phenotype and thus consistent with reactive nature?

10% lymphocytes positive  cd20, cd3 cd79a negative for cd10. Results indicate a mixed b and t cell phenotype and thus consistent with reactive nature?

See below: If the pathology report didn't indicate monoclonality or lymphoproliferative disorder, it means that probably it is not lymphoma. ...Read more

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The lymphoid population consists of polyclonal b cells cd19,cd20,cd45 pos, cd5, cd10 neg w/o light chain. What does this mean on flow cytometry?

This is normal: We would worry if you had Monoclonal Lymphocyte excess, a polyclonal pattern is normal. But why did you have the Flow cytometry done in the first place? Give us more detailed history if you need our guidance. ...Read more

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What are the benefits of azd 6244 mek inhibitor & mk 2206 akt inhib. For adenocarcinoma. 70yrs..115lbs (lost 40)..8mth chemo..Radio..Gamma-11mth diag?

What are the benefits of azd 6244 mek inhibitor & mk 2206 akt inhib. For adenocarcinoma. 70yrs..115lbs (lost 40)..8mth chemo..Radio..Gamma-11mth
diag?

These are brand new: The drugs that you have mentioned are new anticancer drugs which are still experimental, not fda approved for general use. Your doctor(oncologist) has to answer all your questions that you ask before signing up for receiving these drugs. There is not a lot known about them yet. But azd6244 has been tested and found to have some anticancer activity. But more can be found out from your oncologist. ...Read more

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0.6 cd4/cd8 ratio, 40% of T-cells are cd4, HIV/HTLV negative, no reason found. Is this idiopathic cd4 lymphocytopenia? Even if cd4 are 40% no lower?

0.6 cd4/cd8 ratio, 40% of T-cells are cd4, HIV/HTLV negative, no reason found. Is this idiopathic cd4 lymphocytopenia? Even if cd4 are 40% no lower?

LEUKOCYTOSIS: LEUKOCYTOSIS = elevated WBC. These labs associated with infection/leukemia /lymphoma and demand prompt evaluation You need an Exam/Labs/UAC&S and CXR to start. Also ct scan of chest/abd/pelvis .If no source is found then a hematology consult with bone marrow biopsy may be warranted. If BMB IS NEGATIVE IT MAY BE CLASSIFIED IDIOPATHIC AND BE CLOSELY MONITORED. ...Read more

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Which is more effective: Avastin (bevacizumab) or Erbitux?

Which is more effective: Avastin (bevacizumab)  or Erbitux?

Identical: Data on Bevacizumab or Erbitux in patients with metastatic colorectal cancer, patients who do not have a KRAS 12/13 gene mutation, have nearly identical survival rates. These identical results were seen after chemotherapy, where survival with chemo alone was about 5 months vs. 7-8 months using either bevacizumab (Avastin) or cetuximab (Erbitux). ...Read more

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Muscle Biopsy Results Meaning? rare chronic inflammatory cells, composed of CD3/CD8 positive T-lymphocytes and CD68 positive macrophages.

Muscle Biopsy Results Meaning? rare chronic inflammatory
cells, composed of CD3/CD8 positive T-lymphocytes and CD68 positive macrophages.

All lab test need ..: With data we need clinical context. That is why you are having trouble. There is not enough information to provide an interpretation. ...Read more

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Best institution for experimental protocol to add to nexavar (sorafenib) for metastatic HCC - 34 yo Asian male, s/p omental resection?

Best institution for experimental protocol to add to nexavar (sorafenib) for metastatic HCC - 34 yo Asian male, s/p omental resection?

Many: The top Cancer Centers are located in Houston(MD Anderson) and New York(Sloan Kettering Center. Tell us which state you live in, we might be able to help you find someone closer to your home ...Read more

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How effective is avastin (bevacizumab) as targeted therapy for the metastatic colorectal cancer?

How effective is avastin (bevacizumab) as targeted therapy for the metastatic colorectal cancer?

See below: It is not a curall for colon cancer but is effective therapy to a large extent it depends onthe size and wehre it is. Almost certianly it requires more than this drug to get a cure if acure is possible. ...Read more

Dr. Alvin Lin Dr. Lin
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What was the tnt cohort study about?

Dr. Alvin Lin Dr. Lin
1 doctor agreed:
What was the tnt cohort study about?

Lower LDL-C goal: Wow! that's a pretty deep/involved question. Treating to new targets (tnt) was announced/published in 2005. The idea was to see if more aggressive treatment of cholesterol (aiming for lower goals) would improve outcomes. Indeed it appears that aiming for goal LDL <70mg/dl leads to lower risk of cardiac events in stable heart disease. Read more at http://www.Theheart.Org/article/399675.Do. ...Read more