Doctor insights on:
Causes Of Upper Motor Neuron Lesion
Extensor respons: The presence of a Babinski sign suggests an upper motor neuron lesion, although in infants the presence of the dorsiflexion of the great toe with plantar stimulation can be normal. Simplifying, it's thought by some it may be related to the difference between the anatomical flexors behaving differently, more as extensors. Medicine Decoded has a reasonable explanation of this. ...Read more
Higher brain centers: Babies normally have babinski responses but lose it as they mature. The response remains deep in the brain and spinal cord but is suppressed by the higher brain centers. If the higher brain centers become damaged, these primitive responses return because they are no longer being suppressed. Hope this helps to simplify the prior excellent answer. ...Read more
Neurologist: The physical exam findings will be more difficult to see, but a neurologist will be able to examine the patient and might elect to do testing such as an EMG which tests the conduction of the nerves. ...Read more
What are the symptoms and signs of the upper motor neuron lesion (cortex, internal capsule, brainstem, spinal cord)?
Variable, but: Typical results of a stroke affecting brainstem and rostral structures, could see focal weakness over unilateral arm and leg, with possible problem with speech. Spinal cord smaller area and maybe both legs and less commonly unilateral arm and leg. ...Read more
Paralyzis and hyperalgesia in one limb initiated 2 weeks after scoliosis surgery. Sphincter incont Clonus. Spasticity. Upper motor neuron lesion? Why?
Postop complication: One has to worry about a delayed postoperative complication-significant!!!! Need to see operating surgeon. Potential causes would be hematoma (blood) compressing spinal cord or even a spinal cord lesion remote from operative site ...Read more
Paralyzis in one limb initiated 2 weeks post scoliosis surgery. Clonus spasms and dorsal back pain. Upper motor neuron lesion? Why? Mri and CT normal.
The upper motor neurons also called “Cortical Motor Neurons” are located in the motor cortex of the brain. The the spinal motor neurons are the lower motor neurons. Signs of UMN is a stiffness and resistance to movement. Signs of LMN damage include weakness, muscle atrophy.
Hope it helps. ...Read more
Unknown: In the etiology of this disease toxic substances (like heavy metals, specific chemicals) infectious e.g. Viral) genetic and environmental factors have been implicated but no definite theory exists. ...Read more
Maybe, if...: ... you're a lab rat being given huge doses. No evidence caffeine is "neurotoxic" in us. "Neurotoxicity" used as you are using it is like saying your car has "engine trouble": It's meaningless without a specific definition. Which nerves? We have a lot of different kinds. Timeline? Permanent or temporary? What is specific pathology? There are all kinds of qualifiers. ...Read more
Antipsychotics: Demyelinating disease is generally autoimmune in nature -- different from the effects of antipsychotic medications. In fact some research indicates that quetiapine may protect against demyelination. http://www. Plosone. Org/article/info%3adoi%2f10.1371%2fjournal. Pone.0042746 nevertheless, long-term use of some antipsychotic agents can affect neuronal function -- just differently. ...Read more
Depression is a: Descriptive term for a set of symptoms. Although drugs that boost certain neurotransmitters are often helpful, there is little if any evidence that depression is caused by any neurotransmitter deficiency. Genetics, life circumstances & negative thinking patterns contribute to depression, but a precise cause is unknown. ...Read more
Call her doctor: The physician who made the diagnosis (most likely a neurologist) is the best person to ask as he or she has examined her and I assume has done the proper testing required. ...Read more
If EBV virus invaded specific cells or neurons could this cause a severe autoimmune response to mistakenly attack those cells or neurons?
Correct assessment: Ebstein-barr virus is associated with infectious mononucleosis, can be associated with the acute immune polyneuritis, guillain-barre syndrome, and appears associated with adult ms in over 99% of all cases. So, clearly, can influence immune disorders both in peripheral and central nervous systems. ...Read more
Can the destruction of neurons nerve cells body cause chaos in the brain and body and affect chemical and electrical signals in the body?
Sometimes Yes: This question is vague and unclear, but with that said I can acknowledge that brain and body are electrical energy systems connected by miles of nerve fibers. There is much yet to be understood about the brain, but enough is known about spinal cord and brain dysfunction to know that a significant enough insult or damage to any one area can disrupt various other system processes. ...Read more
Morton's neuron. ..does it cause 1foot to swell and sharp pain in-between pinkie and toe next to pinkie toe?
Foot pain: Morton's neuroma generally develops between the 3-4 th or 4-5th toes, on the forum if the foot. A nerve ending swells and becomes painful with pressure. Ill fitting shoes may be a cause. Treatments can include injections, topical treatments, or surgery. See an orthopedist or podiatrist who will be happy to evaluate your problem and suggest treatments options, including how to prevent this as well ...Read more
Is it true that methylphenidate can cause changes in the brain like neurons structure after long term use (years)?
Not in monkeys: There is no data yet that convincingly show long-term problems with methylphenidate. In fact one study done in monkeys specifically showed no change in brain structure on pet scan. The ultimate study of course remains to be done on humans. I think that it's safe to say that the basic science research looks very good but the final studies in human beings still need to be carried out. So far however there was no signal that long-term structural changes are occurring. Hopefully will find this reassuring and helpful. Best wishes. ...Read more
Why can the EBV virus not be a possible cause for ALS? Especially if the virus could enter neurons and the immune system could attack those neurons.
EBV: Invades both motor and sensory neurons, while ALS is a disorder affecting only Alpha motor neurons. ...Read more
What are the causes for clonus hyperreflexia in both arms and legs. MRI shows no signs of MS or neuron impairment?
MRI only tells: .. part of the story. If you have myoclonus and hyper-reflexia, you must establish a strong relationship with a good neurologist in order to get diagnosed and treated as soon as possible. North of the equator, there are several devastating neurological disorders that cause these symptoms, multiple sclerosis being only one of them. Please get yourself diagnosed quickly. ...Read more
Multiple sources: Headaches can result from sinus pressure ; both sinusitis and changes in barometric pressure. Tension headaches can result from increased muscle tone. Nerves that run up the back of the head cause headaches (occipital nerves). Finally, the upper spine (cervical spine) has several sources of headache generators. ...Read more
Neurons transmit sig: Neurons transmits electric. They also process and transmit information between two cells. Or introduce synapses, the specialized sites where neurons send and receive information from other cells, They also allow groups of neurons to coordinate complex processes. Without neurons, central nervous system does not function. Schwann cells lay down myliene around it which protects it and helps in fas ...Read more
No cure.: There truly is no effective treatment, and often, the bulbar musculature is afflicted causing both swallowing and breathing issues, which promotes early demise. Main issue, in most cases, is the preservation cognitive function, allowing patient to witness the devastation and anticipate problems. (variant associated with front-temporal dementia may be less intense) bad disease. ...Read more
Gruesome: Patient needs assistance with nutrition due to inability to swallow, and chokes on secretions, so a peg feeding tube is placed. Cannot breathe so a tracheostomy is employed. Infections overwhelm the system, and diffuse weakness or even paralysis from the muscle atrophy is present. But most patients intact cognitively and appreciate the catastrophe. Rather horrendous situation. ...Read more
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