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Doctor insights on: Causes Of Progeria Disease

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Dr. Elizabeth Guardiani
44 Doctors shared insights

Progeria (Definition)

A rare hereditary condition affecting the blood vessels, skin and musculoskeletal system that creates the impression of accelerated aging. Some aging processes are truly accelerated such as atherosclerosis of the coronary and carotid arteries, resulting early death. Most of the other illnesses of aging such as cancer, cataracts, and dementia do not occur but deposition of a substance associated with aging, liposuction, in vital organs leads to impairment of the liver, heart, adrenal glands, brain and skeletal system. Another protein, progeria, leads to defective DNA expression and repair. This protein also enhances the development of atherosclerosis. Children with progeria have brittle bones, pathological fractures, feeding problems, dental abnormalities, hearing loss, growth failure, ...Read more


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How can progeria cause heart disease?

How can progeria cause heart disease?

Unknown...: Children with progeria are genetically predisposed to premature, progressive heart disease. Death occurs almost exclusively due to widespread heart disease. As with any person suffering from heart disease, the common events for progeria children are strokes, high blood pressure, angina, enlarged heart, and heart failure, all conditions associated with aging. ...Read more

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How exactly does progeria cause heart disease?

How exactly does progeria cause heart disease?

Abnormal metabolism: The accelerated aging syndrome known as progeria truly accelerates the patients aging and illness profile. Their metabolism is marked by the same abnormalities in cholesterol and fat metabolism in childhood as that seen in adult stroke and heart attack victims. Most succumb to complications of coronary heart disease as early as their teens. ...Read more

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What is the disease progeria caused by?

What is the disease progeria caused by?

Excellent website...: For an excellent website on progeria, visit the progeria research foundation at:
http://www. Progeriaresearch. Org/progeria_101.Html. ...Read more

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What is the genetic disorder progeria caused by? Is it a simple recessive trait?

What is the genetic disorder progeria caused by? Is it a simple recessive trait?

Two likely forms: Progeria syndrome is considered a sporadic (new mutation) phenomenon that has few prenatal indicators. At an average birth wt of 6lb (2.7kg), the relatively small size during gestation is not specific to this disorder. There are rare instances of siblings to normal parents, showing that an autosomal recessive form exists. Most begin to show signs by 6-18mo. ...Read more

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What disease is the opposite of progeria?

What disease is the opposite of progeria?

None yet: There are at least three people who showed slower aging than normal. One, Brooke, was evaluated and her DNA examined. The genes responsible for Progeria were unaffected in her and the cause of her poor growth was never found, Another, now over 40 years old and depicted here, is physically like a ten year old but has no language and so far has had no etiology found for his growth ...Read more

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Could you give me some information on the disease progeria?

Could you give me some information on the disease progeria?

Progeria: Progeria is a self limited process with most recorded cases appearing as new mutations in families that have other normal children. There are rare sibships reported indicating an autosomal recessive form exists. Most don't survive their teens. The oldest on record died at 27. Death is often due to advanced heart disease. ...Read more

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Where can I find a doctor who is knowledgeable on the diseases progeria or pica?

Where can I find a doctor who is knowledgeable on the diseases progeria or pica?

FINDING TOP PLAYERS: I would enter the problem and search with a second word such as: expert, article, book, specialist, best doctor and treatment.

You should see someone or more than one to choose from. You can call them and ask if they know anyone c;lose to you--typically mention the closest city.

Other smart physicians may have another approach, and I do not criticize them. ...Read more

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Diseases like parkinson's, progeria, alzheimer's, leukemia, aids, motor neurone disease etc. Is there hope for any sort of cure?

There is always hope: Lot of research is being done and hopefully something useful will be discovered. Progeria is least likely to be cured because it is a genetic disease. ...Read more

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What is the cause of progeria?

What is the cause of progeria?

Most new mutations: Progeria is a self limited process with most recorded cases appearing as new mutations in families that have other normal children. There are rare sibships reported indicating an autosomal recessive form exists. Most don't survive their teens. ...Read more

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What is progeria and what causes it?

What is progeria and what causes it?

Supportive care: This rare pattern of premature aging is caused by a random new genetic mutation. Assessment and confirmantion of any such DX by a geneticist is imperitive. Most work with a team of specialists who can monitor the DX specific healthrisks & provide guidence for your local source of care. They can also help you find support groups & other parents in the same situation. ...Read more

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How is progeria caused in the chromosomes?

New mutation of gene: There is no particular pattern like autosomal dominant, recessive or x-linked. It is new mutation go genes ...Read more

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What is the cause, symptoms, treatment of progeria?

What is the cause, symptoms, treatment of progeria?

Supportive care: This rare pattern of premature aging is caused by a random new genetic mutation. Assessment and confirmantion of any such DX by a geneticist is imperitive. Most work with a team of specialists who can monitor the DX specific healthrisks ; provide guidence for your local source of care. They can also help you find support groups ; other parents in the same situation. ...Read more

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Before scientists realized progeria was caused by a mutated gene, what explanation was given as the cause of progeria?

Still genetic: Even before the genetics of progeria were known, scientists/physicians still knew that it was a "genetic something", though couldn't prove what it was. ...Read more

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What is cause of the lack of hair in people with progeria?

Lamin A/C mutation: Different mutations within the lamin a/c gene cause different genetic disorders. Lamin a/c is needed to provide stability to the cell. With the particular mutation found in progeria, skin and hair (along with other systems) get damaged. Though I'm not sure, I suspect that rapid cell division makes skin and hair more likely to get damaged sooner from this particular lamin a/c mutation. ...Read more

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What is progeria?

What is progeria?

Supportive care: This rare pattern of premature aging is seldom seen by primary care providers. Assessment and confirmantion of any such DX by a geneticist is imperitive. Most work with a team of specialists who can monitor the DX specific healthrisks & provide guidence for your local source of care. They can also help you find support groups & other parents in the same situation. ...Read more

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Is there backwards progeria?

No: I think it would be great if we could reverse the clock to some degree, but unfortunately, brad pitt's benjamin button, is only fiction. ...Read more

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What are the tests for progeria?

What are the tests for progeria?

See below: The gene responsible for progeria has been identified (lamin a) in april 2003. A blood test can now be performed progeria is due to a point mutation in this gene. It is not usually passed down in families. The gene change is a chance, rare occurrence. ...Read more

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How can progeria be transmitted?

Most new mutations: Progeria is a self limited process with most recorded cases appearing as new mutations in families that have other normal children. There are rare sibships reported indicating an autosomal recessive form exists. Most don't survive their teens. ...Read more

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Waht is the prognosis of progeria?

Progeria: A genetic disease which leads to premature cell death, progeria has no known cure. The average life expectancy is around the early teens though a few patients have survived into their twenties. ...Read more