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Doctor insights on: Causes Of Porphyria

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Causes of hypergammaglobulinemia?

Causes of hypergammaglobulinemia?

Mono or Polyclonal: High levels of immunoglobulins (hypergammaglobulinemia) can be monoclonal (specific) - due to malignant proliferation of plasma cells or lymphocytes as in myeloma or waldenstrom's macroglobulinemia. Polyclonal (many types) hypergammaglobulinemia is a benign condition due to infection, inflammation causing non-specific gamma globulin production such as in hepatitis, immune and allergic disorders. ...Read more

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Dr. Aletha Tippett
93 doctors shared insights

Porphyria (Definition)

A group of rare hereditary conditions involving abnormal metabolism of heme. A common form, Porphyria cutanea tarda affects the skin, with blisters, itching and rash that are worse after sun exposure. In Acute Intermittent Porphyria, abdominal pain, muscle pain, numbness or tingling, seizures, and ...Read more


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What are causes and onsets of symptoms of huntington's disease?

What are causes and onsets of symptoms of huntington's disease?

Movement & Behavior: The cause of huntington's disease is a genetic mutation on chromosome 4. Major symptoms are changes in behavior, e.g., hallucinations, irritability, moodiness and psychosis, and abnormal movements including extra facial and limb movements and loss of coordination, dementia, and eventually impairments of speech and swallowing. More information: huntington's disease society of america: www.Hdsa.Or. ...Read more

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Causes of aniocytosis?

Causes of aniocytosis?

Anisocytosis, having: Red blood cells (rbc's) of different sizes, can be caused by iron deficiency & sickle cell anemias, folate (folic acid) or vitamin B12 deficiency, autoimmune hemolytic anemia, cytotoxic chemotherapy, chronic liver disease, myelodysplastic syndrome, thalassemia major, & thalassemia intermedia. The unequal-sized rbc's are small in some of these disorders & large in others. ...Read more

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Causes of chrons disease?

Causes of chrons disease?

Not known yet: The cause seems to be a combination of genetics (different immune defects) and environmental triggers. The subtypes of crohn's disease may also have different immune defects, and for this reason people may respond differently to treatments. Though much more is known now about cd, we still don't know the cause. But stress and some foods can make it worse. Decreasing stressors can help a lot. ...Read more

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What are the causes of alcoholism?

What are the causes of alcoholism?

Alcoholism: It's an incredibly complex combination of genetic and environmental factors that are poorly understood. Alcoholism can run quite strongly, suggesting a genetic component, but also, the environment plays heavily into the clinical picture, i.e., how much one is around alcohol. Proponents of Alcoholics Anonymous believe that alcoholism is a spiritual problem, or one of characterological defect. ...Read more

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What are the pathophysiology of anaemia of chronic diseases?

What are the pathophysiology of anaemia of chronic diseases?

Anemia: Really need provide more info concerning age, other conditions- diabetes, heart disease, . The. Most common i encounter are patients with chronic kidney disease. As kidney function decreases, signals to none marrow to produce blood decreased. Kidneys also controll blood pressues, etc. Generally, the body adapts to this type of anemia, treatment only when treatment needed. Other diseases. Space limi. ...Read more

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What causes episodes of pancreatitis?

What causes episodes of pancreatitis?

Several things: Alcoholism and gall stones are the most commonly known causes of pancreatitis. High triglycerides can cause it as well, though most causes are referred to as idiopathic. That is, of unknown origin. ...Read more

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What are the causes of symptoms in pernicious anemia?

What are the causes of symptoms in pernicious anemia?

Lack of vitamin B12: Pernicious anemia is due to a lack of vitamin b12. B12 is necessary for the normal function of the nervous system and the formation of red blood cells. ...Read more

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What are the causes of asbestosis symptoms?

What are the causes of asbestosis symptoms?

Variety: Asbestosis is scarring of the airspaces of the lungs and thickening of the walls between them (also known as the interstitium). This in turn causes shortness of breath, low oxygen levels and chronic cough. Asbestosis is from prior exposure to asbestos. ...Read more

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Causes of myoclonus?

Causes of myoclonus?

It is a condition: Myoclunus just means jumping or jerking limbs. Usually it is the legs but can be any muscle. At night it may wake you up causing daytime fatigue. It can occur by itself or be part of a number of conditions where nerves in the head are not communicating with the nerves in the spine such as ms, head injury or pinched spinal nerves. Have a neurologist evaluate. ...Read more

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What are the causes of digestive diseases?

What are the causes of digestive diseases?

Multiple: Evrybody has at one time experienced a GI illness--heartburn is very common, as is diarrhea, constipation, gastroenteritis, etc. Most of these are not serious, self-limiting, and usually get better by themselves. Likewise, serious GI illnesses are also quite common, as your gut is about 25 feet long from mouth to anus, and exposed to a variety of environmental insults every day! ...Read more

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What are causes of encephalopathy in liver diseases?

What are causes of encephalopathy in liver diseases?

Ammonia: Ammonia is the waste product that is normally utilized by a healthy liver. When the liver is sick, it will not process ammonia and it will poison the brain. ...Read more

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What are the causes of chronic constipation?

What are the causes of chronic constipation?

In most : Cases is it is not enough fiber, not enough fluids and excess caffeine and alcohol. Also some medications contribute to constipation and thus your fluid intake needs modification to offset the constipating effects of the meds. There also may be some pathology in your bowel that has yet to be properly evaluated. See a GI doctor or colorectal surgeon if the above measures dont help after 2 weeks. ...Read more

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Causes of microcephaly?

Causes of microcephaly?

Varied: There are literally hundreds of things that can cause this including various syndromes, prenatal infections and lack of oxygen during birth just to name a few of the more common causes. ...Read more

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What are the main causes of cotard's syndrome?

What are the main causes of cotard's syndrome?

Hypothesis: This syndrome is also called "walking dead" because those suffering from it deny they exist; or sometimes that parts of their body are real.Cause is believed to be malfunction in 2 parts of the brain: fusiform gyrus (recognizes faces) & amygdala (processes your emotions. When these 2 areas go haywire and a person cannot recognize what should be familiar faces, holding on to reality is tough. ...Read more

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What are the causes of tay-sachs disease?

What are the causes of tay-sachs disease?

Birth defect: Tay sachs disease is caused by a chromosomal abnormality and would be because both parents passed the gene (autosomal recessive) and is seen in 1:3000 babies seen in ashkenazi jewish population. ...Read more

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What are the causes of a autoimmune disease?

What are the causes of a autoimmune disease?

Genetics and enviro: It is a combination of genetics and the right enviromental triggers. We do not know all these triggers yet, but some people may the genes, but never have them turned on despite being exposed to a trigger. Hope that helps. ...Read more

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What are the causes of raynauds syndrome?

What are the causes of raynauds syndrome?

Usually cold: Raynauds involves cold or stress induced vasospasm of small vessels in hands and feet. It is really more of an annoyance than a harmful problem. Calcium channel blockers are the most common medication that physicians use to treat the symptoms of raynauds. The main drawback is the side effects from these medicines. Keeping your hands and feet warm remains the best treatment. ...Read more

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What types of cancer can alcoholism cause?

What types of cancer can alcoholism cause?

Many: Alcohol abuse is associated with liver, mouth, throat, esophagus, and stomach cancers. It is likely one of the most significant cancer risk factors, second only to tobacco. Even moderate alcohol use is linked to an increased risk of breast and colon cancer. For more info: http://www.Cancer.Org/acs/groups/content/@healthpromotions/documents/document/acsq-017622.Pdf. ...Read more

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What are common causes of cardiomyopathy?

What are common causes of cardiomyopathy?

Several: One of the most common causes of cardiomyopathy (cm) is atherosclerosis.By blocking or impairing blood flow the heart muscle suffers. Heart attacks can cause permanent scarring and fibrosis. Other causes can be viral or physiologic conditions like pregnancy (peripartum cm).Toxins like excessive alcohol can cause CM (usually reversible if caught early) or chemotherapy agents.Some causes are unknown. ...Read more

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What cause a porphyria attack?

What cause a porphyria attack?

Porphyria results…: From lack of an enzyme in the path for making heme, the oxygen-carrying part of blood. There are many triggers for attacks:alcohol; smoking; drugs (barbiturates, sulfa antibiotics) phenytoin; progesterone; sun exposure; increased iron intake; chronic viral illness (hcv, hiv); stress (illness, emotional/ psycho-logical, physical); dieting/fasting. http://www.porphyriafoundation.com/ for more info. ...Read more

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What is porphyria? What are the specific problems caused by porphyria?

What is porphyria? What are the specific problems caused by porphyria?

A rare disease: Porphyria is a very rare disease due to a problem is the production of porphoryin which become part of the hem molecule that eventually gets placedinto the hemoglobin to make red blood cells. The disease can cause skin problem abdominalmpain and other problems. ...Read more

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What can cause porphyria victims to crave blood?

What can cause porphyria victims to crave blood?

Old legend: There's an idea, probably ill-founded, that congenital erythropoietic porphyria, which produces hairiness, a mutilated face, red teeth, and pain on going into sunlight is the origin of vampire / werewolf tales. The tale that these people crave blood (this isn't a classic feature) may have been added as the story grew, though heme is one factor that suppresses some forms of the illness. ...Read more

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Can porphyria cause high bilirubin?

Can porphyria cause high bilirubin?

Might occur: Some variants of porphyria can affect the liver and cause abnormal liver testing. You can get answers by analyzing your urinary and serum porphyrin levels, and this could allow interventional approaches to bring under full control. ...Read more

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Can porphyria cause high urinary copper?

Can porphyria cause high urinary copper?

No, it does not: However, there are several copper metabolism issues that can occur, including Wilson's disease, and a serum ceruloplasmin level can objectify some of the concerns. ...Read more

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Can acute porphyria cause problems with fine motor skills?

Can acute porphyria cause problems with fine motor skills?

Acute porphyria: Muscle weakness can be a symptom can comes with exacerbation of acute intermittent porphyria. Fine motor skill difficulties alone is unlikely to be the result of acute porphyria. See your PCP for any concerns about fine motor skills. Here is info on acute intermittent porphyria. http://www.porphyriafoundation.com/about-porphyria/types-of-porphyria/AIP ...Read more

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Does porphyria cause joint pain?

Does porphyria cause joint pain?

Not typically: There are small vessel obstruction so i would expect the pain to be areas and not joints. ...Read more

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Can acute intermittent porphyria cause mental illness or psychosis?

Can acute intermittent porphyria cause mental illness or psychosis?

Short answer- YES: The diagnosis of AIP should always be in the differential diagnosis of a person who becomes psychotic& who fits a certain clinical profile which usually includes vague GI symptoms and abdominal pain unexplained neuropathy, and other characteristic symptoms. Feel free to write me more questions on this topic and I'll be happy to answer: www.healthtap.com/drsaghafi ...Read more

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In regards to acute intermittent porphyria, what causes abdominal pain?

In regards to acute intermittent porphyria, what causes abdominal pain?

Great question: AIP causes an axonal neuropathy which starts in proximal arms but spreads throughout limbs, and likely throughout the body. During the cramping attacks, there is an increase in delta-aminolevulinic acid and porphobiilnogen which likely stimulates abnormal nerve activity within the gut. ...Read more

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Why does acute intermittent porphyria (aip) sometimes cause abdominal pain?

Why does acute intermittent porphyria (aip) sometimes cause abdominal pain?

AIP attacks: Summarized in the following link: https://www.isitaip.com/patient/common-symptoms-of-aip?gclid=CjwKEAjwse7JBRCJ576SqoD7lCkSJABF-bKuavsrIeqpmL2IbvtWeLN7qn1yRJPDCXD3KZWVAwA98xoC-Jfw_wcB

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What's porphyria?

What's  porphyria?

Disease family: Maybe 1 person in 1000 is born with a strong tendency to porphyria cutanea tarda and some forms of hepatitis can bring it out even in a normal person; it blisters and scars sun-exposed skin. Other porphyrias masquerade as abdominal pain, mental illness, constipation, low sodium, and chronic nerve pain -- and screening tests are often done wrong. Good luck. ...Read more

Dr. K. Olson Dr. Olson
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How does one get porphyria?

Dr. K. Olson Dr. Olson
5 doctors agreed:
How does one get porphyria?

Inherited: Typically inherited problem in the breakdown of red blood cells, in particular heme. The abdominal pain and crises can be set off by medications, alcohol, or low calorie diets. Medications that cause include but are not limited to barbiturates, anticonvulsants, estrogens, oral contraceptives, or even supplements (chromium for example). ...Read more

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Can men have acute porphyria?

Can men have acute porphyria?

Yes: Both men and women can have acute porphyria. However, attacks are more common in women because of hormonal changes that occur during the menstrual cycle. ...Read more

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Can porphyria improve with age?

Can porphyria improve with age?

With treatment: Since most forms of porphyria are inherited there is not a cure for them. Depending on the type, treatment can relieve symptoms and improve quality of life. Acquired porphyria can improve with removal of the triggering causes. ...Read more

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Is porphyria progressive or lethal?

It can be: There are many forms of porphyria, some of which are rather mild and inconsequential, others of which are progressive and possibly lethal. If you suspect that you have porphyria, then you need to see your doc right away for diagnosis and treatment. ...Read more

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What is the prognosis of porphyria?

What is the prognosis of porphyria?

Very challenging: Porphyrias are life-long diseases with symptoms that come and go. Some forms of the disease cause more symptoms than others. Proper treatment and avoidance of triggers can help prolong the time between attacks. But attacks are quite painful and can be fatal. Life is a real struggle for someone with porphyria but it is possible to even do great things - some historical figures have suffered it. ...Read more

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What are the symptoms of porphyria?

What are the symptoms of porphyria?

See below: Porphyrias involve three major symptoms: •abdominal pain or cramping (only in some forms of the disease) •light sensitivity causing rashes, blistering, and scarring of the skin (photodermatitis) •problems with the nervous system and muscles (seizures, mental disturbances, nerve damage). ...Read more

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What precipitates a porphyria attack?

What precipitates a porphyria attack?

Depends on the type: There are 8 different kinds of porphyria. Depending on the type of porphyria, an attack can be precipitated by sunlight exposure, alcohol, inadequate diet, carbohydrate restriction, certain drugs or chemicals, hormonal changes & stress. Often a combination of triggers can precipate an attack. For more info, see the porphyria foundation's website: http://www.Porphyriafoundation.Com/about-porphyria. ...Read more

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