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Doctor insights on: Causes Of Porphyria

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What cause a porphyria attack?

What cause a porphyria attack?

Porphyria results…: From lack of an enzyme in the path for making heme, the oxygen-carrying part of blood. There are many triggers for attacks:alcohol; smoking; drugs (barbiturates, sulfa antibiotics) phenytoin; progesterone; sun exposure; increased iron intake; chronic viral illness (hcv, hiv); stress (illness, emotional/ psycho-logical, physical); dieting/fasting. http://www.porphyriafoundation.com/ for more info. ...Read more

Dr. Aletha Tippett
89 doctors shared insights

Porphyria (Definition)

The porphyrias are metabolic disorders caused by abnormalities in the synthesis of heme, the portion of hemoglobin which carries the iron inside red blood cells. The manifestations of porphyria vary considerably depending on the mutation involved, ranging from light sensitivity to liver failure to nerve damage to bouts of terrible pain. Special testing is required to ...Read more


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What is porphyria? What are the specific problems caused by porphyria?

What is porphyria? What are the specific problems caused by porphyria?

A rare disease: Porphyria is a very rare disease due to a problem is the production of porphoryin which become part of the hem molecule that eventually gets placedinto the hemoglobin to make red blood cells. The disease can cause skin problem abdominalmpain and other problems. ...Read more

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What can cause porphyria victims to crave blood?

What can cause porphyria victims to crave blood?

Old legend: There's an idea, probably ill-founded, that congenital erythropoietic porphyria, which produces hairiness, a mutilated face, red teeth, and pain on going into sunlight is the origin of vampire / werewolf tales. The tale that these people crave blood (this isn't a classic feature) may have been added as the story grew, though heme is one factor that suppresses some forms of the illness. ...Read more

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Can porphyria cause high bilirubin?

Can porphyria cause high bilirubin?

Might occur: Some variants of porphyria can affect the liver and cause abnormal liver testing. You can get answers by analyzing your urinary and serum porphyrin levels, and this could allow interventional approaches to bring under full control. ...Read more

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Can porphyria cause high urinary copper?

Can porphyria cause high urinary copper?

No, it does not: However, there are several copper metabolism issues that can occur, including Wilson's disease, and a serum ceruloplasmin level can objectify some of the concerns. ...Read more

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Can acute porphyria cause problems with fine motor skills?

Can acute porphyria cause problems with fine motor skills?

Acute porphyria: Muscle weakness can be a symptom can comes with exacerbation of acute intermittent porphyria. Fine motor skill difficulties alone is unlikely to be the result of acute porphyria. See your PCP for any concerns about fine motor skills. Here is info on acute intermittent porphyria. http://www.porphyriafoundation.com/about-porphyria/types-of-porphyria/AIP ...Read more

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Does porphyria cause joint pain?

Does porphyria cause joint pain?

Not typically: There are small vessel obstruction so i would expect the pain to be areas and not joints. ...Read more

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Can acute intermittent porphyria cause mental illness or psychosis?

Can acute intermittent porphyria cause mental illness or psychosis?

Short answer- YES: The diagnosis of AIP should always be in the differential diagnosis of a person who becomes psychotic& who fits a certain clinical profile which usually includes vague GI symptoms and abdominal pain unexplained neuropathy, and other characteristic symptoms. Feel free to write me more questions on this topic and I'll be happy to answer: www.healthtap.com/drsaghafi ...Read more

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In regards to acute intermittent porphyria, what causes abdominal pain?

In regards to acute intermittent porphyria, what causes abdominal pain?

Great question: AIP causes an axonal neuropathy which starts in proximal arms but spreads throughout limbs, and likely throughout the body. During the cramping attacks, there is an increase in delta-aminolevulinic acid and porphobiilnogen which likely stimulates abnormal nerve activity within the gut. ...Read more

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What's porphyria?

What's  porphyria?

Disease family: Maybe 1 person in 1000 is born with a strong tendency to porphyria cutanea tarda and some forms of hepatitis can bring it out even in a normal person; it blisters and scars sun-exposed skin. Other porphyrias masquerade as abdominal pain, mental illness, constipation, low sodium, and chronic nerve pain -- and screening tests are often done wrong. Good luck. ...Read more