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Doctor insights on: Causes Of Polyclonal Gammopathy

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What would cause constant recurring goosebumps in left leg for no reason?. Have neuropathy as well. Normal brain MRI but have polyclonal gammopathy.

What would cause constant recurring goosebumps in left leg for no reason?. Have neuropathy as well. Normal brain MRI but have polyclonal gammopathy.

Neuropathy: Goosebumps are caused by stimulation of the autonomic system - which innervate the small muscles attached to each hair. Anything that causes an adrenaline rush or other activation of your sympathetic nerves (such as fear, or cold) will cause goose bumps (also known as "pilo erection"). It's also possible this is caused by a condition called autonomic hyperreflexia. Talk with your neurologist. ...Read more

Dr. Michael Kleerekoper
31 doctors shared insights

Gammopathy (Definition)

A gammopathy is an abnormal gammaglobulin or gammaglobulin level. A monoclonal gammopathy is a single abnormal protein that can indicate a bone marrow cancer called multiple myeloma, or a lymphoma. Further evaluation is required to determine if a monoclonal gammopathy ...Read more


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What is mild polyclonal gammopathy that's what the dr said I have but I haven't seen him yet?

What is mild polyclonal gammopathy that's what the dr said I have but I haven't seen him yet?

Means little alone: You have more antibodies on board than most people. Maybe you're just getting over an illness, or it's your celiac disease, or it's just you. This is meaningful only as part of a workup for other illness. ...Read more

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I have for 3 years high rcp and esr and polyclonal gammopathy. Why? Should I investigate with my family Dr?

I have for 3 years high rcp and esr and polyclonal gammopathy. Why? Should I investigate with my family Dr?

Yes: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, All of the test results suggest chronic inflammation and it should be investigated. ...Read more

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I was diagnosed with RA a couple years ago. Just did ife and pe serum and it is suggested an apparent polyclonal gammopathy. What is that?

I was diagnosed with RA a couple years ago. Just did ife and pe serum and it is suggested an apparent polyclonal gammopathy. What is that?

Active immune system: The part of blood that contains antibodies is gamma globulin. Polyclonal refers to the fact that many different antibodies are present. The increase in quantity reflects a broadly activated immune system cranking out lots of antibodies. This is common in autoimmune disease and is not a concern. ...Read more

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How does having polyclonal gammopathy correlate with lupus- I have lupus and polyclonal gammopathy does having this mean you have a more severe form of lupus, they did an spep be4 lupus and i had that?

Polyclonal gamma pat: Polyclonal gammoparhy is seen frequently in chronic inflammation/ autoimmune disorder etc. Lupus is certainly one of the condition that causes/ associated with polyclonal gammopathy . The presence of polyclonal gammopathy does not tell you whether the lupus will be more severe or less severe . Discuss with your rheumatologist further. ...Read more

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In protein's electrophoresis Is polyclonal gammopathy alway pathological? Thanks

Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, What is total gamma globulin level? If it is more than 2.0 gm/dL it needs to be evaluated. There are many causes of polyclonal gammopathy., and some of those are serious. ...Read more

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What does elevated Igg-2364 and gamma globulin 2.2 mean with polyclonal gammopathy and Kappa and lambda typing increased?

Nothing serious: Polyclonal gammopathy does not have the seriousness of monoclonal gammpathy. Firstly your IgG and total globulin levels are only mildly elevated, so It may not mean any disease. One cause is chronic inflammation(infections) such as Chronic arthritis or chronic liver disease, conditions which can be checked out or ruled out easily if you ask your doctor and seek his/her advice about it. ...Read more

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What is a polyclonal gammopathy? Dr did protein serum test, a2, beta, gamma and crp is high. High wbc anc is also high, with tear drop cells 25%

What is a polyclonal gammopathy? Dr did protein serum test, a2, beta, gamma and crp is high. High wbc anc is also high, with tear drop cells 25%

Go to your doctor: you need to have a hematologist review the results. If your doctor ordered these tests, they should review the results with you . ...Read more

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Been diagnosed with peripheral neuropathy blood test showed high immunoglobulin m w/polyclonal gammopathy. Kappa/lambda increase. Possible meaning?

Been diagnosed with peripheral neuropathy   blood test showed high immunoglobulin m w/polyclonal gammopathy. Kappa/lambda increase. Possible meaning?

PlasmaCellDIsorder: May have plasma cell disorder/multiple myeloma. Plasma cells are a type of white blood cells that produces immunoglobulin(antibodies). Multiple myeloma is a cancerous or excessive proliferation of these plasma cells which may lead to excessive high levels of calcium/bone pain/renal failure/anemia (low blood counts). Need to see hematologist (blood doctor specialist). ...Read more

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What can cause monoclonal gammopathy?

What can cause monoclonal gammopathy?

Mayo Clinic say: Plasma cells are a type of white blood cell. They are found in your bone marrow. Plasma cells produce some of the antibodies that help your body fight infection. Monoclonal gammopathy of undetermined significance occurs when plasma cells in your bone marrow produce an abnormal protein called monoclonal protein (m protein). ...Read more

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What are possible causes of highly elevated ImM levels with low ImG levels with no monoclonal gammopathy present?

May not be a problem: This may depend on your genetic background and not be a medical problem. We would need an explanation of your problems, blurred vision, night sweats. Why are you on opiates ...Read more

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Can monoclonal gammopathy cause osteomyelitis?

Can monoclonal gammopathy cause osteomyelitis?

Not realy: It's estimated that between 10 and 25 percent of people with monoclonal gammopathy of undetermined significance develop a more serious condition, such as multiple myeloma or other cancers or blood disorders. Other complications include fractures and blood clots. ...Read more