Doctor insights on:
Causes Of Polyclonal Gammopathy
What would cause constant recurring goosebumps in left leg for no reason?. Have neuropathy as well. Normal brain MRI but have polyclonal gammopathy.
Neuropathy: Goosebumps are caused by stimulation of the autonomic system - which innervate the small muscles attached to each hair. Anything that causes an adrenaline rush or other activation of your sympathetic nerves (such as fear, or cold) will cause goose bumps (also known as "pilo erection"). It's also possible this is caused by a condition called autonomic hyperreflexia. Talk with your neurologist. ...Read more
A gammopathy is an abnormal gammaglobulin or gammaglobulin level. A monoclonal gammopathy is a single abnormal protein that can indicate a bone marrow cancer called multiple myeloma, or a lymphoma. Further evaluation is required to determine if a monoclonal gammopathy ...Read more
I have for 3 years high rcp and esr and polyclonal gammopathy. Why? Should I investigate with my family Dr?
I was diagnosed with RA a couple years ago. Just did ife and pe serum and it is suggested an apparent polyclonal gammopathy. What is that?
Active immune system: The part of blood that contains antibodies is gamma globulin. Polyclonal refers to the fact that many different antibodies are present. The increase in quantity reflects a broadly activated immune system cranking out lots of antibodies. This is common in autoimmune disease and is not a concern. ...Read more
How does having polyclonal gammopathy correlate with lupus- I have lupus and polyclonal gammopathy does having this mean you have a more severe form of lupus, they did an spep be4 lupus and i had that?
Polyclonal gamma pat: Polyclonal gammoparhy is seen frequently in chronic inflammation/ autoimmune disorder etc. Lupus is certainly one of the condition that causes/ associated with polyclonal gammopathy . The presence of polyclonal gammopathy does not tell you whether the lupus will be more severe or less severe . Discuss with your rheumatologist further. ...Read more
Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, What is total gamma globulin level? If it is more than 2.0 gm/dL it needs to be evaluated. There are many causes of polyclonal gammopathy., and some of those are serious. ...Read more
What does elevated Igg-2364 and gamma globulin 2.2 mean with polyclonal gammopathy and Kappa and lambda typing increased?
Nothing serious: Polyclonal gammopathy does not have the seriousness of monoclonal gammpathy. Firstly your IgG and total globulin levels are only mildly elevated, so It may not mean any disease. One cause is chronic inflammation(infections) such as Chronic arthritis or chronic liver disease, conditions which can be checked out or ruled out easily if you ask your doctor and seek his/her advice about it. ...Read more
Can you explain what this might mean: "apparent polyclonal gammopathy: igm. Kappa and lambda increased". Immunoglobulin m is also high at 437.?
Monoclonal processes: Are often malignant or pre malignant. Polyclonal processes are usually reactive/infectious/inflammatory. ...Read more
What is a polyclonal gammopathy? Dr did protein serum test, a2, beta, gamma and crp is high. High wbc anc is also high, with tear drop cells 25%
Go to your doctor: you need to have a hematologist review the results. If your doctor ordered these tests, they should review the results with you . ...Read more
Slightly elevated beta fraction from serum protein electrophoresis. Beta 1.07 (high) (0.52-0.98) increased beta fraction, no monoclonal or polyclonal gammopathy seen. Immunofixation normal.
This report is of no: These values are of no particular concern. This test is mainly useful to check for monoclonal peaks...Which you do not have. ...Read more
Been diagnosed with peripheral neuropathy blood test showed high immunoglobulin m w/polyclonal gammopathy. Kappa/lambda increase. Possible meaning?
PlasmaCellDIsorder: May have plasma cell disorder/multiple myeloma. Plasma cells are a type of white blood cells that produces immunoglobulin(antibodies). Multiple myeloma is a cancerous or excessive proliferation of these plasma cells which may lead to excessive high levels of calcium/bone pain/renal failure/anemia (low blood counts). Need to see hematologist (blood doctor specialist). ...Read more
Mayo Clinic say: Plasma cells are a type of white blood cell. They are found in your bone marrow. Plasma cells produce some of the antibodies that help your body fight infection. Monoclonal gammopathy of undetermined significance occurs when plasma cells in your bone marrow produce an abnormal protein called monoclonal protein (m protein). ...Read more
What are possible causes of highly elevated ImM levels with low ImG levels with no monoclonal gammopathy present?
May not be a problem: This may depend on your genetic background and not be a medical problem. We would need an explanation of your problems, blurred vision, night sweats. Why are you on opiates ...Read more
I understand that monoclonal gammopathy can cause a high CRP. As a matter of interest, does it typically elevate the WBC as well?
Neither: Neither an elevated CRP nor elevated WBC are part of the pathology in uncomplicated monoclonal gammopathy. ...Read more
Blood urine and bone:
Blood tests. A serum protein electrophoresis.
Urine tests. Urine tests may be performed to determine if the abnormal protein is being released in the urine or to diagnose any kidney damage as a result of the protein.
Bone marrow tests. A bone marrow biopsy may be completed to determine the severity of the problem. ...Read more
According to mayo clinic were the diease was discovered.No treatment is required for people diagnosed with monoclonal gammopathy of undetermined significance (mgus).
About 20 percent of people with mgus develop a more serious condition, such as multiple myeloma or other cancers or blood disorders. Therefore, careful observation and follow-up are important. ...Read more
Immoglobulin finding: If a person has an unusually large number of antibodies, but not a single one in great excess, we speak of a polyclonal gammopathy; it's never a specific finding. An abundance of a single antibody is a monoclonal antibody "spike" that is quite common but may indicate or precede (often by decades) plasma cell "multiple" myeloma. ...Read more
See below: A gammopathy is an abnormal gammaglobulin or gammaglobulin level. A monoclonal gammopathy is a single abnormal protein that can indicate a bone marrow cancer called multiple myeloma, or a lymphoma. Further evaluation is required to determine if a monoclonal gammopathy represents a serious disease. ...Read more
MGUS: Is a common precancerous condition affecting people 50 years of age and older. It was first described by mayo clinic researchers in 1978 and is characterized by the presence of an abnormal protein in the blood called a (monoclonal) protein or m protein.Mgus has a small risk (1 percent each year) of progressing to a blood cancer called multiple myeloma or a related condition. ...Read more
Nope: You don't treat an mgus, it is a condition that can ultimately lead to multiple myeloma (risk is about 1% per year) but as of itself does not need therapy (assuming it was correctly diagnosed). You need to have labs checked at least 1 or 2 times a year so you should follow up with your doc indefinitely. ...Read more
A monoclonal: Gammopathy is an elevation in a specific type of immune protein in the blood. The work-up includes tests of urine protein, bones and blood production. If no serious associated disease is found then the clinical finding is called mgus. The patient is followed over time to see if the gammopathy becomes "significant." some patients declare themselves later with multiple myemoma or lymphoma. ...Read more
Blood & urine tests: Mgus is the presence of an abnormal protrein in the blood made by a type of white blood cell called a plasmacyte. In most cases, it is at a low level and is something that just has to be followed. However, it can be the precursor of the disease called multiple myeloma and as such a hematologist or medical oncologist will order tests to rule this out which may include blood, urine and simple x-rays. ...Read more
My IgM level went from normal to very low. Down to 28. What is going on? I am being followed for biclonal gammopathy. Should I worry
Keep Following: There are a number of variables which could be contributing to this and for the sake of brevity (i'm only allowed a 400 letter answer) i suggest that you keep your appointments with your specialist. ...Read more
It is a medical diso: A medical disorder where your body is making excess of proteins(Gamma Globulins). It can manifest in 2-3 different ways(MGUS or Multiple Myeloma). So you need your doctor to explain which of these conditions do you have and theen get further testing, monitoring and you may or may not need treatment depending on whether it is mGUS(early) or Myeloma(later developemnt...that is a type of Blood Cancer ...Read more
How reliable are blood tests that look for monoclonal gammopathy in elevated ImM levels ? Are false negatives possible?
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