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Doctor insights on: Causes Of Pleomorphic Adenoma

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Hi. I need help. Will you please tell me or explain to me the pathophysiology of pleomorphic adenoma? Thanks

Hi. I need help. Will you please tell me or explain to me the pathophysiology of pleomorphic adenoma? Thanks

Little to it: The anatomic pathology of pleomorphic adenoma is amazingly complex, and we are learning a bit about its molecular biology. The lesions are benign but locally destructive, especially endangering the facial nerve if in the parotid. Wide excision is required as the lesion sends out projections. Around 1% is the site of origin for a real cancer. ...Read more

Pleomorphic (Definition)

We use the term pleomorphic often in pathology; it literally means "many shapes". Pleomorphic cells in a tumor may tell of the genetic instability that's central to cancer, but the benign pleomorphic adenoma of the salivary glands merely has many different tissue types. The ...Read more


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I ve 1.8cm *1.3cm pleomorphic adenoma on superficial lobe of patotid gland. Scared to do surgery. Possible complications of surgery? Postoperative care?

I ve 1.8cm *1.3cm pleomorphic adenoma on superficial lobe of patotid gland. Scared to do surgery. Possible complications of surgery? Postoperative care?

Surgery mandatory: The benign tumor will just get bigger and bigger and the risks of nerve damage will be higher. Procedure safe with an experienced surgeon.
Recommend Jeffrey Spiro, M.D., Professor, Department of Surgery. U Conn Medical Center, Framingham CT
860-679-2804 ...Read more

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I ve pleomorphic adenoma in parotid gland. Dr performed fnac. Does fnac spread tumor cells. Scared. Size is 1.5cm. Entire gland needs removal?

Spread not likely: Pleomorphic adenoma is benign and there is minimal risk of spread with a fine needle aspirate. Removal is warranted as the lesion can become larger. ...Read more

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If you had a benign pleomorphic adenoma in a minor salivary gland for approx 5 years would you have it surgically removed?

If you had a benign pleomorphic adenoma in a minor salivary gland for approx 5 years would you have it surgically removed?

Yes: These lesions can grow and can undergo malignant transformation. I almost always rec excision. Find an ENT doctor who does frequent parotidectomies with facial nerve dissections. ...Read more

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Could my son get cancer if he was diagnosed with pleomorphic adenoma, 3 tumors in the neck and 1 in cheek?

Rarely: Pleiomorphic adenomas are benign tumors of saliva glands. It is unusual for them to be in the neck itself, but they can arise "rests" of salivary tissue in the neck. They tend not to spread to other parts of the body but can grow back in the areas where they arose in about 20% of patients who had surgery. Rarely they can turn cancerous and spread to other organs. Best wishes. ...Read more

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My son was diagnosed with pleomorphic adenoma, 3 tumors in the neck and 1 in cheek. Could this become cancer?

Pleomorphic adenomas: These salivary gland tumors are usually benign. If the tumor is of the mixed type it could become cancerous ...Read more

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My mum was diagnosed with pleomorphic parotid adenoma and she has a heart condition. Is an operation really necessary? My mum is 79

My mum was diagnosed with pleomorphic parotid adenoma and she has a heart condition. Is an operation really necessary? My mum is 79

An operation: Is generally necessary. Ask your doctor whether or not her medical risks outweigh benefits of surgery, because a lot depends on the severity of her heart condition. ...Read more

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What do you suggest if my son was diagnosed with pleomorphic adenoma, 3 tumors in the neck and 1 in cheek. Can this turn into cancer?

What do you suggest if my son was diagnosed with pleomorphic adenoma, 3 tumors in the neck and 1 in cheek. Can this turn into cancer?

Early ENTinvolvement: Close follow-up with the ENT, surgical resection is required. Yes, these have a high rate of malignant transformation. ...Read more

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I have had surgery twice of the parotid gland (pleomorphic adenoma). Now from last 1 month my intra parotid lymph nodes are swollen, why?

Many possible reason: If you are certain this is an intraparotid lymph node (as opposed to a nodule of recurrence of pleomorphic adenoma), there could be many possible causes ranging from some infection, to inflammatory diseases either specific to the parotid or more general, to some other tumor. The person who did your most recent parotid surgery is probably in the best position to answer this question. ...Read more

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Will hole in roof of mouth to sinus area from pleomorphic adenoma removal heal closed or will I require another surgery?

Need more info: If the adenoma was removed recently and the hole is small, I would say that healing by secondary intention could occur. However, without knowing more about your case, I cannot say more except that you need to ask your surgeon that question. ...Read more

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Few days ago I have left parotid pleomorphic adenoma Specimen Type left superfacial parotid gland but after surgery I have salivary leakage probl?

Few days ago I have left parotid pleomorphic adenoma Specimen Type left superfacial parotid gland but after surgery I have salivary leakage probl?

Fistula: It sounds like you have a salivary fistula which is a rare complication of partial parotidectomy. Usually will close spontaneously in a few weeks and very rarely persists for months or chronically. However, since you are "fresh post-op"only a few days after surgery, PLEASE call the surgeon and make sure s/he sees you. Get well soon ...Read more

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Small pleomorphic adenoma (<2cm) on postero inferior part of superficial parotid gland. Traditional incision needed? Anyone do micro parotidectomy in ct?

Small pleomorphic adenoma (<2cm) on postero inferior part of superficial parotid gland. Traditional incision needed? Anyone do micro parotidectomy in ct?

Traditional incision: Pleomorphic adenoma of the superficial lobe of parotid requires removal of the superficial lobe. This operation is not performed on the lobe per se but on identifying the facial nerve and its branches and lifting the lobe off the nerve. The incision is designed to give landmarks that define the trunk of the nerve as it comes out of the stylomastoid foramen. Procedure this way is under 1 hr. ...Read more

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What is the definition or description of: pleomorphic?

What is the definition or description of: pleomorphic?

Many shapes: We use the term pleomorphic often in pathology; it literally means "many shapes". Pleomorphic cells in a tumor may tell of the genetic instability that's central to cancer, but the benign pleomorphic adenoma of the salivary glands merely has many different tissue types. The context gives the meaning. ...Read more

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What are pleomorphic bacteria, and are they dangerous to humans?

What are pleomorphic bacteria, and are they dangerous to humans?

Change shape: Pleomorphic bacteria are ones that don't always exist in a single, set shape. Their level of danger depends on what they are and their virulence; there is nothing about being pleomorphic itself that makes them dangerous. ...Read more

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What is pleomorphic rhabdo sarcoma?

What is pleomorphic rhabdo sarcoma?

Cancer, usually kids: Pleomorphic rhabdomyosarcoma is a rare cancer that occurs primarily in kids and rarely in adults. Chemotherapy is given to all patients followed by surgery and/or radiation, depending on the specific case. If caught before it spreads, it can often be cured. ...Read more

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What kind of cancer is a pleomorphic xanthoastrocytoma?

What kind of cancer is a pleomorphic xanthoastrocytoma?

Generally Benign: This is a neoplasm of the brain that generally affects children and teenagers. They are considered generally benign and are classified as grade 2 astrocytomas. They develop from astrocytes which are cells of our brains. They are usually slow growing and often present with sudden onset of seizures due to pressure in the brain. Very rarely do these tumors undergo malignant transformation. ...Read more

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My diag mammo stated presence of a small tightly grouped microcalcifications slightly pleomorphic and represent interval how serious? Going to see BS

My diag mammo stated presence of a small tightly grouped microcalcifications slightly pleomorphic and represent interval how serious? Going to see BS

Mammography: Hi, Pleomorphic Microcalcifications on mammogram are concerning and deserve further evaluation including Ultrasound/MRI and biopsy. Please talk to your surgeon.
Good luck. ...Read more

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My mammogram shows clustered pleomorphic calcification should I be worried?

My mammogram shows clustered pleomorphic calcification should I be worried?

Be concerned!: By your description a biopsy would be indicated. This can be performed with ultrasound guidance if there are findings by u/s in the region, or if not, with stereotactic guidance. These can easily be performed by a radiologist skilled in these procedures, or by a breast surgeon. This should be done as soon as possible. ...Read more

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Suspicious clusters of pleomorphic calcifications found on one breast only during mammogram?

Suspicious clusters of pleomorphic calcifications found on one breast only during mammogram?

Needs biopsy: Suspicious cluster opleomorphic microcalcifications on mgram may be due to breast cancer. Therefore you need to undergo a biopsy. Usually they sggest a stereotactic biopsy which is a type od percutaneous needle biopsy n a special x-ray table. Please follow with a breast carer specialist or a radiologist experien in this procedure. ...Read more

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Had mgram which showed pleomorphic calcs in r breast. Have biopsy in monday. What is rate of cancer assoc with this type? Can they be benign too?

Had mgram which showed pleomorphic calcs in r breast. Have biopsy in monday. What is rate of cancer assoc with this type? Can they be benign too?

Probably benign: There's about a 12% risk these will prove to be malignant. That leaves an 88% chance of benignancy. Good luck with the biopsy - I hope you get good results. ...Read more

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Internet info states that if breast calc are defined pleomorphic that risk of being malignant goes way up to 1 in 4. Is this true? Have biopsy mon

Internet info states that if breast calc are defined pleomorphic that risk of being malignant goes way up to 1 in 4. Is this true? Have biopsy mon

Relax: Relax until you get your results. Then, have the doctor explain until you understand - or have a close person along to also get the info. Before results there is nothing you can do - so try to stay calm. Afterwards ask for a referral to a supportive therapist to help you through the treatment choices. It can make a big difference in your outcome and adjustment. I hope it goes well for you. ...Read more

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Is there any connection between a swollen lymph node in the breast and clustered pleomorphic microcalcifications?

Is there any connection between a swollen lymph node in the breast and clustered pleomorphic microcalcifications?

Breast calcification: There may or may not be a connection. Microcalcifications can be present in both benign and malignant breast conditions. I'd consult with a breast surgeon to see if biopsies should be obtained now or would watchful waiting be reasonable. ...Read more

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Mammogram with punctate pleomorphic calcifications. Is that breast cancer?

Mammogram with punctate pleomorphic calcifications. Is that breast cancer?

Needs investigation: Although breast calcifications may not necessarily mean cancer, pleomorphic calcifications are suspicious. A biopsy should be done. Talk to your doctor. Pleomorphism means that something is of varying shape and characteristics. A non-cancerous or benign calcification will be read as "benign-appearing". Don't delay your biopsy. ...Read more

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Can pituitary adenoma be caused by stress?

Can pituitary adenoma be caused by stress?

No: They are not caused by stress. They are benign tumors of unknown cause. ...Read more

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Does pituitary adenoma causes irritaion and angryness? Does it leads to death?

Generally benign: These are ggenerally benign lesions; however can cause over- secredtion of certain brain chemicals, have your physician check, since it is possible that it can cause mood changes. ...Read more

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Can pituitary adenoma cause forgetfulness?

Can pituitary adenoma cause forgetfulness?

No: Memory loss is not a symptom of a pituitary adenoma. Even if a pituitary adenoma was causing abnormal production of certain hormones from the pituitary gland, memory loss would not result. ...Read more

Dr. Murthy Andavolu
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Adenoma (Definition)

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