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Doctor insights on: Causes Of Plasma Cell Leukemia

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How bad is the prognosis for plasma cell leukemia?

How bad is the prognosis for plasma cell leukemia?

Bad but there's hope: Plasma cell leukemia is a very aggressive cancer of marrow plasma cells with survival sometimes measured in months. Newer drugs however along with stem cell transplant appear promising to improve the prognosis. See Expert Rev Hemtol 2010 Oct 3,p543 ...Read more

Dr. Liawaty Ho
1,118 doctors shared insights

Leukemia (Definition)

Leukemia is a malignant hematologic neoplasm that originates in the bone marrow and represents a clonal proliferation of hematopoietic elements belonging to any of the myeloid, lymphoid, erythroid, and megakaryocytic lineages. Of note, other hematologic neoplasms like lymphoma or myeloma may demonstrate a leukemic phase without actually originating in the bone marrow ...Read more


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Ibrutinib: do you know if this drug works with plasma cell leukemia?

Ibrutinib: do you know if this drug works with plasma cell leukemia?

I am not aware: of data using Ibrutinib to treat plasma cell leukemia. It is being used to treat chronic lymphocytic leukemia which is a different disease ...Read more

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Dear dr's. I have been recently diagnosed with plasma cell leukemia. I have been advised to have autologus stem cell transplant. Really beneficial?

Dear dr's. 
I have been recently diagnosed with plasma cell leukemia.  I have been advised to have autologus stem cell transplant. Really beneficial?

Yes: This is likely a form of myeloma from your description. This is a more aggressive form of that disease. There are a number of therapies to control this disease. Stem cell therapy is one that is often recommended. ...Read more

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What is the defect in the cell cycle that causes leukemia?

What is the defect in the cell cycle that causes leukemia?

The cell cycle: ...is activated in the immature "blast" cells of acute leukemia. This is not so much a defect, as it is also a normal attribute of immature blood cells. A major problem is the lack of maturation of these cells into normal non-dividing blood cells. Various transcription factors are mutated and these may cause increased proliferation. CLL is characterized by decreased apoptosis (cell death). ...Read more

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Does high white cell count 15.4 and headaches on and off for 6 weeks always indicate leukemia? Or could there still be other causes?

Does high white cell count 15.4 and headaches on and off for 6 weeks always indicate leukemia? Or could there still be other causes?

Absolutely not: You can raise your white count to 20,000 by spending a half hour swimming in cold water. If the cells are normally formed, and the rest of your blood count is reasonable, look around for some other cause; you may not find one. Look for a cause of headaches as well -- it may be as simple as needing new eyeglasses. Good luck. ...Read more

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Question about leukemia. Do any viruses infect white blood cells and cause leukemia?

Question about leukemia.  Do any viruses infect white blood cells and cause leukemia?

Virus and cancers: There are a lot of different viruses known. Only a few of them linked to devlopment of cancer such as hpv to cervical cancer/head and neck cancer, ebv to hodgkin's lymphoma, nasopharyngeal ca; HIV to kaposi sarcoma, etc. Yes, htlv-1 virus is related to adult t cell leukemia/lymphoma, ebv is also associated with burkitt's lymphoma- which can transform into more severe case- burkitt's leukemia. ...Read more

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What makes leukemia cells different from regular cells?

They are cancerous: Leukemia is a Cancer of the blood cells. So this scells grow in an uncontrolled fashion and over power normal cells. Unless their growth is checked with chemotherapy, this disease can be fatal. ...Read more

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What are the chances of surviving hairy cell leukemia?

What are the chances of surviving hairy cell leukemia?

Over 90%!: If I had to pick a leukemia to have, this would be the one. Most patients go into remission permanently with their first cycle of a drug called cladribine. Patients who don't usually respond to a second cycle of treatment with the same drug, or to removal of their spleen. It's a curable leukemia! It's named for the hairy projections on the cells. ...Read more

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Plasma Cell (Definition)

A plasma cell is a special white cell typically found in the bone marrow which is responsible for making antibodies. When it becomes cancerous, it causes a condition ...Read more


Plasma (Definition)

It is the fluid portion of both the blood and lymph system in which the ...Read more