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Doctor insights on: Causes Of Plasma Cell Leukemia

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How bad is the prognosis for plasma cell leukemia?

How bad is the prognosis for plasma cell leukemia?

Bad but there's hope: Plasma cell leukemia is a very aggressive cancer of marrow plasma cells with survival sometimes measured in months. Newer drugs however along with stem cell transplant appear promising to improve the prognosis. See Expert Rev Hemtol 2010 Oct 3, p543 ...Read more

Dr. Liawaty Ho
1,149 Doctors shared insights

Leukemia (Definition)

A malignant hematologic neoplasm that originates in the bone marrow and represents a clonal proliferation of hematopoietic elements belonging to any of the myeloid, lymphoid, erythroid, and megakaryocytic lineages. Of note, other hematologic neoplasms like lymphoma or myeloma may demonstrate a leukemic phase without actually originating in the bone marrow ...Read more


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Ibrutinib: do you know if this drug works with plasma cell leukemia?

Ibrutinib: do you know if this drug works with plasma cell leukemia?

I am not aware: Of data using Ibrutinib to treat plasma cell leukemia. It is being used to treat chronic lymphocytic leukemia which is a different disease ...Read more

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Dear dr's. I have been recently diagnosed with plasma cell leukemia. I have been advised to have autologus stem cell transplant. Really beneficial?

Dear dr's. I have been recently diagnosed with plasma cell leukemia. I have been advised to have autologus stem cell transplant. Really beneficial?

Yes: This is likely a form of myeloma from your description. This is a more aggressive form of that disease.
There are a number of therapies to control this disease. Stem cell therapy is one that is often recommended. ...Read more

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What is the defect in the cell cycle that causes leukemia?

What is the defect in the cell cycle that causes leukemia?

The cell cycle: ...is activated in the immature "blast" cells of acute leukemia. This is not so much a defect, as it is also a normal attribute of immature blood cells. A major problem is the lack of maturation of these cells into normal non-dividing blood cells. Various transcription factors are mutated and these may cause increased proliferation. CLL is characterized by decreased apoptosis (cell death). ...Read more

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Does high white cell count 15.4 and headaches on and off for 6 weeks always indicate leukemia? Or could there still be other causes?

Does high white cell count 15.4 and headaches on and off for 6 weeks always indicate leukemia? Or could there still be other causes?

Absolutely not: You can raise your white count to 20, 000 by spending a half hour swimming in cold water. If the cells are normally formed, and the rest of your blood count is reasonable, look around for some other cause; you may not find one. Look for a cause of headaches as well -- it may be as simple as needing new eyeglasses. Good luck. ...Read more

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Question about leukemia. Do any viruses infect white blood cells and cause leukemia?

Question about leukemia. Do any viruses infect white blood cells and cause leukemia?

Virus and cancers: There are a lot of different viruses known. Only a few of them linked to devlopment of cancer such as hpv to cervical cancer/head and neck cancer, ebv to hodgkin's lymphoma, nasopharyngeal ca; HIV to kaposi sarcoma, etc. Yes, htlv-1 virus is related to adult t cell leukemia/lymphoma, ebv is also associated with burkitt's lymphoma- which can transform into more severe case- burkitt's leukemia. ...Read more

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What makes leukemia cells different from regular cells?

They are cancerous: Leukemia is a Cancer of the blood cells. So this scells grow in an uncontrolled fashion and over power normal cells. Unless their growth is checked with chemotherapy, this disease can be fatal. ...Read more

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What are the chances of surviving hairy cell leukemia?

What are the chances of surviving hairy cell leukemia?

Over 90%!: If I had to pick a leukemia to have, this would be the one. Most patients go into remission permanently with their first cycle of a drug called cladribine. Patients who don't usually respond to a second cycle of treatment with the same drug, or to removal of their spleen. It's a curable leukemia! It's named for the hairy projections on the cells. ...Read more

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What is the count of platlets and white cells that should make me suspect leukemia?

What is the count of platlets and white cells that should make me suspect leukemia?

Let me answer this b: Leukemia is a cancer of the white blood cells...Platelets may or may not go down as a result of acute leukemia. Your need to have a CBC and differential count. In cases of leukemia white cell count can be low, normal or high but it is the immature white cells in the blood which are indicators of acute leukemia. The final diagnosis requires bone marrow examination to check if there is leukemia or. ...Read more

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Could you please give me a way to give myself leukemia, or lymphoma? I'm willing to purchase cells or other necessities. Thank you.

Could you please give me a way to give myself leukemia, or lymphoma? I'm willing to purchase cells or other necessities. Thank you.

Will not do it!: The first principle in medicine is, "First do no harm". None of us would intentionally harm a patient. Giving some one a disease is against all the moral, ethical and common sense practices in medicine.
May I urge that you consult a psychiatrist to ascertain why do you want to harm yourself.
May God bless you with good health, happiness and prosperity! ...Read more

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Is hairy cell leukemia hereditary?

Is hairy cell leukemia hereditary?

No: Leukemia is generally not hereditary but having a first degree relative with leukemia may slightly increase your risk. ...Read more

Dr. Liawaty Ho Dr. Ho
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What are the tests for hairy cell leukemia?

Dr. Liawaty Ho Dr. Ho
1 doctor agreed:
What are the tests for hairy cell leukemia?

Hcl diagnosis: Clinical history and examination as well as simple blood work will reveal evidence of pancytopenia (low white blood cell, red blood and platelet level) and enlargement of spleen and symptoms associated with above. This information is important. Ultimately, a bone marrow biopsy is essential to be done to diagnose hairy cell leukemia. Discuss further with
your oncologist. ...Read more

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What are the symptoms of hairy cell leukemia?

What are the symptoms of hairy cell leukemia?

Fatigue: Hairy cell leukemia is a very rare disorder. It is diagnosed, usually, when a person presents with severe fatigue, and anemia is detected. A large spleen is often detected on examination. ...Read more

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What is the treatment for hairy cell leukemia?

Hairy cell: Treatment options for hairy cell leukemia will include : purine analogs such as cladribine or pentostatin - these two are very effective therapy for hcl. Interferon alpha, splenectomy are also used in certain cases. In refractory/relapse disease, in addition to cladribine/pentostatin, anti cd 20, anti cd 22 and anti cd 25 also are available. Discuss in detail with your oncologist. ...Read more

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Can children get hairy cell leukemia?

Can children get hairy cell leukemia?

Not in kids: Hairy cell leukemia is not a disease in children. It is a very rare disease in adults-only 600-800 cases/ year in usa- and the median age is 52 year-old. ...Read more

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Can you tell me anything about hairy cell leukemia?

Hope this helps.: Hcl is caused by the abnormal growth of b cells. The cells look "hairy" under the microscope because they have fine projections coming from their surface.

Hcl usually leads to low numbers of normal blood cells.

The cause of this disease is unknown. It affects men more often than women. The average age of diagnosis is 55. ...Read more

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What is the definition or description of: Hairy cell leukemia?

What is the definition or description of: Hairy cell leukemia?

See below: Please consult this site: https://www. Mayoclinic. Org/diseases-conditions/hairy-cell-leukemia/basics/definition/CON-20026432
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex, if you have sex. ...Read more

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Define differential diagnosis of prolymphocytic leukemia or mantle cell leukemia.

Define differential diagnosis of prolymphocytic leukemia or mantle cell leukemia.

They are too differe: There should be no confusion between these two entities. One is a lymphoma (nodal disease) the other one is a blood cancer that should not affect the lymph nodes. Rather easy diagnosis if you are seeing the right type of specialist! ...Read more

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What happens to your red blood cells during leukemia?

What happens to your red blood cells during leukemia?

Anemia is common.: Both during the diagnosis and during treatment, anemia is common. Leukemia and the treatments cause red blood cells not to be produced normally, which causes anemia. This often requires transfusions. ...Read more

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What are the usual and not so usual signs of relapsed Hairy Cell Leukemia? Can a person not lose weight and still be relapsing?

What are the usual and not so usual signs of relapsed Hairy Cell Leukemia? Can a person not lose weight and still be relapsing?

Yes but unspecific: If one had remission from chemotx or other modalities, hairy cell leukemia recurs a number of ways. This is one chronic B cell leukemia that affects blood, marrow, spleen and hence relapse may manifests as tummy fullness if spleen still present, weakness fatigue, infection symptoms like fever and chills, easy bruising if all blood elements depressed by leukemia. Considerflow c. tests in blood, call PMD, ...Read more

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Is cladribine a good medication for hairy cell leukemia?

Yes it is: Yes, it is. There are other medications besides cladribine that are also used for hairy cell leukemia. Discuss further with your oncologist. ...Read more

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Could you tell me what happens to red blood cells during leukemia?

Could you tell me what happens to red blood cells during leukemia?

In leukemia: The bad cells "crowd out" the healthy cells, including those that produce red blood cells. Many leukemia patients develop severe anemia, and this worsens when the treatment includes strong chemotherapy. ...Read more

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What are mv4-11 cells of acute myeloid leukemia? What does this mean?

MV-4-11: ...this is the name of a leukemia cell line used by cancer researchers. They originally came from a 10 year old boy with acute leukemia and they have the convenient property of being able to grow endlessly in a lab cell culture dish. Cancer researchers might use them for various purposes, such as testing new drugs, before trying them in people. ...Read more

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What are the most promising treatments for t-cell prolymphocytic leukemia?

Campath (alemtuzumab): T-cell pll is considered a relatively chemotherapy resistant disease. Although treatments with chop, cop, fludarabine, etc are used they usually do not result in long term control of the disease. More recently Campath (alemtuzumab) has been used with increased success. Lastly, bone marrow transplant once in remission is being looked at as a possible consolidation therapy with some promise. ...Read more

Plasma Cell (Definition)

A plasma cell is a special white cell typically found in the bone marrow which is responsible for making antibodies. When it becomes cancerous, it causes a condition ...Read more


Plasma (Definition)

It is the fluid portion of both the blood and lymph system in which the ...Read more