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Doctor insights on: Causes Of Plasma Cell Dyscrasia

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Panicking skin biopsy cd3 failed to reveal significant t cell dyscrasia. Do I have the start of lymphoma?

Panicking skin biopsy cd3 failed to reveal significant t cell dyscrasia.  Do I have the start of lymphoma?

Can you clarify?: You list varying ANA results, one set of low compliment results, fatty liver, hysteroscopy and biopsy negative for cancer, and a skin biopsy that some pathologist stained up with cd3 for some reason and didn't find lymphoma. Lymphoma announces itself as an obvious mass or obvious symptoms. Why in the world are you panicking? Is this a communication failure with your physician? ...Read more

Plasma Cell (Definition)

A plasma cell is a special white cell typically found in the bone marrow which is responsible for making antibodies. When it becomes cancerous, it causes a condition ...Read more


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Is thrombocytopenia purpura as the same as blood dyscrasia?

Is thrombocytopenia purpura as the same as blood dyscrasia?

Different: Thrombocytopenic purpura (ttp) is an acute condition involving destruction of blood components including red cells and platelets and can be life threatening. Blood dyscrasia is a general term referring to a chronic or inherited blood compnent disorder such as hemophilia, leukemia, thalassemia, etc. ...Read more

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Could IgG subclass deficiencies be caused by plasma b cell diseases/disorders?

Could IgG subclass deficiencies be caused by plasma b cell diseases/disorders?

Yes: It is possible to have malfunction of immunoglobulins or low levels in b cell disorders. A subclass deficiency by itself is usually not clinically significant and does not warrant treatment but if an underlying b cell disorder exists, it should be remedied. ...Read more

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What happens to the plasma membrane of the red blood cells of humans with liver disease to cause the formation of acanthocytes? Thank you.

What happens to the plasma membrane of the red blood cells of humans with liver disease to cause the formation of acanthocytes? Thank you.

Change in lipids: The liver is responsible for general metabolism in the body, and the plasma membrane has a complex collection of lipids that are responsible for its "fluidity" and shape. It is believed that the apolipoproteins are abnormal in liver disease and cause fragility of the rbc membrane causing fragmentation and formation of acanthocytes. See also: http://en.Wikipedia.Org/wiki/acanthocyte. ...Read more

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What types of treatment exist for multiple myeloma and other plasma cell cancer types?

What types of treatment exist for multiple myeloma and other plasma cell cancer types?

"Many": Myeloma and other plasma cell dyscrasia treatments has evolved from standard cytotoxic approaches (eg mp, vad, hypercvad) to "novel" therapies. Immunomodulatory drugs (imids) - eg thalidomide, lenalolidomide, pomalidomide proteasome inhibitors - eg, bortezomib, carfilzomib, etc other: hsp90 inhibitors, hdaci, b-raf, etc. Over the last few years multiple new drugs have been approved for myeloma. ...Read more

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What is the definition or description of: plasma cell?

What is the definition or description of: plasma cell?

Plasma cell: A plasma cell is a special white cell typically found in the bone marrow which is responsible for making antibodies. When it becomes cancerous, it causes a condition known as multiple myeloma. ...Read more

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How bad is the prognosis for plasma cell leukemia?

How bad is the prognosis for plasma cell leukemia?

Bad but there's hope: Plasma cell leukemia is a very aggressive cancer of marrow plasma cells with survival sometimes measured in months. Newer drugs however along with stem cell transplant appear promising to improve the prognosis. See Expert Rev Hemtol 2010 Oct 3,p543 ...Read more

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Is plasma cell myeloma hereditary?

Is plasma cell myeloma hereditary?

Majority Not: Majority of myeloma cases is not hereditary. A small but unknown fraction of cases are familial. The risk of developing myeloma is approximately 3.7-fold higher for persons with a first degree relative with myeloma. ...Read more

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Ibrutinib: do you know if this drug works with plasma cell leukemia?

I am not aware: of data using Ibrutinib to treat plasma cell leukemia. It is being used to treat chronic lymphocytic leukemia which is a different disease ...Read more

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Plasma (Definition)

It is the fluid portion of both the blood and lymph system in which the ...Read more