Doctor insights on:
Causes Of Pernicious Anemia
Autoimmune disease: Pernicious anemia is an autoimmune disease producing autoantibodies against intrinsic factor found in the lining of the stomach. This leads to lack of absorption of vitamin B12 which is important in making blood cells and for nourishment of the nervous system. Treatment would be by replacement of B12 via injections or absorption into the body by other means (nasal spray). ...Read more
Many: There are many causes for anemia (RBC), just list a few: 1) decreased production due to not enough nutrition, B12/folate/iron def, or bone marrow diseases or bone marrow suppression from drugs/radiations or due to chronic kidney disease (not enough epoietin); 2) increased destruction: intravascular or extravascular hemolysis; 3) blood loss or chronic disease/cancer or some congenital diseases. ...Read more
Iron deficiency: There are many types of anemia caused by many types of disorders. Red blood cells require iron in order to develop properly. Without iron, we do not produce adequate numbers of cells which results in anemia. Iron deficiency needs to be explained always and requires an examination and further testing. Simply replacing iron without an investigation and or examination can result in missed diseases. ...Read moreSee 1 more doctor answer
Hemolytic anemia: Anemia can be due to many factors and to even begin to know, clues are found on the size(normo, macro, micro) and coloration (hypo(pale color), normochromic(normal red color). When red cells lack a normal center, as in spherical forms, " hyperchromic" is used loosely, though the correct term may be spherocytes. Hemolytic anemia, with many causes, lead to normochromic "hyperchromic"anemia. ...Read more
Anisocytosis, having: Red blood cells (rbc's) of different sizes, can be caused by iron deficiency & sickle cell anemias, folate (folic acid) or vitamin B12 deficiency, autoimmune hemolytic anemia, cytotoxic chemotherapy, chronic liver disease, myelodysplastic syndrome, thalassemia major, & thalassemia intermedia. The unequal-sized rbc's are small in some of these disorders & large in others. ...Read moreSee 1 more doctor answer
Not usually: Microcytic anemia is usually due to iron deficiency, rather than hypothyroidism. If associated with hypothyroidism, anemia is usually macrocytic (often secondary to pernicious anemia). Either way, an anemia deserves a thorough workup with your medical doctor, and treatment of your hypothyroidism. Best wishes! ...Read moreSee 1 more doctor answer
Pernicious = Vit B12: Megaloblastic anemia refers to any condition which causes large red blood cells (folate (folic acid) deficiency, vitamin B12 deficiency, etc.) pernicious anemia can be thought of as a *type* of megaloblastic anemia which is caused by vitamin B12 deficiency secondary to malabsorption. ...Read moreSee 1 more doctor answer
Cell maturation: B12 and folic acid are need for DNA synthesis and maturation of all cells. The cells affected are not only red cells, white cell, and platelets but almost all cells in the body, including brain and spinal cord cells. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, low fat milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. Get HPV vaccine. ...Read more
Early IDA possible: Hypochromic suggests low iron (which can be measured by ferritin, transferrin, etc). Usually this would be from blood loss. Usually iron deficiency anemia (ida) is also assoc w/ microcytic (low mcv) red blood cells (rbcs). It depends on the numbers, other tests & history, but could be early iron deficiency/blood loss &/or more than one process -- eg b12/folate deficiency & ida. See md. ...Read more
No: Unaware of any association. True pernicious anemia is an autoimmune disease, caused by antibodies to the cells in our stomachs that produce intrinsic factor, which is needed to absorb vitamin B12 from our intestines. It may be hereditary or acquired. There are other causes of B12 deficiency, including stomach and intestinal diseases/surgery, and lack of B12 in diet. A hematologist can help. ...Read moreSee 1 more doctor answer
No: Bit both should be worked up.Get a more detailed answer ›
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