Doctor insights on:
Causes Of Pernicious Anemia
Autoimmune disease: Pernicious anemia is an autoimmune disease producing autoantibodies against intrinsic factor found in the lining of the stomach. This leads to lack of absorption of vitamin B12 which is important in making blood cells and for nourishment of the nervous system. Treatment would be by replacement of B12 via injections or absorption into the body by other means (nasal spray). ...Read more
It is a decline in the amount of red cells in the circulation as a result of impaired production in the bone marrow resulting from a lack of vitamin b12. This is most commonly as a consequence of impaired absorption due to an autoimmune condition affecting the stomach lining. If untreated, it may also lead to brain and spinal cord problems. It is easily ...Read more
No: Unaware of any association. True pernicious anemia is an autoimmune disease, caused by antibodies to the cells in our stomachs that produce intrinsic factor, which is needed to absorb vitamin B12 from our intestines. It may be hereditary or acquired. There are other causes of B12 deficiency, including stomach and intestinal diseases/surgery, and lack of B12 in diet. A hematologist can help. ...Read moreSee 1 more doctor answer
Not likely: Methadone is a very strong opioid medication, with a long list of serious side effects. But pernicious anemia is NOT one of them. Contact your doctor for specific information about your case, re your anemia and specific doses of methadone you are taking. Anemia may be related to other meds you are taking, or an underlying illness. Check with your MD. ...Read more
Can 7yrs of undiagnosed coeliacs cause pernicious anemia, irreversible villi damage and miscarriages?
Gi issues: This is a question best answered by a gastro intestinal specialist , i would seek a consult to find this answer. ...Read more
The two are linked: This finding goes back to 1964, believe it or not: http://www.Ncbi.Nlm.Nih.Gov/pmc/articles/pmc1552204/?Page=1 there are autoimmune antibodies in both conditions, so while one might not cause the other, the two are related. ...Read more
Low vitamin B12: Pernicious anemia is a condition in which the body is unable to absorb vitamin B12 through the stomach due to loss of a protein called intrinsic factor in the stomach. Treatment invovles replacing b!2 through injections or nasal sprays- taking oral pills is ineffective. ...Read more
Pernicious anemia...: Is due to B12 def arising from loss of intrinsic factor production by parietal cells in the stomach and required for B12 absorption in the gut. Anything that produces B12 def can cause these symptoms. Classically, pa is one such diagnosis that is due to destruction of parietal cells by the immune system (ie., an autoimmune disorder). I suspect elevated igg is true, true and unrelated. See your dr. ...Read more
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