Doctor insights on:
Causes Of Paraproteinemia
Excess of Plasma cel: Plasma cells in our bone marrow make antibodies. Sometimes they become overly active/reactive and produce abnormal proteins called paraproteins. Most such protein production is benign and not uncommon in older folks. Sometimes it is excessive(more than 1gram/day) then we get concerned about a condition called multiple myeloma (paraproteins over 3 grams). ...Read more
My 81 yr old father is diagnosed with monoclon paraproteinemia, what does that mean and what are the causes?
Varied: We have 3 entities which cause paraprotein production. The most benign is called MGUS which is often benign and the other two are Smoldering Myeloma and the most serious is called Multiple myeloma. You need to have your doctor explalin which of these conditions he/she thinks is causing this paraproteinemia. ...Read more
Different causes: Malignant paraproteinemia is a harmful presence of a single kind of antibody, made by a known malignancy such as lymphoma or myeloma. Benign paraproteinemia is a harmful presence of a single kind of antibody in someone who has no such malignancy. It is presumably due to a benign clonal expansion of one type of lymphocyte. ...Read more
Abnormal Proteins/My: Paraproteins are abnormal proteins which are often produced by Cancer cells unless proven otherwise. So it requires detailed testing looking for cancerous cell called Plasma cells in the bone marrow. There is one variant which may behave beningnly and is called monoclonal gammopathy of undetermined significance(MGUS). But some of the patients with MGUS do develop multiple myeloma,causing paraprot ...Read more
Is there a cure medication to completely remove eradicate paraproteinemia from my blood stream its at 1.5 level im told.or is it incurable ?
Hematologist: You need to consult a hematologist/oncologist for treatment. There are effective treatments using chemotherapy and the using person's own stem cells to correct the defect. Consult this site for info. http://www.mayoclinic.org/diseases-conditions/multiple-myeloma/basics/definition/con-20026607 ...Read more
Serum -tiny IgM kappa monoclonal protein b2 region, urine - tiny IgM k paraproteinemia in gamma region. Was a mistake made or is lab normal?
Monoclonal: •multiple myeloma (g>a>m>e, d) •primary macroglobulinemia (waldenstrøm’s, igm) •monoclonal gammopathy of undetermined significance (mgus) (converts at 2% per year to myeloma) •miscellaneous conditions •(converts at 2% per year to myeloma) these all have to be thought of by the hematologist. ...Read more
None, but...: The presence of a monoclonal (para)protein in the blood (on spep) or urine (on upep) with or without an abnormal free light chain (flc) k/l ratio is a laboratory finding. This may be mgus (monoclonal gammopathy of unknown significance), myeloma, lymphoma, cll, etc. A few classic symptoms of myeloma are crab -- hypercalcemia, renal insufficiency, anemia, bone (lytic) lesions. Other sx possible... ...Read more
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