Doctor insights on:
Causes Of Necrosis
Many concerns: Necrosis is "death" or destruction of a nerve, and this sometimes is necessitated to alleviate pain, by an alcohol injection. If a nerve is cut or transected, or if a nerve cell body dies (apoptosis), from a variety of inflammatory or degenerative causes, recovery is not possible. So, nerve death can occur both in central and peripheral nervous systems. Timely treatment is always best. ...Read more
What is it about cold injury that kills the organs? Could I ng term exposure cause organ necrosis and kill the victim?
GivinTheColdShoulder: Your question is a bit vague. But generally, if tissue is actually frozen (frostbite), water crystals form inside the cells and that messes-up the works. When thawed, the tissue is mush. If you are talking about hypothermia, the colder you get the slower your metabolism to the point that the lack of energy formation overcomes the overall slowness of the metabolic processes and then the cells die. ...Read more
Yes: This is a known complication of taking steroids, especially if you had to take prolonged courses during your chemo regimen (for acute lymphoblastic leukemia, for example). Depending on the location and extent, treatment ranges from physical therapy and waiting, to some orthopedic surgery procedures. If you are still on steroids, you and your oncologist will have the risk/benefit ratio of stopping. ...Read more
Possibly but others: Although avascular necrosis can be related to corticosteroids it is important to know that there are other causes of avascular necrosis. There is a decrease in blood flow to the area involved. Although corticosteroids can be associated, it depends on dose and time and thus chemo steroids are less likely to be associated. Other causes: alcohol, joint injury and increased pressure ...Read moreSee 1 more doctor answer
Why is the " corticosteroid administration " can cause " avascular necrosis" ?
* i need the mechanism how does the " corticosteroid" work.
Not Known: While it is generally agreed that the key problem in avn is compromised blood flow to the bone, the mechanism by which corticosteroid use contributes to avn is not known. It is important to remember that this is a rare and not a common problem in corticosteroid users. ...Read more
Still unknown: Even though there is this very well-established connection between chronic Prednisone use and avascular necrosis, how this occurs remains unclear. Numerous hypotheses abound. Some argue that increased lipids seen with steroids cause vessels to joints to clog, leading to oxygen starvation & bone death. A more popular view is that vessel (venous) walls undergo thickening, leading to poor blood flow. ...Read more
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