Doctor insights on:
Causes Of Necrosis
Many concerns: Necrosis is "death" or destruction of a nerve, and this sometimes is necessitated to alleviate pain, by an alcohol injection. If a nerve is cut or transected, or if a nerve cell body dies (apoptosis), from a variety of inflammatory or degenerative causes, recovery is not possible. So, nerve death can occur both in central and peripheral nervous systems. Timely treatment is always best. ...Read more
What is it about cold injury that kills the organs? Could I ng term exposure cause organ necrosis and kill the victim?
GivinTheColdShoulder: Your question is a bit vague. But generally, if tissue is actually frozen (frostbite), water crystals form inside the cells and that messes-up the works. When thawed, the tissue is mush. If you are talking about hypothermia, the colder you get the slower your metabolism to the point that the lack of energy formation overcomes the overall slowness of the metabolic processes and then the cells die. ...Read more
Yes: This is a known complication of taking steroids, especially if you had to take prolonged courses during your chemo regimen (for acute lymphoblastic leukemia, for example). Depending on the location and extent, treatment ranges from physical therapy and waiting, to some orthopedic surgery procedures. If you are still on steroids, you and your oncologist will have the risk/benefit ratio of stopping. ...Read more
No specific level: Fat necrosis can occur when blood lipase is high due to pancreatisis. The the lesion may be intra-abdominal and occasionally in the fat elsewhere in the body. Fat necrosis can occur with normal lipase levels due to trauma to fat tissue. In diabetics, fat necrosis can occur without trauma and without elevated lipase. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more
Possibly but others: Although avascular necrosis can be related to corticosteroids it is important to know that there are other causes of avascular necrosis. There is a decrease in blood flow to the area involved. Although corticosteroids can be associated, it depends on dose and time and thus chemo steroids are less likely to be associated. Other causes: alcohol, joint injury and increased pressure ...Read moreSee 1 more doctor answer
Why is the " corticosteroid administration " can cause " avascular necrosis" ?
* i need the mechanism how does the " corticosteroid" work.
Not Known: While it is generally agreed that the key problem in avn is compromised blood flow to the bone, the mechanism by which corticosteroid use contributes to avn is not known. It is important to remember that this is a rare and not a common problem in corticosteroid users. ...Read more
Still unknown: Even though there is this very well-established connection between chronic Prednisone use and avascular necrosis, how this occurs remains unclear. Numerous hypotheses abound. Some argue that increased lipids seen with steroids cause vessels to joints to clog, leading to oxygen starvation & bone death. A more popular view is that vessel (venous) walls undergo thickening, leading to poor blood flow. ...Read more
Does taking weight gaining capsules/tablets continously for two years or so cause avascular necrosis of hips or other joints ? I m having it. Plz say.
Several causes: Whether your medications are contributing depends on what you are taking, and what conditions you are taking them for. Avascular necrosis (avn) can be caused by trauma, by medications such as prednisone, by chronic alcoholism, and by many illnesses such as lupus or sickle cell anemia. Your doctor can help you determine what may have caused the avn. ...Read moreSee 1 more doctor answer
Can constant breast binding cause fatty necrosis? I have binded my whole puberty and now I have a lump on upper breast. I'm female, 16
Wouldn't think so: The common cause of lumps at your age include localized fibro adenomas or generalized fibrocystic changes. I would start with having your doc examine the area. If the exam is inconclusive an ultrasound of the breast usually points to the cause. ...Read moreSee 1 more doctor answer
Does chemotherapy cause avascular necrosis? Does having cancer treatments such as chemo or radiation increase my risk of avascular necrosis?
Perhaps: Certain chemo and radiation can cause avn. Certain cancers and disease can as well. It is best to discuss this with your oncologist or internist. ...Read more
Does chemotherapy cause avascular necrosis? Does having cancer treatments such as chemo or radiation increase my risk of avascular necrosis? .
Possible: Certain therapeutics, although not chemotherapy, that are commonly used in cancer patients can be associated with avascular necrosis (avn). Examples of these agents include: zometa, xgeva (denosumab) and avstin that can be associated with osteonecrosis of the jaw. Dexamethasone and radiation therapy can also cause avn. ...Read moreSee 1 more doctor answer
Can cortisone injections to elbow cause avascular necrosis of elbow? I had 4 injections. Last two to elbow joint
Can brown recluse spider venom cause avascular necrosis of the hip the bite was 5 inches above the knee the hip pain began 1 month after spider bite ?
Not likely!: There are no associated reports of this linkage. Both are not uncommon and coincidently may occur together. Avascular necrosis is a severe form of arthritis of the hip caused by disruption of the blood supply to the cartilage on top of the hip. Ultimately leading to hip replacement. Stop gap procedures are in my opinion, ineffectual. ...Read moreSee 1 more doctor answer